• BMB Reports
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• v.40 no.6
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• pp.979-985
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• 2007

Induction of growth hormone (GH) by Glycyrrhizae Radix (GR), one of the most popular herbal medicine, and its major ingredients were studied in rat pituitary cells in vitro and in vivo assay. The MeOH extract and the n-hexane (HX) fraction of GR induced rat GH (rGH) release up to 1.89 times ($0.34{\pm}0.04 nM$) and 4.59 times ($0.83{\pm}0.03 nM$), compared to the basal level (p < 0.05). Among many ingredients isolated and purified from GR both glycyrrhetinic acid and glycyrrhizin induced significantly rGH release compared to the control (p < 0.05). After an intravenous injection of rat growth hormone releasing hormone (rGHRH) ($10{\mu}g$/kg) as positive control, in SD rats, $T_{max}$ of plasma rGH level was 10 min, $C_{max}$ was $3.84{\pm}0.01 nM$ (n = 3), and enhanced plasma rGH level returned to the baseline in 90 min. Both $AUC_{0-90}$ (area under the curve) of plasma rGH level after HX fraction and that after rGHRH administration were increased significantly from the basal level, respectively (p < 0.01). In conclusions, HX fraction is the most active fraction of MeOH extract of GR in rGH induction.

• The Journal of Pediatrics of Korean Medicine
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• v.28 no.4
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• pp.64-70
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• 2014

Objectives The purpose of this study is to find out how taking oriental herbal medicine may affect the sex hormone levels in a patient who was diagnosed with prematurity. Methods We prescribed 120 cc of oriental herbal medicine twice daily for a month to a patient suspected of the precocious puberty due to 11 pg/ml of the estradiol level. Upon finishing the course of oriental herbal medicine, the patient was retested for the follicular stimulating hormone, luteinizng hormone and estradiol levels. Results After administration, all levels of luteininzing hormone, follicular stimulating hormone and estradiol were decreased. There was no diagnosable evidence for the idiopathic central precocious puberty in the gonadotropin releasing hormone stimulation. Conclusions Oriental herbal medicine is a good alternative treatment of choice for the precocious puberty. However, more in-depth studies are to be followed.

• Korean journal of applied entomology
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• v.31 no.2
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• pp.144-152
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• 1992

The juvenile hormone(JH) titers and juvenile hormone esterase (JHE) activities were mea¬sured in larval homogenates of the chestnut gall waL,J, Dryocosmus kuriphilus Yasumatsu, parasiting a susceptible and two resistant chestnut ( Cheuk-Pa, and Dan- Tak) varieties by GLC, Galleria wax test and Liquid scintilation counter. JH of the chestnut gall wasp was identified as JH- I. Their juvenile hormone titers were 35,800 GU/g(Cheuk-Pa), 30,900 GU/g (Dan-Tak), and 28,600 GU/g(susceptible variety). The juvenile hormone esterase activities were 1.48 n mole/min/ml(Cheuk-Pa), 1.63 n mole/min/ml(Dan- Tak), and 1.89 n mole/mini ml(susceptible variety). JH titer activity of the chestnut gall wasp parasiting resistant varie¬ties were higher than that from susceptible, whereas their JHE activity was higher in those from susceptible variety than those from resitant varieties. JH titer and JH specific esterase activity was inversely proportional.

• Journal of the Korea Convergence Society
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• v.12 no.6
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• pp.39-47
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• 2021

The purpose of this study is to analyze the differences among short statured children with growth hormone deficiency, idiopathic, and normal children in order to find the effect of growth hormone deficiency on tooth developmental stage. We classified children diagnosed with short stature at the Pediatrics in Yeungnam University Hospital as subjects due to idiopathic and growth hormone deficiency. We analyzed the relationship between short stature and tooth development through the measuring of oral panorama and body index. Only the eruption of lateral incisors showed significant difference between short statured with growth hormone deficiency and idiopathic. Almost all tooth eruption was significantly delayed on short statured children with growth hormone deficiency compared to average group. In conclusion, short stature children with either growth hormone deficiency or idiopathic were affected not only in their somatic stature but also dental maturity. We look forward to this study presenting basic data for orthodontic therapy.

• 대한생식의학회:학술대회논문집
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• 2007.11a
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• pp.119-119
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• 2007

• 대한생식의학회:학술대회논문집
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• 2007.11a
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• pp.122-122
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• 2007

• Proceedings of the Zoological Society Korea Conference
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• 1996.10a
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• pp.256.2-256
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• 1996

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 1997.10b
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• pp.191.2-191
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• 1997

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 1999.10b
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• pp.182.2-182
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• 1999

No Abstract, See Full Text

• Bulletin of the Korean Chemical Society
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• v.32 no.11
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• pp.4021-4026
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• 2011

Functions of the luteinizing hormone releasing hormone (LHRH) and its induced release by divalent metal ions have received great attention because this neurotransmitter subsequently regulates the secretion of luteinizing hormone (LH). Metal-LHRH complexes were synthesized by addition of various Cu(II),Ni(II),Zn(II) ions into LHRH in order to understand how the induced release of LHRH is possible. The degree of complexation was monitored by $^1H$, $^{13}C$-NMR chemical shifts, and final products were identified by Mass spectrometry. Solutionstate structure determination of Zn(II)-LHRH out of metal-complexes was accomplished by using NMR and NMR-based distance geometry (DG). Interproton distance information from nuclear Overhauser effect spectroscopy was utilized for structure determination. Structure obtained in this study has a cyclic conformation exhibiting a specific ${\alpha}$-helical turn with residue numbers His[2]-Leu[7] out of 10 amino acids. Comparison of chemical shifts and EPR studies of Ni(II),Cu(II)-LHRH complexes exhibit that these metal complexes have 4-coordination geometry.