• Journal of Pharmaceutical Investigation
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• v.35 no.3
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• pp.143-150
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• 2005

Solid lipid nanoparticles(SLNs) are particulate systems for parenteral drug administration and have good biocompatibility and stability. SLNs were prepared with lauric acid, as the lipid core. Tween 20 and tween 80 were used as surfactant. 5-fluorouracil and l-benzoyl-5-fluorouracil were used as model drugs. Drug-loaded SLNs were prepared by the hot homogenization technique in order to evaluate the physical stability, entrapment efficiency of drugs as well as release profile. The particle size of SLNs was $40{\sim}600$ nm. By increasing speed, the mean particle size of SLNs was decreased. And entrapment efficiency in the case of using 1-Benzoyl-5-fluorouracil was higher than using 5-Fluorouracil. The higher surfactant concentration, the faster release rate at the range of $1.5{\sim}2.5%$.

• Structural Engineering and Mechanics
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• v.66 no.4
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• pp.495-504
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• 2018

The current study is dedicated to study the thermal effects of wave propagation in beams, reinforced by carbon nanotubes (CNT). Beams, made up of carbon nanotube reinforced composite (CNTRC) are the future materials in various high tech industries. Herein a Winkler elastic foundation is assumed in order to make the model more realistic. Mostly, CNTs are pervaded in cross section of beam, in various models. So, it is tried to use four of the most profitable reconstructions. The homogenization of elastic and thermal properties such as density, Yong's module, Poisson's ratio and shear module of CNTRC beam, had been done by the demotic rule of mixture to homogenize, which gives appropriate traits in such settlements. To make this investigation, a perfect one, various shear deformation theories had been utilized to show the applicability of this theories, in contrast to their theoretical face. The reigning equation had been derived by extended Hamilton principle and the culminant equation solved analytically by scattering relations for propagation of wave in solid bodies. Results had been verified by preceding studies. It is anticipated that current results can be applicable in future studies.

• Journal of Ocean Engineering and Technology
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• v.24 no.1
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• pp.153-160
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• 2010

This paper deals with the topology optimized design of the riser support structures for floating production storage and offloading units (FPSOs) under global and local loading conditions. For a preliminary study and validation of the numerical approach, a simplified plate under static loading is first evaluated with the representative topology optimization methods, the Homogenization Design Method (HDM) and Density Method (DM) or Simple Isotropic Material with Penalization (SIMP). In the context of the corresponding riser support structures, the design problem is formulated such that structure shapes based on design domain variables are determined by minimizing the compliance subject to a mass target, considering the stress criterion. An initial design model is generated based on an actual FPSO riser support configuration. The topology optimization results present improved design performances under various loading conditions, while staying within the allowable limit of the offshore area.

• Journal of KIBIM
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• v.7 no.2
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• pp.44-55
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• 2017

Recently, there has been a growing interest in the life cycle management field of buildings through the introduction of BIM. And as BIM application is expanded, BIM ordering guidelines and guidelines are becoming popular. Also, as diverse forms of buildings including super high-rise building have been generalized, attention to the importance of curtain walls that are advantageous for construction period shortening, building lighting and quality homogenization has been increasing. However, all BIM information from the design stage to the maintenance stage is not accumulated in stages. And the input information is not improved in proportion to the level of appearance of the BIM model. Also, current curtain wall designs rely heavily on curtain wall consulting firms or utilize accumulated data from existing processes. In this study, curtain wall components, shape and property information were derived by analyzing BIM guidelines and curtain wall construction standards to contribute to solving these problems. And the curtain wall smart BIM library which can be converted according to LOD(Level of Development) has been produced and its applicability has been verified. Through the library, curtain wall information can be systematically managed in the library from design to construction and maintenance. And the library will contribute to the expansion and activation of the BIM library market in the future.

• Proceedings of the KIEE Conference
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• 2002.07a
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• pp.320-326
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• 2002

Distribution system loss minimization re-configuration is 0-1 planning problem, and the number of combinations requiring searches is extremely large when dealing with typical system scales. For this reason, the application of a genetic algorithm (GA) seems attactive to solve this problem. Although Genetic algorithms are a type of random number search method, they incorporate a multi-point search feature and are therefore superior to one-point search techniques. The efficiency of GAs for solving large combinational problem has received wide attention. Further, parallel searching can be performed and the optimal solution is more easily reached. In this paper, for improving GA convergence characteristics in the distribution system loss minimization re-configeration problem, a chromosome "Limited Life" concept is intro duced. Briefly, considering the population homogenization and genetic drift problems, natural selection is achieved by providing this new concept, in addition to natural selection by fitness. This is possible because individuals in a population have an age value. Simulations were carried out using a model system to check this method's validity.

• Economic and Environmental Geology
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• v.27 no.5
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• pp.499-505
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• 1994

Local stress concentrations often cause new micro-damaging induced by a healed pre-existing defects, and the macro-damage is developed by propagation and coalescence of the micro-damage. The micro-damage causes non-linear deformation in rock material. Considerable work has also been applied to describe mathematically the behavior of cracks under stress. Although these mathematical models can usually be made to agree quite well with the measured data, but it is questionable how well the models describe real rock including microcracks in pre-failure state, such as their micro-damage mechanisms. In the present study, micro-damage initiation and propagation in granitic rock under increasing stress were observed directly. Furthermore, a stress analysis considering the bisphere model was carried out using the homogenization theory to analyze the mechanics of the stress-induced micro-damage.

• Journal of Pharmaceutical Investigation
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• v.28 no.4
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• pp.249-255
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• 1998

Solid Lipid Nanoparticle(SLN), one of the colloidal carrier systems, has many advantages such as good biocompatibility, low toxicity and stability. In this paper, the effects of drug lipophilicity and surfactant on the drug loading capacity, particle size and drug release profile were examined. SLNs were prepared by homogenization of melted lipid dispersed in an aqueous surfactant solution. Ketoprofen, ibuprofen and pranoprofen were used as model drugs and tweens and poloxamers were tested for the effect of surfactant. Mean particle size of prepared SLNs was ranged from 100 to 150nm. The drug loading capacity was improved with the most lipophilic drug and low concentration of surfactant. Particle size and polydispersity of SLNs were changed according to the used lipid and surfactant. The rates of drug release were controlled by the loading drug and surfactant concentration. SLN system with effective drug loading efficiency and proper particle size for the intravenous or oral formulation can be prepared by selecting optimum drug and surfactant.

• Journal of the Korea Safety Management & Science
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• v.14 no.1
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• pp.101-108
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• 2012

In this study was conducted numerical analysis to evaluate the stability of BTR(Built-in Timber Roof Tunneling Method), which is one of construction methods of underground structures in the non-opening state. The discretion method was applied to individually model reinforcing members of BTR, and the homogeneity analysis technic by area ratio was used to verify the feasibility comparing this result with that from conventional analysis method. The parameter study was performed to evaluate the effect varying ground depth, distance length of reinforcing supports and to verify the field applicability of new analysis method. The results showed the very precise value with allowable error, so this method can be applied in the field, The more length of supporting members caused the more vertical displacement and the top displacement increment of support members is larger than that of ground surace. The effect of ground depth was more impressive than that of distance length of reinforcing supports.

• Nuclear Engineering and Technology
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• v.45 no.2
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• pp.191-202
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• 2013

A numerical analysis of thermal stratification in the upper plenum of the MONJU fast breeder reactor was performed. Calculations were performed for a 1/6 simplified model of the MONJU reactor using the commercial code, CFX-13. To better resolve the geometrically complex upper core structure of the MONJU reactor, the porous media approach was adopted for the simulation. First, a steady state solution was obtained and the transient solutions were then obtained for the turbine trip test conducted in December 1995. The time dependent inlet conditions for the mass flow rate and temperature were provided by JAEA. Good agreement with the experimental data was observed for steady state solution. The numerical solution of the transient analysis shows the formation of thermal stratification within the upper plenum of the reactor vessel during the turbine trip test. The temporal variations of temperature were predicted accurately by the present method in the initial rapid coastdown period (~300 seconds). However, transient numerical solutions show a faster thermal mixing than that observed in the experiment after the initial coastdown period. A nearly homogenization of the temperature field in the upper plenum is predicted after about 900 seconds, which is a much shorter-term thermal stratification than the experimental data indicates. This discrepancy may be due to the shortcoming of the turbulence models available in the CFX-13 code for a natural convection flow with thermal stratification.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2015.05a
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• pp.112-112
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• 2015

The purposed of this work was to determine nanotube shape variation on the Ti-xNb alloys with alloying elements and applied potentials. Samples were prepared by arc melting, followed by followed by homogenization for 12 hr at $1000^{\circ}C$ in argon atmosphere. This study was evaluated the phase and microstructure of Ti-xNb alloys using an X-ray diffraction (XRD) and optical microscopy (OM). The morphology of the samples was investigated with a field-emission scanning electron microscope (FE-SEM) and energy dispersive X-ray spectroscopy (EDS). The nanotube on the alloy surface was formed in 1 M $H_3PO_4$ with small additions of NaF 0.8 wt.%. All anodization treatments were carried out using a scanning potentiostat (Model 362, EG&G, USA) at constant voltage 30 V for 120 min, respectively. The morphology of the samples was investigated with a field-emission scanning electron microscope (FE-SEM) and energy dispersive X-ray spectroscopy (EDS). Surface characteristics of nanotbue formed on Ti-xNb alloys was investigated by potentiodynamic test and potentiostatic in 0.9% NaCl solution at $36.5{\pm}1^{\circ}C$. It was observed that the changed ${\alpha}$ phase to ${\beta}$ phase with Nb content.