• Journal of Pharmaceutical Investigation
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• 제26권4호
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• pp.299-308
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• 1996

In order to develop the controlled release of a drug from the suppsitories, in vitro drug release and in vivo absorption in rabbits were investigated. Various suppository forms with hollow cavities, into which drugs in the form of fine powder or solid dispersion system(SDS) could be placed, were utilized. The polyvinyl alcohol(PVA) hydrogel as a base, and propranolol HCl(PPH) as a model drug were employed. In vitro drug dissolution studies showed that the dissolved amounts(%) of PPH from PPH-methylcellulose(MC)-SDS and PPH-ethylcellulose(EC)-SDS reached 100% and 63% in 4.5-hours, respectively. In the relative strength test for PVA hydrogel, PVA hydrogel became harder and more rigid when the number of freezing-thawing cycles and the ratio of PVA 2000 were increased. In vitro drug release profile revealed that the release rate(%) of PPH from PPH-EC-SDS and PPH-MC-SDS hollow type suppositories were sustained. The release amount(%) of PPH from PPH-EC-SDS hollow type suppositories was not affected by storage time, but since the use of hydrophilic MC made PPH diffuse into the hydrogel after it absorbed the water of base, the various release patterns were appeared as the storage time went by. In vivo absorption experiments with rabbits showed that PPH-EC-SDS(PPH : EC=1:3) hollow type suppository delayed the absorption of PPH, significantly. The $C_{max}$, $AUC_{0{\rightarrow}8}$ and MRT of PPH powder hollow type suppository were $196.37{\pm}5.63\;ng/ml$, 1105.26 ng/ml/min and 8.66 min, respectively. The $C_{max}$, $AUC_{0{\rightarrow}8}$ and MRT of PPH-EC-SDS(PPH : EC=1:3) were $91.30{\pm]14.14\;ng/ml$, 554.69 ng/ml/min, 235.99 min, respectively.

• 한국세라믹학회지
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• 제54권5호
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• pp.429-437
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• 2017

Micro hollow plate type silica with low refraction properties was synthesized and its hollow structure was applied as an optical structure to develop a light diffusion material that simultaneously satisfies the requirements of good light diffusibility, high transmissibility, and high luminance. The developed light diffusion material was applied to a light diffusion film and the film's optical properties were assessed. Hollow silica was synthesized by precipitation method using $Mg(OH)_2$ core particles, sodium silicate, and ammonium sulfate as the silica precursors. The concentration of the silica precursor was adjusted to control hollow silica shell thickness. The total light transmittance of the light diffusion film composed of the hollow silica was 94.55%, which was 4.57% higher than that of the PC film; new film's haze was 71.20%, which was 70.9% higher. Furthermore, the luminance increased by 5.34% compared to that of the light source. The reason for the results is not only that the micro plate type hollow silica, which has a low refractive property, played a role in reducing the difference in refractive index between the medium boundaries, but also that there was a light-concentrating effect due to the changing of light paths to the front direction inside the hollow structure. Optical simulation verified the enhanced optical properties when hollow silica was applied to the light diffusion film.

• 소성∙가공
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• 제21권8호
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• pp.493-498
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• 2012

A wheel nut wrench is one of the hand tools used to loosen and tighten lug nuts on automobile wheels and it has generally a solid-type geometry for commercial vehicles. However, the solid-type wheel nut wrenches manufactured by hot forging processes exhibit several drawbacks such as heavy weight and rough surface finish. Thus, many efforts have been devoted to change the part geometry and improve the manufacturing process. For this purpose, the weight of the final product can be reduced drastically using a hollow tube as the initial stock, which can be manufactured by the more economical manufacturing process of cold forging. In this study, the cold forging of a hollow-type wheel nut wrench for commercial vehicles was designed based on the results of fundamental experiments and CAE analyses using the commercial finite element code DEFORM-3D. In addition, cold forging experiments were conducted on a special-purpose forming machine for hollow wheel nut wrenches in order to validate the designed process sequence. As results, it was found that the final products with a weight reduction of 39% and better surface appearance can be manufactured without any defect with the newly designed cold forging process.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2010년도 춘계 학술대회 제22권1호
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• pp.59-60
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• 2010

본 연구는 도넛형 중공 형성체를 적용한 중공 슬래브의 뚫림 전단 성능을 실험적으로 파악하였다. 그리고 이를 통하여, 위험단면 내 중공 슬래브 적용가능성을 검토하였으며, 중공형성체 고정철물의 뚫림 전단 보강성능을 파악하였다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1997년도 추계학술대회 논문집
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• pp.808-811
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• 1997

MMC has excellent mechanical properties in many ways in automotive industrial, and get into the spotlight as a light materials substituted for iron and steel. But the know-how about MMC research lack, MMC is expensive and difficult to apply the sound parts. Especially it is difficult to produce the hollow type parts composed with MMC. Therefore, hollow type parts of metal composites by using thixoforming process which as co-existing solidus-liquidus phase, it is very important to obtain forming condition. In this study, MMC billet producted by electro-magnetic stirring and mechanical stirring process is formed to hollow type parts of thixoforming process and inspected of suitability for application. It is optimized production condition, and applied to experiment. After variable materials were produced for thixoforming process, it were inspected of suitability for application by comparsion with mechanical properties. In this study, used materials were A357, A380 10%vol, and 20%vol SiCp, and the size of particultes were 14$\mu\textrm{m}$ and 5.5$\mu\textrm{m}$.

• 전기학회논문지
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• 제56권12호
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• pp.2221-2225
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• 2007

Hollow-type microneedle array can be used for painless, continuous and stable drug delivery through a human skin. The needles must be sharp and have sufficient length in order to penetrate the epidermis. An array of hollow-type silicon microneedles was fabricated by using deep reactive ion etching and HNA wet etching with two oxide masks. Isotropic etching was used to create tapered tips of the needles, and anisotropic etching of Bosch process was used to make the extended length and holes of microneedles. The microneedles were formed by three steps of isotropic, anisotropic, and isotropic etching in order. The holes were made by one anisotropic etching step. The fabricated microneedles have $170{\mu}m$ width, $40{\mu}m$ hole diameter and $230{\mu}m$ length.

• 한국지능시스템학회논문지
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• 제20권6호
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• pp.843-847
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• 2010

최근 지능형 로봇 및 산업용 로봇 분야에서 최대 관심 중의 하나는 일체형 구조의 중공형 관절 모듈을 위한 모션 네트워크 기반 서보 드라이버 모듈의 설계 및 구현이다. 본 논문에서는 중공형 드라이버를 설계하고 이를 구현하였으며, 실험을 통하여 개발된 모듈의 성능을 검증하였다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2011년도 춘계학술대회 논문집
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• pp.937-938
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• 2011

• Journal of Pharmaceutical Investigation
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• 제28권4호
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• pp.275-282
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• 1998

In order to develop a desirable in vitro release which correlates well with in vivo bioavailability, hollow type suppository containing Propranolol HCl(PPH) powder in the cavity and conventional type suppository with dispersed PPH in the base were prepared. Polyvinyl alcohol (PVA) hydrogel as a base and PPH as a model drug were used for the preparation of suppository. The rates of drug release from the suppositories were studied by Paddle method, Muranish method, Dialysis tubing method and Rotating dialysis cell method. The release profiles from suppositories using the four different release tests were compared. After a rectal administration in rat, the mean $C_{max}$ of hollow type suppository was significantly lower than that of conventional type, but $T_{max}$, $AUC_{0{\to}12}$ and MRT of hollow type were significantly higher 1.6 times, 1.2 times and 1.9 times than those of conventional type, respectively. The computer program was used to simulate plasma concentration from in vitro released amounts of drug and in vivo pharmacokinetic parameters. Based on comparison of the simulated bioavailability from computer program with experimental bioavailability in rat we have found out in vitro release test which correlates well with in vivo bioavailability. Our results have shown the best correlation between in vitro release and in vivo bioavailability in PPH-PVA hydrogel hollow type suppository for the paddle method and conventional type suppository for the rotating dialysis cell method. In this work we propose that PPH-PVA hydrogel suppository shows in vitro-in vivo correlation. This data should help to optimize the formulation of the drug and provide a basis for quality control procedures.

• 한국강구조학회 논문집
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• 제29권6호
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• pp.443-453
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• 2017

본 연구에서는 데크형 중공슬래브의 중공률을 확보하기 위한 방안으로 기존의 중공슬래브에 일반적으로 사용되는 구형형상의 경량체 대신 사다리꼴 형상의 경량체를 적용하고, 이에 따른 휨 및 전단 내력 성능을 실험을 통해 확인하였으며, 일방향 데크플레이트의 설치방향에 따른 구조특성을 검토하였다. 그 결과 휨내력 측면에서는 기존 구형형상의 경량체를 가진 중공슬래브와 동등한 수준의 성능을 발휘하는 것을 확인하였으며, 전단내력 측면에서는 경량체 형상 변화에 따른 차이보다는 데크플레이트의 트러스철선의 기여에 따라 큰 전단내력성능을 발휘하는 것을 확인하였다. 중공체 설치시 콘크리트 유효단면의 감소로, 전단 강도가 약 50~60% 정도로 저하된다는 기존 연구에 따른 계산한 전단내력값과 비교하였을 때, 폭방향으로 데크를 설치하여 트러스철근이 전단에 영향을 미치지 않을 것으로 가정한 실험체도 트러스철근의 트러스프레임 거동에 의한 영향으로 저감 전 값 대비 87%의 성능을 보여 기존 연구에 따른 계산전단내력보다 최대하중이 더 크게 나타났다.