• Journal of Pharmaceutical Investigation
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• v.26 no.4
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• pp.299-308
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• 1996

In order to develop the controlled release of a drug from the suppsitories, in vitro drug release and in vivo absorption in rabbits were investigated. Various suppository forms with hollow cavities, into which drugs in the form of fine powder or solid dispersion system(SDS) could be placed, were utilized. The polyvinyl alcohol(PVA) hydrogel as a base, and propranolol HCl(PPH) as a model drug were employed. In vitro drug dissolution studies showed that the dissolved amounts(%) of PPH from PPH-methylcellulose(MC)-SDS and PPH-ethylcellulose(EC)-SDS reached 100% and 63% in 4.5-hours, respectively. In the relative strength test for PVA hydrogel, PVA hydrogel became harder and more rigid when the number of freezing-thawing cycles and the ratio of PVA 2000 were increased. In vitro drug release profile revealed that the release rate(%) of PPH from PPH-EC-SDS and PPH-MC-SDS hollow type suppositories were sustained. The release amount(%) of PPH from PPH-EC-SDS hollow type suppositories was not affected by storage time, but since the use of hydrophilic MC made PPH diffuse into the hydrogel after it absorbed the water of base, the various release patterns were appeared as the storage time went by. In vivo absorption experiments with rabbits showed that PPH-EC-SDS(PPH : EC=1:3) hollow type suppository delayed the absorption of PPH, significantly. The $C_{max}$, $AUC_{0{\rightarrow}8}$ and MRT of PPH powder hollow type suppository were $196.37{\pm}5.63\;ng/ml$, 1105.26 ng/ml/min and 8.66 min, respectively. The $C_{max}$, $AUC_{0{\rightarrow}8}$ and MRT of PPH-EC-SDS(PPH : EC=1:3) were $91.30{\pm]14.14\;ng/ml$, 554.69 ng/ml/min, 235.99 min, respectively.

• Journal of the Korean Ceramic Society
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• v.54 no.5
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• pp.429-437
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• 2017

Micro hollow plate type silica with low refraction properties was synthesized and its hollow structure was applied as an optical structure to develop a light diffusion material that simultaneously satisfies the requirements of good light diffusibility, high transmissibility, and high luminance. The developed light diffusion material was applied to a light diffusion film and the film's optical properties were assessed. Hollow silica was synthesized by precipitation method using $Mg(OH)_2$ core particles, sodium silicate, and ammonium sulfate as the silica precursors. The concentration of the silica precursor was adjusted to control hollow silica shell thickness. The total light transmittance of the light diffusion film composed of the hollow silica was 94.55%, which was 4.57% higher than that of the PC film; new film's haze was 71.20%, which was 70.9% higher. Furthermore, the luminance increased by 5.34% compared to that of the light source. The reason for the results is not only that the micro plate type hollow silica, which has a low refractive property, played a role in reducing the difference in refractive index between the medium boundaries, but also that there was a light-concentrating effect due to the changing of light paths to the front direction inside the hollow structure. Optical simulation verified the enhanced optical properties when hollow silica was applied to the light diffusion film.

• Transactions of Materials Processing
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• v.21 no.8
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• pp.493-498
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• 2012

A wheel nut wrench is one of the hand tools used to loosen and tighten lug nuts on automobile wheels and it has generally a solid-type geometry for commercial vehicles. However, the solid-type wheel nut wrenches manufactured by hot forging processes exhibit several drawbacks such as heavy weight and rough surface finish. Thus, many efforts have been devoted to change the part geometry and improve the manufacturing process. For this purpose, the weight of the final product can be reduced drastically using a hollow tube as the initial stock, which can be manufactured by the more economical manufacturing process of cold forging. In this study, the cold forging of a hollow-type wheel nut wrench for commercial vehicles was designed based on the results of fundamental experiments and CAE analyses using the commercial finite element code DEFORM-3D. In addition, cold forging experiments were conducted on a special-purpose forming machine for hollow wheel nut wrenches in order to validate the designed process sequence. As results, it was found that the final products with a weight reduction of 39% and better surface appearance can be manufactured without any defect with the newly designed cold forging process.

• Proceedings of the Korea Concrete Institute Conference
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• 2010.05a
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• pp.59-60
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• 2010

This paper presents the flexural capacities of biaxial hollow slab with donut type hollow sphere. To verify the punching shear capacities of this biaxial hollow slab, punching shear tests were performed. The test parameter was the areas of critical section which were determined by the number of hollow spheres in critical section.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.808-811
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• 1997

MMC has excellent mechanical properties in many ways in automotive industrial, and get into the spotlight as a light materials substituted for iron and steel. But the know-how about MMC research lack, MMC is expensive and difficult to apply the sound parts. Especially it is difficult to produce the hollow type parts composed with MMC. Therefore, hollow type parts of metal composites by using thixoforming process which as co-existing solidus-liquidus phase, it is very important to obtain forming condition. In this study, MMC billet producted by electro-magnetic stirring and mechanical stirring process is formed to hollow type parts of thixoforming process and inspected of suitability for application. It is optimized production condition, and applied to experiment. After variable materials were produced for thixoforming process, it were inspected of suitability for application by comparsion with mechanical properties. In this study, used materials were A357, A380 10%vol, and 20%vol SiCp, and the size of particultes were 14$\mu\textrm{m}$ and 5.5$\mu\textrm{m}$.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.12
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• pp.2221-2225
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• 2007

Hollow-type microneedle array can be used for painless, continuous and stable drug delivery through a human skin. The needles must be sharp and have sufficient length in order to penetrate the epidermis. An array of hollow-type silicon microneedles was fabricated by using deep reactive ion etching and HNA wet etching with two oxide masks. Isotropic etching was used to create tapered tips of the needles, and anisotropic etching of Bosch process was used to make the extended length and holes of microneedles. The microneedles were formed by three steps of isotropic, anisotropic, and isotropic etching in order. The holes were made by one anisotropic etching step. The fabricated microneedles have $170{\mu}m$ width, $40{\mu}m$ hole diameter and $230{\mu}m$ length.

• Journal of the Korean Institute of Intelligent Systems
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• v.20 no.6
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• pp.843-847
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• 2010

Recently, one of the most interesting issue in the intelligent robot and the industrial robot area is the design and an implementation of servo driver module based on motion network for hollow type joint module of all-in-one structure. In this paper, we designed and implemented for hollow type driver, and also verified the performance of the developed module through the experiment.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.937-938
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• 2011

• Journal of Pharmaceutical Investigation
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• v.28 no.4
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• pp.275-282
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• 1998

In order to develop a desirable in vitro release which correlates well with in vivo bioavailability, hollow type suppository containing Propranolol HCl(PPH) powder in the cavity and conventional type suppository with dispersed PPH in the base were prepared. Polyvinyl alcohol (PVA) hydrogel as a base and PPH as a model drug were used for the preparation of suppository. The rates of drug release from the suppositories were studied by Paddle method, Muranish method, Dialysis tubing method and Rotating dialysis cell method. The release profiles from suppositories using the four different release tests were compared. After a rectal administration in rat, the mean $C_{max}$ of hollow type suppository was significantly lower than that of conventional type, but $T_{max}$, $AUC_{0{\to}12}$ and MRT of hollow type were significantly higher 1.6 times, 1.2 times and 1.9 times than those of conventional type, respectively. The computer program was used to simulate plasma concentration from in vitro released amounts of drug and in vivo pharmacokinetic parameters. Based on comparison of the simulated bioavailability from computer program with experimental bioavailability in rat we have found out in vitro release test which correlates well with in vivo bioavailability. Our results have shown the best correlation between in vitro release and in vivo bioavailability in PPH-PVA hydrogel hollow type suppository for the paddle method and conventional type suppository for the rotating dialysis cell method. In this work we propose that PPH-PVA hydrogel suppository shows in vitro-in vivo correlation. This data should help to optimize the formulation of the drug and provide a basis for quality control procedures.

• Journal of Korean Society of Steel Construction
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• v.29 no.6
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• pp.443-453
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• 2017

In this study, a trapezoidal hollow ball is used, instead of a spherical hollow ball commonly used in void slab, to secure the high hollow ratio in the deck type void slab. The bending and shear performance was measured with consideration for the shape change of the hollow ball. And to confirm the effect of deck plate and truss wire on shear performance, experiments were performed depending on the installation directions of the one-way deck plate. As a result, the bending performance of the deck type void slab with a trapezoidal hollow ball was similar to that of the void slab with a spherical hollow ball. However, according to the data of shear strength examined, the contribution of shear performance enhancement of the truss wire had a more effect on the shear performance of deck type void slab, rather than the influence by changing of the shape of hollow ball. In the previous studies, the shear strength is reduced to about 60%, due to the reduction of the effective section of concrete by installation of hollow ball. But in this experiment, the maximum load of specimen, in which the deck was installed in horizontal direction, so expected to have no influence on the shear performance, was only reduced to about 87%, due to the truss framework of truss wire.