• 한국항만경제학회지
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• 제34권3호
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• pp.93-112
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• 2018

본 연구는 중국과의 전자상거래 교역에 해상으로 운송되는 화물의 흐름을 분석하고 지역별/품목별로 화물의 특성을 파악하여, 중국으로의 전자상거래 수출 증진 방안을 모색하고자 한다. 이를 위해 기종점 분석 및 시각화 기법을 활용하여 2015년부터 2018년 1분기까지 해상운송을 이용한 대(對)중국 전자상거래 수출입자료를 분석하였다. 분석 결과, 현재 중국과 해상특송 서비스를 제공하고 있는 인천항에서 가장 많은 대(對)중국 전자상거래 화물이 수입되고 있었으며, 평택항의 경우, 중국으로부터 수입된 전자상거래 화물이 다시 인천세관으로 운송되어 통관 절차를 거치는 비효율이 발생하고 있음도 파악할 수 있었다. 또한, 최종 배송지가 전국적으로 분포되어 있는 전자상거래 수입의 경우와는 달리, 해상을 통해 중국으로 수출되는 전자상거래 제품들은 배송대행업체 및 포워더 업체들이 밀집된 서울과 경기지역에만 국한되어 나타남을 알 수 있었다. 또한, 전자상거래 수입과는 달리, 해상을 통해 수출되는 전자상거래 품목은 주로 의류와 화장품류에 국한되어 있었으며, 수출 규모 역시 수입에 비해 적게 나타나고 있다. 해상을 통한 대(對)중국 전자상거래 수출 활성화 방안으로는 전자상거래 환적을 통해 중국으로의 수출 제품 다변화로 수출 화물량을 증가시키는 방안과 더불어, 중국과의 전자상거래 운송에 콜드체인(cold chain)을 구축하여 수출품의 다변화를 도모하는 방안이 도출되었다.

• 한국체육학회지인문사회과학편
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• 제56권5호
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• pp.665-677
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• 2017

이 연구는 U-12 유소년 축구선수를 대상으로 운동수행력과 의학적 평가를 상세히 분석한 후에 축구를 통한 운동수행력의 변화 및 의학적 문제점을 파악하는데 그 목적이 있다. 연구대상은 유소년 축구클럽에 참여하고 있는 초등학교 선수를 유소년 축구선수 집단(Youth football players group; YFG, n=15; $11.2{\pm}0.9$ 세)과 축구를 하지 않는 건강한 일반 유소년을 통제 집단(Control group; CON, n=15; $11.5{\pm}0.6$ 세)으로 각각 분류하여 운동수행력(건강관련 체력, 운동관련 체력, 기능적 움직임 및 동적 균형) 및 의학적 평가(하지정렬, 관절가동범위 및 도수근력검사)를 측정하였다. 왕복 오래달리기, 50-m 달리기, 눈 감고 외발서기, 능동적 하지직거상, 회전 안정성 및 비주측의 종합점수는 CON과 비교해서 YFG에서 긍정적인 결과를 보였다. 하지만, 하지정렬에서 주측 및 비주측의 Q각, 관절가동범위에서 비주측의 발목관절 발등굽힘, 주측 및 비주측의 발목관절 발바닥굽힘, 도수근력검사에서 주측의 엉덩관절 폄 및 벌림, 무릎관절 굽힘 및 폄, 비주측의 무릎관절 굽힘 및 폄은 CON과 비교해서 YFG에서 부정적인 결과를 초래하였다. 따라서 이 연구에서 U-12 유소년 축구선수는 부분적으로 운동수행력은 우수하게 나타났지만, 의학적 평가에서는 부정적인 결과를 확인하였다.

• 한국수산과학회지
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• 제56권4호
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• pp.380-387
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• 2023

Stocking density is associated with Paralichthys olivaceus growth; thus, fish should be rapidly reared at high densities for commercial reasons. Studies have reported that high stocking density retards growth; however, few have investigated the malformations caused by stocking density stress. This study compared the growth and malformation rates of P. olivaceus at different densities and stress- and immune-related gene expression between malformed and normal fish. Forty days post-hatching, fish (total length, 1.49±0.02 cm) were reared at 800 (low density; LD), 1500 (medium density; MD), and 4000 (high density; HD) fish/m², and the growth rate was measured weekly. On day 30, RNA was extracted from the kidneys, and the expression of stress-, immune-, and malformation-related genes was analyzed using qRT-PCR. The malformation rate in the HD groups was approximately three times higher (62%) than that in the LD and MD groups (approximately 20%), and growth was lower regarding length and weight. The stress-related (HSP70 and GPX) and immune-related (PIR and IgM) genes showed higher mRNA expression in the HD group and malformed fish than in the LD group and normal fish. However, TLR3 showed the opposite results. In summary, high stocking density suppressed growth and increased malformation risk in P. olivaceus.

• 한국지반공학회논문집
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• 제23권7호
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• pp.5-16
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• 2007

수중 산사태의 관측 및 조사는 산사태의 메커니즘의 이해, 설계 및 시공의 유용성, 그리고 손실 감소에 도움을 준다. 본 논문은 실험실 조건의 수중 산사태를 확인하기 위하여 전기저항, 초음파 반사 이미지, 그리고 전단파 토모그래피의 3가지 고해상도 지구물리탐사기법을 수행하였다. 전기저항 탐침에 의한 흙의 전기저항 프로파일은 밀리미터 단위의 해상도로 흙의 공간적 분포 평가를 위한 자세한 정보를 제공해 준다. 임피던스가 다른 물질의 경계면부터의 반사 자료에 의한 초음파 반사 이미지는 밀리미터 단위의 해상도로 사면 형상 및 시료 층상을 탐지해 낼 수 있다. 전단파 이동 시간으로부터 얻어지는 경계 정보의 역산에 의한 픽셀단위 수중 산사태의 이미지를 만들 수 있다. 실험결과 초음파 이미지와 전기저항은 서로 보완적인 정보를 제공할 수 있으며, 전단파 토모그래피 이미지와 연합하여 수중 산사태의 3차원 이미지를 얻을 수 있다. 본 연구는 지구물리탐사기법들이 수중 산사태 및 해안의 공간적 분포의 탐지에 효과적인 기법이 될 수 있음을 보여준다.

• 디지털융복합연구
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• 제20권3호
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• pp.201-209
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• 2022

군(軍)이 가상현실 기술을 다양한 교육훈련체계에 도입을 검토하여 충분히 활용하기 위해서는 해당 기술 및 교육체계의 특성을 반영하는 사업화 특성에 대한 정확한 파악과 선별적인 적용이 중요할 것이다. 본 연구에서는 가상현실 기반의 교육훈련체계 사업화 시 고려해야 할 요인들에 대해서 AHP(Analitic Hierarchy Process)기법을 통해 평가기준을 선정하고 추진 과제들의 우선순위를 판단해보았다. 선행연구를 기초로 초기 AHP 모델을 구성하여 레벨 1의 평가 기준으로 현실성 등 6개 요소에 대한 상대적인 중요도를 분석하였다. 다음으로 레벨 2는 6개의 평가 기준에 11개 과제별 중요도의 확인을 위해 각각의 평가 기준을 대상으로 분석하여 과제별 우선순위를 선정하였다. 분석결과 레벨 1에서는 현실성 및 파급성이 다른 요소에 비해 높은 중요도를 나타내었다. 최종 상대적 중요도를 평가한 결과는 ① 비행훈련, ② 재난훈련, ③ 포탄 사격, ④ 차량 운전 순으로 우선순위가 나타났다. 본 연구에서 제시한 모델의 레벨 1과 2에서 결정된 상대적 우선순위를 바탕으로 국방 가상현실 과제 연구 우선순위의 최종 의사결정에 필요한 사업별 중요도를 제시하였다. 본 연구를 통해 국방 분야의 교육훈련체계 사업화에 대한 우선순위 선정에 참고자료로 활용될 수 있을 것으로 기대된다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.17-17
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• 2023

Chrysanthemum zawadskii (C. zawadskii) is used in traditional East Asian medicine for the treatment of various diseases, including inflammatory disease. However, it has remained unclear whether extracts of C. zawadskii inhibit inflammasome activation in macrophages. The present study assessed the inhibitory effect of an ethanol extract of C. zawadskii (CZE) on the activation of the inflammasome in macrophages and the underlying mechanism. Bone marrow[-derived macrophages (BMDMs) were obtained from wild-type C57BL/6 mice. The release of IL-1β and lactate dehydrogenase in response to nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activators, such as ATP, nigericin and monosodium urate (MSU) crystals, was significantly decreased by CZE in lipopolysaccharide(LPS)-primed BMDMs. Western blotting revealed that CZE inhibited ATP-induced caspase-1 cleavage and IL-1β maturation. To investigate whether CZE inhibits the priming step of the NLRP3 inflammasome, we confirmed the role of CZE at the gene level using RT-qPCR. CZE also downregulated the gene expression of NLRP3 and pro-IL-1β as well as NF-κB activation in BMDMs in response to LPS. Apoptosis associated speck-like protein containing a caspase-recruitment domain (CARD) oligomerization and speck formation by NLRP3 inflammasome activators were suppressed by CZE. By contrast, CZE did not affect NLR family CARD domain containing protein 4 (NLRC4) or absent in melanoma 2 (AIM2) inflammasome activation in response to Salmonella typhimurium and poly(dA:dT) in LPS-primed BMDMs, respectively. The results revealed that three key components of CZE, namely linarin, 3,5-dicaffeoylquinic acid and chlorogenic acid, decreased IL-1β secretion in response to ATP, nigericin and MSU. These findings suggest that CZE effectively inhibited activation of the NLRP3 inflammasome.

• Nuclear Engineering and Technology
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• 제55권10호
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• pp.3874-3897
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• 2023

A high-fidelity computational fluid dynamics (CFD) analysis was performed using the Large Eddy Simulation (LES) model for the lower plenum of the High-Temperature Test Facility (HTTF), a ¼ scale test facility of the modular high temperature gas-cooled reactor (MHTGR) managed by Oregon State University. In most next-generation nuclear reactors, thermal stress due to thermal striping is one of the risks to be curiously considered. This is also true for HTGRs, especially since the exhaust helium gas temperature is high. In order to evaluate these risks and performance, organizations in the United States led by the OECD NEA are conducting a thermal hydraulic code benchmark for HTGR, and the test facility used for this benchmark is HTTF. HTTF can perform experiments in both normal and accident situations and provide high-quality experimental data. However, it is difficult to provide sufficient data for benchmarking through experiments, and there is a problem with the reliability of CFD analysis results based on Reynolds-averaged Navier-Stokes to analyze thermal hydraulic behavior without verification. To solve this problem, high-fidelity 3-D CFD analysis was performed using the LES model for HTTF. It was also verified that the LES model can properly simulate this jet mixing phenomenon via a unit cell test that provides experimental information. As a result of CFD analysis, the lower the dependency of the sub-grid scale model, the closer to the actual analysis result. In the case of unit cell test CFD analysis and HTTF CFD analysis, the volume-averaged sub-grid scale model dependency was calculated to be 13.0% and 9.16%, respectively. As a result of HTTF analysis, quantitative data of the fluid inside the HTTF lower plenum was provided in this paper. As a result of qualitative analysis, the temperature was highest at the center of the lower plenum, while the temperature fluctuation was highest near the edge of the lower plenum wall. The power spectral density of temperature was analyzed via fast Fourier transform (FFT) for specific points on the center and side of the lower plenum. FFT results did not reveal specific frequency-dominant temperature fluctuations in the center part. It was confirmed that the temperature power spectral density (PSD) at the top increased from the center to the wake. The vortex was visualized using the well-known scalar Q-criterion, and as a result, the closer to the outlet duct, the greater the influence of the mainstream, so that the inflow jet vortex was dissipated and mixed at the top of the lower plenum. Additionally, FFT analysis was performed on the support structure near the corner of the lower plenum with large temperature fluctuations, and as a result, it was confirmed that the temperature fluctuation of the flow did not have a significant effect near the corner wall. In addition, the vortices generated from the lower plenum to the outlet duct were identified in this paper. It is considered that the quantitative and qualitative results presented in this paper will serve as reference data for the benchmark.

• 한국식품저장유통학회지
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• 제30권2호
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• pp.235-246
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• 2023

Yellowball (Citrus hybrid cv. Yellowball ) is a new citrus hybrid between Haruka (C. tamurana × natsudaidai ) and Kiyomi (C. unshiu × sinensis) and is known to possess strong antioxidant activity. However, detailed information on the antioxidant components of its peel has not yet been reported. This study evaluated the antioxidant activity of the peel and identified the antioxidant components by fractionating a methanolic extract of Yellowball peels using liquid-liquid extraction with n-hexane, ethyl ether (ether), ethyl acetate (EA), butanol, and water. The phenolic contents and antioxidant activities of the n-hexane, ether, and EA fractions were higher than those of the other fractions, and these fractions were further separated by semi-preparative high-performance liquid chromatography (HPLC). Four antioxidant peaks, EA1, EA2, EA3, and He1, were isolated and analyzed using ultra-performance liquid chromatography-quadrupole-time- of-flight mass spectrometry (UPLC-Q-TOF MS). Sinapoyl glucoside and hesperidin were identified in EA2 and EA3, respectively, and a polymethoxylated flavone (PMF) complex (5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone, natsudaidain, tetrameth- oxyflavone, and tangeretin) was identified in He1. A compound in EA1 with m/z 223.0246 [M-H] could not be identified and was named unknown2. The antioxidant activity of unknown2 (IC₅₀=69.17 ㎍/mL) was similar to that of Trolox, which was noted as a major antioxidant in Yellowball peel. Further studies on the antioxidant capacity of Yellowball peel are required; however, these results provide a foundation for using Yellowball peel as an antioxidant.

• Korean Journal of Radiology
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• 제24권8호
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• pp.772-783
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• 2023

Objective: Imaging-based survival stratification of patients with gliomas is important for their management, and the 2021 WHO classification system must be clinically tested. The aim of this study was to compare integrative imaging- and pathology-based methods for survival stratification of patients with diffuse glioma. Materials and Methods: This study included diffuse glioma cases from The Cancer Genome Atlas (training set: 141 patients) and Asan Medical Center (validation set: 131 patients). Two neuroradiologists analyzed presurgical CT and MRI to assign gliomas to five imaging-based risk subgroups (1 to 5) according to well-known imaging phenotypes (e.g., T2/FLAIR mismatch) and recategorized them into three imaging-based risk groups, according to the 2021 WHO classification: group 1 (corresponding to risk subgroup 1, indicating oligodendroglioma, isocitrate dehydrogenase [IDH]-mutant, and 1p19q-codeleted), group 2 (risk subgroups 2 and 3, indicating astrocytoma, IDH-mutant), and group 3 (risk subgroups 4 and 5, indicating glioblastoma, IDHwt). The progression-free survival (PFS) and overall survival (OS) were estimated for each imaging risk group, subgroup, and pathological diagnosis. Time-dependent area-under-the receiver operating characteristic analysis (AUC) was used to compare the performance between imaging-based and pathology-based survival model. Results: Both OS and PFS were stratified according to the five imaging-based risk subgroups (P < 0.001) and three imaging-based risk groups (P < 0.001). The three imaging-based groups showed high performance in predicting PFS at one-year (AUC, 0.787) and five-years (AUC, 0.823), which was similar to that of the pathology-based prediction of PFS (AUC of 0.785 and 0.837). Combined with clinical predictors, the performance of the imaging-based survival model for 1- and 3-year PFS (AUC 0.813 and 0.921) was similar to that of the pathology-based survival model (AUC 0.839 and 0.889). Conclusion: Imaging-based survival stratification according to the 2021 WHO classification demonstrated a performance similar to that of pathology-based survival stratification, especially in predicting PFS.

• Korean Journal of Radiology
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• 제22권4호
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• pp.584-595
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• 2021

Objective: Immune checkpoint inhibitor (ICI) therapy has shown activity against melanoma brain metastases. Recently, promising results have also been reported for ICI combination therapy and ICI combined with radiotherapy. We aimed to evaluate radiologic response and adverse event rates of these therapeutic options by a systematic review and meta-analysis. Materials and Methods: A systematic literature search of Ovid-MEDLINE and EMBASE was performed up to October 12, 2019 and included studies evaluating the intracranial objective response rates (ORRs) and/or disease control rates (DCRs) of ICI with or without radiotherapy for treating melanoma brain metastases. We also evaluated safety-associated outcomes. Results: Eleven studies with 14 cohorts (3 with ICI combination therapy; 5 with ICI combined with radiotherapy; 6 with ICI monotherapy) were included. ICI combination therapy {pooled ORR, 53% (95% confidence interval [CI], 44-61%); DCR, 57% (95% CI, 49-66%)} and ICI combined with radiotherapy (pooled ORR, 42% [95% CI, 31-54%]; DCR, 85% [95% CI, 63-95%]) showed higher local efficacy compared to ICI monotherapy (pooled ORR, 15% [95% CI, 11-20%]; DCR, 26% [95% CI, 21-32%]). The grade 3 or 4 adverse event rate was significantly higher with ICI combination therapy (60%; 95% CI, 52-67%) compared to ICI monotherapy (11%; 95% CI, 8-17%) and ICI combined with radiotherapy (4%; 95% CI, 1-19%). Grade 3 or 4 central nervous system (CNS)-related adverse event rates were not different (9% in ICI combination therapy; 8% in ICI combined with radiotherapy; 5% in ICI monotherapy). Conclusion: ICI combination therapy or ICI combined with radiotherapy showed better local efficacy than ICI monotherapy for treating melanoma brain metastasis. The grade 3 or 4 adverse event rate was highest with ICI combination therapy, and the CNS-related grade 3 or 4 event rate was similar. Prospective trials will be necessary to compare the efficacy of ICI combination therapy and ICI combined with radiotherapy.