• Title/Summary/Keyword: History of research

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Ki-67/MIB-1 as a Prognostic Marker in Cervical Cancer - a Systematic Review with Meta-Analysis

  • Piri, Reza;Ghaffari, Alireza;Gholami, Nasrin;Azami-Aghdash, Saber;PourAli-Akbar, Yasmin;Saleh, Parviz;Naghavi-Behzad, Mohammad
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.16
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    • pp.6997-7002
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    • 2015
  • Background: In cervical cancer patients it has been reported that there in a significant Ki-67/MIB-1 expression is correlated with survival in cervical cancer patients. However, the prognostic value is still not well understood. Materials and Methods: In the present meta-analysis the prognostic value of Ki-67/MIB-1 with regard to overall survival (OS) and disease-free survival (DFS) in cervical cancer was investigated. The databases of PubMed, ISI Web of Science, Cochrane Central Register of Controlled Trials, EMBASE, Science Direct and Wiley Online Library were used to identify appropriate literature. Results: In order to explore the relationship between Ki-67/MIB-1 and cervical cancer, we have included 13 studies covering 894 patients in the current meta-analysis. The effect of Ki-67/MIB-1 on OS for pooled random effects HR estimate was 1.63 (95%confidence interval (CI) 1.09-2.45; P<0.05). The pooled HR for DFS was 1.26 (95%CI 0.58-2.73; P>0.05) and the subgroup analysis indicated Ki-67/MIB1 was associated with DFS (HR=3.67, 95%CI 2.65-5.09) in Asians. Conclusions: According to this meta-analysis, Ki-67/MIB-1 has prognostic value for OS in patients suffering from cervical cancer. For better evaluation of the prognostic role of Ki-67/MIB-1 on DFS, studies with larger numbers of patients are needed to validate present findings in the future.

A Study on History-Tourism Information Service Using Mobile Augmented Reality Technology (모바일 증강현실 기술을 이용한 역사관광정보 서비스에 관한 연구)

  • Jung, Da-Woon;Kang, Young-Ok
    • Spatial Information Research
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    • v.20 no.2
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    • pp.59-70
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    • 2012
  • Advances in science and technology, especially the increasing popularity of smart phone has opened up infinite possibilities for the information retrieval. And the augmented reality technology which has started getting attention to various fields has allowed us to get an information in an innovative way by providing additional information to a real world before our eyes. The purpose of this study is to suggest and to construct mobile application service which give history-tourism information efficiently based on augmented reality technology. As a result of study, we suggest that it is needed to find the view point that the most accurate information can be provided to the users according to each contents such as maps, pictures, drawings etc. and to provide the function to the users which shows the view points information efficiently. The purpose of this study is to investigate the possibility whether the technology studied in private sector by using augmented reality based on smart phone can also be applied in public sector for the service of history tourism information. We expect that this study can be the basis for providing the more advanced augmented reality service in the near future.

Proposal of Acceleration Time History Prediction Method Based on Seismic Observation Data (관측 자료를 활용한 지진가속도 시간이력 추정방법 제안)

  • Lee, Kyeong-Seok;Ahn, Jin-Hee;Park, Jae-Bong;Choi, Hyoung-Suk
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.24 no.2
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    • pp.15-22
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    • 2020
  • In this paper, seismic ground motion generation method based on the observbation data from the Korea Meteorological Administration is proposed to predict the acceleration time history at an arbitrary location after earthquake. The proposed method assumes that the magnitude of the seismic accelrations obtained from the near stations decreases linearly with the distance from the epicenter to the corresponding station and the accelerations measured at the adjacent stations are assumed to have similar maximum acceleration and time shape functions. These two assumptions allow for the prediction of seismic acceleartion motion without geotechnical information where no seismic accelerometer is installed. This study verified the applicability of the prediction method using seismic observation data from Gyeongju Earthquake (2016), Pohang Earthquake (2017) and Sangju Earthuqkae (2019). The comparison results show that the proposed method is effective for predicting the seismic acceleration response spectrum and time history at arbitary locations.

Methods for Investigating of Edit History about MS PowerPoint Files That Using the OOXML Formats (OOXML형식을 사용하는 MS 파워포인트 파일에 대한 편집 이력 조사 방법)

  • Youn, Ji-Hye;Park, Jung-Heum;Lee, Sang-Jin
    • The KIPS Transactions:PartC
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    • v.19C no.4
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    • pp.215-224
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    • 2012
  • Today, individuals and businesses are a lot of paperwork through a computer. So many documents files are creating to digital type. And the digital type files are copied, moved by various media such as USB, E-mail and so on. A careful analysis of these digital materials can be tracked that occurred during the document editing work history. About these research are on the compound document file format, but has not been studied about the new OOXML format that how to analyze linkages between different document files, tracking an internal order, finding unsaved file for identify the process of creating the file. Future, the use of OOXML format digital documents will further increase, these document work history traceability in digital forensic investigation would be a big help. Therefore, this paper on the new OOXML format(has a forensic viewpoint) will show you how to track the internal order and analyze linkages between the files.

A Study of the Āyurveda Herbal theory in the 『Suśruta-saṃhitā·Sūtrasthāna』 (Āyurveda(아유르베다)의 약물 지식에 관한 연구 - 『Suśruta-saṃhitā·Sūtrasthāna (수슈르따-상히따·수뜨라스타나)』를 중심으로 -)

  • Seo, Ji-Young;Lee, Byung-Wook;Kim, Hak-Dong;Kim, Ki-Wook
    • The Journal of Korean Medical History
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    • v.27 no.1
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    • pp.135-156
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    • 2014
  • Through a simple translation and analysis of the "Su$\acute{s}$uta-saṃhit$\bar{a}$(The fascinating tales) S$\bar{u}$trasth$\bar{a}$na(The Introduction)", I have summarized the results of the research into the $\bar{A}$yurveda Herbal theory. 1. The title of chapter 40 is "dravya-rasa-guṇa-vip$\bar{a}$ka-vij$\tilde{n}$anīya(Medcation Taste Nature Effects Digestion)", and it states theoretical knowledge on materia medica. It says that 'matter' is the most important thing, and that it decides the curing effect. Although it does acknowledge the reason behind the doctors that emphasized things like 'taste', it mainly has a critical tone. The difference in philosophies and medical theory can be seen when we compare this to the "Caraka-saṃhit$\bar{a}$", 'theory on taste'. 2. The title of chapter 41 is "dravya-vi$\acute{s}$eṣa-vij$\tilde{n}$anīya(A Discussion on the Characteristics of Materia Medica)", and the contents of the chapter have a similar tone to the thoughts of the S$\bar{a}$mkhya(數論派). All 'matter' was created by the combination of the five elements of earth, water, fire, wind, and ether, and the predominant element makes it have an earth, water, fire, wind, or ether nature. Earth has an unmoving and down going nature, and makes the body strong. Water has an irrigating nature, and moistens the tissue and induces secretion and excretion. Fire has an upward-going nature, and improves sight and complexion. Wind relaxes and dries the body, and makes the mind and body agile. Ether gives flexibility, porosity, and candidness. The title of chapter 42 is "rasa-vi$\acute{s}$eṣa-vij$\tilde{n}\bar{a}$nīya(A Discussion on the Types of Rasa(taste))". "Rasa" is an important concept in $\bar{A}$yurveda. Sometimes it is translated as 'one of the seven types of bodily tissue' and seen as chyle, and sometimes it is seen as the tastes that can be felt with the tongue such as spicy, sweet, sour, bitter, salty, and astringent(澁). Volume 1, chapter 42 of the "Caraka-saṃhit$\bar{a}$" is dedicated to the "types of taste", and in chapter 26, it theorizes the concept of 'taste'.

A Study on analysis tools in the SWF file URL (SWF 파일의 URL정보 분석도구)

  • Jang, Dong-Hwan;Song, Yu-Jin;Lee, Jae-Yong
    • Journal of Korea Society of Industrial Information Systems
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    • v.15 no.5
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    • pp.105-111
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    • 2010
  • SWF(Shock Wave Flash) file is a format file for vector graphics produced by Adobe. It is widely used for a variety of contents such as advertising at websites, widgets, games, education, and videos and it contains various types of data such as sound sources, script, API and images. Many SWF files contain URL information on action script for communication in the network and they can be used as important research data as well as PC users' Web Browser history in terms of forensic investigation. And a decompiler for analyzing SWF files exists by which SWF files can be analysed and URL information can be verified. However, it takes a long time to verify the URL information on action scripts of multiple SWF files by the decompiler. In this paper, analysis of URL information on action scripts and extraction of URL information from multiple SWF files by designing analysis tools for URL information in SWF files is studied.

Non-Practice of Breast Self Examination and Marital Status are Associated with Delayed Presentation with Breast Cancer

  • Ghazali, Sumarni Mohd;Othman, Zabedah;Cheong, Kee Chee;Lim, Kuang Hock;Wan Mahiyuddin, Wan Rozita;Kamaluddin, Muhammad Amir;Yusoff, Ahmad Faudzi;Mustafa, Amal Nasir
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.2
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    • pp.1141-1145
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    • 2013
  • Delay in seeking treatment for breast cancer is a barrier to the early diagnosis and management of the disease, resulting in a poorer prognosis. We here estimated the prevalence of delayed presentation for breast cancer and identified possible influential sociodemographic factors in a cross-sectional study of 250 patients diagnosed with primary breast cancer at the Radiotherapy and Oncology Clinic in Kuala Lumpur Hospital. Data were collected by face-to-face interview using a structured questionnaire and from medical records. We examined associations between delayed presentation (presenting to a physician more than 3 months after self-discovery of a symptom) and sociodemographic characteristics, practice of breast self examination (BSE), history of benign breast disease, family history of breast cancer and type of symptom, symptom disclosure and advice from others to seek treatment using multiple logistic regression. Time from self-discovery of symptom to presentation ranged from tghe same day to 5 years. Prevalence of delayed presentation was 33.1% (95%CI: 27.4, 39.3). A significantly higher proportion of delayers presented with late stages (stage III/IV) (58.3% vs. 26.9%, p<0.001). Divorced or widowed women (OR: 2.23, 95% CI: 1.11, 4.47) had a higher risk of delayed presentation than married women and women who never performed breast self examination were more likely to delay presentation compared to those who regularly performed BSE (OR: 2.74, 95% CI: 1.33, 5.64). Our findings indicate that delayed presentation for breast cancer symptoms among Malaysian women is high and that marital status and breast self examination play major roles in treatment-seeking for breast cancer symptoms.

Recent Research Trends on Hypertension in Traditional Chinese Medicine (현대 중의학 관점의 고혈압 연구동향 분석)

  • Kim, Chang-Seok;Song, Mi-Young;Yang, Chang-Sop;Kim, Young-Eun;Yea, Sang-Jun;Kim, Chul
    • The Journal of Korean Medical History
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    • v.26 no.1
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    • pp.107-132
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    • 2013
  • Objectives : This study was performed to investigate the research trends of hypertension in Traditional Chinese Medicine(TCM), and it aims to promote hypertension research in Korean Medicine. Methods : We first collected more than 1,900 papers about hypertension research, and finally selected 108 papers related to this study. They were analyzed by the annul situation, the subject of the study, the perspective of TCM, the study stream, the research fields, the diagnostic patterns, and the distinguishing treatments of TCM. Results : The first review about hypertension in TCM was performed in 1963, and the number of studies has increased since 2000s. Doctors and researchers in China tried various diagnostic patterns to treat the patient because the diagnostic patterns were not unified. For this reason, most researches were reported to the diagnostic patterns and the treatments. Also we have discovered the diversity in treatments methods such as not only the typical herbal medicine, acupuncture, and Qigong but also specific treatments like Chuna, herbal acupoints stimulation, footbath, and pillow. Conclusions : Based on the results of this study, it can be proposed as follows : First, the various approach about hypertension in Korean Medicine is required. Second, the domestic research is needed to be extended to the external treatments as the distinguishing treatments of TCM.

A Review of the History of and Recent Trends on Emotion Research in Science Education (과학 교육에서 정서 연구의 역사와 최근 동향에 관한 고찰)

  • Oh, Phil Seok;Han, Moonhyun
    • Journal of The Korean Association For Science Education
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    • v.41 no.2
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    • pp.103-114
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    • 2021
  • The purpose of this study is to investigate the history of and recent trends in science education research on emotion and explore the direction of future development. A comprehensive review of literature was conducted, and the results were organized according to research questions. Science education research on emotion began in the state of confusion because a number of concepts coexisted and overlapped in the concept of affect. More systematic approaches were then used when science-related attitudes were divided into the two categories of scientific attitudes and attitudes toward science. The research continued to study on positive and negative emotions relevant to science learning. However, the complex relationship between cognition and emotion and the limitation of the dichotomy dealing with emotions as external factors influencing student learning were revealed. By contrast, the recent research on epistemic emotions were based on the new perspective that scientific practices are accompanied with emotions and that cognition and emotion are integrated into the practices, influencing each other. Therefore, research should be carried out in ways that can help science educators understand a variety of emotions emerging in learning science through scientific practices and respond appropriately to even negative emotions of students.

Tumor necrosis $factor-\;{\alpha}$, interleukin-6 and interleukin-10 polymorphisms in the Korean stroke patients

  • Kim, Kyung-Min;Lee, Sang-Hoon;Lee, Jae-Dong;Choi, Do-Young
    • Journal of Acupuncture Research
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    • v.22 no.2
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    • pp.1-12
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    • 2005
  • Objective: With the onset of stroke, white blood cells release several proinflammatory cytokines, including interleukin (IL)-6, IL-10, and tumor necrosis factor $(TNF)-{\alpha}$. It has been proven in previous studies that the release of these cytokines is related to the extent of damage to the brain and to overall prognosis. However, no studies have yet been performed to determine the connection with IL-6 and IL-10. Thus, this study is performed to see whether polymorphisms of IL-6, IL-10, and $TNF-{\alpha}$ genes that show increased serum concentration with the onset of stroke are related to stroke attack in Koreans. Methods : Peripheral blood samples derived from patients with stroke (n=100) and healthy controls (n=100) were taken under informed consent. In subjects with stroke, blood samples were obtained within 24 hours of stroke onset. Genomic DNA was isolated using the Wizard DNA Purification Kit (Promega, Madison, WI). Results : 1. Subjects with Heterozygote (GA) and Homozygote (AA) $TNF-{\alpha}$ gene types showed 2.433 and 20.457 times higher risks of being attacked by stroke, respectively, compared to subjects with wild type (GG) $TNF-{\alpha}$ gene type. The data was still statistically significant after adjusting for age, sex, history of smoking, and history of alcohol drinking. 2. Subjects with Homozygote (CC) IL-6 gene type showed 182.033 times higher risk of being attacked by stroke, compared to subjects with wild type (GG) IL-6 genes. This data was statistically insignificant (p=0.700). The data was still statistically insignificant after adjusting for age, sex, history of smoking, and history of alcohol drinking. 3. Subjects with Heterozygote (GA) and Homozygote (GG) IL-10 gene types showed 8.785 and 3.303 times higher risks of being attacked by stroke, respectively, compared to subjects with wild type (AA) IL-10 genes. The data was still statistically insignificant after adjusting for age, sex, history of smoking, and history of alcohol drinking. Conclusion : Our results suggest that the investigated $TNF-{\alpha}$ and IL-10 gene polymorphisms play an important role in stroke attack, but IL-6 gene polymorphism has not been found to associated with stroke.

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