• Title/Summary/Keyword: Histiocytoma

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Undifferentiated Pleomorphic Sarcoma in the Mandibular Ramus and Post-Operative Recurrence: A Case Report (하악지 영역에 발생한 미분화성 다형성 육종: 수술 후 재발한 증례)

  • Ahn, Jaemyung;Jang, Seung-Il;Hong, Jongrak;Paeng, Jun Young
    • The Korean Journal of Oral and Maxillofacial Pathology
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    • v.42 no.5
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    • pp.135-143
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    • 2018
  • Undifferentiated pleomorphic sarcoma (UPS) in the mandible region is a rare malignant neoplasm. We encountered the case of a patient who had been diagnosed with deep benign fibrous histiocytoma (DBFH) prior to surgery, but the final biopsy revealed the presence of tumor tissues in the resected margin, which indicated a UPS. Therefore, radiotherapy was conducted post-operatively, but the tumor recurred approximately 3 years later and a second surgery was performed. The difference between the initial and final diagnoses was considered to be due to the characteristics of the tumor, as it involved both benign and malignant components. DBFH and UPS can occur in young women. DBFH can transform to a malignancy and UPS may also appear as a benign tumor during early biopsy. Hence, attention should be paid to diagnosis and treatment methods, and ongoing close observation is required.

Treatment of MFH(Malignant fibrous histiocytoma) in Extremity (사지에 발생한 악성섬유조직구종의 치료 경험)

  • Kang, Jong Hwa;Lee, Won Jai;Lew, Dae Hyun;Rah, Dong Kyun;Tark, Kwan Chul
    • Archives of Plastic Surgery
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    • v.35 no.4
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    • pp.439-445
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    • 2008
  • Purpose: Malignant fibrous histiocytoma(MFH) is the most common soft tissue sarcoma in adult. As to this date, tissue development, treatment and prognosis of the tumor has not been definitely clarified, however, it has been reported that wide surgical resection of the tumor along with the radiotheraphy and chemotheraphy is needed for treatment. In MFH with high recurrence rate, the reconstruction method and points to be considered for reconstruction in recurrent case were studied in 10 patients who were treated in our hospital. Methods: From August of 1991 to August 2007, location of tumor, initial mass size, 1st recurred period, lymph node metastasis, recurrence rate, treatment modality, complication, reconstruction in recurrent defect, and follow up period was studied in 10 patients who underwent reconstruction at our Plastic surgery department following wide excision. Results: The average age was 62.8(46 - 73) years old, average follow up period was 7.7(1 - 17) years. Various reconstructions has been performed for recurrent cases and postoperative chemotheraphy and radiotheraphy was done. As for reconstruction in recurrent cases, After wide excision, local flap was performed in 6 cases, and free flap in 2 cases. After radiotherapy, osteoradionecrosis was occurred in 4 cases. Recurrence rate was 1 - 5(2.6) times and reconstruction due to recurrence was 7 out of 10 cases(70%). Conclusion: The treatment modality of MFH is not yet defined. Due to it's high recurrence rate, radiotherapy and chemotherapy is commonly combined with surgery. Even still, additional excision and reconstruction may be required. Therefore, possibility of re-operation must be considered when performing every excision and reconstruction; in case a recurrence or osteoradionecrosis occurs. Free flap coverage should be left as the last resort, according to the principle of reconstruction. Nevertheless, if the defect is large or osteoradionecrosis is present, it will benefit greatly to the patient's quality of life.

Imaging and Clinical Findings of Primary Malignant Fibrous Histiocytoma of the Urinary Bladder: A Case Report (방광의 일차 악성 섬유성 조직구종의 영상 및 임상 소견: 증례 보고)

  • Yoon Jung Lee;Eun Ji Lee;Jae Heon Kim;So Young Jin;Seong Sook Hong;Jiyoung Hwang;Yun-Woo Chang
    • Journal of the Korean Society of Radiology
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    • v.85 no.3
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    • pp.654-660
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    • 2024
  • Primary malignant fibrous histiocytoma (MFH) is a malignant tumor of mesenchymal origin that rarely occurs in the urinary tract, particularly in the urinary bladder. Unlike urothelial carcinoma, which accounts for most bladder cancers, it occurs in the submucosal portion of the bladder wall and consists of the lamina propria, muscularis propria, and adventitia. It is presumed to originate from poorly differentiated pluripotent mesenchymal cells in which fibroblasts and histiocytes are partially differentiated. Radiologically, it is known as the "non-papillary tumor" and is commonly diagnosed as a large mass without necrosis, which shows invasion beyond the muscularis propia. Although the prognosis of this rare malignancy depends on pathological parameters, it generally has a poor prognosis with high local tumor recurrence. Here, we present a case of primary MFH in the urinary bladder with clinical symptoms of lower abdominal pain without gross hematuria that recurred rapidly and showed an aggressive disease course.

Sclerosing hemangioma of the lung -3 cases report- (폐에 발생한 경화성 혈관종 -3예 보고-)

  • 소동문
    • Journal of Chest Surgery
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    • v.22 no.1
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    • pp.163-169
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    • 1989
  • Sclerosing hemangiomas of the lung are uncommon benign tumors. Although their histologic appearances are distinct and well-defined, their histogenesis is uncertain. Liebow and Hubbell reported seven cases of unusual pulmonary lesions which they named sclerosing hemangiomas in 1856. Similar cases had previously been reported under different names: Xanthoma, pulmonary histiocytoma, Xanthofibroma. We have experienced 3 cases of sclerosing hemangioma of lung at the Department of Thoracic and Cardiovascular Surgery, Yonsei University, college of Medicine, Seoul, Korea during a period of December 1985 through September 1988. This report is an early result of surgical treatment of three patients with pulmonary sclerosing hemangioma and their pathologic findings.

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A Case of Primary Malignant Fibrous Histiocytoma of the Lung (폐장의 원발성 악성 섬유성 조직구종 1예)

  • Shin, In-Cheol;Lee, Sun-Woo;Na, Moon-Jun;Park, In-Won;Choi, Byoung-Whui;Hue, Sung-Ho;Kim, Mi-Kyoung;Song, Kye-Yong;Sohn, Dong-Suep;Yang, Ki-Min
    • Tuberculosis and Respiratory Diseases
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    • v.38 no.3
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    • pp.309-316
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    • 1991
  • Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of late adult life. This tumor occurs principally as a mass on an extremity or in the abdominal cavity or retroperitoneum of adult but primary pulmonary MFH is rare. MFH may be subclassified into storiform-pleomorphic, myxoid, giant cell, inflammatory, and angiomatoid type and the prognosis is no different among the histologic subtypes. We experienced one patient who was consistent with primary MFH of the lung. The patient complained dyspnea and intermittent hemoptysis and showed bilateral suprahilar mass on simple chest film and chest CT. Histological findings by open lung biopsy was storiform-pleomorphic type and individual cells showed histiocyte-like and fibroblast-like appearance.

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A Case of Pleomorphic Hyalinizing Angiectatic Tumor of Neck Mimicking Neurogenic Tumor (신경성 종양으로 오인된 경부에 발생한 다형성 유리질 혈관확장성 종양 1례)

  • Yoo, Seok Chan;Yeo, Chang Ki;Shin, Hyeong Chan
    • Korean Journal of Head & Neck Oncology
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    • v.36 no.2
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    • pp.37-40
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    • 2020
  • Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare, low grade neoplasm which usually occurs in subcutaneous soft tissue. Histologically, it features ectatic blood filled vessels surrounded by hyalinized stroma and pleomorphic spindle cells. Clinically and histologically, PHAT could be misdiagnosed as such tumor as neurogenic tumor, malignant fibrous histiocytoma. About 100 cases of PHAT have been reported so far, and it is even rarer in head and neck area. We experienced a case of PHAT in 41-year-old male with several months of history of gradually enlarging neck mass which was surgically removed by wide excision.

Clinical Study of the Primary Mediastinal Tumor (원발성 종격동 종양에 관한 임상적고찰)

  • Choe, Pil-Jo;Lee, Jong-Su;Lee, Seong-Gwang
    • Journal of Chest Surgery
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    • v.23 no.1
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    • pp.141-145
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    • 1990
  • Author made a clinical study of 48 cases of primary mediastinal tumors experienced in the dept. of the thoracic and cardiovascular surgery of Pusan National University Hospital during the 12 years period from march 1978 to march 1989. There were 34 males and 14 females. Their age distribution was from 4 months to 70 years, with the mean age of 34.4 years. 8.3 % of the patients were younger than 15 years old. There were teratoma 14 cases[29%], thymoma 11 cases[23%], neurogenic tumor 10 cases[21 %], lymphoma 6 cases[13 %], benign cyst 6 cases[13 %], and one case of fibrous histiocytoma in the histological distribution. The malignant tumors were 12 cases[25 %]. The common symptoms were chest pain and discomfort[35.4], coughing[18.8], general weakness and dyspnea. 16.7% of the patients were asymptomatic at admission. The successful removal was done in all cases of benign mediastinal tumors. In malignant cases, the surgical removal could be done in 5 cases. There was not postop. mortality. The frequent complications were atelectasis, infection, bleeding.

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Intracranial Undifferentiated Sarcoma Arising from a Low-Grade Glioma : A Case Report and Literature Review

  • Kim, Bum-Joon;Kim, Jong-Hyun;Chung, Hung-Seob;Kwon, Taek-Hyun
    • Journal of Korean Neurosurgical Society
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    • v.57 no.6
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    • pp.469-472
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    • 2015
  • Undifferentiated sarcomas are rarely identified in the intracranial region. A 23-year-old man was admitted with a chief complaint of headache. Initial magnetic resonance images showed signs of low-grade glioma in the frontal lobe. Stereotactic biopsy was performed, and a diagnosis of diffuse astrocytoma was confirmed. Three months later, the patient presented with a high-grade tumor as seen on imaging studies. He underwent total resection of the tumor and histopathological tests identified an undifferentiated sarcoma. The patient died eight months later due to massive tumor bleeding. To the best of our knowledge, this is the first report of undifferentiated sarcoma arising from low-grade glioma without any chemotherapy or radiotherapy.

Malignant Inflammatory Fibrous Histiocytoma in a Pointer Dog

  • Do, Sun-hee;Jeong, Kyu-shik
    • Proceedings of the Korean Society of Veterinary Pathology Conference
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    • 2003.10a
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    • pp.54-54
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    • 2003
  • Malignant fibrous histiocytomas (MFHs) is the most common type of soft tissue sarcoma in the old animal with a aggressiveness, a high local recurrence rate and significant metastatic rate, which associated with a poor prognosis. In most histologic and immunohistological studies, the tumor cells raised from a fibroblastic and/or myofibroblastic phenotype, presumably from undifferentiated mesenchymal cell origin. MFHs are usually firm and invasive, arising in the subcutis; metastasis depends on tumor grade (many are grade 3) [1,2]. The primary tumor cells are pleomorphic, varying in appearance from fusiform to round. Often nucleoli are prominent and irregular [5]. Extracellular amorphous eosinophilic material may be prominent and likely represents reactive collagen production by the tumor [5]. (omitted)

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Rare experience of keloidal dermatofibroma of forehead

  • Kim, Ji Min;Cho, Hyun Jun;Moon, Suk-Ho
    • Archives of Craniofacial Surgery
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    • v.19 no.1
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    • pp.72-74
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    • 2018
  • Dermatofibromas most commonly occur on limbs and rarely occur on the face. Dermatofibroma occurring on the face is associated with unusual clinicopathologic features and a more aggressive clinical course in comparison to typical cases. Additionally, the most common subtype found in previous studies was benign fibrous histiocytoma, with the keloid type being very rare (about 1% of reported cases). The aim of this study was to present our experience with a keloidal dermatofibroma of the face, which is usually missed clinically, and to discuss the treatment of a keloidal dermatofibroma in this location.