• Journal of Microbiology and Biotechnology
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• 제28권11호
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• pp.1771-1781
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• 2018

The emergence of multidrug-resistant microorganisms, as well as fungal infectious diseases that further threaten health, especially in immunodeficient populations, is a major global problem. The development of new antifungal agents in clinical trials is inferior to the incidence of drug resistance, and the available antifungal agents are restricted. Their mechanisms aim at certain characteristics of the fungus in order to avoid biological similarities with the host. Synthesis of the cell wall and ergosterol are mainly targeted in clinical use. The need for new approaches to antifungal therapeutic agents or development alternatives has increased. This review explores new perspectives on mechanisms to effectively combat fungal infections and effective antifungal activity. The clinical drug have a common feature that ultimately causes caspase-dependent cell death. The drugs-induced cell death pathway is associated with mitochondrial dysfunction, including mitochondrial membrane depolarization and cytochrome c release. This mechanism of action also reveals antimicrobial peptides, the primary effector molecules of innate systems, to highlight new alternatives. Furthermore, drug combination therapy is suggested as another strategy to combat fungal infection. The proposal for a new approach to antifungal agents is not only important from a basic scientific point of view, but will also assist in the selection of molecules for combination therapy.

• Steel and Composite Structures
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• 제4권4호
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• pp.281-301
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• 2004

The paper begins by presenting a unified variational approach to the lateral-torsional buckling (LTB) analysis of doubly symmetric prismatic and tapered thin-walled beams with open cross-sections, which accounts for the influence of the pre-buckling deflections. This approach (i) extends the kinematical assumptions usually adopted for prismatic beams, (ii) consistently uses shell membrane theory in general coordinates and (iii) adopts Trefftz's criterion to perform the bifurcation analysis. The proposed formulation is then applied to investigate the influence of the pre-buckling deflections on the LTB behaviour of prismatic and web-tapered I-section simply supported beams and cantilevers. After establishing an interesting analytical result, valid for prismatic members with shear centre loading, several elastic critical moments/loads are presented, discussed and, when possible, also compared with values reported in the literature. These numerical results, which are obtained by means of the Rayleigh-Ritz method, (i) highlight the qualitative differences existing between the LTB behaviours of simply supported beams and cantilevers and (ii) illustrate how the influence of the pre-buckling deflections on LTB is affected by a number of factors, namely ($ii_1$) the minor-to-major inertia ratio, ($ii_2$) the beam length, ($ii_3$) the location of the load point of application and ($ii_4$) the bending moment diagram shape.

• 동의생리병리학회지
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• 제30권6호
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• pp.370-375
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• 2016

Recent advances in systems biology are shedding a new light on the traditional medicine research. The systems biology highlights the way each component interacts with each other within a system, and the network behavior that emerges from such interactions. This feature of systems biology can accent the systemic aspects of Korean medicine such as the mechanism of action of herbal formulae, pattern differentiation, and the meridian systems, as both the Korean medicine and the systems biology theorize the human physiological functions and phenomena from a holistic point of view. This paper outlines the meaning of the recent Korean medicine research using the systems biology methodology. We discuss the methodologies of the two fields in a comparative manner, and overview the advantages and limitations of the integrated approaches. Finally, we suggest the future prospects for the systems biology inspired approaches to the Korean medicine research. The systems biology may provide a new modernized research methodology for the Korean medicine that can highlight its unique features.

• 한국초전도학회:학술대회논문집
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• 한국초전도학회 2000년도 High Temperature Superconductivity Vol.X
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• pp.107-110
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• 2000

($^{11}$B NMR measurements have been performed on single crystals of LuNi$_2$B$_2$C superconductor to investigate vortex lattice structures and dynamical behavior. The spectrum in the superconducting state is significantly broadened by local field inhomogeneity due to the vortex lattice and the peak point of the spectrum shifts toward low magnetic field due to the imperfect field penetration. The linewidth of the spectrum reflecting local field variation is much smaller than expected for conventional vortex lattices and shows peculiar increase at low temperature. Furthermore, the transverse relaxation rate, 1/T$_2$, probing the slow motion of vortices, exhibits a single peak as temperature decreases. These prominent results highlight significant fluctuation of vortices even for this low T$_c$, and nearly isotropic 3D superconductor.

• 가정∙방문간호학회지
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• 제24권1호
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• pp.44-51
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• 2017

Purpose: This descriptive study was conducted to identify the attitudes of nursing college students to North Korean refugees (NKR) and to examine factors influencing these attitudes. Methods: A total of 195 participants completed a structured questionnaire between September and October 2016. Data were analyzed using the SPSS 21.0 program. Results: The results of this study were as follows: attitudes toward NKR was 2.74 out of 4 points; cultural receptivity was 3.25 out of 5 points; nationalism was 2.46 out of 4 points. Cultural receptivity (r=.26, p<.001) and nationalism (r=-.18, p=.036) were significantly related to attitudes toward NKR. Unification attitude (${\beta}=0.27$, p <.001) and cultural receptivity (${\beta}=0.20$, p=.005) explained 13.7% of the variance in attitudes toward NKR. Conclusion: The findings of this study provide fundamental data for the development of a nursing education program on multicultural perspectives. Furthermore, these findings might highlight the need for a nursing education program that could enhance understanding of patients from different backgrounds and recognize their differences, going beyond a national point of view as commonly found in Korea. The nursing education program should also promote an open and receptive attitude.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2345-2348
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• 2012

Epidemiological studies of cancer incidence in Kazakhstan have revealed an uneven distribution for cervical cancer. Incidence and mortality rates were calculated for different regions of the republic, including the two major cities of Almaty and Astana, in 1999-2008. Defined levels for cartograms for incidence were low (up to 12.8/100,000), medium (12.8 to 15.9) and high (above 15.9) and for mortality were up to 7.1, 7.1 to 10.8 and more than 10.8, respectively. Basically high incidence rates were identified in the eastern, central and northern parts of the country and in Almaty. Such differences in cervical cancer data, and also variation in mortality/ incidence ratios, from a low of 0.4 in Almaty to a high of 0.71 in Zhambyl, point to variation in demographic and medical features which impact on risk and prognistic factors for cervical cancer in the country. Further research is necessary to highlight areas for emphasis in cancer control programs for this important cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5049-5054
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• 2013

Background: To assess the treatment pattern and expenditure incurred by cancer patients undergoing treatment at government tertiary hospitals in India. Materials and Methods: A cross-sectional study of 508 cancer patients randomly selected from tertiary cancer hospitals funded by central/state governments located in major cities of five states in India, namely Kerala, Maharashtra, Rajasthan, West Bengal and Mizoram, during March - May 2011 was conducted. Information related to direct costs, indirect costs and opportunity costs incurred on investigations and treatment, major source of payment and difficulties faced by patients during the course of treatment was collected. Results: About 45% of the patients used private health facilities as the first point of contact for cancer related diseases as against 32% in public hospitals. About 47% sought private health facilities for cancer investigations, 21% at district/sub-district hospitals, and about 4% contacted primary health care facilities. A majority of the patients (76%) faced financial problems while undergoing treatment. Conclusions: The results highlight the importance of involving the primary health care system in the cancer prevention activities.

• 한국산학기술학회논문지
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• 제12권10호
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• pp.4348-4353
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• 2011

본 논문은 은유적 표현이 단순한 수사학적인 표현이 아닌 사고의 영역에 관련되어 있다는 인지언어학적인 관점을 따른다. 이러한 관점은 은유는 특정한 사고의 틀(frame)을 동원하여 그 틀에 의해 대상을 보게 하므로 어떤한 면을 부각시키는 반면 여전히 실재하는 다른 면을 감추기도 하면서 우리의 삶에 영향을 주고 있음에 주목한다. 정치에서의 은유표현들은 정치적 의도를 관철시키기 위해 사용된다. Lakoff는 미국의 보수주의에는 '엄한 아버지' 모델이 라는 도덕관이 작동하고 있다고 주장한다. 본고는 '엄한 아버지' 모델에 근거한 동일한 은유가 조지 H. 부시 대통령의 걸프전 연설문과 조지 W. 부시 대통령의 이라크전 연설문에 공통적으로 사용되고 있음을 확인하였다.

• 세라미스트
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• 제22권1호
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• pp.70-81
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• 2019

Breath analysis is rapidly evolving as a non-invasive disease recognition and diagnosis method. Metal oxide gas sensors are one of the most ideal platforms for realizing portable, hand-held breath analysis devices in the near future. This paper reviewed the recent developments in metal oxide gas sensors detecting exhaled biomarker gases such as nitric oxides, acetone, ammonia, hydrogen sulfide, and hydrocarbons. Emphasis was placed on strategies to tailor sensing materials/films capable of highly selective and sensitive detection of biomarker gases with negligible cross-response to ethanol, the major interfering breath gas. Specific examples were given to highlight the validity of the strategies, which include optimization of sensing temperature, doping additives, utilizing acid-base interaction, loading catalysts, and controlling gas reforming reaction. In addition, we briefly discussed the design and optimization method of gas sensor arrays for implementing the simultaneous assessment of multiple diseases. Breath analysis using high-performance metal oxide gas sensors/arrays will open new roads for point-of-care diagnosis of diseases such as asthma, diabetes, kidney dysfunction, halitosis, and lung cancer.

• Mycobiology
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• 제39권4호
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• pp.235-242
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• 2011

In contrast to the nuclear genome, the mitochondrial genome does not follow Mendelian laws of inheritance. The nuclear genome of meiotic progeny comes from the recombination of both parental genomes, whereas the meiotic progeny could inherit mitochondria from one, the other, or both parents. In fact, one fascinating phenomenon is that mitochondrial DNA in the majority of eukaryotes is inherited from only one particular parent. Typically, such unidirectional and uniparental inheritance of mitochondrial DNA can be explained by the size of the gametes involved in mating, with the larger gamete contributing towards mitochondrial DNA inheritance. However, in the human fungal pathogen Cryptococcus neoformans, bisexual mating involves the fusion of two isogamous cells of mating type (MAT) a and MAT${\alpha}$, yet the mitochondrial DNA is inherited predominantly from the MATa parent. Although the exact mechanism underlying such uniparental mitochondrial inheritance in this fungus is still unclear, various hypotheses have been proposed. Elucidating the mechanism of mitochondrial inheritance in this clinically important and genetically amenable eukaryotic microbe will yield insights into general mechanisms that are likely conserved in higher eukaryotes. In this review, we highlight studies on Cryptococcus mitochondrial inheritance and point out some important questions that need to be addressed in the future.