• 한국광학회지
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• 제16권4호
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• pp.334-339
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• 2005

디지털 영상 장치에서 홀로그램 광 저대역 필터를 사용할 때 해상도 저하 문제를 개선하기 위해 다중 위상 홀로그램을 설계하였다. 자체 제작한 몬테-카를로 방식의 홀로그램 설계 프로그램을 이용하여 회절광 세기 분포가 원형에 가깝도록 홀로그램을 설계하였고 그 회절 효율과 MTF를 구하였다. 설계 결과 홀로그램의 한 주기를 구성하는 셀의 개수는 MTF 특성에 별로 영향을 미치지 못한 반면에 홀로그램의 위상 수는 큰 영향을 미침을 확인하였다. 4 위상 홀로그램은 2 위상 홀로그램과 회절 효율이 같고 MTF 또한 2 위상에서와 같이 저주파수 영역에서 직선 형태가 되어 필터로서의 특성이 변하지 않았다. 그러나 8 위상 홀로그램의 경우에는 회절 효율도 2 위상에 비해 크게 개선되었고 저주파수 영역에서의 MTF 값도 증가하여 필터의 성능이 크게 향상되었다. 16 위상인 경우에는 회절 효율도 더 증가하고 MTF 그래프도 더 위로 볼록한 모양이 되었으나 그 증가 폭은 크게 감소하였다. 설계된 8 위상 홀로그램을 제작하고 MTF를 측정하여 2 위상보다 MTF 특성이 향상됨을 실험적으로 확인하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권10호
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• pp.4002-4014
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• 2015

ITU-R M.1842-1, as a well-known specification dedicated to maritime mobile applications, has standardized wireless transmission protocols according to the particular characteristics of a maritime communications scenario. A time division multiple access (TDMA) frame structure, along with modulation schemes to achieve a high data rate, has been described clearly in ITU-R M.1842-1. However, several specification items are still under "to be decided" status, which brings ambiguity to research works. In addition, the current version of ITU-R M.1842-1 is focused mainly on maritime transmissions in open-sea areas, where the cyclic prefix (CP) is set to zero and only 16-QAM is used in the multi-carrier (MC) system. System performance might be dramatically degraded in coastline areas due to the inter-symbol interference (ISI) caused by selective fading. This is because there is a higher probability that the signal will be reflected by obstacles in coastline areas. In this paper, we introduce the transmission resource block (TRB) dedicated to ITU-R M.1842-1 for a ship ad-hoc network (SANET), where the pilot pattern of TRB is based on the terrestrial trunked radio (TETRA). After that, we evaluated SANET performance under the maritime channel model in a coastline area. In order to avoid noise amplification and to overcome the ISI caused by selective fading, several strategies are suggested and compared in the channel estimation and equalization procedures, where the link-level simulation results finally validate our proposals.

• 농업생명과학연구
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• 제46권6호
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• pp.157-163
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• 2012

새송이버섯(Pleurotus eryngii)은 인기 있는 식용버섯 중의 하나로서 항산화, 항암 또는 면역조절 기능 등의 인체에 유익한 생리활성 기능을 지닌다. 본 연구에서는 새송이버섯 균사체 배양 시 커피음료 생산과정으로부터 폐기되는 커피박(spent coffee ground: SCG) 첨가에 의한 균사체의 생장과 기능성의 변화를 조사하였다. 그 결과, SCG(1-10%, w/v) 첨가 시 생장속도가 상당히 증가하는 경향을 나타내었다. 특히 1% SCG 첨가 시 무첨가에 비해 건조중량이 2.5배 증가함으로써 SCG가 탁월한 새송이버섯 균사체의 생장촉진제 기능이 제시되었다. SCG 첨가에 의하여 균사체의 polysaccharide 함량은 변화가 없었으나 polyphenol량 및 항산화능의 증대를 확인할 수 있었다.

• Smart Structures and Systems
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• 제15권1호
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• pp.135-150
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• 2015

Large concrete structures are prone to cracks and damages over time from human usage, weathers, and other environmental attacks such as flood, earthquakes, and hurricanes. The health of the concrete structures should be monitored regularly to ensure safety. A reliable method of real time communications can facilitate more frequent structural health monitoring (SHM) updates from hard to reach positions, enabling crack detections of embedded concrete structures as they occur to avoid catastrophic failures. By implementing an unconventional mode of communication that utilizes guided stress waves traveling along the concrete structure itself, we may be able to free structural health monitoring from costly (re-)installation of communication wires. In stress-wave communications, piezoelectric transducers can act as actuators and sensors to send and receive modulated signals carrying concrete status information. The new generation of lead zirconate titanate (PZT) based smart aggregates cause multipath propagation in the homogeneous concrete channel, which presents both an opportunity and a challenge for multiple sensors communication. We propose a time reversal based pulse position modulation (TR-PPM) communication for stress wave communication within the concrete structure to combat multipath channel dispersion. Experimental results demonstrate successful transmission and recovery of TR-PPM using stress waves. Compared with PPM, we can achieve higher data rate and longer link distance via TR-PPM. Furthermore, TR-PPM remains effective under low signal-to-noise (SNR) ratio. This work also lays the foundation for implementing multiple-input multiple-output (MIMO) stress wave communication networks in concrete channels.

• Journal of Neurogastroenterology and Motility
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• 제24권4호
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• pp.643-655
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• 2018

Background/Aims Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether the high-affinity choline transporter 1 (CHT1), a determinant of cholinergic signaling capacity, modulates intestinal motility associated with stress-induced IBS. Methods A rat IBS model was established using chronic water avoidance stress (WAS). Colonic pathological alterations were evaluated histologically and intestinal motility was assessed by intestinal transit time and fecal water content (FWC). Visceral sensitivity was determined by visceromotor response to colorectal distension. RT-PCR, western blotting, and immunostaining were performed to identify colonic CHT1 expression. Contractility of colonic muscle strips was measured using isometric transducers. enzyme-linked immunosorbent assay was used to measure acetylcholine (ACh). We examined the effects of MKC-231, a choline uptake enhancer, on colonic motility. Results After 10 days of WAS, intestinal transit time was decreased and fecal water content increased. Visceromotor response magnitude in WAS rats in response to colorectal distension was significantly enhanced. Protein and mRNA CHT1 levels in the colon were markedly elevated after WAS. The density of CHT1-positive intramuscular interstitial cells of Cajal and myenteric plexus neurons in WAS rats was higher than in controls. Ammonium pyrrolidine dithiocarbamate partly reversed CHT1 upregulation and alleviated colonic hypermotility in WAS rats. Pharmacological enhancement of CHT1 activity by MKC-231 enhanced colonic motility in control rats via upregulation of CHT1 and elevation of ACh production. Conclusion Upregulation of CHT1 in intramuscular interstitial cells of Cajal and myenteric plexus neurons is implicated in chronic stress-induced colonic hypermotility by modulation of ACh synthesis via nuclear factor-kappa B signaling.

• 대한약침학회지
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• 제22권1호
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• pp.16-27
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• 2019

Generative and vegetative parts of the cactuses have had a long-lasting position in folk medicine and their effects could partly be confirmed in scientific experiments. Nowadays, the cactus, fruits, and cladodes are the focus of many studies because of their desirable properties. Therefore, the summarized reports of valuable properties of medicinal plants may be a good way to familiarize researches with a new source of drugs with lower side effects and higher efficacy. Opuntia dillenii, a well-known member of the Cactaceae family, is used as a medicinal plant in various countries and grows in the desert, semi-desert, tropical and sub-tropical areas. It shows diverse pharmacological activities such as: antioxidant, anti-inflammatory, anti-tumor, neuroprotective, hepatoprotective, hypotensive etc. OD fruit also possesses valuable constitutes for instance: betalains, ascorbic acid, total phenol, protein as well as essential elements which suggest the significant potential of this plant as a complementary therapy against several pathological conditions. This review describes experimental evidence about pharmacological and therapeutic potential of OD in order to give the basis of its application in the prevention and treatment of some chronic diseases. More studies on OD can help better understanding of its pharmacological mechanism of action to explain its traditional uses and to identify its potential new therapeutic applications.

• Biomolecules & Therapeutics
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• 제27권1호
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• pp.63-70
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• 2019

Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a heterogeneous cell population frequently observed in cancer, infection, and autoimmune disease. Immune checkpoint molecules, such as programmed death 1 (PD-1) expressed on T cells and its ligand (PD-L1) expressed on tumor cells or antigen-presenting cells, have received extensive attention in the past decade due to the dramatic effects of their inhibitors in patients with various types of cancer. In the present study, we investigated the expression of PD-1 on MDSCs in bone marrow, spleen, and tumor tissue derived from breast tumor-bearing mice. Our studies demonstrate that PD-1 expression is markedly increased in tumor-infiltrating MDSCs compared to expression in bone marrow and spleens and that it can be induced by LPS that is able to mediate $NF-{\kappa}B$ signaling. Moreover, expression of PD-L1 and CD80 on $PD-1^+$ MDSCs was higher than on $PD-1^-$ MDSCs and proliferation of MDSCs in a tumor microenvironment was more strongly induced in $PD-1^+$ MDSCs than in $PD-1^-$ MDSCs. Although we could not characterize the inducer of PD-1 expression derived from cancer cells, our findings indicate that the study on the mechanism of PD-1 induction in MDSCs is important and necessary for the control of MDSC activity; our results suggest that $PD-1^+$ MDSCs in a tumor microenvironment may induce tumor development and relapse through the modulation of their proliferation and suppressive molecules.

• 한국음향학회지
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• 제37권6호
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• pp.404-411
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• 2018

본 논문은 수중에서 은밀성을 확보하기 위해 FSK(Frequency Shift Keying)를 이용하여 돌고래 휘슬음을 모방하는 통신 기법과 다중경로 결합 이득을 이용하여 BER(Bit Error Rate) 성능을 높이는 방법을 제안한다. 제안하는 방법은 휘슬음을 짧은 시간 구간으로 나누고 그 구간에 심볼의 직교성을 보장하는 FSK 변조신호를 만든다. 그리고 휘슬음을 모방할 때 다중경로 채널에서 심볼간의 ISI(Inter Symbol Interference)가 줄어드는 특징을 이용하여 다중경로 결합 이득을 얻는 방법이다. 제안한 방법의 성능을 보이기 위해 전산모의실험과 실제 호수실험을 진행하였다. 전산모의실험을 통해 다중경로에 의해 추가적인 다중경로 결합 이득이 발생함을 보였다. 호수 실험에서는 제안된 FSK 방법이 20 msec의 심볼 길이와 900 Hz의 변조 대역을 갖는 경우 다중경로 결합 이득을 얻어 0.002의 BER갖고 0.185의 BER을 갖는 CSS(Chirp Spread Spectrum)보다 우수함을 보였다. 그리고 모방한 신호와 실제 휘슬 신호의 시간-주파수 영역에서 평균 상호 상관 값을 통해 모방도를 분석하여 제안된 FSK방법이 CSS방법에 비해 높은 모방도를 보였다.

• Imaging Science in Dentistry
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• 제49권2호
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• pp.139-151
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• 2019

Purpose: This study was performed to investigate the effect of exposure parameters on image quality obtained using a cone-beam computed tomography (CBCT) scanner and the relationship between physical factors and clinical image quality depending on the diagnostic task. Materials and Methods: CBCT images of a SedentexCT IQ phantom and a real skull phantom were obtained under different combinations of tube voltage and tube current (Alphard 3030 CBCT scanner, 78-90 kVp and 2-8 mA). The images obtained using a SedentexCT IQ phantom were analyzed technically, and the physical factors of image noise, contrast resolution, spatial resolution, and metal artifacts were measured. The images obtained using a real skull phantom were evaluated for each diagnostic task by 6 oral and maxillofacial radiologists, and each setting was classified as acceptable or unacceptable based on those evaluations. A statistical analysis of the relationships of exposure parameters and physical factors with observer scores was conducted. Results: For periapical diagnosis and implant planning, the tube current of the acceptable images was significantly higher than that of the unacceptable images. Image noise, the contrast-to-noise ratio (CNR), the line pair chart on the Z axis, and modulation transfer function (MTF) values showed statistically significant differences between the acceptable and unacceptable image groups. The cut-off values obtained using receiver operating characteristic curves for CNR and MTF 10 were useful for determining acceptability. Conclusion: Tube current had a major influence on clinical image quality. CNR and MTF 10 were useful physical factors that showed significantly associations with clinical image quality.

• 융합정보논문지
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• 제9권5호
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• pp.125-129
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• 2019

본 논문은 위상코드 펄스압축(PCPC) 레이더의 재밍 효과에 대해서 기술하였다. 대표적인 PCPC 레이더인 Barker code 레이더는 송신 펄스를 13개 또는 31개의 작은 펄스로 분리하여 각 펄스신호를 위상변조하여 송신함으로써 레이더 탐지효율을 높이고 잡음이나 재밍에 대한 영향을 감소시킨다. 일반적으로 레이더는 재밍을 받으면 탐지거리는 짧아지고 탐지 에러율은 높아진다. PCPC 레이더에 잡음재밍이나 반송파 재밍을 실시한 경우에는 펄스코드 융합이 없어서 재밍 영향이 매우 작았지만, DRFM 등을 이용하여 펄스코드 신호를 복재하여 재밍신호로 사용한 동기재밍 경우에는 재밍효과가 크게 나타났다. 특히 펄스코드 신호 복재시간이 길어지면 재밍효과가 증가되는 것을 볼 수 있다. 본 연구는 펄스압축 레이더와 전자전 재밍장치 재밍신호 설계에 유용하게 활용할 수 있다고 판단된다.