• 제목/요약/키워드: High-risk factor

검색결과 1,427건 처리시간 0.03초

미확정 편평상피세포와 인체 유두종바이러스와의 비교 (Comparison of ASCUS and Human Papilloma Virus)

  • 박미순;장병수
    • 한국콘텐츠학회논문지
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    • 제13권8호
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    • pp.308-313
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    • 2013
  • 세포선별검사에서 ASCUS로 진단된 검체 중 F-UP이 진행되지 않은 검체 179건을 대상으로 HPV high risk factor, low risk factor를 확인하기 위해서 Hybrid Capture II Test를 하였다. 시험 결과 high risk factor 양성 및 low risk factor 양성은 전체 179 cases 중 26 cases로 나타났으며, 전체 검체 중 약 15%에 해당되었다. 또한 전체 15%의 양성검체 중 high risk factor 양성은 96%에 해당되는 것을 확인하였다. 결론적으로 효과적인 검진 체계를 갖춘 나라에서도 자궁경부암의 예방이 완전히 해결되지 않고 있는 문제점이 있는 여건을 고려해 볼 때 추적 관찰이 용이하지 않은 경우를 대비해 자궁경부암으로 진행될 수 있는 precancerous lesion의 원인 인자인 HPV 존재 유무를 세포선별검사와 HPV Hybrid Capture II Test를 동시에 시행하는 것이 효과적이라고 사료된다.

데이터 마이닝을 적용한 실업계 고등학생의 가출 예측모형 (A Forecast Model on Vocational High School for Runaway Students Using Data Mining)

  • 이주리
    • 가정과삶의질연구
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    • 제27권2호
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    • pp.203-211
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    • 2009
  • This study was conducted to evaluate a forecast model designed to describe a vocational high school for runaway students. The study included 2000 adolescents from the KEEP(Korean Education and Employment Panel). A Data mining decision tree model revealed that: (1) Suicide ideation was a risk factor for running away among smokers. (2) High self-evaluation was a risk factor for running away among individuals that smoked and had no suicide ideation. (3) Drinking was predicted as a risk factor for no smokers, while family life dissatisfaction was predicted as a risk factor among non-smokers that drank. (4) Negative relationship with mother was predicted as a risk factor among non-drinking non-smoking.

미확정 편평 상피세포와 인체 유두종 바이러스와의 비교 (Comparison of ASCUS and HPV Hybrid Capture II Test Results)

  • 박미순;장병수
    • 한국콘텐츠학회:학술대회논문집
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    • 한국콘텐츠학회 2012년도 춘계 종합학술대회 논문집
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    • pp.175-176
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    • 2012
  • 세포선별검사에서 ASCUS로 진단된 검체 중 F-UP이 진행되지 않은 검체 179건을 대상으로 HPV High risk factor, Low risk factor를 확인하기 위해서 Hybrid Capture II Test를 하였다. 결과 High risk factor 양성 및 Low risk factor 양성은 전체 179 cases 중 25 cases로 나타났으며, 전체 검체 중 약 15%에 해당되었다. 또한 전체 15%의 양성검체 중 High risk factor 양성은 87%에 해당되는 것을 확인하였다. 결론적으로 효과적인 검진 체계를 갖춘 나라에서도 자궁경부암의 예방이 완전히 해결되지 않고 있는 문제점이 있는 여건을 고려해 볼 때 추적 관찰이 용이하지 않은 경우를 대비해 자궁경부암으로 진행될 수 있는 precancerous lesion의 원인 인자인 HPV 존재 유무를 세포선별검사와 HPV Hybrid Capture II Test를 동시에 시행하는 것이 효과적이라고 사료된다.

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The efficacy of chemotherapy in the patients with stage II colon cancer associated with number of high-risk factors

  • Kim, Min Joo;Baek, Seung-hyun;Ko, Sanghwa
    • 대한종양외과학회지
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    • 제14권2호
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    • pp.116-119
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    • 2018
  • Purpose: This study assessed the effect of chemotherapy over stage II colon cancer in terms of presence of high-risk factors. Methods: Data were retrospectively reviewed for 364 patients with stage II colon cancer who underwent curative surgery between January 2007 and December 2012. High-risk factors of stage II colon cancer were examined, and the overall survival (OS) rates were analyzed. Survival benefit of adjuvant chemotherapy was also analyzed. Results: One hundred and fifteen cases had exclusively single high-risk factor and 194 cases were negative for high-risk factors. Postoperative chemotherapy was performed in 262 of 364 patients (72.0%). The 5-year OS was 79.4% and 86.6% for patients without adjuvant chemotherapy and those with chemotherapy, respectively. The 5-year OS was 88.2% and 83.3% for patients having exclusively single high-risk factor with adjuvant chemotherapy and those without chemotherapy, respectively. Conclusion: Adjuvant chemotherapy for patients with stage II colon cancer having exclusively single high-risk factor could be omitted, weighing up the survival benefit and side effect of chemotherapy.

장기소비 위험을 이용한 통화포트폴리오 수익률에 관한 연구 (A Study on the Long-Run Consumption Risk in Foreign Currency Risk Premia)

  • 유원석;손삼호
    • 유통과학연구
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    • 제11권10호
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    • pp.55-62
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    • 2013
  • Purpose - The purpose of this study is to suggest a risk factor that significantly explains foreign currency risk premia. In recent years, some studies have found that the performance of the simultaneous consumption risk model improves considerably when tested on foreign currency portfolios, which are constructed based on the international interest rates differentials. However, this paper focuses on the long-run consumption risk factor. In our empirical research, we found that the real excess returns of high interest rate currency portfolios depreciate on average, when the future American long-run consumption growth rate appears low. This makes the high interest rate currency portfolios have relatively high risk premia. Meanwhile, the real excess returns of low interest rate currency portfolios appreciate on average, under the same conditions, which results in relatively low risk premia for these portfolios. Therefore, this long-run consumption risk factor might explain why low interest rate currencies do not appreciate as much as the interest rate differential, and why high interest rate currencies do not depreciate as much as the interest rate differential. Research design, data, methodology - In our explanation, we provide new evidence on the success of long-run consumption risks in currency risk premia by focusing on the long-run consumption risks borne by American representative investors. To uncover the hidden link between exchange rates and long-run consumption growth, we set the eight currency portfolios as our basic assets, which have been built based on the foreign interest rates of eighty countries. As these eight currency portfolios are rebalanced every year, the first group always contains the lowest interest rate currencies, and the last group contains the highest interest rate currencies. Against these basic eight currency portfolios, we estimate the long-run consumption risk model. We use recursive utility framework and the stochastic discount factor that depends on the present value of expected future consumption growth rates. We find that our model is optimized in the two-year period of constructing the durable consumption expectation factor. Our main results surprisingly surpass the performance of the existing benchmark simultaneous consumption model in terms of R2, relatively risk aversion coefficient γ, and p-value of J-test. Results - The performance of our model is superior. R2, relatively risk aversion coefficient γ, and p-value of J-test of our long-run durable consumption model are 90%, 93%, and 65.5%, respectively, while those of EZ-DCAPM are 87%, 113%, and 62.8%, respectively. Thus, we can speculate that the risk premia in foreign currency markets have been determined by the long-run consumption risk. Conclusions - The aggregate long-run consumption growth risk explains a large part of the average change in the real excess returns of foreign currency portfolios. The real excess returns of high interest rate currency portfolios depreciate on average when American long-run consumption growth rate is low, and the real excess returns of low interest rate currency portfolios appreciate under the same conditions. Thus, the low interest rate currency portfolios allow investors to hedge against aggregate long-run consumption growth risk.

고등학생의 자살사고 예측모형 : 데이터마이닝을 적용한 위험요인과 보호요인의 탐색 (A Forecast Model on High School Students' Suicidal Ideation: The Investigation Risk Factors and Protective Factors Using Data Mining)

  • 이주리
    • 대한가정학회지
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    • 제47권5호
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    • pp.67-77
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    • 2009
  • This study examined risk factors and protective factors in high school students’ suicidal ideation. Participants were 2000 adolescents from the KEEP(Korean Education and Employment Panel). Data mining decision tree model revealed that: (1) Irrespective of sex, the most important predictor was father-adolescent relationship. (2) Positive mother-adolescent relationship was predicted as protective factor in condition of negative father-adolescent relationship. (3) Family activities was predicted as risk factor in condition of negative mother-adolescent relationship under the circumstances with negative father-adolescent relationship. (4) Low self-evaluation was predicted as risk factor in condition of serious agony about personality under the circumstances with positive father-adolescent relationship.

혈우병 A의 발병에 관여하는 유전적 요인 (Genetic Risk Factors of Hemophilia A)

  • 심예지;이건수
    • Journal of Genetic Medicine
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    • 제7권1호
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    • pp.1-8
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    • 2010
  • Hemophilia A is a sex-linked recessive coagulation disorder associated with diverse mutations of the factor VIII gene and a variety of phenotypes. The type of mutation involved dictates the activity of factor VIII, and in turn the severity of bleeding episodes and development of alloantibodies against factor VIII (inhibitors). Missense mutations are the most common genetic risk factors for hemophilia A, especially mild to moderate cases, but carry the lowest risk for inhibitor development. On the other hand, intron 22 inversion is the most common mutation associated with severe hemophilia A and is associated with high risk of inhibitor formation. Large deletions and nonsense mutations are also associated with high risk of inhibitor development. Additional mutations associated with hemophilia A include frameshift and splice site mutations. It is therefore valuable to assess the mutational backgrounds of hemophilia A patients in order to to interpret their symptoms and manage their health problems.

중년 남성에서 고정상혈압에 의한 고혈압발생 위험 규명을 위한 코호트내 환자-대조군 연구 (A Nested Case-Control Study on the High Normal Blood Pressure as a Risk Factor of Hypertension in Korean Middle-aged Men)

  • 안윤옥;배종면
    • Journal of Preventive Medicine and Public Health
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    • 제32권4호
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    • pp.513-525
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    • 1999
  • Objectives : High-normal blood pressure' is a factor influencing decision to initiate targeted intensive intervention strategy in westernized populations. JNC-VI offered the vigorous lifestyle modification for persons with 'high-normal blood pressure', who could be early detected. As a hypertension seems to be the result of multiple genetic factors operating in concert with associated environmental factors, it will be necessary to identify the high-normal blood pressure as a risk factor of hypertension for applying primary prevention strategy in Korean people. Methods : Although cohort study design might be adequate to recruit incidence cases, to keep time sequence of events, and to prevent information bias, nested case-control study was chosen for avoiding measurement errors because hypertension is a benign disease. Source population was the 'Seoul Cohort' participants and follow-up was done by using Korea Medical Insurance Corporation's database on the utilization of health services from 1 Jan93 to 30Jun97. Incidence cases were ascertained through the chart review, telephone contacts, and direct blood pressure measurements. Controls included the pairing of 4 individuals to each case on the basis of age. Results : As 75% of 247 incident cases had high-normal blood pressure, the crude odds ratio for hypertension was 2.04 (95% CI 1.47-2.83). Another statistically significant risk factors of hypertension were body mass index, dietary fiber, alcohol consumption, weekly activity and history of quitting smoking. The multivariate odds ratio of high-normal blood pressure adjusted for all risk factors was 1.84 (95% CI 1.31-2.56). Among high-normal blood pressure group, body mass index, weekly ethanol amounts, weekly physical activity, and dietary fiber except history of quitting smoking were still risk factors of hypertension. Conclusion : 'High-normal blood pressure' is a risk factor for hypertension in Korean middle-aged men, which represents that the vigorous lifestyle modification for persons with 'high-normal blood pressure' is need.

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성별에 따른 강박증상의 위험요인으로서 주관적 건강상태 (Self-rated Health as a Sex-based Risk Factor for Compulsion)

  • 김윤영;현혜순;장은수
    • 보건의료산업학회지
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    • 제13권4호
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    • pp.243-252
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    • 2019
  • Objectives: This study aimed to determine whether the self-rated health (SRH) could be a risk factor for compulsion. Methods: Data related with compulsion and SRH information were collected from 532 young adults aged over 20 years in South Korea. The distribution of the high and low SRH groups was analyzed using the chi-square test, whereas difference in quality of life (QoL) was analyzed using the t-test. Logistic regression was used to analyze the odds ratio (OR). Results: In the high and low-SRH groups, 44 (28.8%) and 23 (31.5%) men and 24 (10.4%) and 21 (27.6%) women, respectively, were at risk for compulsion (p<.001). For women, the compulsion scores of the low and high-SRH groups, respectively, were 15.8±9.53 and 9.9±8.47 (t=5.071, p<.001). The low-SRH group had higher ORs compared with the high-SRH group among women (OR 3.277, 95% confidence interval 1.699 - 6.321, p<.001) in the original model, and this phenomenon was significant even after adjusting for age and residence type. Conclusions: Low SRH may be a risk factor for compulsion. Further research for improving SRH by developing preventive measures against compulsion is necessary.

유방암의 위험요인 (Risk Factors of Breast Cancer)

  • 정복례;변혜선;김경덕;김경혜
    • 종양간호연구
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    • 제8권2호
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    • pp.120-127
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    • 2008
  • Purpose: The purpose of this study was secondary analysis to explore about risk factors with breast cancer on a basis of primary literature. Methods: This study was searched articles by using CINAHL, MEDLINE, Riss4u, Internet website regarding breast cancer. This study searched for the journal published in Korea and foreign countries from 2000 to 2008, about risk factors of breast cancer. This study was reviewed 42 articles (5 experimental study, 35 survey, 1 qualitative study, 1 report) suitable for the research objectives. Results: Magnitude of risk breast cancer (++) was age, geographic region, family history, mutations in BRCA1, BRCA2 genes and in other penetrance genes, radiation, history of benign breast disease, late age of menopause, early age of menarch, nulliparity and older age at first birth, high mammographic breast density, high insulin-like growth factor 1 level. Magnitude of risk factor (+) was hormone replacement therapy, oral contraceptives use, obesity, tall stature, alcohol consumption, high prolactin level, high saturated fat and well-done meat intake, polymorphisms in low penetrance gene, high socioeconomic status. Conclusion: A breast cancer screening protocol according to magnitude of risk factors is needed for disease prevention. The nurses need to educate and counsel women with risk factors of breast cancer.

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