• Journal of Microbiology and Biotechnology
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• 제31권3호
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• pp.349-357
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• 2021

Monoclonal antibodies are widely used as diagnostic reagents and for therapeutic purposes, and their demand is increasing extensively. To produce these proteins in sufficient quantities for commercial use, it is necessary to raise the output by scaling up the production processes. This review describes recent trends in high-density cell culture systems established for monoclonal antibody production that are excellent methods to scale up from the lab-scale cell culture. Among the reactors, hollow fiber bioreactors contribute to a major part of high-density cell culture as they can provide a tremendous amount of surface area in a small volume for cell growth. As an alternative to hollow fiber reactors, a novel disposable bioreactor has been developed, which consists of a polymer-based supermacroporous material, cryogel, as a matrix for cell growth. Packed bed systems and disposable wave bioreactors have also been introduced for high cell density culture. These developments in high-density cell culture systems have led to the monoclonal antibody production in an economically favourable manner and made monoclonal antibodies one of the dominant therapeutic and diagnostic proteins in biopharmaceutical industry.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제55권9호
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• pp.442-445
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• 2006

In order to realize the commercial application of HTSC materials, it is necessary to develop the fabrication process of high Tc oxide superconductor materials with desired shape and for practical application and high critical current density as well as good mechanical strength which can withstand high lorenz force generated at high magnetic field. Much studies have been concentrated to develop the fabrication technique for high critical current density but still there are a lot of gap which should be overcome for large scale application of HTSC materials at liquid nitrogen temperature. Recently some new fabrication techniques have been developed for YBaCuO bulk superconductor with high mechanical strength and critical current density. In this project, the establishment of fabrication condition and additive effects of second elements were examined so as to improve the related properties to the practical use of YBaCuO superconductor, and we reported the production of the YBaCuO high Tc superconductor by the pyrolysis method.

• 한국과학교육학회지
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• 제12권2호
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• pp.31-42
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• 1992

The purposes of this study were to find out the degree of formation of the concept of density for the junior high students. The changing pattern of concept in acquiring the concept of density and the degree of development of INRC transformation ability related to the concept of density were also analyzed according to cognitive level and teaching method. The results of this study were as follows. 1) The experimental group were more effective than control group in the formation of the concept of density. 2) Even though students had been taught the concept of density, the various types of preconception were remained and persisted. Especially, the students at concrete level had persisted misconceptions and these misconceptions had been changed to the other misconceptions. 3) In the degree of the formation of the transformation ability of INRC group related to the concept of density in solid phase, the experimental group developed much better on both the abilities of Reciprocal transformation, Correlative transformation and the abilities to manipulate two variables such as volume and mass than control group. 4) The correlation coefficient between GALT score and achivement of the concept of density was 0.67. The correlation coefficient between achivement of the concept of density and the formation the transformation of INRC group related to the concept of density was 0.78.

• 한국마이크로전자및패키징학회:학술대회논문집
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• 한국마이크로전자및패키징학회 1999년도 1st Korea-Japan Advanced Semiconductor Packaging Technology Seminar
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• pp.155-162
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• 1999

A bare chip packaging technology by an encapsulated flip chip bonding on a build-up printed circuit board has emerged in 1991. Since then, it enabled a high density and low cost semiconductor packaging such as a direct chip bonding on mother board and high density surface mount components, such as BGA and CSP. This technology can respond to various requirements from applications and is considered to take over a main role of semiconductor packaging in the next decade.

• 한국통신학회논문지
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• 제21권6호
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• pp.1554-1566
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• 1996

In this paper, a new symbol timing algorithm for a magnetic recording system as HDD, is proposed. Above all, the Lorentzian channel model applied, the distortion and the attenuation problems of playback signals at high speed and storage density were considered. The structure and the operation of popular data detectors for HDD were understood, and the adopted symbol timing algorithm were profoundly analyzed. On the basis of these understanding and analysis, a new symbol timing algorithm for high density HDD was proposed, and the performance evaluation of this proposed algorithm was done.

• Journal of Welding and Joining
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• 제10권2호
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• pp.19-31
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• 1992

A numerical study was performed to investigate the flow field and the heat transfer characteristics occurring in high power density welding which is important in many fields of engineering applications. A two dimensional quasi-steady state of keyhole welding model is simulated by using the finite volume methods. It is shown that the shape of isothermal line is elliptic and the temperature gradient is very steep compared with other welding method and the welding speed has on welding width and observed beam power.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2000년도 제18회 학술발표회 논문개요집
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• pp.194-194
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• 2000

There are difficulties on transport modelling on high density plasma discharge, because of severe restrictions on space grid size and time step size. We present a new unconditionally stable algorithm for fluid simulation of high density process plasma. The origin of the restriction is investigated and a new method to solve the problem is suggested, The simulation result is compared with the other methods previously developed.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2019년도 추계 학술논문 발표대회
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• pp.137-138
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• 2019

The strengths and elastic modulus of high-density polyethylene in compression and tension met the minimum requirements of precast concrete products.

• 한국안전학회지
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• 제25권1호
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• pp.38-43
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• 2010

The smoke density and noxious gas for phenol foam and polyurethane foam were measured according to test methods in ASTM E 662 and KS F 2271. It was observed that phenol foam had the possibility of application for sandwich panel and board compared with polyurethane foam. In the experimental results, phenol foam showed comparatively excellent property than polyurethane foam in smoke density and noxious gas. The polyurethane foam showed comparatively high smoke density and didn't meet the evaluation standard of noxious gas in KS F 2271. From the experimental results of smoke density and noxious gas, it can be said that phenol foam has both comparatively good safety and high possibility of application than polyurethane foam in the building fire of sandwich panel structure because of lower smoke density and noxious gas.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2017년도 춘계 학술논문 발표대회
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• pp.160-161
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• 2017

In In this study, we measured the relative density and the compressive strength in order to select the appropriate W/B for the ultra-high strength concrete development. If W/B is lowered than the W/B of highest relative density, it was confirmed that the strength is lowered. However, if water is increased than the W/B, the relative density is decreased compressive strength was similar. The selection of the W/B of the lower than the highest relative density is not appropriate. Appropriate W/B is selected to be more than the maximum relative density of W/B. This was confirmed for TG-DTA.