• Development and Reproduction
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• v.27 no.1
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• pp.9-24
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• 2023

The advancement in high-throughput sequencing (HTS) technology has revolutionized the field of biology, including genomics, epigenomics, transcriptomics, and metagenomics. This technology has become a crucial tool in many areas of research, allowing scientists to generate vast amounts of genetic data at a much faster pace than traditional methods. With this increased speed and scale of data generation, researchers can now address critical questions and gain new insights into the inner workings of living organisms, as well as the underlying causes of various diseases. Although the first HTS technology have been introduced about two decades ago, it can still be challenging for those new to the field to understand and use effectively. This review aims to provide a comprehensive overview of commonly used HTS technologies these days and their applications in terms of genome sequencing, transcriptome, DNA methylation, DNA-protein interaction, chromatin accessibility, three-dimensional genome organization, and microbiome.

• Management Science and Financial Engineering
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• v.4 no.2
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• pp.43-58
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• 1998

Packet switch is a key component in high speed digital networks. This paper investigates congestion phenomena in the packet switching with input buffers. For large value of switch size N, mathematical models have been developed to analyze asymptotic maximum switch throughput under nonuniform traffic. Simulation study has also been done for small values of finite N. The rapid convergence of the switch performance with finite switch size to asymptotic solutions implies that asymptotic analytical solutions approximate very closely to maximum throughputs for reasonably large but finite N. Numerical examples show that non-uniformity in traffic pattern could result in serious degradation in packet switch performance, while the maximum switch throughput is 0.586 when the traffic load is uniform over the output trunks. Window scheduling policy seems to work only when the traffic is relatively uniformly distributed. As traffic non-uniformity increases, the effect of window size on throughput is getting mediocre.

• IEIE Transactions on Smart Processing and Computing
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• v.3 no.5
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• pp.275-284
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• 2014

This paper considers two-tier networks consisting of macrocells and femtocells operating in the same spectrum. This paper proposes a femtocell spectrum reuse scheme that determines the shared spectrum and transmit power for the femtocells to mitigate the effects of cross-tier interference between the macrocells and femtocells. The proposed scheme provides macrocell throughput that is unaffected by the increasing number of femtocells per cell site and improves the femtocell signal quality at the same time by limiting the cross-tier interference. This study analyzed the per-tier signal-to-interference ratio (SIR) and outage probability of the proposed scheme to investigate the macrocell and femtocell performance. The total throughput of the proposed scheme was analyzed based on the outage probabilities. The analysis and numerical results proved that high femtocell throughput can be achieved using only a small fraction of the spectrum while protecting the macrocell throughput. As a result, an improved total throughput was achieved enforcing higher spatial reuse.

• 한국정보통신설비학회:학술대회논문집
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• 2008.08a
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• pp.107-111
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• 2008

3GPP는 사용자의 다운링크 패킷 데이터 Throughput을 높이고,NodeB에 MAC계층을 위치시켜, 사용자의 스케줄링과 재전송을 담당하게 함으로써, 다운링크 패킷의 전송 지연을 감소시키는 HSDPA(High Speed Data Packet Access)기술을 Release 5에서 도입하였다. NodeB에 위치한 MAC-hs 스케줄러는 각각의 사용자에게 가용한 NodeB의 RF power와 code 자원을 제공하며, R99에서 사용했던 Power control을 이용하는 대신, AMC(Adaptive Modulation and Coding)기능을 제공하여 Radio conditions에 따라 전송되는 Data Format을 조정하여 채널환경이 좋은 사용자에게는 높은 data Throughput을 제공하며, 채널환경이 좋지 않은 사용자에게는 낮은 data throughput을 제공하고 있다. 본 고에서는 매 TTI에 스케줄링된 사용자에게 제공하고도, RF power 및 code 자원이 남아 있을 경우, 스케줄러는 남은 자원을 각각의 사용자에게 재 분배하여, 초기에 추정한 HSDPA Throughput보다 향상된 성능을 갖을 수 있음을 설명하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.12
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• pp.3237-3256
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• 2012

In the context of effective usage of a scarce spectrum resource, emerging wireless communication standards will demand spectrum sharing with existing systems as well as multiple access with higher spectral efficiency. We mathematically analyze the sum throughput of a spectrum sharing space-division multiple access (SDMA) system, which forms a transmit null in the direction of other coexisting systems while satisfying orthogonal beamforming constraints. For a large number of users N, the SDMA throughput scales as log N at high signal-to-noise ratio (SNR) ((J-1) loglog N at normal SNR), where J is the number of transmit antennas. This indicates that multiplexing gain of the spectrum sharing SDMA is $\frac{J-1}{J}$ times less than that of the non-spectrum sharing SDMA only using orthogonal beamforming, whereas no loss in multiuser diversity gain. Although the spectrum sharing SDMA always has lower throughput compared to the non-spectrum sharing SDMA in the non-coexistence scenario, it offers an intriguing opportunity to reuse spectrum already allocated to other coexisting systems.

• Journal of Communications and Networks
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• v.5 no.1
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• pp.25-32
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• 2003

4G mobile communication system requires the throughput of 10-100Mbps. Adaptive modulated OFDM system is promising technique for increasing the throughput. In the pilot symbol assisted high-speed packet transmission system, the data symbol duration is generally considered to be small compared to the coherence time. However, OFDM symbol duration is longer than the symbol duration of a single carrier system, so that the packet duration of the pilot symbol assisted high speed packet transmission system is long. In this case, the change of channel conditions is too fast to be accurately estimated by channel estimator at the receiver in high Doppler frequency, so that many errors occur during demodulation, especially with the data symbols at the end of each packet. In this paper, we consider the BER at various instantaneous $E_b/N_o$ that includes the demodulation errors in high Doppler frequency. When the coherence time is ten times longer than the duration of a single packet, the channel can be closely approximated as an AWGN channel. Otherwise, the approximation breaks down and the above-mentioned errors that occur during demodulation must be taken into consideration. In this paper, we propose the pilot symbol assisted high speed packet transmission system based on adaptive OFDM using a novel lookup table to consider the demodulated errors and evaluate the throughput performance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.8A
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• pp.656-663
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• 2005

This paper presents a multi-channel enhancement scheme for the MAC protocol of IEEE 802.15.3 High-rate WPAN (Wireless Personal Area Network). The current MAC protocol of the IEEE 802.15.3 High-rate WPAN is designed for sharing a single channel among DEVs of a piconet; that is, within a single piconet, PNC prevents interference through MAC layer assignment of time slots to other DEVs using time-division multiple access. When the number of DEVs that communicate with each other frequently, is increased in a single WPAN, the size of the superframe becomes inevitably large, and this may result in a significant throughput drop or a failure to provide QoS guarantee. A multi-channel enhancement scheme for the MAC protocol of IEEE 802.15.3 High-rate WPAN is proposed to significantly increase the aguegate throughput and more reliably provide the QoS guarantees in a piconet

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.3
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• pp.63-69
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• 2017

In next generation satellite broadcasting system, requirement of high throughput efficiency has been increasing continuously. To increase throughput efficiency and improve bit error performance simultaneously, FTN method and LDPC codes are employed in new sattelite standard, DVB-S3 system. This paper considered three kinds of methods for increase throughput efficiency. Firstly, as conventional one, high coding rate parity matrix in LDPC encoder is considered. Secondly, punctured coding scheme which delete the coded symbols according to appropriate rules is considered. Lastly, FTN method which transmit fater than Nyquist rate is considered. Among of three kinds of methods, FTN method is most efficient in aspect to performance while maintain same throughput efficiency.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.4
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• pp.48-58
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• 2016

This paper presents the high-throughput fully-parallel architecture for GF(64) (160,80) regular (2,4) non-binary LDPC (NB-LDPC) codes decoder based on the extended min sum algorithm. We exploit the NB-LDPC code that features a very low check node and variable node degree to reduce the complexity of decoder. This paper designs the fully-parallel architecture and allows the interleaving check node and variable node to increase the throughput of the decoder. We further improve the throughput by the proposed early sorting to reduce the latency of the check node operation. The proposed decoder has the latency of 37 cycles in the one decoding iteration and achieves a high throughput of 1402Mbps at 625MHz.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.12B
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• pp.1665-1676
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• 2001

The effect of spreading gain control on the throughput of a CDMA slotted ALOHA system is considered. Mobile users transmit packets over a shared channel, and the packets transmitted in the same time slot over the shared channel act as simultaneous access interference (SAI). When using spread-spectrum signal, a CDMA slotted ALOHA channel achieves high probability of capture due to the property of high title resolution, and the bit rate of user information is determined by spreading gain. When the SAI level gets larger, the high value of spreading gain enhances the packet throughput by increasing the probability of a successful packet transmission, while it degrades the of the effective throughput by reducing the user information bits carried within a packer. To solve the problem, we investigated the effect of the capture probability and the SAI level on these system throughputs, and evaluated the throughput performance of the system for each spreading gain control scheme. The results showed that the maximum effective throughput could be achieved with an unified method despite the variation of the SAI level by deriving an optimal value of the spreading gain according to 171e system states.