• Title/Summary/Keyword: High step-up

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Early Biologic Treatment in Pediatric Crohn's Disease: Catching the Therapeutic Window of Opportunity in Early Disease by Treat-to-Target

  • Kang, Ben;Choe, Yon Ho
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제21권1호
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    • pp.1-11
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    • 2018
  • The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therapeutic window during the early disease course. Thus, an increasing number of pediatric gastroenterologists are adopting an early biologic treatment strategy with or without an immunomodulator. Although early biologic treatment is effective, cost and overtreatment are issues that limit its early use. Currently, there are insufficient data on who will benefit most from early biologics, as well as on who will not need early or even any biologics. For now, top-down biologics should be considered for patients with currently known high-risk factors of poor outcomes. For other patients, close, objective monitoring and accelerating the step-up process by means of a treat-to-target approach seems the best way to catch the therapeutic window in early pediatric Crohn's disease. The individual benefits of immunomodulator addition during early biologic treatment should be weighed against its risks and decision on early combination treatment should be made after comprehensive discussion with each patient and guardian.

고역률 스텝 업-다운 절연형 AC-DC 컨버터의 입력전류 파형분석에 관한 연구 (A Study on Input Current Waveform Analysis for Step Up-Down AC-DC Converter of High Power Factor added Electric Isolation)

  • 곽동걸;김춘삼;이봉섭;김상훈
    • 전력전자학회:학술대회논문집
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    • 전력전자학회 2008년도 하계학술대회 논문집
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    • pp.34-36
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    • 2008
  • This paper is given a full detail of mathematical analyses of input current for novel active type power factor correction(PFC) AC-DC converter of step up-down added electric isolation. These are compared with harmonics components of input current for a conventional PFC converter of electric isolation type. The proposed PFC converter is constructed in using a new loss-less snubber circuit to achieve a soft switching of control device. Also the proposed converter for discontinuous conduction mode(DCM) eliminates the complicated circuit control requirement and reduces the size of components. The input current waveform in the proposed converter is got to be a sinusoidal form of discontinuous pulse in proportion to magnitude of ac input voltage under the constant duty cycle switching. Therefore, input power factor is nearly unity and the control method is simple. Particularly, the stored energy of loss-less snubber capacitor is recovered with input side and increases input current from resonant operation. The result is that input power factor of the proposed converter is higher than that of a conventional PFC converter. Some simulative results on computer and experimental results are included to confirm the validity of the analytical results.

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TCR을 이용한 Voltage Sag와 Swell 발생장치에 대한 연구 (Voltage Sag and Swell Generator with Thyristor Controlled Reactor)

  • 박태범;권기현;정용호;이진;임계영
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2002년도 하계학술대회 논문집 A
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    • pp.25-27
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    • 2002
  • This paper describes a new economical voltage sag and swell generator suitable to the evaluations of high power custom power devices such as DVR (Dynamic Voltage Restorer) and DSTATCOM (Distribution Static Compensator). This system was designed to generate the several power quality disturbances in MVA power ratings - voltage sag and swell, under voltage, over voltage and harmonic distortions. The basic idea for voltage sag and swell is to use the voltage drop across a reactor, while the voltage swell is to use the step-up transformer and the TCR(Thyristor Controlled Reactor). In this paper, two identical 3 phase TCRs and a step-up transformer with tap changer are used. Additional harmonic filters are added to reduce the voltage distortion when TCRs are operated. Simulation results are given for several cases of voltage sag and swell generations.

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소규모 계통연계형 태양광 시스템의 최적제어에 대한 연구 (Research about most suitable control of small scale system link type photovoltaic system)

  • 황락훈;장은성;남우영
    • 전력전자학회:학술대회논문집
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    • 전력전자학회 2003년도 추계학술대회 논문집
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    • pp.238-243
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    • 2003
  • The solar cells should be operated at the maximum power point because its output characteristics are greatly fluctuated on the variation of insolation, temperature and load. The output power of solar cell is DC, therefore it is necessary to install an inverter among electric power converts. The inverter have to supply a sinusoidal current and voltage to the load and the interactive utility line. In the paper, the proposes a photovoltaic system designed with a step up chopper and single phase PWM voltage source inverter. Synchronous signal and control signal was processed by microprocessor for stable modulation. The step up chopper operates in continuous mode by adjusting the duty ratio so that the photovoltaic system tracks the maximum power point of solar cell without any influence on the variation of insolation and temperature because solar cell has typical dropping character. The single phase PWM voltage source inverter consists of complex type of electric power converter to compensate for the defect, that is, solar cell cannot be developed continuously by connecting with the source of electric power, from 10 to $20\%$. The single phase PWM voltage source inverter operates in situation that its output voltage is in same phase with the utility voltage. The inverter supplies an ac power with high factor and low level of harmonics to the load and the utility power system.

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High Density Silver Nanowire Arrays using Self-ordered Anodic Aluminum Oxide(AAO) Membrane

  • Kim, Yong-Hyun;Han, Young-Hwan;Lee, Hyung-Jik;Lee, Hyung-Bock
    • 한국세라믹학회지
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    • 제45권4호
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    • pp.191-195
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    • 2008
  • Highly ordered silver nanowire with a diameter of 10 nm was arrayed by electroless deposition in a porous anodic aluminum oxide(AAO) membrane. The AAO membrane was fabricated electrochemically in an oxalic acid solution via a two-step anodization process, while growth of the silver nanowire was initiated by using electroless deposition at the long-range-ordered nanochannels of the AAO membrane followed by thermal reduction of a silver nitrate aqueous solution by increasing the temperature up to $350^{\circ}C$ for an hour. An additional electro-chemical procedure was applied after the two-step anodization to control the pore size and channel density of AAO, which enabled us to fabricate highly-ordered silver nanowire on a large scale. Electroless deposition of silver nitrate aqueous solution into the AAO membrane and thermal reduction of silver nanowires was performed by increasing the temperature up to $350^{\circ}C$ for 1 h. The morphologies of silver nanowires arrayed in the AAO membrane were investigated using SEM. The chemical composition and crystalline structure were confirmed by XRD and EDX. The electroless-deposited silver nanowires in AAO revealed a well-crystallized self-ordered array with a width of 10 nm.

내식성 및 표면경도 향상을 위한 AISI 304L 스테인리스강의 저온 플라즈마질화 프로세스 (Low Temperature Plasma Nitriding Process of AISI 304L Austenitic Stainless Steels for Improving Surface Hardness and Corrosion Resistance)

  • 이인섭
    • 대한금속재료학회지
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    • 제47권10호
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    • pp.629-634
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    • 2009
  • The effects of processing parameters on the surface properties of the hardened layers processed by the low temperature plasma nitrocarburizing and the low temperature two-step plama treatment (carburizing+nitriding) were investigated. The nitrogen-enriched expanded austenite structure (${\gamma}_N$) or S phase was formed on all of the treated surface. The surface hardness reached up to 1200 $HV_{0.025}$, which is about 5 times higher than that of untreated sample (250 $HV_{0.1}$). The thickness of hardened layer of the low temperature plasma nitrocarburized layer treated at $400^{\circ}C$ for 40 hour was only $15{\mu}m$, while the layer thicknesss in the two-step plama treatment for the 30 hour treatment increased up to about $30{\mu}m$. The surface thickness and hardness increased with increasing treatment temperature and time. In addition, the corrosion resistance was enhanced than untreated samples due to a high concentration of N on the surface. However, higher treatment temperature and longer treatment time resulted in the formation of $Cr_2N$ precipitates, which causes the degradation of corrosion resistance.

차세대 연료전지 자동차용 25kW, 300kHz 고승압 소프트 스위칭 컨버터 (25 kW, 300 kHz High Step-Up Soft-Switching Converter for Next-Generation Fuel Cell Vehicles)

  • 김선주;하이 뜨란;김진영;기에우 흐우 푹;최세완;박준성;윤혜성
    • 전력전자학회논문지
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    • 제26권6호
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    • pp.404-410
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    • 2021
  • This paper proposes a high step-up converter with zero-voltage transition (ZVT) cell for fuel cell electric vehicle. The proposed converter applies a ZVT cell to a dual floating output boost converter (DFOBC) so that not only the main switch but also the ZVT switch can achieve full-range soft switching. The current rating of the ZVT switch is 17% of the main switch. The proposed converter has high reliability in that no timing issue occurs. Therefore, online calculation is not required. The minimum turn-on time of the ZVT switch that guarantees soft switching at all loads and input/output voltage is obtained by analysis. In addition, the proposed DFOBC allows the use of a 650 V device even at 800 V output and has the advantage of being able to boost the voltage by 3.5 times with 0.56 duty. Planar coupled inductor with PCB winding was successfully implemented with the converter operated at 300 kHz. The 25 kW prototype achieves peak efficiency of 99% and power density of 63 kW/L.

Sr이 치환된 Rosen 타입 압전변압기의 전기적 특성 (Electrical properties of strontium substitution Rosen type piezoelectric transformer)

  • 주현규;김인성;정순종;김민수;송재성;이대수;전소현
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2009년도 제40회 하계학술대회
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    • pp.1305_1306
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    • 2009
  • Recently, piezoelectric transformer is applied to wide fields. Multi layer piezoelectric transformer has the advantage of high step up ratio, high electromechanical coupling coefficient(Kp) and high mechanical quality factor(Qm), however it shows the peeling-phenomenon of electrode, and high price due to high sintering temperature. Therefore this study focus on the method for fabrication of high power rosen type piezoelectric transformers.

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NI PXI-7352를 활용한 PC 기반의 고성능 2축 스텝 모션 제어시스템 개발 (Development of the High Efficient 2-axis Step Motion Control System using NI PXI-7352)

  • 이운선;박만곤
    • 한국멀티미디어학회논문지
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    • 제13권2호
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    • pp.179-184
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    • 2010
  • 인간의 보다 나은 삶을 위한 유비쿼터스 사회에서 센서 네트워크기술과 함께 중요시 되고 있는 기술이 자동제어 및 모션제어기술이다. 산업현장 및 생활환경에서 GUI 환경의 보다 빠르고 정밀한 모션제어 및 위치제어기술에 대한 요구는 날로 늘어가고 있다. 특히, GUI 환경의 개선과 산업현장의 변화에 빠르게 적응할 수 있도록 PC 기반의 모션 제어시스템에 대한 수요가 날로 증가하고 있다. 본 연구에서는 높은 신뢰성과 정밀한 모션제어를 제공하는 NI PXI-7352 컨트롤러와 스텝 모터를 활용하여 사용자인터페이스를 획기적으로 증대시킨 그래픽기반 시스템 프로그래밍언어인 LabVIEW를 기반으로 산업현장에서 다양하게 응용할 수 있는 고성능 2축 스텝 모션 제어시스템을 개발하고자 한다.

부화소 움직임 추정을 위한 고속 탐색 기법 (A Fast Search Algorithm for Sub-Pixel Motion Estimation)

  • 박동균;조성현;조효문;이종화
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2007년도 심포지엄 논문집 정보 및 제어부문
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    • pp.26-28
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    • 2007
  • The motion estimation is the most important technique in the image compression of the video standards. In the case of next generation standards in the video codec as H.264, a high compression-efficiency can be also obtained by using a motion compensation. To obtain the accurate motion search, a motion estimation should be achieved up to 1/2 pixel and 1/4 pixel uiuts. To do this, the computational complexity is increased although the image compression rate is increased. Therefore, in this paper, we propose the advanced sub-pixel block matching algorithm to reduce the computational complexity by using a statistical characteristics of SAD(Sum of Absolute Difference). Generally, the probability of the minimum SAD values is high when searching point is in the distance 1 from the reference point. Thus, we reduced the searching area and then we can overcome the computational complexity problem. The main concept of proposed algorithm, which based on TSS(Three Step Search) method, first we find three minimum SAD points which is in integer distance unit, and then, in second step, the optimal point is in 1/2 pixel unit either between the most minimum SAD value point and the second minimum SAD point or between the most minimum SAD value point and the third minimum SAD point In third step, after finding the smallest SAD value between two SAD values on 1/2 pixel unit, the final optimized point is between the most minimum SAD value and the result value of the third step, in 1/2 pixel unit i.e., 1/4 pixel unit in totally. The conventional TSS method needs an eight.. search points in the sub-pixel steps in 1/2 pixel unit and also an eight search points in 1/4 pixel, to detect the optimal point. However, in proposed algorithm, only total five search points are needed. In the result. 23 % improvement of processing speed is obtained.

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