• YAKHAK HOEJI
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• v.38 no.3
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• pp.345-350
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• 1994

Fourteen melandrin derivatives(I-XIV) were investigated on analgesic, anti-inflammatory and antiviral activities . Compound I [N-(p-hydroxybenzoyl)-5-hydroxyanthranilic acid methvl ester], Xll [N-(2-phenoxypropionyl)-5-hydroxy anthranilic acid propyl ester and XIV [N-(2-phenoxypropionyl)-5-hydroxyanthranilic acid exhibited analgesic activity in tail pressure and Randall-Selitto method. But no anti-inflammatory activity was shown. Compound I exhibited weak antiviral activity on Herpes simplex virus type I F strain by virus-induced cytopathic effect(CPE) assay and it's selectivity index(Sl) was 8.17.

• BMB Reports
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• v.31 no.6
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• pp.585-589
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• 1998

The herpes simplex virus type-1 (HSV-1)-encoded DNA polymerase consists of two subunits, the products of the UL30 and UL42 genes. UL30 and UL42 were coexpressed in Sf9 cells infected with recombinant baculoviruses carrying the two genes. The UL30 and UL42 gene products remained tightly associated throughout the purification, which led to a near homogeneous heterodimer composed of the DNA polymerase and UL42 protein. The DNA polymerase-UL42 protein heterodimer, purified from the recombinant baculovirus-infected Sf9 cells, showed the same high degree of processivity of deoxynucleotide polymerization as the enzyme purified from the HSV-1 infected primate cells. Like the latter, it contained a 3'-5' exonuclease activity that specifically hydrolyzes an incorrectly matched nucleotide at the 3' terminus of a primer, thereby contributing to the fidelity of DNA replication.

• The Korean Journal of Pain
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• v.8 no.1
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• pp.135-138
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• 1995

We experienced two cases of malignancy diagnosed during the treatment of postherpetic neuralgia. One case was a lung cancer and the other case was a pancreatic cancer. Generally, herpes zoster frequently occurred in the patients who have immunosupressive disease, diabetes mellitus, malignancy and tuberculosis, etc. It is necessary to rule out malignancy in the patients who have herpes zoster, especially those patients whth severe eruptive cluster, persisting to the therapy or multifocal pain. So, we must carefully observe and follow up the patients to find out malignancy as well as to diminish the pain.

• The Korean Journal of Pain
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• v.1 no.1
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• pp.9-15
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• 1988

Postherpetic neuralgia, the most feared complication of acute herpes zoster, may agonize the pain clinician because the appropriate management of intractable pain can fail inspite of various and prolonged therapeutic techniques. Of all patients with herpes zoster, approximately 5~10% will develop postherpetic neuralgia. Postherpetic neuralgia is very rare in young patient but very common in patients over 60. In other words, the older, the higher incidence. In our pain clinics, 13 postherpetic neuralgic patients were treated with sympathetic blocks, local infiltration with local anesthetics and steroids, TENS, Laser and various drugs including antiderpressant. The results of management of pain in 13 patents were as follows. 1. Excellent pain control :4(30.8%) 2. Good pain control :3(23.0%) 3. Fair pain control :2(15.4%) 4. No effect :4(30.8%).

• Journal of Acupuncture Research
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• v.40 no.2
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• pp.156-161
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• 2023

Herein, we report the effectiveness of Korean medicine for the treatment of postherpetic upper limb weakness and pain. The patient received a combination of Korean medicine treatment modalities, including electroacupuncture, pharmacopuncture, and herbal medicine. Muscle strength and pain were evaluated using a manual muscle test (MMT) and a Numerical Rating Scale (NRS), respectively. The overall MMT score improved after hospitalization, and elbow extension improved from 3+ at admission to 5 at discharge. The NRS score improved to 2 at discharge. This study suggests the effectiveness of a combination of Korean medicine modalities in treating postherpetic motor nerve paralysis.

• 대한임상약리학회:학술대회논문집
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• 1993.12a
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• pp.46-46
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• 1993

• The Journal of the Korean dental association
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• v.15 no.4
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• pp.279-283
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• 1977

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.7 no.1
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• pp.85-94
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• 1994

• The Korean Journal of Pain
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• v.2 no.2
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• pp.129-134
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• 1989

• The Journal of the Korean dental association
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• v.9 no.10
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• pp.623-631
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• 1971