YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Analgesic, Anti-inflammatory and Antiviral Effects of Melandrin Derivatives

Melandrin유도체의 진통 소염 및 항바이러스 효과

  • Lim, Jung-Ki (College of Pharmacy, Sung Kyun Kwan University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
  • Woo, Won-Sik (Natural Products Research Institute, Seoul National University) ;
  • Lee, Kang-Ro (College of Pharmacy, Sung Kyun Kwan University) ;
  • Lee, Yeong-Sun (Natural Products Research Institute, Seoul National University) ;
  • Ma, Eun-Sook (College of Pharmacy, Hyosung Women's University)
  • 임증기 (성균관대학교 약학대학) ;
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 우원식 (서울대학교 천연물과학연구소) ;
  • 이강노 (성균관대학교 약학대학) ;
  • 이영순 (서울대학교 천연물과학연구소) ;
  • 마은숙 (효성여자대학교 약학대학)
  • Published : 1994.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Fourteen melandrin derivatives(I-XIV) were investigated on analgesic, anti-inflammatory and antiviral activities . Compound I [N-(p-hydroxybenzoyl)-5-hydroxyanthranilic acid methvl ester], Xll [N-(2-phenoxypropionyl)-5-hydroxy anthranilic acid propyl ester and XIV [N-(2-phenoxypropionyl)-5-hydroxyanthranilic acid exhibited analgesic activity in tail pressure and Randall-Selitto method. But no anti-inflammatory activity was shown. Compound I exhibited weak antiviral activity on Herpes simplex virus type I F strain by virus-induced cytopathic effect(CPE) assay and it's selectivity index(Sl) was 8.17.

Keywords