• Journal of Korean Medicine for Obesity Research
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• v.23 no.1
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• pp.28-41
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• 2023

Objectives: This study was aimed to evaluate the hemodynamic feasibility using pulse parameters as a way to establish safe dose guidelines for herbal prescription containing Ephedra herb (Ephedra intermedia Schrenk & C.A.Mey) on weight loss, and to provide a foundation for developing evidence-based guidelines for clinical use. Methods: Forty-two volunteers were recruited to participate in a study examining the changes in pulse wave characteristics following the ingestion of Gambi-hwan, a herbal prescription containing ephedra, over a period of 4 weeks, and pulse wave measurements were taken before and after the administration. Pulse wave parameters were measured in this study using a 3-dimensional radial pulse tonometry device (DMP-Lifeplus). In addition, questionnaire, blood pressure, temperature, and body composition were also measured as secondary measures. Results: Fifteen minutes after administration of Gambi-hwan, the non-adverse event group (non-AE) exhibited a statistically significant increase in several power and pressure-related parameters, including h1, h5, systolic area, pulse area, and pulse width, while the AE group showed a trend of decreasing stroke volume and increasing Radial Augmentation Index (RAI), w, and w/t. After 4 weeks of administration, both groups exhibited significant changes in pulse rate, w/t, RAI, t3/t, stroke volume (SV), and stroke volume Index (SVI). Notably, there are significant differences between AE group and non-AE group in w/t, SV, and SVI. Conclusions: These findings suggest that pulse parameters may be a useful way to establish safe dosing guidelines for weight loss herbal prescription containing ephedra. Further research is needed to confirm these results and to develop evidence-based guidelines for clinical use.

• The Journal of Internal Korean Medicine
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• v.42 no.4
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• pp.628-644
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• 2021

Objectives: This study analyzed, through network analysis and data mining analysis, the relationship between herbs used in osteoporosis prescriptions, diversified the analysis of osteoporosis-related prescriptions, and analyzed the combination of herbs used in osteoporosis-related prescriptions. Methods: The prescriptions used in osteoporosis treatment and experiments were established by conducting a full survey of the papers published by the OASIS site. A database for osteoporosis-related prescriptions was established, herbs were extracted, and the frequency of frequent herbs and prescriptions were investigated using Excel (MS offices ver. 2013). Using the freeware R version 4.0.3 (2020-10-10), igraph, and arules package, network analysis was performed in the first second of prescription composition. Results: Among the osteoporosis-related prescriptions, the most studied prescriptions are as follows.: Yukmijihwang-tang (六味地黃湯) and Samul-tang (四物湯). In the osteoporosis prescription network, herbs with connection centrality, proximity centrality, mediation centrality, and eigenvector centrality appeared in the order of Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Poria Sclerotium, Paeoniae Radix, and Glycyrrhizae Radix et Rhizoma. After extracting the herbal combination network, including the corresponding herbs, and clustering it, it can be divided into drugs of the Yukmijihwang-tang (六味地黃湯) series and the Samul-tang (四物湯). Conclusions: This study could assist researchers in diversifyingy formula analysis in future studies. Moreover, the herbal combination used in osteoporosis prescriptions could be used to search for osteoporosis prescriptions in other databases or to create a new prescription.

• The Journal of Korean Medical History
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• v.18 no.2
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• pp.277-297
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• 2005

As a result of analyzing HyangYakJ ipSeongBang, by focusing on folk medicinal plants, the writer has christened the phrase 'Folk Medical Study' because the medical system of HyangYakJ ipSeongBang was quite different from the usual Korean Medicine or Eastern Medicine. Folk Medicine Study is medical study that emphasizes accessibility of drugs and facility of treatment. Folk Medicine Study is medical study that contains only contents that have been time-tested in our country. Folk Medicine Study is medical study that compiled all herbal knowledge and expertise of prescription of the herbal medicine produced on our land.

• Herbal Formula Science
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• v.7 no.1
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• pp.89-98
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• 1999

We sometimes directed taking medicine by using decoction of Jujubae Fructus in taking herbs medicine. And I studied meaning on using decoction of Jujubae Fructus in taking herbs medicine. The obtained results were follows: 1. In taking medicine by using decoction of Jujubae Fructus, chief effect positions of that prescription were heart, spleen, stomach, and kidney. 2. In taking medicine by using decoction of Jujubae Fructus, chief treatment symptoms were heart throb, sleeplessness, reddish turbid urine, retention of phlegm and fluid, retention of fluid in the body, weakness. 3. In taking medicine by using decoction of Jujubae Fructus, chief pathogenic factors of that prescription were deficiency syndroms of the heart, retention of phlegm and fluid, retention of fluid in the body, consumptive disease, weakness.

• Herbal Formula Science
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• v.25 no.2
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• pp.253-270
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• 2017

Ojectives : To indicate source of prescriptions in "Wenbingtiaobian" and draw pathologic consideration for differences between prescription and source. Methods : Analysed cause and mechanism of disease, pattern identification, treatment, prescriptions and medicinal herbs based on "Translation of Wenbingtiaobian", "Modern Shanhanlun", "Jinkuiyaolueyishi", "Medical collection of Yetianshi" and "Herbal Formula Science". Results : 64.5% of prescriptions in "Wenbingtiaobian" are derived from "Linzhengzhinanyian", "shanghanlun" or "Jinkuiyaolue". Prescriptions from "shanghanlun" or "Jinkuiyaolue" have been modified to fit for heat pattern differentiations, to expand or reduce their medicinal scope, to build up efficacy by adding cold herbs, herbs of nourishing yin, engendering fluid or outthrusting through the exterior, to diffuse water-dampness or warm yang by adding warm herbs. Prescriptions from "Linzhengzhinanyian" have been modified to eliminate cold-dampness, disperse and outthrust with lightness, tonify yin. Conclusions : Wenbingtiaobian" inherited "Linzhengzhinanyian", "shanghanlun" nd "Jinkuiyaolue" andchanged and developed them to cure the febrile disease in the aspect of prescription, mechanism of disease, pattern differentiation and treatment.

• The Journal of Internal Korean Medicine
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• v.39 no.6
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• pp.1281-1289
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• 2018

Objectives: This study is the first report on a case of subclinical hypothyroidism treated with Modified Er-Xian Decoction, which is rarely used in Korea. Methods: Patients were treated for 3 months with Modified Er-Xian Decoction and their therapeutic effects were evaluated through thyroid function tests and Spleen-Kidney deficiency Questionnaire. Results: Initial improvement was apparent after the administration of Modified Er-Xian Decoction. After 3 months of treatment, the patient 's Spleen-Kidney deficiency index improved significantly, and thyroid hormone levels returned to normal. Conclusions: In this case report, symptoms and biochemical improvement were confirmed based on a single herbal medicine prescription for subclinical hypothyroidism. It is necessary to verify the effect of this prescription through well - established clinical trials.

• Herbal Formula Science
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• v.31 no.3
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• pp.203-213
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• 2023

Objectives : The purpose of this study is to report the symptomatic relief effect of a herbal prescription combined with methimazole for hyperthyroidism caused by Graves' disease. Methods : After diagnosis of hyperthyroidism, methimazole was initially administered alone. As the clinical symptoms continued, a herbal medicine combining Gamiondam-tang and Cheongsimyeonja-eum was administered together with methimazole. Blood concentrations of hormones were measured, and the degree of clinical symptoms was measured using the NRS scale. The effect of herbal medicine on heat intolerance was analyzed by Wilcoxon rank sum test, and the relationship between thyroid hormone and heat intolerance was analyzed by Pearson's correlation coefficient. Results : Heat intolerance symptoms were significantly reduced when the herbal prescription was administered in parallel than when methimazole was administered alone (w=296, p=0.001). The decrease in heat intolerance was not related to thyroid hormone levels (p=0.27, 0.37). Conclusions : It was found that the herbal medicine combining Gamiondam-tang and Cheongsimyeonja-eum was effective in treating hyperthyroidism symptoms including heat intolerance.

• Journal of Society of Preventive Korean Medicine
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• v.23 no.3
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• pp.1-12
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• 2019

Objectives : Korean national health insurance data is a useful real-world data representing whole medical bills submitted to Health Insurance Review Agency. This study aims to understand recent benefit trend of insurance herbal preparations for treating bronchiectasis(disease code J47) utilizing insurance data. Methods : We reviewed national health insurance claims data from 2013 to 2017 which have main diagnosis or sub diagnosis code of J47 and with the record of prescribing insurance herbal medication. Frequency analysis was performed to analyze the most frequently prescribed prescription. Results & Conclusions : Both the number of claims statement(770 to 1,746cases) and patients(266 to 484) of insurance herbal preparations increased considerably from 2013 to 2017. Top 10 preparations based on the number of claims statement were 'Samso-eum', 'Yeonkyopaedok-san', 'Socheongryong-tang', 'Bojungikgi-tang', 'Hyangsapyungwi-san', 'Yijin-tang', 'Saengmaek-san', 'Jaeumganghwa-tang', 'Ojeok-san' and 'Gungha-tang'. Top 10 preparations based on the number of patients were 'Samso-eum', 'Socheongryong-Tang', 'Saengmaek-san', 'Yeonkyopaedok-san', 'Haengso-tang', 'Hyangsapyungwi-san', Yijin-tang', 'Jaeumganghwa-tang', 'Bojungikgi-tang' and 'Hyeonggaeyeongyo-tang' in respectiv order. Claims of top 10 frequent preparations occupied more than 60% of total claims. We hope this finding to be utilized as basic data for future research of evidence-based bronchiectasis treatment utilizing Korean traditional medicine.

• The Korea Journal of Herbology
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• v.29 no.3
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• pp.1-10
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• 2014

Objectives : In this study, we investigated Hyangyak in "Single-medicine prescription treatment of domestic herbs" of "Kwangjebikeup" and then conducted further studies focusing on ginseng as it is written in "Single-medicine prescription treatment of domestic herbs". Methods : Through a study of classical literature on Hyangyak and ginseng, information regarding the two was gathered and analyzed, with respect to both time and region. Results : All of the herbs in "Single-medicine prescription treatment of domestic herbs", the 4th volume of "Kwangjebikeup", are domestic herbs. Ginseng was a part of the flora of the Korean Peninsula from long ago and ginseng was cultivated from most of the peninsula. We confirmed cultivation of ginseng in Sungcheon, Pyungan-do and most areas of Hamgyeong-do through geography books such as "Geography Monograph of King Sejong". Because the natural environmental condition of the Korean Peninsula was conducive to growing wild ginseng, it was possible to cultivate ginseng. In the late Chosun period, cultivated ginseng was so prevalent that people would have been able to collect and use ginseng without great difficulty. In "Kwangjebikeup", ginseng shows superior efficacy in terms of first-aid. "Kwangjebikeup" contains practical herbal medicines that were based on obtainable ingredients. Conclusions : The purpose of publication of this book was to make medical knowledge available to general public in an easy-to-understand form. And through added clinical experiences of the author, we know that "Kwangjebikeup" played a role in settlement and spreading of foreign knowledge to civilians.

• Journal of Environmental Science International
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• v.17 no.1
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• pp.129-133
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• 2008

This study is an endeavor to evaluate the safety of medicines from heavy metals, prescribed on the basis of herbal medicinal system and oriental medical prescription which are circulated much recently. For that, three globular types, four extract granular types and four liquid types of herbal medicine were bought to compare and analyze the content of heavy metals, such as As, Pb, Cd and Hg, which are harmful to human body. The concentration of Pb was found to be 0.552 ppm in Sachiltang, 2.552 ppm in Anjungjogiwhan and 1.735 ppm in Cheongsangbohwawhan in case of pill type herbal medicine, and liquid type herbal medicine, Maekmundongtang was 0.002 ppm, Galgeuntang was 0.003 ppm, Sangwhatang was 0.004 ppm, 20jeon Daebotang was 0.0185 ppm. And the concentration of Pb was found to be 0.322 ppm in Banhasasimtang, 0.47 ppm in Eungjosan, 0.29 ppm in Yukmijihwangtang, 0.64 ppm in Socheongryongtang in case of granular type. It was found that the liquid types herbal medicines were relatively safer than three pill types of, four granular types of and four liquid types herbal medicines were tested for concentration of heavy metals. It is considered that is required in the stage of raw material treatment, manufacturing and packaging because those herbal medicines are directly taken in and absorbed into human body through the final treatment process.