• Journal of Korean Medicine for Obesity Research
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• v.2 no.1
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• pp.13-23
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• 2002

Background & Methods: In order to study the effect of electro-lipolysis-acupuncture, 57 outpatients who have had herbal medication in Kirin Oriental Hospital were devided to two groups; acupuncture-treated group(46) vs non-acupuncture-treated group(11) Acupuncture-treated group was given electro-lipolysis-acupuncture at least two times a week and administered with herbal diet medication, whereas non-acupuncture-treated group was administered only with herbal diet medication. Results: Mean age, body weight and BMI of these two group at the start point of the treatment were $27.22({\pm}7.64)\;vs \;29.09({\pm}8.73),\;67.76({\pm}9.34)\;vs\;67.00({\pm}10.69),\;and\;26.20({\pm}3.02)\;vs\;26.14({\pm}4.10)$ in the order of acupuncture-treated and non-acupuncture groups. After one month of treatment, change rate of body weight, BMI, total fat, percentage of fat was significantly higher in acupuncture-treated group. Also the change rate of arm circumference, hip circumference and thigh circumference was significantly higher in acupuncture-treated group. The change rate of abdominal circumference and WHR of acupuncture-treated group was higher than that of non-acupuncture-treated group with no statistical significance. The circumference reduction rate according to herbal dieting program was higher in this order, abdomen, arms, chest, thighs and hips. On the other hand, chest circumference change rate over weight loss rate, which is the portion no acupuncture treatment was given to, and AMC change rate was higher in non-acupuncture-treated group. Conclusion: These results imply that herbal dieting program combined with electro-lipolysis-acupuncture is more effective on reducing body fat, size reduction of localized obesity and preservation of muscle than herbal prescription only dieting program.

• The Korea Journal of Herbology
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• v.27 no.3
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• pp.7-13
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• 2012

Objective : This study was conducted to observe the anti-hyperlipidemic and anti-inflammatory effects, as well as the metabolic benefits, of pear extract and herbal drug mixture (Lycii Fructus, Coicis Semen, Alimatis Rhizoma, and Astragali Radix) on rats fed with a high fat diet. Methods : The animals used were male rats and the control group was fed a high fat diet only. The experimental groups were divided into four. Exp I group was fed a high fat diet with a mixture of pear extract and 3% Lycii Fructus; Exp II group was fed a high fat diet with a mixture of pear extract and 3% Coicis Semen; Exp III group was fed a high fat diet with a mixture of pear extract and 3% Alimatis Rhizoma; and Exp IV group was fed a high fat diet with a mixture of pear extract and 3% Astragali Radix for 4 weeks. Results : The body weight gain increased in all groups, but attenuated gradually in the experimental groups compared to the control group. The food intakes were significantly lower in Exp I and Exp III groups than the control group. The concentrations of serum total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, and triglyceride (TG) were significantly higher in Exp II than in the control group, and lower in Exp III group than in the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp III group than in the control group. In inflammatory activities, the Exp II group was significantly lower than the control group. Conclusion : The results indicated that Exp III group (administered a mixture of pear extract and Alimatis Rhizoma) most efficiently reduced fat accumulation and body weight, while the Exp II group (administered the mixture of pear extract and Coicis Semen) had the highest elevated lipid metabolism and immune activity.

• The Korea Journal of Herbology
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• v.27 no.5
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• pp.1-7
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• 2012

Objectives : This study was conducted to 9% compared with the previous experimental obesity-induced metabolic function in rats that it was a mixture of pear extract and herbal drugs(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on high fat diet-induce obesity rats. Methods : The animals were used in male rats. Control group fed high-fat diet only. Experimental groups were divided four, ExpI group was fed high-fat diet with a mixture pear extract and Lycii Fructus 9%, Exp II group was fed high-fat diet with a mixture pear extract and Coicis Semen 9%, Exp III group was fed high-fat diet with a mixture pear extract and Alimatis Rhizoma 9%, and Exp IV group was fed high-fat diet with a mixture pear extract and Astragali Radix 9% for 4 weeks. Results : The body weight gain increased in all groups, but attenuated gradually in the experimental groups compared to the control group. The food intakes were significantly lower in all Exp groups than the control group. The concentrations of serum total cholesterol (TC), LDL-cholesterol, and free fatty acid were significantly lower in Exp II than in the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp IV group than in the control group. In inflammatory activities, the Exp II, IV group was significantly lower than the control group. Conclusion : The results indicated that Exp I group (administered a mixture of pear extract and Lycii Fructus) reduced fat accumulation, body weight and the highest elevated lipid metabolism, while the Exp II group (administered the mixture of pear extract and Coicis Semen) and Exp IV group (administered the mixture of pear extract and Astragali Radix) had the highest elevated immune activity.

• Journal of Acupuncture Research
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• v.25 no.2
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• pp.211-226
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• 2008

Objectives : This research was performed to investigate the effects of Fructus Hordei Germiniatus-herbal acupuncture(HA; herbal acupuncture) at acupoint Jung-wan($CV_{12}$) on weight gain, food consumption, food efficiency, serum of lipid concentrations and liver function of rats fed high fat diet for 7weeks. Methods : Experimental groups were divided into high fat diet group(Control), high fat diet and saline injection at acupoint $CV_{12}$ treated group(Saline), high fat diet and Fructus Hordei Germiniatus-HA at acupoint $CV_{12}$ treated groups. According to HA concentration, HA groups were classified into 4 groups ; HA-1($0.108mg/g/m{\ell}$), HA-2($0.054mg/g/m{\ell}$), HA-3($0.022mg/g/m{\ell}$), HA-4($0.011mg/g/m{\ell}$). HA was treated at $20{\mu}{\ell}$ per 4days, total 12times in 49days. Results : 1. Body weight per week was significantly decreased in HA-1, HA-2, HA-3 and HA-4 And body weight per day was significantly decreased in HA-3. 2. Food consumption per week was significantly decreased in HA-1, HA-2, HA-3 and HA-4. 3. Food efficiency per week was significantly decreased in HA-2, HA-3 and HA-4 And food efficiency per day was significantly decreased in HA-3. 4. The level of serum total cholesterol was significantly decreased in HA-1 and HA-3 And the level of serum HDL-cholesterol was significantly decreased in HA-1. 5. The level of serum triglyceride was significantly decreased in HA-1, HA-2, HA-3 and HA-4. And the level of serum total bilirubin was significantly decreased in HA-1and HA-2. 6. The level of serum AST was significantly decreased in HA-2 and HA-3 And the level of serum ALT, r-GTP were significantly decreased in HA-2. Conclusions : According to the above results, Fructus Hordei Germiniatus-HA at acupoint $CV_{12}$ can control body weight, food consumption, food efficiency, serum lipid concentrations and liver function. Asthe same time this kind of Fructus Hordei Germiniatus-HA does not seem to be injurious on liver function. To use Fructus Hordei Germiniatus-HA for obesity, further studies about their underlying mechanism may be needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1272-1280
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• 2005

The study was performed by examining the effects of fermented liquid of Crataegi Fructus on the lipid profile improvement in rats fed high fat diets. Sprague-Dawley rats of weighting $180.0{\pm}30g$ were randomly divided into five groups : basal diet (Normal control group, NCG), only high fat diet (High fat control group, HFC), high fat diet and supplemented with 1.69 mg/100 g body weight, 3.38 mg/100 g body weight, 6.76 mg/100 g body weight by fermented liquid of Crataegi Fructus - HFL, HFM, HFH group). These experimental diets were fed for 6 weeks. The fermented liquid of Crataegi Fructus fed groups had more significantly decreased in the levels of serum total cholesterol, triglyceride, LDL-cholesterol and atherogenic index than the high fat control group, while the HDL-cholesterol was higher when compared to the normal control group. Total lipid, total cholesterol, triglyceride, LDL-cholesterol contents in liver were decreased in high fat experimental groups. But the degree of increment was reduced by administration of fermented liquid of Crataegi Fructus. while the fermented liquid of Crataegi Fructus fed group had ore significantly increased in the level of HDL-cholesterol than the high fat control group. The singularity of the unsaturated fatty acid contents attracted our attention. Especially, the polyunsaturated fatty acid compositions were 36.36%, 34.70%, 20.31%in serum, liver and fecal of fermented liquid of Crataegi Fructus fed groups, respectively. These results imply that the fermented liquid of Crataegi Fructus can be used as possible food resources and medicinal food materials.

• Journal of Microbiology and Biotechnology
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• v.29 no.5
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• pp.739-748
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• 2019

Cheonggukjang and chaga mushrooms have numerous health benefits, and have been used in alternative medicine. Therefore, a powder mixture of 98: Cheonggukjang and 2: Chaga extracts was fermented with Lactobacillus acidophilus KCTC3925 (FCC) and its anti-obesity effects in high-fat diet (HFD)-induced obese mice were determined. Five-week-old male ICR mice were fed a normal diet or HFD in the presence or absence of 3% and 5% FCC by weight (n = 10 per group). After 12 weeks, the mice were sacrificed, and the serum and tissue samples were collected for analysis. Body weight and epididymal fat pad weight were significantly lowered in the 3% and 5% FCC groups compared with those in the HFD control group (p < 0.01). FCC supplementation suppressed serum triglyceride and increased serum HDL-C levels (p < 0.01). Serum GOT, GPT, and leptin levels, hepatic COX-2 mRNA expression, and splenic COX-2 and IL-4 mRNA expression were significantly higher in the HFD groups than in the control group (p > 0.05); however, except for splenic IL-4 levels, the increases were significantly attenuated by FCC supplementation. Expression of ICAM-1, an aortic inflammatory marker, was significantly increased in the HFD group; this effect was suppressed in the 3% FCC group (p < 0.01) but not in the 5% FCC group. FCC suppressed the body weight and epididymal fat pad weight gain, as well as inflammatory responses in the liver and spleen of HFD-fed mice. Thus, FCC supplementation will be beneficial for the treatment of obesity-related effects.

• Biomedical Science Letters
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• v.19 no.3
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• pp.206-212
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• 2013

The herbal composition Gyeongshingangjeehwan 18 (GGEx18), which is composed of three herbs, Laminaria japonica Aresch (Laminariaceae), Rheum palmatum L. (Polygonaceae), and Ephedra sinica Stapf (Ephedraceae), has been used as an anti-obesity drug in Korean local clinics. Thus, we investigated whether GGEx18 regulates obesity by suppressing appetite in high fat diet-induced obese C57BL/6J mice. Administration of GGEx18 to obese mice for 9 weeks significantly decreased body weight gain, epididymal adipose tissue weight, and food efficiency ratio. GGEx18 also caused a significant decrease in the circulating levels of leptin, which were increased by about 450% in obese control mice compared with normal lean mice. Concomitantly, GGEx18 decreased mRNA levels of a potent appetite-stimulating hormone neuropeptide Y, but increased an appetite-suppressing hormone pro-opiomelanocortin mRNA levels. These results suggest that GGEx18 may prevent obesity through regulating appetite in nutritionally obese mice.

• Herbal Formula Science
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• v.11 no.1
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• pp.151-159
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• 2003

Effects of siho(Bupleuri Radix) extracts on lipid composition and antioxidant system were investigated in rat fed high fat diet. body weight gain, concentration of plasma triglyceride, total cholesterol, LDL-cholesterol showed a tendency to decrease in siho(Bupleuri Radix) extracts groups. However, the concentration of HDL-cholesterol showed no significantly different among treatments. Plasma and liver TBARS concentration showed a low values in siho(Bupleuri Radix) extracts groups. Activities of SOD, GSH-Px and CAT showed a tendency to increase in siho(Bupleuri Radix) extracts groups.

• Journal of Korean Medicine for Obesity Research
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• v.6 no.2
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• pp.105-112
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• 2006

We experienced an abdominal obese patient with postpartum disease. From the 15th of July 2006 to the 16th of September 2006 we applied herbal medications (Gungguijohyeoleumgamibang and Taeeumjouitanggamibang), acupuncture, auricular acupuncture, electrolipolysis, low calorie diet, aerobic exercise, behavioral therapy to her. We examined the changes in body weight, BMI, PBF and WHR and the changes in cold hypersensitivity of lower extremities and pain of wrists and ankles. Her weight decreased from 49.6kg to 44.5kg, BMI from $20.9kg/m^2$ to $18.8kg/m^2$, PBF from 27.7% to 23.9%, WHR from 0.84 to 0.78. Cold hypersensitivity of lower extremities and pain of wrists and ankles, symptoms typical of postpartum disease disappeared after treatment. Despite a low calorie diet, lactational performance was not impaired.

• Journal of Korean Medicine for Obesity Research
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• v.3 no.1
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• pp.69-74
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• 2003

Childhood obesity is harmful to health and growth. We had experienced a childhood obese patient. From Feb. 28. 2003 to July. 14. 2003. We applied Chegameuiyin-tang(體感意苡仁湯), electrolipolysis and VLCD(very low calorie diet), behavioral therapy, aerobic exercise, infra-red therapy, auricular acupuncture, and aqua-massage. Through this obesity treatment during 5 months, total weight loss was 12.2kg, reduction of percent body fat was 13.4% (from 38.5 to 25.1), her condition and hepatic index(AST, ALT) was improved.