• Journal of Acupuncture Research
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• 제22권3호
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• pp.77-92
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• 2005

가시오가피약침(五加皮藥鍼)이 대사증후군(代謝症候群)에 미치는 영향을 알아보기 위하여 ICR mouse에 고지방식이로 비만과 대사증후군(代謝症候群)을 유도하면서 신유(腎兪)(BL23)에 상응하는 부위에 일정한 방법으로 가시오가피약침(五加皮藥鍼)후 체중, 식이효율, 혈중 glucose, insulin level, insulin resistance, 경구내당능, 혈압, 혈중지질의 변화, 지방조직의 중량과 면적, 조직학적 변화와 GLUT-4 mRNA 및 UCP-1 mRNA의 발현을 관찰하여 유의한 결과를 얻었다. 1. 가시오가피약침(五加皮藥鍼)은 체중의 증가와 식이효율의 상승을 억제하였다. 2. 가시오가피약침(五加皮藥鍼)은 혈중 glucose, insulin level 및 insulin resistance의 상승을 억제하고, 경 구내당능을 개선시켰다. 3. 가시오가피약침(五加皮藥鍼)은 혈압의 상승을 억제하였다. 4. 가시오가피약침(五加皮藥鍼)은 혈중지질의 이상을 개선시켰다. 5. 가시오가피약침(五加皮藥鍼)은 WAT, BAT 및 liver 중량의 증가를 억제하였고, WAT와 BAT의 면적과 직경의 증가를 억제하였다. 6. 가시오가피약침(五加皮藥鍼)은 GLUT-4 mRNA 및 UCP-1 mRNA 발현의 증가를 억제하였다.

• 대한약침학회지
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• 제5권2호
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• pp.120-136
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• 2002

Objectives : The purpose of this study is to investigate Acute and Subacute Toxicity, and Anti-cancer Effect of H Herbal-acupuncture on mice and rats. Methods : Balb/c mice were injected intraperitoneally with H Herbal-acupuncture for $LD_{50}$ and acute toxicity test. Sprague-Dawley rats were experimented in the same way for subacute toxicity test. H Herbal-acupuncture was injected into abdomen of mice having S-180 cancer cell line. Result : 1. During the test, $LD_{50}$ could not be counted since there was no expired subjects. 2. In an acute toxicity test, the loss of motility and reflex action was observed, but weight increased in the treatment group, compared with those in the normal group (P<0.05). 3. In an acute toxicity test of serum biochemical values of mice, glucose increased in the treatment group II while total cholesterol was increased in the all treatment groups (P<0.05). 4. In a subacute toxicity test, a little loss of motility and reflex action was observed in the treatment group. Weight of mice in the treatment group decreased on the 28th day. 5. In a subacute toxicity test, liver weight was decreased but lung weight of mice increased in the all treatment groups (P<0.05). 6. As a result of measuring Complete Blood Count test (CBC) of rat, HCT was decreased in treatments even though it was not significant, compared with the normal group (P<0.05). 7. In a serum biochemical value test of subacute toxicity, total protein and albumin decreased in the all treatment groups. Creatinine, glucose, GOT increased in the treatment group I compared with the control group. Alkaline phos-phatase decreased in treatment II group, compared with the control group (P<0.05). 8. Median survival time that was measured in the rats treated with sarcoma-180 cancer cell Median decreased in the treatment group, compared with the control group (P<0.05). 9. Natural killer cell activity showed significant reduction at 100:1 and 10:1 E/T ratio while it increased at 50:1 E/T ratio. It is inferred that there was an error in the experiment (P<0.05). 10. In an interleukin-2 productivity test, even though it decreased in lung cancer, and increased in abdomen cancer, but it was only a small difference (P<0.005). 11. After injecting B16F10 cell into a capillary vessel of C57BL/6 mice and generating metastasized lung cancer, the lung was examined with the naked eye. It was not possible to see metastasized cancer in the all groups on the seventh day but the cancer was viewed on the fourteenth day. The number and volume of metastasized cancer in the treatment group enlarged in the treatment group, compared with the control group. Conclusion : According to the results, H herbal-acupuncture took no effects in cancer.

• 대한약침학회지
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• 제9권3호통권21호
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• pp.105-116
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• 2006

Objectives : To investigate the effect of Ga-mee-Gwui-ryong-tang herbal acupuncture(GR-HA) at GB39 and ST36 and the effect of Yuk-mee-ji-hwang-tang herbal acupuncture(YM-HA) at GB39 and KI10 on growth in mice. Methods : Mice were divided into 7 group(n=10) ; saline-ST36, saline-GB39 and KI10, GR-HA-ST36 group treated with GR-HA at right ST36, GR-HA-GB39 group treated with GR-HA at right GB39, YM-HA-GB39 group treated with YM-HA at right GB39, YM-HA-KI10 group treated with YM-HA at right KI10. Saline-ST36 group, saline-GB39 group and saline-KI10 group were injected with saline at right ST36, GB39, KI10 respectively. Saline injection and HA were performed 3 times a week for 18 days. The length(total height, body length and tail length), weight and the protein efficiency ratio were measured as well as IGF-1 level in serum. Results : 1. GR-HA at GB39 and GR-HA at ST36 promoted growth in weight, tail length and total height but there was no statistical significance. 2. GR-HA at GB39 significantly promoted protein efficiency on the 14th day and GR-HA at ST36 on the 3rd day. 3. GR-HA at GB39 significantly increased serum IGF-1. GR-HA at ST36 increased IGF-1 slightly but with no statistical significance. 4. YM-HA at GB39 and YM-HA at KI10 promoted growth in weight, height, tail length and total height but there was no statistical relevance. 5. YM-HA at GB39 and YM-HA at KI10 significantly promoted protein efficiency on the 14th day. 6. YM-HA at GB39 and YM-HA at KI10 significantly increased serum IGF-1. Serum IGF-1 level of YM-HA-KI10 group was significantly higher than that of YM-HA-GB39 group. 7. Serum IGF-1 level of GR-HA-GB39 group was significantly higher than that of YM-HA-GB39 group. Conclusions : GR-HA and YM-HA both may promote growth. This study suggests that herbal acupuncture at GB39 is more effective with Gwui-ryong-tang than Yuk-mee ji-hwang-tang to promote growth. It also suggests that Yuk-mee ji-hwang-tang herbal acupuncture is more effective at KI10 than at GB39.

• Journal of Acupuncture Research
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• 제29권6호
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• pp.119-125
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• 2012

Objectives : Rotator cuff tear is a common disease that causes shoulder pain and disability. Sometimes surgical treatment is demanded and appropriate rehabilitation is also needed to provide functional recovery. This report is intended to estimate the effect of oriental treatment for the patients in rotator cuff surgery rehabilitation period. Methods : From 29th October, 2012 to 13th November, 2012, One male patient who received rotator cuff surgery was treated with acupuncture, pharmacopuncture and herbal medication. NRS and ROM were evaluated to demonstrate the effect of treatment. Results : The patient showed the improvement in shoulder pain and ROM. Conclusion : Oriental treatments such as acupuncture, pharmacopuncture, herbal medication can be effective for relieving pain and increasing ROM in rotator cuff surgery rehabilitation period.

• Journal of Acupuncture Research
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• 제24권4호
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• pp.99-105
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• 2007

목적 : 본 연구는 최근 임상에서 많이 사용하는 자하거 약침액의 nitric oxide(NO)에 대한 소거 효과를 분석하기 위하여 실행되었다. 방법 : 양성대조군으로 비타민C와 실험군으로 자하거 약침액에 NO를 분비하는 S-nitroso-N-acetylpenicillamine(SNAP)을 투여한 후 NO의 농도를 540nm 파장의 자외선 흡수량을 측정하여 평가하였다. 결과 : 실험에 사용된 자하거 약침액의 NO 소거 효과는 강력한 항산화제인 비타민C보다 우수하지는 못하였으나 0.005 및 0.001mg/ml 농도에서 12시간 동안 SNAP를 투여한 후 생성된 NO를 유의성 있게 소거하는 효과가 나타났다. 결론 : 이상의 결과를 통하여 자하거 약침액이 NO를 소거하는 효과가 있는 것이 확인이 되었으나 추후 농도별 실험과 다른 시료와의 비교실험이 더 요구된다.

• Journal of Acupuncture Research
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• 제39권1호
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• pp.59-63
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• 2022

Spontaneous osteonecrosis of the knee (SONK) is a common form of osteonecrosis of the knee and mainly affects the medial condyle due to localized vascular insufficiency. We report a case of SONK in a 65-year-old woman who had severe knee pain in her left knee whichimpeded her capacityto walk beyond 10 minutes. Bilateral knee X-rays revealed degenerative osteoarthritis of both knees and magnetic resonance imaging revealed R/O SONK in the lateral aspect of the medial femoral condyle, as well as a medial meniscal posterior horn root tear, and a Grade 1 medial collateral ligament injury. She was hospitalized at Jaseng Hospital of Korean Medicine for 21 days and receivedcombination therapy includingacupuncture, pharmacopuncture, and herbal medicine. Patient-reported scales indicated that her pain and physical functional limitations were alleviated. Combination therapy consisting of Korean traditional medicine may bean alternative nonoperative treatment approach for patients with SONK.

• 한방재활의학과학회지
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• 제32권3호
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• pp.37-53
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• 2022

Objectives This study was conducted to investigate a randomized controlled trial study on the clinical treatment of herbal medicines for avascular necrosis of the femoral head. Methods By March 2022, the China National Knowledge Infrastructure (CNKI) was reviewed about randomized controlled trial studies on the herbal treatment of avascular necrosis of the femoral head through. The publication year, evaluation criteria, treatment period, treatment method and effectiveness were analyzed for articles published from 2017 to 2022. Results 16 articles were selected and 14 kinds of herbal medicines were used. In most studies, Western medical treatments such as injection therapy, oral drug administration, traction therapy and mid-frequency electric therapy were treated alone in the control group, and a combination of Western medical treatment and herbal treatment was administered to the experimental group. Conclusions In China, there have been many studies on herbal treatment for avascular necrosis of the femoral head. In Korea, more clinical studies on the herbal treatment of avascular necrosis of the femoral head are needed. This study will be helpful for future research in Korean medicine on avascular necrosis of the femoral head.

• 대한한방내과학회지
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• 제39권5호
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• pp.1004-1014
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• 2018

This case reports the effect of herbal medicine and acupuncture therapy on the scoring atopic dermatitis (SCORAD) index for an adult atopic dermatitis patient. An adult male in his 30s with complaints of severe eczema on the whole body was diagnosed with heat toxin blazing exuberance pattern (熱毒內蘊) and treated with herbal medicine, including an orally-administrated decoction, externally-applied decoction, extracted powder capsule, and acupuncture for a total of 30 days. We observed skin symptoms, SCORAD index, follow-up photographs, and any adverse events. After treatment, SCORAD index decreased from 74.5 to 38.7 (51.9% from baseline). Skin symptoms such as redness, itching, and exudation were improved without any adverse events reported. This case suggests that herbal medicine and acupuncture therapy could be effective in improving eczema in adult atopic dermatitis patients.

• 대한예방한의학회지
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• 제17권1호
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• pp.107-116
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• 2013

Objectives : This study was aimed to facilitate mutual comprehension between Western and Traditional Korean Medicine (TKM) by analyzing recognition of medical school students on traditional medical prescription and treatment such as herbal medicines and acupuncture. Methods : We conducted a survey targeting medical school students of four medical schools from April through May 2009, and analyzed 208 cases responded. Results : Survey results revealed that medical school students took knowledge of traditional medicine from TV programs and on the Web in general. They thought they had considerable traditional medical knowledge but did not almost understand for professional contents. Regardless of some positive recognition for traditional herbal medicine, negative perspectives were more common and its safety and efficacy on the drug reference were considered as a major reason. On the other hand, recognition on acupuncture was comparatively positive. Scientific data for both herbal medicine and acupuncture are lacking in reality but the attitude only for acupuncture was different. Of the survey respondents, 57.8% had negative attitude against diagnostic methods of TKM and 59.1% opposed to the usage of modern medical equipments by TKM doctors. With regard to the future position of TKM, they tacitly approved that TKM would be absorbed into the complementary and alternative medicine (CAM) and importance of TKM objectification, followed by Government's support. Conclusions : Medical school students neither affirm nor deny TKM as a whole but the state of awareness for each item was similar to the physician. In terms of TKM its internal and external innovation would be required to continuously establish objectification of TKM prescription and scientific research on treatment technology.

• 동의생리병리학회지
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• 제35권5호
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• pp.199-209
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• 2021

The purpose of this study was to explore objective indicators(outcomes) which are used to evaluate clinical efficacy and figure out the mechanisms of herbal medicine, acupuncture and moxibustion treatment for Irritable bowel syndrome(IBS). We searched randomized controlled trials(RCTs) that mediated with herbal medicine, acupuncture and moxibustion treatment for IBS and used objective indicators for outcome from November 1, 2020 to December 31, 2020. The RCTs that were published in Korean, English and Chinese were included in this study. The selected literatures were analyzed about methods of result measurement and assessed by Cochrane's risk of bias(RoB). Total 18 RCTs were included in this study. There were lots of objective indicators for result measurement; the concentration of hormones in blood and neurotransmitters, the sensitivity of rectum, the functional assessment of central nerve and autonomic nerve system, the change of intestinal flora, the concentration of serum cytokines. Various objective indicators can be used to evaluate the clinical efficacy of with herbal medicine, acupuncture and moxibustion treatment for IBS, but due to the limitations of the quality of the included studies, systematic review and meta-analysis will be needed.