• Proceedings of the Korean Society of Toxicology Conference
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• 2001.05a
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• pp.119-119
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• 2001

Traditional herbal medicines(HM) are frequently taken in combination with conventional medications in Korea, but few reports have been addressed to herb-drug interaction. We assessed the inhibitory potential of 15 commonly used HMs in Korea on CYP450 isoforms.(omitted)

• Korean Journal of Medicinal Crop Science
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• v.12 no.1
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• pp.67-72
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• 2004

For discrimination the origins and the commercial herb medicines of three Angelicae Radixes (Danggui), anatomical characters of leaves, petioles, and root cross-section were investigated and those were compared each other. The key for discrimination of these herb medicines was made by below simple characters: development of periderm, absent and present of collenchyma under the periderm, and distribution of latex tube in cortex. The result of discrimination for the commercial herb medicines based on the discrimination key, Angelicae gjgantis Radix (Angelica Gigas Root), Angelicae Radix (Japanese Angelica Root), and Radix Angelicae Sinensis (Danggui) were correctly identified for Angelica gigas Nakai, A acutiloba Kitagawa, and Angelica sinensis (Oliv.) Diels., respectively. Consequently, anatomical characters could be utilized for useful method to discriminate three Angelicae Radixes (Danggui).

• Journal of Life Science
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• v.16 no.1
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• pp.141-147
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• 2006

The effect of traditional Doenjang supplemented with the extracts of herb medicines (refer as DHM) on the taste component and microbial properties was investigated. The DHMs were divided to four group. Fatty acid compositions were similar between DHMs and control as ratio of each fatty acid to total fatty acids. Concentration of total free amino acid from groups II , III and IV was higher than that of control. Major organic acids were phytic acid, lactic acid, and butyric acid. In isoflavone of DHMs, free daidzein and genistein contents were mostly similar among the groups, and groups m and W were slightly higher as compared with control. Viable cell count of DHMs was shown to be $2.5\times10^7\;CFU/ml$, a similar trend of control. Protease activity of DHMs was higher than that of control(67.65 units), but amylase activity between DHMs and control was almost identical Sensory scores of group II and IV were shown to be brighter than those of group I and II, and decreasing off-odor was more effective. In over all eating-quality, group III and IV were evaluated to be favorable as compared with control and the other DHMs because of supplementing the sweet taste of extracts to Korean indigenous Doenjang.

• The Journal of Internal Korean Medicine
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• v.29 no.4
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• pp.846-855
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• 2008

Objects : The aim of this study was to investigate the influence of five herbal medicines on cytochrome P450 3A4 drug-metabolizing enzymes in human liver microsomes. Methods : To use human liver microsomes, an extract of five herbal medicines, which are Artemisia princeps Pampan, Sophora jeponica Linne, Panax notoginseng F. H. Chen, Lithospermum Erythrorhizon Sieb., and Cirsium maackii Maxim, which together are called Jihyulyak(止血藥, drugs for arresting bleeding, hemostatics), was co-incubated and measured for relative enzyme activity in incubation condition compared to ketoconazole, a representative inhibitor of CYP 3A4. Results : We showed that all five of the traditional herbal medicines had no inhibition effect of CYP 3A4 at 10, 20, 30, 40, and $50{\mu}g/ml$ doses in human liver microsomes, although Sophora japonica Linne(SJL) showed a little inhibition at about 81% inhibition rate of control. However, this result is not enough to prove that SJL has a CYP 3A4 inhibition effect. Moreover, we can't make sure that those rates had significant induction effect on CYP 3A4. Conclusions : The result of this study could support that those herbal medicines are safer than chemical drugs, even if this is the basic step to prove that result.

• CELLMED
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• v.3 no.3
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• pp.22.1-22.10
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• 2013

Traditional Chinese medicine (TCM) in single herb or formula prescription has been used for thousands of years. Many of them possess antioxidant activity and the activity may contribute the therapeutic effect. This paper would review the relationship of traditional herbal medicine and antioxidant with particular reference to ginseng. This medicinal herb has been used worldwide with extensive tonic effect. The comet assay, a technique for DNA protecting and damaging investigation would be introduced and the application of comet assay on TCM would be discussed.

• The Journal of Korean Medical History
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• v.26 no.2
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• pp.123-134
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• 2013

Traditional medicine has been exchanged constantly from prehistoric times up to the present. As the global market trade on traditional medicine increases, people now emphasized the importance of traditional medicine. Previously, knowledge about herbal medicines are taught or learned indirectly. Most of it was learned through medical books. But in these contemporary times, herbal medicine's knowledge is shared through journals, congress and some other events in where traditional medicine's information are shared. In the international congress gathering; traditional medicine's experts from many countries shared some additional knowledge. First, "an attitude to medicine that emphasizes on Naturalism". Second, "respect for experienced in traditional medicine". Third, "respect for locality on traditional medicine". Fourth, "a protection for domestic traditional medicine industry" Fifth, "acceptance of traditional medicine from other countries according to domestic health care system".

• CELLMED
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• v.7 no.1
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• pp.2.1-2.3
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• 2017

World health organization has recently published a strategic plan for the development and promotion of traditional system of medicine. Herbal pathies especially Unani and Ayurvedic systems of medicines have great scope in this aspect. But, there are several problems with these pathies in the current era, as the way of research and identification is still on classical system. The correct identification of medicinal plant is one of the major problems in both the system. This should be corrected with the modern tools and techniques. The various types of data including recent discoveries, economical growth, ethnobotanical literature and extremely rapid increase in herbal journals and books have emerged great scope for these pathies. At the same time several challenges and threats are present including herb-drug interaction, false reports, toxicity studies etc. In this review paper, opportunities, threats, and researches to be focused will be discussed.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.12 no.2
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• pp.148-160
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• 1999

In order to strengthen objectivity and availability of oriental herb medicine, the standard formula for herbs has been attempted to set up by documentary testing original herbs which were recorded in authorized document. The object herb medicines are CARYOPHYLLI FLOS. After this study, additional experimental verification is required as a matter of fact. As comparison materials, this thesis will be utilized. Specially the internal and external morphological standard in this study is expected to supply the search for several physiochemical reaction, biological reaction, determination of indicator material and identification of gene with basic sources in the future.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.384.1-384.1
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• 2002

The antifungal activities of the essential oils from Citrus borgamia. Ciderus atlantica. Cymbopogon ditratus, Eucalyptus globulus. Juniperus communis. Lavandula angustifolia. Melaeuca aterinfolia. Pelargonium graveolens. Pogestemon patchouli. Rosmarinus officinalis. Styrax tonkinensis. and Thymus vulgaris, which are recommended for the treatment of microbial infections in aromatherapy and complementary medicines. were tested against Trichophyton spp. The activities were measured by broth dilution method and disk diffusion assay. As the results, most of the test oils inhibited growth of T. tonsurans. T.mentagrophytes. T. ferugineum. and T. rubrum. Eapecially, the essential oils from C. atlantica. C. ditratus. e. globulus, and P. graveolens showed the strongest activity among the tested herb oils showing MICs between < 0.09 and 0.39 mg/ml.

• YAKHAK HOEJI
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• v.46 no.5
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• pp.352-357
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• 2002

The three crude drugs of the Kalopanax pictus (Araliaceae) roots (K), Pueraria thunbergiana (Leguminosae) flowers (P), and the Rhus verniciflua (Anacardiaceae) heartwood(R) used for anti-thirst drugs in Oriental herb medicine were extracted with MeOH, respectively, and the successive fractionation of the extract gave EtOAc extract. Certain amount ratios of the three extracts were also prepared to compare the antimutagenicity in Ames test. In N-methyl-N(-nitro-N-nitrosoguanidine (MNNG; 0.4 (g/plate)-induced test, the activities of complex mixture were observed between the highest antimutagenic activity of K extract and the lowest P extract. In aflatoxin (AFB$_1$)-induced test, the EtOAc complex (K : P : R=l : 1 : 3) labeled E-113 decreased the revertants of Salmonella typhimurium TA100 by 95％, which activity were highest among other extracts or complexes mixture used. Fractionation of organic solvent mostly increased the antimutagenicity. These trends were also observed in the antimutagenicity test of the mixture of each active component of kalopanaxsaponin A, tectorigenin and sulfuretin. These results supported that many kinds of anti-thirst herb medicine in the prescription could effectively prevent cancer disease.