• 동아시아식생활학회지
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• 제10권6호
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• pp.530-540
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• 2000

Weight reducing methods were surveyed by questionnares in March through May, 1998 with 641 women living in Inchon to provide the information for the education of proper weight control. Methods that they have used for weight-reduction were exercise (33.1%), diet therapy(29.6%), sauna(7.3%), ingestion of special food(4.8%), administration of drugs(4.0%) and herb-medicines. The respondents considered exercise(38.4%) and diet therapy(31.5%) as the most effective methods in reducing weight and the response was different with ages at p<0.01. They have practiced the diet therapy by reducing the amount of food(27.7%), skipping one or two meals a day (20.8%), avoiding high calorie snacks(8.8%) and regulating food items in a meal(3.8%). Exercises which they have done were walking(48.0%), aerobics(2.3%), swimming(23%) and using the health instruments(6.7%). Their choices in kinds of exercises were significantly dependent upon ages, marriage and their occupation(P<0.01). Acupuncture(38.0%) was the most frequently used oriental medicine therapy and original drugs(32.2% ) and moxibustion(22.0%) were also used. The women have taken drugs was 9.5%. Among them cream-typed cosmetics(41%), weight reducing drugs(30%), diuretics(18% ), and smoking(7%) were used. Fifty respondents out of 641 had expericences to have special food therapy such as grape, apples and vinegar(42%) and enzymes(18%) for some period of time.

• 한국의사학회지
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• 제31권2호
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• pp.73-82
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• 2018

Chalbyungyogyul (察病要訣) is a book of Korean Medicine which contains simple knowledges combined with experienced prescriptions. This study intends to introduce a manuscript of Chalbyungyogyul handed down in a family in Yeongwol-gun and analyze the Eui'an (醫案) in it. This book includes common sense in medicinal herbs and 142 cases of Eui'ans. The Eui'ans in Chalbyungyogyul can be divided into three types. Some Eui'ans state miraculous effects. External medical treatments are used in another group of Eui'ans. In the other Eui'ans, prescriptions composed by a single herb are applied. These characteristics are differentiated from those of preexisting Eui'ans in the history of Korean medicine which mainly include complexly prescribed internal medicines and medical discussions. This book vividly describes medical practice in the early 20th century and shows the realization of theoretical writings. Above all, it is a valuable discovery of Eui'an compilation which is rare in the history of Korean medicine.

• The Korean Journal of Physiology and Pharmacology
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• 제27권3호
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• pp.221-230
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• 2023

Diabetic kidney disease is one of the most serious complications of diabetes. Although diabetic kidney disease can be effectively controlled through strict blood glucose management and corresponding symptomatic treatment, these therapies cannot reduce its incidence in diabetic patients. The sodium-glucose cotransporter 2 (SGLT2) inhibitors and the traditional Chinese herb "Gegen" have been widely used in diabetes-related therapy. However, it remains unclear whether the combined use of these two kinds of medicines contributes to an increased curative effect on diabetic kidney disease. In this study, we examined this issue by evaluating the efficacy of the combination of puerarin, an active ingredient of Gegen, and canagliflozin, an SGLT2 inhibitor for a 12-week intervention using a mouse model of diabetes. The results indicated that the combination of puerarin and canagliflozin was superior to canagliflozin alone in improving the metabolic and renal function parameters of diabetic mice. Our findings suggested that the renoprotective effect of combined puerarin and canagliflozin in diabetic mice was achieved by reducing renal lipid accumulation. This study provides a new strategy for the clinical prevention and treatment of diabetic kidney disease. The puerarin and SGLT2 inhibitor combination therapy at the initial stage of diabetes may effectively delay the occurrence of diabetic kidney injury, and significantly alleviate the burden of renal lipotoxicity.

• Journal of Ginseng Research
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• 제47권3호
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• pp.359-365
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• 2023

Ginseng was the most revered of the herbs in ancient times in China, Korea, Japan, America. Ginseng was discovered over 5000 years ago in the mountains of Manchuria, China. References to ginseng are found in books dating back more than two millennia. It is revered by the Chinese people as it is considered a herb for everything use and therefore for a wide range of diseases (currently its Latin name derived from the Greek panacea, meanings, that is, for everything). So, it was used exclusively by the Chinese Emperor's, and they were willing to pay the price without problems. Increasing its fame, ginseng brought a flourishing international trade that allowed Korea to supply China with silk and medicines in exchange for wild ginseng and later along with what grows in America.

• 대한중풍순환신경학회지
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• 제16권1호
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• pp.49-56
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• 2015

This patient was 18 year-old man who had severe nausea, vomiting, stomachache but medical examination revealed no abnormality. The symptom lasted for 2 months and he lost 15kilograms. The patient had no underlying diseases. He was treated by korean medicine, containing acupuncture, cupping therapy and herb medicines during 9 days. The severity of nausea was scored by the Numerous Rating Scale and the frequency of vomitng was evaluated by count. After that period, patient's symptom was improved and his other conditions were also better, compared with his admission. This study suggests that Korean medicine could have a therapeutic effect for nausea, vomiting, stomachache and rapid weight loss that the cause has not been diagnosed by Western medicine. It could help to improve patient's symptoms and make general conditions better.

• 한국컴퓨터정보학회논문지
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• 제28권10호
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• pp.113-121
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• 2023

한의학 및 중의학 분야에서 네트워크 약리학은 계산학적인 방법을 통해 한약의 분자생물학적인 기전을 연구하기 위해 널리 활용된다. 개별 연구를 위해 사용되는 데이터베이스, 분석기법, 분석기준 등은 다양하나, 대부분의 한의학 네트워크 약리학 연구들은 약재-성분 네트워크 구축, 성분-표적 네트워크 구축, 표적의 해석이라는 유사한 단계로 수행된다. 효율적이고 일관성있는 한의학 네트워크 약리학 분석을 위해서, 우리는 일반적으로 적용할 수 있는 한의학 네트워크 분석 파이프라인 시스템을 설계하고 구현하였다. 우리는 이 시스템의 신뢰성을 약재의 네트워크 약리학 분석을 위해 널리 사용되는 데이터베이스를 활용해서 확인하였다. 제안된 시스템은 다양한 한약에 대한 네트워크 약리학적 분석을 용이하게 하고, 일관성 있는 분석을 도울 것이다.

• 미생물학회지
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• 제47권3호
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• pp.241-248
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• 2011

식품의 상품성과 보존을 위하여 사용하는 합성 첨가물이 소비자들의 소비 습관의 변화와 첨가물의 안전성에 대한 사회적 쟁점화로 천연의 소재를 활용한 다양한 연구와 조사가 진행되고 있다. 본 연구에서도 천연물 중 한의학의 소재로 사용되는 생약제제 79종을 사용하여 식품 중 상품성이 훼손된 음료에서 분리한 세균에 대한 항균성을 조사하였다. 13종의 Bacillus sp.와 3종의 Paenibacillus sp.에 대한 메탄올 추출물의 항균성을 조사한 결과 43종의 생약제제가 분리한 세균에 대한 항균성을 나타내었다. 이 중 8종의 한약재를 선별하고 이들을 대상으로 물, 에탄올, 메탄올과 에틸아세테이트를 추출 용매로 하여 항균성을 조사한 결과 오매, 오배자와 황련이 분리된 세균에 대한 항균성이 우수한 것으로 조사되었으며 특히 물과 에탄올을 사용한 경우에 우수한 항균성을 나타내어 이 결과를 바탕으로 이들 소재를 활용한 천연보존료의 개발 가능성을 확인할 수 있었다. 특히 다른 생약제제와 비교할 때 오매에 대한 연구가 상대적으로 미진한 것으로 판단되어 향후 지속적인 연구를 통한 제품의 개발도 가능할 것으로 판단하였다.

• 한국식품위생안전성학회지
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• 제29권2호
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• pp.152-157
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• 2014

국내에 유통되고 있는 국산과 수입산 한약재 11종 116건을 대상으로 잔류이산화황에 대한 모니터링을 수행한 결과 108건(93.1%)은 불검출이었고 6건(5.2%)는 이산화황 허용기준치 30 mg/kg을 초과하였고 2건은 30 mg/kg 미만으로 검출되었다. 116건의 이산화황 평균함량은 $17.6{\pm}144.2mg/kg$이고 최대 검출량은 구기자(1,546.3 mg/kg)이었고 중국산 현호색(66.6%)의 이산화황 검출 빈도가 가장 높게 나타났다. 국내산 한약재는 71건 중 1건(1.4%), 수입산 한약재는 45건 중 7건(15.6%)에서 이산화황이 검출되었고 국내산 1건(36.7 mg/kg)과 수입산 5건(118.1 mg/kg)이 허용기준치를 초과하여 국내산보다 수입산 한약재에 이산화황 잔류량이 많았다. 본 연구를 통해 이산화황 허용기준을 초과하는 부적합율은 다소 낮아지고 있지만 이산화황 허용기준을 초과하는 한약재들 중 일부 한약재에서는 잔류이산화황 함량이 높게 나타났고, 특히 국내산 약재에 비해 수입산 약재는 부적합율이 높게 나왔다. 한약재는 일반적으로 수세 및 가열과정을 거치므로 실제 섭취하는 형태의 탕액에서는 원재료보다 이산화황의 잔류량이 크게 감소하지만 완전히 제거되지는 않으므로 유통되는 한약재의 안전성 확립이 절실히 요구되어진다. 강화된 기준이 정착하여 안전한 한약재가 유통될 수 있도록 수입통관시 특별관리가 요구되며, 보다 적극적인 검사 요주의 품목에 대한 지속적인 잔류이산화황 모니터링이 필요할 것으로 사료된다.

• 대한한의학회지
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• 제31권1호
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• pp.162-173
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• 2010

Objectives: In order to confirm a remedial effect and related influence of the clinic treatment by prescribing herb medicines to hypertensives experiencing angiotensin converting enzyme (ACE) inhibitor dosage and suffering from common side effect generally known as dry cough. Methods: 1. We selected the 19 patients who visited National Oriental Medical Center, from August 21, 2007 to August 16, 2008 and suffering from dry cough caused by taking ACE inhibitor, with no other possible diseases causing dry cough. 2. We separated the 19 patients into two groups (Type 1: Bi-Qi hie (脾氣虛) group prescribed Samchuljojung-tang & Type 2: Qi-hie dam-wul (氣虛痰鬱) group prescribed Samsoumgamibang). 3. We then observed the symptom level and post-treatment effect, and recorded changes of dry cough intensity level for each group. Results: 1. Type 1: In the survey of 12 patients, initial level recorded 16.33 at entry diagnosis, and next level meant changing of symptoms, recorded as 2.75 at Stage 1 and reaching 3.33 at Stage 2. 2. Type 2: 7 patients, with initial level recorded as 18.71 at entry diagnosis, and 1.86 at Stage 1 and reaching to 3.29 at Stage 2. 3. No additional prescriptions were issued at Stage 2 or afterwards, and final result indicates that the mean value ended at 3.95 in the total group. Conclusions: It is concluded that there is a significant remedial effect and related influence of the clinic treatment between the Oriental medicine treatment and one of the common side effects of ACE inhibitor, dry cough.

• 대한예방한의학회지
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• 제12권2호
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• pp.13-25
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• 2008

The purpose of this study was to investigate extract from mixed culture with Trichloloma matsutake mycelium in oriental medicine and cereal medium(OCM) to develop new material for pharmaceutical products and medicinal food for diabetes mellitus. To evaluate of hypoglycemic activity of OCM extracts, we examined the inhibitory activity of ${\alpha}$-glucosidasein OCM, blood glucose level and liver function of streptozotocin(STZ) induced diabetic rat. Experimental group was divided into 6 groups: first, it was divided into normal control group(hereafter NC group) and diabetes-induced group, and diabetes-induced group was subdivided into diabetic control group(DC group), treated by hot water extracts group(HE), ultra sonic waves, micro waves, and micro bubble extracts g roup(UE), crude polysaccharide of HE group (HEE) and crude polysaccharide of UE group(UEE) at a dose of 300mg/kg/body weight, respectively. In diabetic-induced groups, after streptozotocin was melted in 0.01M citrate buffer at 50mg/kg/body weight, when the non-fasting blood glucose levelwas 300 mg/dl or more in blood collected from the tail vein, it was regarded as diabetic induction and then such diabetic-induced experimental animals were used in this experiment. At the end of the experiment, blood glucose level increased by 4.19% in DC group but significantly decreased by 32.34%, 19.19%, 17.81% and 17.64%, respectively in UEEE, UE, HE, and HEE groups. In the cases of AST, ALT, and ALP, the experiment group treated with extracts showed significantly lowerblood glucose level than DC group. The levels of BUN and uric acid were found to be lower in the UMPM extract group(UE) than HW extract group(HE), which implies that herb medicine medium extracts in which Tricholoma matsutake mycelia were cultured are effective in reducing impaired liver function as well as high blood glucose level caused by diabetes. In addition, the administration of low temperature UMPM extracts was found to produce better results than that of high temperature hot water extracts. In this regard, it is expected that extracts from herb medicine obtained by cultivating Tricholoma matsutake mycelia will be widely used as new ingredients for foods and medicines for prevention and treatment of diabetes.