• 대한의용생체공학회:의공학회지
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• 제22권5호
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• pp.393-402
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• 2001

전체 심혈관계의 혈류역학적 특성을 분석할 수 있는 수치해석 방법을 개발하였다. 이는 12개의 요소들로 구성된 lumped parameter모델에 기초하고 있으며 인체의 신경계에 의한 자율조절기능을 모사하기 위해 주로 혈압의 단기적 조절을 위한.baroreflex system뿐 아니라 cardiopulmonary reflex 메커니즘가지도 구현하여 모델에 포함시켰다. 또한 교감 및 부교감 신경에 의한 자극-반응 전달을 구현함에 있어 생리학적 데이터에 기초한 방법을 사용하였다. 본 연구의 수치해석 코드를 검증하기 위하여 우선 보통 상태의 심혈관계에 대하여 혈류역학적 계산 결과를 기존의 참고문헌들에서의 값들과 비교 검토하였다. 심혈관계 모델의 혈류역학적 자극에 대한 반응 결과를 조사하기 위하여. 20% 출혈이 발생하는 경우와 LBNP(Lower Body Negative Pressure) 모사를 수행하였다. 두 경우 모두. 비교적 실험치와 잘 일cl하고 있음을 확인할 수 있었다. 특히 LBNP 수행 시, 외부압력의 크기가 커질수록 baroreflex만을 포함하고 있는 방법은 baroreflex와 cardiopulmonary reflex 모두를 포함하고 있는 방법에 비하여 다소 부정확한 결과를 보여주고 있는데. 이는 cardiopulmonary reflex 메커니즘의 중요성을 보여주고 있다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1679-1682
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• 2008

Pulsatile Extracorporeal Membrane Oxygenation(ECMO) can mitigate the heart load and raise the patient's blood perfusion. But If the ECMO pulsate the blood flow during the systolic period, It can burden to the patient's heart. To avoid the heart injury, we have to consider the relation between output of ECMO, hemodynamic states and heart movement. To raise the efficacy of the pulsatile ECMO, we investigated the coronary perfusion, cardiac muscle tension and hemodynamic states during the ECMO perfusion by using the mathematical model of human blood circulatory system and ECMO. The outflow data of the pulsatile ECMO(T-PLS, Bioheartkorea, Korea) was obtained in vitro experiments. According to the phase and pumping rate of the ECMO, the heart's load and coronary perfusion could be adjusted to the proper levels. The results of the human- ECMO lumped parameter model showed that the synchronizing operation of the pulsatile ECLS can be helpful at stabilizing the patient's hemodynamic states.

• 대한의용생체공학회:의공학회지
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• 제24권4호
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• pp.329-337
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• 2003

선천적 혹은 후천적인 이유로 인하여 인체 특정 부위의 정맥과 동맥이 서로 관통하여 동맥계의 혈류가 말초 혈관계를 우회하여 정맥계로 흐르게 되는 동정맥루는 인체 심혈관계의 혈류 역학적 거동에 큰 영향을 미치게 된다. 본 연구에서는 lumped parameter 모델을 기반으로 하는 수치 해석 방법을 사용하여 우측 하지에 위치한 급성 동정맥루가 전체 심혈관계에 미치는 영향을 해석적으로 고찰하였다. 이를 위하여 동정맥루가 포함된 인체 심혈관계를 전기 회로 상사계로 구성하였으며. 부위별 혈압과 관련된 상미분 연립 방정식을 4차의 Runge-Kutta방법으로 풀어서 시간에 따른 혈류 역학적 변수들을 구하였다 이때 급성 동정맥루의 생성에 따른 혈류 역학적 보상작용을 분석하기 위하여 arterial baroreflex 제어계를 모델에 포함하였다.

• 대한전기학회논문지:시스템및제어부문D
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• 제50권10호
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• pp.494-501
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• 2001

In this study, the effects of vascular parameter changes and electrodes on VOP measurement based on IPG were simulated mathematically. For the evaluation of the effects of hemodynamic changes on VOP, a mathematical model, which consists of cardiovascular system model and venous occlusion model, was developed and the model solution representing the blood flow and pressure in measuring point was found by 2nd order Runge-Kutta method. And, with sensitivity coefficients obtained from finite element solution of electric field in measuring point, the effects of electrode system on measurement were evaluated. As increasing the resistance, the venous capacitance was not changed but the venous outflows were decreased and the decreased compliance reduced the venous capacitance. And, for several configurations of round electrodes and band electrodes, the sensitivity coefficients were computed using the electric field distribution along deep vein. In conclusion, the proposed mathematical cardiovascular model could be applied to the simulation study on the effects of hemodynamic parameters on DVT diagnosis with IPG. And, also the sensitivity coefficients could provide effective electrode configuration for exact measurement of VOP.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회B
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• pp.2941-2946
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• 2007

A model of the cardiovascular system coupling cell, hemodynamics and autonomic nervecontrol function is proposed for analyzing heart mechanics. We developed a comprehensive cardiovascular model with multi-physics and multi-scale characteristics that simulates the physiological events from membrane excitation of a cardiac cell to contraction of the human heart and systemic blood circulation and ultimately to autonomic nerve control. Using this model, we delineatedthe cellular mechanism of heart contractility mediated by nerve control function. To verify the integrated method, we simulated a 10% hemorrhage, which involves cardiac cell mechanics, circulatory hemodynamics, and nerve control function. The computed and experimental results were compared. Using this methodology, the state of cardiac contractility, influenced by diverse properties such as the afterload and nerve control systems, is easily assessed in an integrated manner.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1660-1664
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• 2008

Extra-corporeal Life Support System (ECLS) is the device used in emergency cases to substitute a extracorporeal circulation in open heart surgery, cardiac arrest or in acute cardiopulmonary failure. To obtain the effect of counter-pulsation on hemodynamic response in the ECLS quantitatively, we developed cardiovascular model which consists of 12 compartment model of heldt et al. and 3 compartment model of Schreiner et al. based on windkessel approximation. We compared coronary perfusion, arterial pulse pressure, cardiac output, and left ventricular pressure-volume diagram according to flow configuration such as counter-pulsation, copulsation, and continous flow. When counter-pulsation was applied, 5% higher coronary perfusion, 26% lower pulse pressure, and 2% higher cardiac output than copulsation condition were calculated. We conclude that counter-pulsation configuration in the ECLS is hemodynamically more stable than copulsation and influences the positive effect to recover ventricles.

• 제어로봇시스템학회논문지
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• 제10권12호
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• pp.1181-1188
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• 2004

This paper reviews the main aspects of cardiovascular system dynamics with emphasis on modeling hemodynamic characteristics using a lumped parameter approach. Methodological and physiological aspects of the circulation dynamics are summarized with the help of existing mathematical models: The main characteristics of the hemodynamic elements, such as the heart and arterial and venous systems, are first described. Lumped models of micro-circulation and pulmonary circulation are introduced. We also discuss the feedback control of cardiovascular system. The control pathways that participate in feedback mechanisms (baroreceptors and cardiopulmonary receptors) are described to explain the interaction between hemodynamics and autonomic nerve control in the circulation. Based on a set-point model, the computational aspects of reflex control are explained. In final chapter we present the present research trend in this field and discuss the future studies of cardiovascular system modeling.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.713-716
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• 2002

Aging effect on the cardiovascular circulation is simulated by lumped parameter model. Aging phenomena can be hemodynamically explained as (1) the increase of flow resistance induced by remodeling of artery vessels and increased viscosity of blood and (2) the reduction of the vessel capacitance caused by arteriosclerosis. Appropriate physiological parameters are evaluated from the clinical data of adults and old men. Simulation results well explain the hypertension with aging of cardiovascular system.

• International Journal of Vascular Biomedical Engineering
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• 제2권2호
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• pp.16-26
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• 2004

The object of this study is to develop a mathematical model of the hemodialysis system including the mechanism of solute kinetics, water exchange and also cardiovascular dynamics. The cardiovascular system model used in this study simulates the short-term transient and steady-state hemodynamic responses such as hypotension and disequilibrium syndrome (which are main complications to hemodialysis patients) during hemodialysis. It consists of a 12 lumped-parameter representation of the cardiovascular circulation connected to set-point models of the arterial baroreflexes, a kinetic model (hemodialysis system model) with 3 compartmental body fluids and 2 compartmental solutes. We formulate mathematically this model in terms of an electric analog model. All resistors and most capacitors are assumed to be linear. The control mechanisms are mediated by the information detected from arterial pressoreceptors, and they work on systemic arterial resistance, heart rate, and systemic venous unstressed volume. The hemodialysis model includes the dynamics of urea, creatinine, sodium and potassium in the intracellular and extracellular pools as well as fluid balance equations for the intracellular, interstitial, and plasma volumes. Model parameters are largely based on literature values. We have presented the results on the simulations performed by changing some model parameters with respect to their basal values. In each case, the percentage changes of each compartmental pressure, heart rate (HR), total systemic resistance (TSR), ventricular compliance, zero pressure filling volume and solute concentration profiles are represented during hemodialysis.

• 대한의용생체공학회:의공학회지
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• 제23권2호
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• pp.131-137
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• 2002

이동 작동기형 인공 심장의 원격 모니터링을 위한 시스템을 설계, 구현하였다 동물 실험이나 환자에의 임상 실험 후 인공 심장 동작 상황에 대한 원격 모니터링은 필수적이다. 본 논문에서는 담당자가 환자로부터 멀리 떨어진 곳에 있을 때에도 인터넷을 통해 간편하게 인공 심장의 동작 상황과 혈류역학 정보를 확인할 수 있는 시스템을 제안하여 그 성능을 확인하였다. 기존의 시스템과 쉽게 연결하여 사용할 수 있도록. 또 쉬운 관리와 기능 향상을 위하여 COM(Component Object Model) 기술 기반의 콤포넌트 모듈로 데이터 전송 부분을 구현하였고. 범용의 브라우저를 이용하여 인터넷에 연결, 확인토록 자바 애플릿을 이용하여 실행되도록 하였다. 또한 정해진 룰에 따라 판단하여 인공 심장의 이상 동작시 관리자에게 알려주도록 하였다. 구현된 시스템을 1개월 이상 생존하는 동물에 적용하여 본 결과 아무런 문제없이 정상 동작함을 확인하였다.