• Journal of the Korean Society for Precision Engineering
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• v.31 no.6
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• pp.521-525
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• 2014

Circulating tumor cells (CTCs) in the bloodstream of cancer patients provide an accessible source for detection, characterization, and monitoring of nonhematological cancers. The effectiveness of the CTC-Chip for the isolation of ovarian cancer cells was demonstrated by adapting the herringbone-chip (HB-Chip). The motions of the particles on the HB chip were simulated by a unique combination of buoyant, gravitational forces, and helical flows with a computational modeling. The motions of cells are demonstrated by applying polystylene bead and ovarian cancer cells into the microfabricated HB-Chip. The experimental results from beads and cells are well accordance with the simulated ones, as previously reported by Toner group. Thus, I expect that these modeling and experimental skills will play key roles in the clinical applications on CTC isolation as well as the basic research on characterization of CTCs under flow.

• Journal of Korean Institute of Industrial Engineers
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• v.26 no.1
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• pp.73-80
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• 2000

To determine the exact direction and location of the human joint in motion is crucial in developing a more accurate human model and producing a more fitting artificial joint. There have been several reports on the biomechanical analysis of the joint to determine the anatomy and movement of joints. However, all the previous researches were made in vitro study, that is, they investigated the passive movement of the joint from cadavers and the suggested location of the joint axis was difficult to make practical applications due to the lack of the direction of joint axis. Also, in many biomechanical models, each joint axis is assumed to lie horizontally or vertically to the adjacent links. Such an assumption causes inherent inaccuracy. In this study, the direction and location of the transverse elbow axis was obtained with respect to the global coordinate system whose origin is on the lateral epicondyle of the humerus. The suggested result based on the global coordinate system lying on the external landmark will be helpful to understand the information of the axis and to make an application. From the experiments conducted for five subjects, the direction and location of the elbow transverse joint was determined for each subject by the helical axis method. A statistical validation was also performed to confirm the result. Finally, the result was applied to develop a simple elbow model which is a part of the kinematic arm model. The simple elbow movement model was developed to validate the significance of the result and the kinematic arm model was able to describe the geometry of any complex linkage system. As a result, the errors incurred from the proposed model were significantly reduced when compared to the ones from the previous approach.

• Progress in Medical Physics
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• v.23 no.3
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• pp.145-153
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• 2012

In this study, we quantify the residual motion artifact in 4D-CT scan using the dynamic lung phantom which could simulate respiratory target motion and suggest a simple one-dimension theoretical model to explain and characterize the source of motion artifacts in 4DCT scanning. We set-up regular 1D sine motion and adjusted three level of amplitude (10, 20, 30 mm) with fixed period (4s). The 4DCT scans are acquired in helical mode and phase information provided by the belt type respiratory monitoring system. The images were sorted into ten phase bins ranging from 0% to 90%. The reconstructed images were subsequently imported into the Treatment Planning System (CorePLAN, SC&J) for target delineation using a fixed contour window and dimensions of the three targets are measured along the direction of motion. Target dimension of each phase image have same changing trend. The error is minimum at 50% phase in all case (10, 20, 30 mm) and we found that ${\Delta}S$ (target dimension change) of 10, 20 and 30 mm amplitude were 0 (0%), 0.1 (5%), 0.1 (5%) cm respectively compare to the static image of target diameter (2 cm). while the error is maximum at 30% and 80% phase ${\Delta}S$ of 10, 20 and 30 mm amplitude were 0.2 (10%), 0.7 (35%), 0.9 (45%) cm respectively. Based on these result, we try to analysis the residual motion artifact in 4D-CT scan using a simple one-dimension theoretical model and also we developed a simulation program. Our results explain the effect of residual motion on each phase target displacement and also shown that residual motion artifact was affected that the target velocity at each phase. In this study, we focus on provides a more intuitive understanding about the residual motion artifact and try to explain the relationship motion parameters of the scanner, treatment couch and tumor. In conclusion, our results could help to decide the appropriate reconstruction phase and CT parameters which reduce the residual motion artifact in 4DCT.

• Bulletin of the Korean Chemical Society
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• v.29 no.6
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• pp.1233-1242
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• 2008

The hydration effect on the intrinsic magnetism of natural salmon double-strand DNA was explored using electron magnetic resonance (EMR) spectroscopy and superconducting quantum interference device (SQUID) magnetic measurements. We learned from this study that the magnetic properties of DNA are roughly classified into two distinct groups depending on their water content: One group is of higher water content in the range of 2.6-24 water molecules per nucleotide (wpn), where all the EMR parameters and SQUID susceptibilities are dominated by spin species experiencing quasi one-dimensional diffusive motion and are independent of the water content. The other group is of lower water content in the range of 1.4-0.5 wpn. In this group, the magnetic properties are most probably dominated by cyclotron motion of spin species along the helical π -way, which is possible when the momentum scattering time (${\tau}_k$) is long enough not only to satisfy the cyclotron resonance condition (${\omega}_c{\tau}_k$ > 1) but also to induce a constructive interference between the neighboring double helices. The same effect is reflected in the S-shaped magnetization-magnetic field strength (M-H) curves superimposed with the linear background obtained by SQUID measurements, which leads to larger susceptibilities at 1000 G when compared with the values at 10,000 G. In particular, we propose that the spin-orbital coupling and Faraday's mutual inductive effect can be utilized to interpret the dimensional crossover of spin motions from quasi 1D in the hydrate state to 3D in the dry state of dsDNA.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.7
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• pp.567-574
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• 2018

Swirl injection induces not only the increase in fuel regression rate but also the reduction of combustion pressure oscillation. This acts, in turn, to stabilize combustion process. Thus, this study primarily focuses on the change in flow structure in the main chamber by swirl injection. Then examining the change in flow structure was done to understand the physical process for stabilizing combustion. In the results, the application of swirl injection could suppress the generation of p' and q' in 500Hz band and could shift the phase difference and cross correlation. Further investigations with combustion visualization also show that the development of helical motion near surface region affects the small-sized vortex generation and shedding yielding combustion stabilization eventually.

• Earthquakes and Structures
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• v.18 no.3
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• pp.275-284
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• 2020

The scope of this study is the comparison between experimental results of tests performed on a base isolated building using helical wire rope isolators (WRs), and results of Nonlinear Response History Analyses (NRHAs) performed using SAP 2000, a commercial software for structural analysis. In the first stage of this research, WRs have been tested under shear deformation beyond their linear range of deformation, and analytical models have been derived to describe the nonlinear response of the bearings under different directions of loading. On the following stage, shaking table tests have been carried out on a 1/3 scale steel model isolated at the base by means of curved surface sliders (CSS) and WRs. The response of the structure under ground motion excitation has been compared to that obtained using numerical analyses in SAP 2000. The feasibility of modelling the nonlinear behavior of the tested isolation layer using multilinear link elements embedded in SAP 2000 is discussed in this paper, together with the advantages of using WRs as supplemental devices for CSSs base isolated structures.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.16 no.1
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• pp.16-25
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• 2004

The flow and heat/mass transfer in the falling-film of a heat exchanger can be influenced by the motion of the surrounding refrigerant vapor. In this study, the effect of the vapor flow direction on the absorption heat transfer has been investigated for a falling-film helical coil which is frequently used as the absorber of ammonia/water absorption refrigerators. The experiments were carried out for different solution concentration. The heat and mass transfer performance was measured for both parallel and counter-current flow. The effect of vapor flow on the heat and mass transfer is found to be increased with decreasing solution concentration. In the experiments with low solution concentration, whose vapor specific volume is great, the counter-current flow of vapor resulted in uneven distribution of falling-film and reduced the heat transfer performance of the absorber. The direction of the vapor flow hardly affected the thermal performance as the solution concentration became stronger since the specific volume of the ammonia/water vapor was much smaller than that of the water vapor.

• The Korean Journal of Nuclear Medicine
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• v.39 no.3
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• pp.174-181
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• 2005

Purpose: Reduction of respiratory motion artifacts in PET images was studied using respiratory-gated PET (RGPET) with moving phantom. Especially a method of generating simulated helical CT images from 4D-CT datasets was developed and applied to a respiratory specific RGPET images for more accurate attenuation correction. Materials and Methods: Using a motion phantom with periodicity of 6 seconds and linear motion amplitude of 26 mm, PET/CT (Discovery ST: GEMS) scans with and without respiratory gating were obtained for one syringe and two vials with each volume of 3, 10, and 30 ml respectively. RPM (Real-Time Position Management, Varian) was used for tracking motion during PET/CT scanning. Ten datasets of RGPET and 4D-CT corresponding to every 10% phase intervals were acquired. from the positions, sizes, and uptake values of each subject on the resultant phase specific PET and CT datasets, the correlations between motion artifacts in PET and CT images and the size of motion relative to the size of subject were analyzed. Results: The center positions of three vials in RGPET and 4D-CT agree well with the actual position within the estimated error. However, volumes of subjects in non-gated PET images increase proportional to relative motion size and were overestimated as much as 250% when the motion amplitude was increased two times larger than the size of the subject. On the contrary, the corresponding maximal uptake value was reduced to about 50%. Conclusion: RGPET is demonstrated to remove respiratory motion artifacts in PET imaging, and moreover, more precise image fusion and more accurate attenuation correction is possible by combining with 4D-CT.

• The Journal of Korean Society for Radiation Therapy
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• v.19 no.2
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• pp.123-129
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• 2007

Purpose: CT scan shows that significant tumor movement occurs in lesions located in the proximity of the heart, diaphragm, and lung hilus. There are differences concerning three kinds of type to get images following the Scan type called Axial, Helical, Cine (4D-CT) mode, when the scanning by CT. To know how each protocol describe accurately, this paper is going to give you reappearance using the moving phantom. Materials and Methods: To reconstruct the movement of superior-inferior and anterior-posterior, the manufactured moving phantom and the motor following breathing were used. To distinguish movement from captured images by CT scanning, a localizer adhered to the marker on the motor. The moving phantom fixed the movement of superior-inferior upon 1.3 cm /1 min. The motor following breathing fixed the movement of anterior-posterior upon 0.2 cm /1 min. After fixing each movement, CT scanning was taken by following the CT protocols. The movement of A localizer and volume-reappearance analyzed by RTP machine. Results: Total volume of a marker was 88.2 $cm^3$ considering movement of superior-inferior. Total volume was 184.3 $cm^3$. Total volume according to each CT scan protocol were 135 $cm^3$ by axial mode, 164.9 $cm^3$ by helical mode, 181.7 $cm^3$ by cine (4D-CT) mode. The most closely describable protocol about moving reappearance was cine mode, the marker attached localizer as well. Conclusion: CT scan should reappear concerning a exact organ-description and target, when the moving organ is being scanned by three kinds of CT protocols. The cine (4D-CT) mode has the advantage of the most highly reconstructible ability of the three protocols in reappearance of the marker using a moving phantom. The marker on the phantom has always regular motion but breathing patients don't move like a phantom. Breathing education and devices setting patients were needed so that images reconstruct breathing as exactly as possible. Users should also consider that an amount of radiation to patients is being bombed.

• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.1
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• pp.129-137
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• 2006

This paper studies the effects of the swirl for the variation of intake port configuration that is key parameters in the flow field of direct injection diesel engines. In-cylinder flow characteristics is known to have significant effects on air-fuel mixing, combustion, and emissions. To investigate the effects of the swirl flow, various rpm(250, 500, 750) and two different intake port were used. And to evaluate the swirl motion in the flow field visualization engine, steady state flow test was conducted. Helical port intake port and SCV(Swirl Control Valve) were selected as the design parameters to increase the swirl flow and parametric study was performed. In the case of non-SCV, intake flow rate and non-dimensional swirl ratio were higher than those of SCV for the swirl head type. So, we could strengthen the swirl in the flow field with the swirl head type and don't using SCV. From the results of steady state flow test, non-swirl head type has the most good advantage for intake flow rate, and also the flow rate could be increased by using the SCV slightly. The effects of the type of engine head on intake air flow capability are dominant with respect to the existence of the SCV. We could measure the qualitative grade of swirl by capturing the scattering signal of microballoon from ICCD camera in the visualization diesel engine.