• The Korean Journal of Physiology and Pharmacology
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• 제18권2호
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• pp.177-182
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• 2014

This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects.

• Molecules and Cells
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• 제41권3호
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• pp.234-243
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• 2018

In recent years, the interest towards the relationship between incretins and bone has been increasing. Previous studies have suggested that glucagon-like peptide-1 (GLP-1) and its receptor agonists exert beneficial anabolic influence on skeletal metabolism, such as promoting proliferation and differentiation of osteoblasts via entero-osseous-axis. However, little is known regarding the effects of GLP-1 on osteoblast apoptosis and the underlying mechanisms involved. Thus, in the present study, we investigated the effects of liraglutide, a glucagon-like peptide-1 receptor agonist, on apoptosis of murine MC3T3-E1 osteoblastic cells. We confirmed the presence of GLP-1 receptor (GLP-1R) in MC3T3-E1 cells. Our data demonstrated that liraglutide inhibited the apoptosis of osteoblastic MC3T3-E1 cells induced by serum deprivation, as detected by Annexin V/PI and Hoechst 33258 staining and ELISA assays. Moreover, liraglutide upregulated Bcl-2 expression and downregulated Bax expression and caspase-3 activity at intermediate concentration (100 nM) for maximum effect. Further study suggested that liraglutide stimulated the phosphorylation of AKT and enhanced cAMP level, along with decreased phosphorylation of $GSK3{\beta}$, increased ${\beta}-catenin$ phosphorylation at Ser675 site and upregulated nuclear ${\beta}-catenin$ content and transcriptional activity. Pretreatment of cells with the PI3K inhibitor LY294002, PKA inhibitor H89, and siRNAs GLP-1R, ${\beta}-catenin$ abrogated the liraglutide-induced activation of cAMP, AKT, ${\beta}-catenin$, respectively. In conclusion, these findings illustrate that activation of GLP-1 receptor by liraglutide inhibits the apoptosis of osteoblastic MC3T3-E1 cells induced by serum deprivation through $cAMP/PKA/{\beta}-catenin$ and $PI3K/Akt/GSK3{\beta}$ signaling pathways.

• Journal of Electrical Engineering and Technology
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• 제10권4호
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• pp.1726-1733
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• 2015

In order to study the effect of the high-altitude and dusty weather in northwest of China on the corona characteristics of transmission lines, a corona caged based experimental system with sandy and dusty flow condition is numerically investigated and designed. This system overcomes the difficulties caused by harsh environment and offers easy usage for off-site tests. The design parameters are mainly determined by the characteristics of strong sandstorm in northwest region and test requirements. By the comparison of numerical simulation of the particle diffusion in four programs with rectangular or circular air-duct, a practical technology, which introduces swirl to control the particle diffusion length, is obtained. Accordingly, the structure of round air-duct with swirl elbow in inlet and outlet of high level segment is selected as final program. Systems of control and measurement are designed at the same time. Field tuning results show that the test system could ensure the range of sandy and dusty coverage. The wind speed, sandy and dusty concentration could be controlled and meet the requirements of accuracy. The experimental system has many features, such as simple structure, easy to be assembled, disassembled, transported and operated, small space occupied.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2004년도 학술발표회
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• pp.72-76
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• 2004

Wetland is an important eco-system on the earth and can effectively control agricultural non-point source pollution. Reed is a typical wetland plant for land/inland water ecotone in north China. The studies indicated that reed had a underground rooted-stem, which formed a 'high speeded-connecting vessels' i.e. reed root channel (RRC) in Baiyangdian lake of Hebei province. It spread predominantly along horizontal direction underground and are mainly distributed at 18-75 cm. The results of field work from healthy reed-wetland (HRW) and regarded reed-wetland (RRW) showed that the reed, averagely, in HRW is 4.2 m height, 1 cm diameter, 65/m2 density; in RRW is 2.4 m height, 3 mm diameter, 86/m2 density. These results indicated the regradation of the function of RRC in RRW. The results of laboratory work of sewage purification from reed soil column (RSC) $(0\~100cm)$ and wheat soil column (WSC) showed that the efficiency of purification to sewage, in RSC, is high than in WSC, especially for phosphorus. The efficiency of purification, in RSC, is $92.6\%$ for total phosphorus, $43.5\%$ for total nitrogen, $54.1\%$ fur COD, respectively; in WSC, is $86.0\%$ for total phosphorus, $241.3\%$ for total nitrogen, $29.8\%$ for COD, respectively.

• Journal of Veterinary Science
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• 제23권4호
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• pp.57.1-57.9
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• 2022

Background: Classical swine fever virus (CSFV), the causative agent of classical swine fever (CFS), is a highly contagious disease that poses a serious threat to Chinese pig populations. Objectives: Many provinces of China, such as Shandong, Henan, Hebei, Heilongjiang, and Liaoning provinces, have reported epidemics of CSFV, while the references to the epidemic of CSFV in Yunnan province are rare. This study examined the epidemic characteristics of the CSFV in Yunnan province. Methods: In this study, 326 tissue samples were collected from different regions in Yunnan province from 2015 to 2021. A reverse transcription-polymerase chain reaction (RT-PCR), sequences analysis, and phylogenetic analysis were performed for the pathogenic detection and analysis of these 326 clinical specimens. Results: Approximately 3.37% (11/326) of specimens tested positive for the CSFV by RT-PCR, which is lower than that of other regions of China. Sequence analysis of the partial E2 sequences of eleven CSFV strains showed that they shared 89.0-100.0% nucleotide (nt) and 95.0-100.0% amino acid (aa) homology, respectively. Phylogenetic analysis showed that these novel isolates belonged to the subgenotypes 2.1c and 2.1d, with subgenotype 2.1c being predominant. Conclusions: The CSFV was sporadic in China's Yunnan province from 2015 to 2021. Both 2.1c and 2.1d subgenotypes were found in this region, but 2.1c was dominant.

• 한국한의학연구원논문집
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• 제12권2호통권17호
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• pp.63-73
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• 2006

In the original plant of Arisaematis Rhizomas, the features of external and internal shape of Arisaema amurense var. serratum $N_{AKAI}$ and A. amurense $_{MAXIM}$. are as follows. 1. In the external shape of original plant, Arisaema amurense var. serratum $N_{AKAI}$ has high stem, an oval-elliptic leaflet and a serrate leaf margin. But A. amurense $M_{AXIM}$ has a relatively low stem, an upside oval leaflet and no serrate leaf margin. 2. On the herbs character of original plant, Ansaema amurense var. serratum $N_{AKAI}$ is small in height and diameter, but A. amurense $M_{AXIM}$ is relatively large in height and diameter. 3. On the gathered herbs character of original plant, the section of Arisaema amurense var. serratum $N_{AKAI}$ is brightly white, easily spilt and strong scent. But the section of A. amurense $M_{AXIM}$ is thin yellowish brown, not easily spilt and weak scent. Also the grade of gathered herbs, both can be classified by diameter and external scent. 4. In the current herbs character, Korean and Sichuan Province products are irregullar shape and have no scent, Jilin Province products are regular shape. Also, Guangxi Province products are small size and concave in one side, Hebei Province products are irregular size and shape. 5. In internal shape of original plant, epidermal cell of Arisaema amurense var. serratum is very tight. With the except of micro difference in parenchyma cell of cortex, on the whole there are nearly no differences with A. amurense $M_{AXIM}$. Also, samely in the internal shape, according to collecting sites, epidermis exhibits a lot layer in curving state and secreting duct is developed and vascular bundle and exists between parenchyma cell of cortex. In the future, additional study is needed to distinguish herb and effect between same genus-degree of relatedness.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.1346-1348
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• 2003

In this paper, the interferometric coherence was estimated and the amplitude intensity was extracted using the repeat-pass interferometric data, acquired by European Remote Sensing Satellite 1 and 2. Then discrimination and classification of surface land types in Zhangjiakou test site, Hebei Province were carried out based on the coherence estimation and the intensity extraction. Seven types of land were discriminated and classified, including in two different types of meadows, woodland, dry land, grassland, steppe and water body. The backscatter and coherence characteristics of these land types on the multi-temporal images were analyzed, and the change of surface features with time series was also discussed.

• Journal of Preventive Medicine and Public Health
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• 제43권2호
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• pp.166-173
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• 2010

Objectives: On December 7, 2007, the Hebei Spirit oil tanker spilled out 12,547 kl of crude oil on the Yellow Sea 10 km away from the cost of Taean Province, Korea. As the coastline has been contaminated, local residents have been exposed to crude oil. Because the residents were showing many symptoms, we investigated the acute health effects of this oil spill on them. Methods: We conducted a cross-sectional study consisting of the heavy and moderately oil soaked area in Taean and the lightly oil soaked area in Seocheon. Ten seashore villages were selected from each area, and 10 male and female adults were selected from each village. We interviewed the subjects using a structured questionnaire on the characteristics of residents, the cleanup activities, the perception of oil hazard, depression and anxiety, and the physical symptoms. The odds ratios and 95% confidence intervals were analyzed using logistic regression analysis. The logistic regression model was adjusted for age, gender, education, smoking, the perception of oil hazard and anxiousness. Results: The more highly contaminated the area, the more likely it was for residents to be engaged in cleanup activities and have a greater chance of exposure to oil. The indexes of anxiety and depression were higher in the heavy and moderately oil soaked areas. The increased risks of headache, nausea, dizziness, fatigue, tingling of limb, hot flushing, sore throat, cough, runny nose, shortness of breath, itchy skin, rash, and sore eyes were significant. Conclusions: The results suggest that exposure to crude oil is associated with various acute physical symptoms. Long-term investigation is required to monitor the residents' health.

• Earthquakes and Structures
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• 제26권4호
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• pp.261-267
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• 2024

With the increase in the exploitation depth of offshore oil and gas, it is possible to control the global buckling of deep-sea pipelines by the snake lay method. Previous studies mainly focused on the analysis of critical buckling force and critical temperature of pipelines under the snake-like laying method, and pipelines often suffer structural failure due to seismic disasters during operation. Therefore, seismic action is a necessary factor in the design and analysis of submarine pipelines. In this paper, the seismic action of steel pipes in the operation stage after global buckling has occurred under the active control method is analyzed. Firstly, we have established a simplified finite element model for the entire process cycle and found that this modeling method is accurate and efficient, solving the problem of difficult convergence of seismic wave and soil coupling in previous solid analysis, and improving the efficiency of calculations. Secondly, through parameter analysis, it was found that under seismic action, the pipe diameter mainly affects the stress amplitude of the pipeline. When the pipe wall thickness increases from 0.05 m to 0.09 m, the critical buckling force increases by 150%, and the maximum axial stress decreases by 56%. In the pipe soil interaction, the greater the soil viscosity, the greater the pipe soil interaction force, the greater the soil constraint on the pipeline, and the safer the pipeline. Finally, the pipeline failure determination formula was obtained through dimensionless analysis and verified, and it was found that the formula was accurate.

• Journal of Construction Engineering and Project Management
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• 제7권1호
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• pp.37-49
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• 2017

The Jinshanling section of the Great Wall of China is a series of fortifications in northern China that was constructed for strategic military defenses. This section was first built in the beginning of the Ming Dynasty in AD 1368 and then underwent major construction, reconstruction and renovation during the late Ming Dynasty, approximately in AD 1569. The Jinshanling section is 10.5 km long, a very short section compared with the entire 21,200 km wall. The wall section is located in Luanping County, Hebei province, China. This research paper focuses on the construction methods and materials of the wall and the towers in the area. The research methodology includes site visits, knowledge acquisition of experts and 3D graphic modeling. This study reveals that the materials selected for the structure include rubbles and rammed earth, bricks, stones, timber, and mortar. The erection sequence of the wall and the towers was a bottom-up fashion using various ancient construction techniques, such as the fire-setting rock blasting techniques and the surveying techniques from the Sea Island Mathematical Manual.