• 대한한방부인과학회지
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• 제20권4호
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• pp.101-110
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• 2007

Purpose: Oligomenorrhea is clinically important because it can be progressed to amenorrhea. The purpose of this study is to analyse Autonomic Nerve Function of some oligomenorrheic patients by using HRV(Heart Rate Variability). Methods: We studied 35 patients visiting OO Oriental Hospital from 1st November 2006 to 31th May 2007. One woman who takes antidepressant is excluded. 17 oligomenorrheic group and 17 normal menstrual cycle group were compared with HRV. The SPSS 12.0 for windows was used to analyze the data and Mann Whitney U-test were used to verify the results. Results: Mean PR, LF norm, LF/HF ratio of oligimenorrheic group are higher than normal menstrual cycle group. But there is no statistically significance. SDNN, RMS-SD, ln TP, ln VLF, ln LF, ln HF, HF norm of oligimenorrheic group are lower than normal menstrual cycle group. But there is no statistically significance. Conclusion: It can be suggested that oligomenorrhea can be related to increased activities of sympathetic nerve and decreased activities of general autonomic nerve function. But, we need study with more subjects for settling this.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1929-1932
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• 2005

We investigated the activities of autonomic nervous system during foot bathing. The effect of foot bathing was evaluated for four subjects by observing the characteristic of heart rate variability and bodily temperatures. The foot bathing was done with a commercial foot spa (Duches Co.) utilizing the four functional modes of the spa for two different temperatures of $35^{\circ}C\;and\;40^{\circ}C$. The four functional modes were clam, vibration, air bubbles, and both vibration and air bubbles. The experimental results showed that the temperature of foot and that of face right after foot bathing were not that different from each other. But, for heart rate variability, the activation of parasympathetic nerve showed distinctive increase at $40^{\circ}C$ of water temperature. In the analysis of heart rate variability for different functional modes, the change was not distinctive for different modes at $35^{\circ}$ of water temperature. However, at $40^{\circ}C$, the activation of sympathetic nerve showed distinctive increases with the increase in the complexity of functional modes.

• Journal of Acupuncture Research
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• 제28권2호
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• pp.107-116
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• 2011

Objectives : This study was performed to investigate the effects of fixed-intensity and varied-intensity electroacupuncture on heart rate variability in healthy people with stress task. Methods : Forty healthy subjects were randomly assigned to either group A or group B or C. Group A received fixed-intensity electroacupuncture(F-EA) at $ST_{36}$ and $ST_{37}$. After 1 week wash out period to prevent overlapping residual effects, they received varied-intensity electroacupuncture(V-EA) in which the intensity was changed every two minutes based on individual heart rate variability at the same points. Group B received the treatments in reverse order. Group C received no intervention as a control group. Results : Control group showed a significant increase of LF and LF/HF during the 2nd working memory task, while both F-EA and V-EA did not. In addition, V-EA showed a significant increase of HF during 2nd rest while F-EA did not. Conclusions : These results suggest that F-EA and V-EA can inhibit sympathetic activation more than control group and that V-EA can enhance parasympathetic activation more than F-EA.

• 대한한의학회지
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• 제29권1호
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• pp.134-145
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• 2008

Objectives : This study investigated the relationship between drinking, smoking and stress of workers by analyzing heart rate variability. The subjects were workers in the automobile manufacturing industry. Methods : The subjects consisted of 21,239 and 19,999 industrial workers who had received health examination by Korean oriental medicine and submitted questionnaires about drinking history and smoking history, during 8 months from April to November. The subjects were categorized into drinking history and smoking history. The heart rate variability was measured for five minute at rest using SA-3000P (Medicore) and reported stress severity as stress index, stress resistance and fatigue. We analyzed the relationship between drinking, smoking and stress into frequencies, $x^2$-test using the SPSS Ver. 12.0. Results : Regarding the relationship between drinking and stress index orstress resistance, there was no statistically significant difference, but regarding the relationship between drinking and fatigue, the drinker group had a significantly higher level of fatigue than the non-drinker group. There was a statistically significant difference in stress index, stress resistance and fatigue between the current-smoker group and others. Stress resistance of the current-smoker group had lower levels than the non-smoker group or ex-smokers. On the other hand, stress index and fatigue of the current-smoker group had higher levels than the non-smoker group or ex-smokers. Conclusions : The above results revealed that drinking and smoking could put workers under a lot of stress. Smoking workers were especially apt to be under stress and had difficulty in alleviating stress.

• Journal of Acupuncture Research
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• 제25권1호
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• pp.15-23
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• 2008

Objectives : The aim of our study was to demonstrate the clinical application of a diagnosis relating the 7-zone-diagnostic system and heart rate variability. Materials and Methods : Subjects were divided into two groups according to the factor AA form of the 7-zone-diagnostic system(VEGA-DFM722, VEGA, Germany). Subjects in group A showed a factor-AA red bar graph in which zone 2 was higher than the normal range, and zone 6 was lower than the normal range. Subjects in group B showed a factor-AA red bar graph in which zone 2 was lower than the normal range, and zone 6 was higher than the normal range. We investigated how to differentiate the index of heart-rate variability(HRV, LX-3202, LAXTHA, Korea) for each group. We did independent sample t-tests and evaluated the results of the HRV at the 5% significance level using SPSS 10.0 for Windows. Results : The differences of the MeanRR, MeanHRV, SDNN, complexity, HRV-index, RMSSD, SDSD, and pNN50 values between the groups was not significant. The differences of the Ln(TP), Ln(VLF), Ln(HF), LF/(LF+HF), LF/HF, norm LF, and norm HF values between the groups was also not significant. The differences were not significant, but generally the values of SDNN, complexity, RMSSD, SDSD, Ln(VLF), Ln(HF) and norm LF for group B were higher than those for group A, and the values of pNN50 and norm HF for group B were lower than those for group A. Conclusions : This study suggests that differences in the HRV values between the groups was not significant, but group B has a tendency to be healthier than group A because of stress. Accordingly, further study will be required.

• Journal of Acupuncture Research
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• 제24권5호
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• pp.1-12
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• 2007

목적 : 양심안영(養心安營), 청신녕지(淸神寧志), 조리기혈(調理氣血)의 효능을 가진 심유혈(心兪穴)($BL_{15}$)이 자율신경의 안정에 기여할 수 있다는 것을 입증하기 위하여 객관적으로 자율신경의 활성과 심장의 많은 연관성이 있다고 알려진 HRV(Heart Rate Variability)를 이용하였다. 방법 : 안정을 취한 후 29명의 남자 대상자를 HRV가 먼저 측정하였다. HRV 측정 후 대상자의 량측(兩側) 심유혈(心兪穴)에 자침하고 전침으로 지속적인 자극을 주었으며, 15분간 이 상태로 류침(留鍼)하였다. 발침(拔鍼) 후 다시 HRV를 측정하여 이를 측정 전과 비교하였다. 측정 결과의 비교 항목은 MHRT, SDNN, RMSSD, TP, VLF, LF, HF, Norm LF, Norm HF, LF/HF ratio로 하였다. 결과 : MHRT는 유의성이 있었다. SDNN은 유의성이 없었다. RMSSD는 증가하였으나, 유의성이 없었다. TP는 감소하였으나, 유의성이 없었다. VLF는 감소하였으나, 유의성이 없었다. LF는 감소하였으나, 유의성이 없었다. HF는 증가하였으나, 유의성은 없었다. Norm LF는 감소하였으나, 유의성이 없었다. Norm HF는 증가하였으나, 유의성은 없었다. LF/HF ratio는 감소하였으나, 유의성이 없었다. 결론 : 심유혈(心兪穴) 자침 결과는 교감 신경의 흥분을 가라앉히고 부교감 신경의 안정성을 증대하여, 심장의 안정도에 기여하는 것으로 보이나, 이는 통계적으로 의미가 없었다. 본 연구의 대상 집단이 소규모이며 스트레스가 아주 심하지 않은 집단이라는 점에서 유의성이 상대적으로 부각되지 못했다. 향후 비교할 만한 대조군을 설정하여 더 심한 스트레스를 받은 큰 집단을 대상으로 한 연구가 필요할 것으로 사료된다.

• 대한한방소아과학회지
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• 제25권3호
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• pp.77-84
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• 2011

Objectives: This study was performed to investigate the effect of hot spring therapy on children weight, body composition and heart rate variability. Methods: The study was carried out from 30 children who visited the spa from August 1, 2011 to August 31, 2011. We measured the change of weight, body composition, and heart rate variability after hot spring therapy for an hour per day. Results: The subject was consisted of 13 boys and 17 girls. This study revealed that their weight got lost from a hot spring therapy, which was statistically significant. Their body mass index(BMI) was decreased in from a hot spring therapy, which was not statistically significant. Total body water, muscle, protein, and mineral were decreased from a hot spring therapy, which was statistically significant. We measured HRV(heart rate variability) before and after the hot spring therapy. The mean HRT was increased, which was statistically insignificant. SDNN(standard deviation of the NN interval) and RMSSD(square root of the mean of the sum of the square of differences) were not different before and after the hot spring therapy. ln TP was decreased insignificantly. ln VLF was not affected before and after hot spring therapy. ln LF and ln HF was decreased, LF norm was increased, and HF norm was decreased, which were not statistically significant. Also, LF/HF ratio was increased insignificantly. Conclusions: From these results, we concluded that the weight, total body water, muscle, protein, and mineral got lost from the hot spring therapy. However, the HRV was not affected from the hot spring therapy.

• 전자공학회논문지SC
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• 제38권6호
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• pp.56-64
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• 2001

본 논문에서는 자기회귀모델을 이용한 심박변동의 파워스펙트럼해석에서 복잡한 계산과정을 수행하지 않으면서 심박변동의 특성을 반영한 간단한 모델차수법을 제안하였다. 자기회귀모델을 이용한 심박변동의 단구간 시계열에 대한 파워스펙트럼해석은 모델차수에 따라 스펙트럼 추정의 분해능이 변화한다. 제안한 모델차수법과 기존의 AIC와 고정차수법에 대하여 비교실험을 하였다. 실험결과, AIC 보다 계산과정이 매우 간단해졌으며 낮은 분해능의 문제를 해결하였고 고정차수의 단점인 시계열의 특성에 대응한 모델차수를 선택 할 수 있었다. 또한 제안된 방법으로 파워스펙트럼말도를 추정한 결과 AIC에서 나타나는 낮은 분해능 문제 와 적은 시계열 개수에서 나타나는 고정차수에 의한 잡음성 파워성분 저l거 등이 가능함을 확인하였다.

• 대한불안의학회지
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• 제2권2호
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• pp.101-107
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• 2006

Object : Since autonomic nerve system dysfunction was known as the mechanism of panic disorder, many researchers used heart rate variability (HRV) as means of measuring autonomic nerve function of patients with panic disorder. We aimed to examine the effect of paroxetine medication for 3 months on symptom improvement and change of heart rate variability of the patients with panic disorder. Methods : The subjects were patients with panic disorder who visited the psychiatric outpatient clinic of Samsung Medical Center in Seoul. We included panic disorder patients who were aged from 20 to 50 and in normal BMI range (from 18 to 30) to minimize the effect of age and weight on HRV data. We excluded the patients with EKG abnormalities, hypertension or other major psychiatric disorders. They took 20-40 mg paroxetine medication a day for 3 months. Alprazolam was used only during the first month to control the acute panic symptoms and was tapered off after that. We measured the acute panic inventory (API), Hamilton rating scale for anxiety and depression (HAM-A & HAM-D), Spielberger state-trait anxiety inventory (STAIS, STAIT), and Beck depression inventory (BDI) in order to assess clinical improvement of the patients. And we measured time and frequency domain HRV in the resting, standing and cognitive stress states to assess the change of HRV. All measurements were done before and after paroxetine treatment. Result : After paroxetine medication, patients showed significant improvement in all psychiatric scales. In time domain of HRV, standard deviations of all R-R intervals (SDNN) were significantly increased in all states. In frequency domain of HRV, the ratio of high frequency to total power (HF/TP) in the standing state was significantly increased. Conclusion : After 3 months paroxetine medication, panic disorder patients showed significant clinical improvement and change in HRV data such as SDNN in all states and HF/TP ratio in the standing state. This result suggests that paroxetine medication is effective for the improvement of autonomic nerve system dysfunction in panic disorder patients.

• 대한한방부인과학회지
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• 제28권4호
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• pp.46-56
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• 2015

Objectives : Cold hypersensitivity has been regarded to be associated with Autonomic Nervous System (ANS). This study aims to investigate the indicator of cold hypersensitivity of hands and evaluate the correlation between indicator of coldness of hands and Heart Rate Variability (HRV). Methods : We studied 55 patients with cold hypersensitivity of hands who visited in SeMyung University Hospital from 17 August 2015 to 21 August 2015. Thermometer and VAS scale were used for the diagnosis of cold hypersensitivity. After careful examination to rule out other disease which may affect thermometer and HRV data, patients were taken thermometer, those with thermal difference between upper arm (L4) and palm(P8), also asked to answer a VAS scale of cold hypersensitivity of hands, VAS more than 4 were enrolled for evaluation. Results : There was significant correlation between L4-P8 temperature difference and VAS score of cold hypersensitivity. In HRV data, normalized high frequency (HF normal) was significantly correlated with L4-P8 temperature difference, which was objective indicator of cold hypersensitivity of hands. Conclusions : L4-P8 temperature difference using thermometer is objective indicator of cold hypersensitivity, based on VAS scale. Cold hypersensitivity is highly related with ANS, regulating body heat and temperature. HRV is considered to be widely used in cold hypersensitivity in hands for evaluation of ANS.