• 한국산업보건학회지
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• 제5권2호
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• pp.128-136
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• 1995

The purpose of this study is to evaluate the difference of noise level according to noise measuring methods in the noisy working environments. Sound pressure level(SPL), equivalence sound level(Leq) and personal noise exposure dose(Dose) in the fifty-nine unit workplaces of the twenty-eight industries were measured and relating factors which were affected noise level were investigated. The results were as follows ; 1. The noise levels were $88.70{\pm}5.68dB(A)$ by SPL, $89.07{\pm}5.41dB(A)$ by Leq and $89.07{\pm}5.69$ by Dose. The differences of noise levels by three measuring methods were statistically significant(P<0.001) by repeated measure ANOV A. 2. Comparing with noise levels by general classes of noise exposure, noise levels of continuous noise were $89.14{\pm}5.19dB(A)$ by SPL, $89.45{\pm}4.65dB(A)$ by Leq and $90.04{\pm}5.09$ by Dose. Noise levels of intermittent noise were $87.90{\pm}6.52dB(A)$ by SPL, $88.40{\pm}6.63dB(A)$ by Leq and $90.10{\pm}6.80$ by Dose. The differences noise level of noise measuring methods by general classese of noise exposure were statistically not significant by repeated measure ANOV A. 3. Interaction between general classese of noise exposure and noise measuring methods for noise level was not statistically significant by repeated measure ANOVA. And the noise level by noise measuring methods were statistically significant by repeated measure ANOV A(P<.001) 4. Comparing with noise levels by unit workplace size, noise levels of large unit workplace were $90.73{\pm}5.87dB(A)$ by SPL, $91.32{\pm}5.50dB(A)$ by Leq and $91.82{\pm}6.06$ by Dose and noise levels of middle unit workplace were $88.31{\pm}5.26dB(A)$ by SPL, $88.41{\pm}4.83dB(A)$ by Leq and $89.69{\pm}5.05$ by Dose. And noise levels of small unit workplace were $94.89{\pm}4.10dB(A)$ by SPL, $85.35{\pm}4.11dB(A)$ by Leq and $86.87{\pm}4.98$ by Dose. The noise level differences of noise measuring methods by unit workplace size were statistically significant by repeated measure ANOV A(P<.05). 5. The noise level by noise measuring methods were statistically significant by repeated measure ANOV A(P<.001). But Interaction between workplace size and noise level measuring methods for noise level was not statistically significant by repeated measure ANOVA. According to the above results, there was a difference of the noise level among the three measuring methods. Therefore we must use the personal noise exposure dose using by noise dose meter, possible, to prvent occupational hearing loss in noisy working environment.

• Clinical and Experimental Pediatrics
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• 제53권6호
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• pp.694-700
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• 2010

Purpose: To assess the validity of individual and combined prognostic effects of severe bronchopulmonary dysplasia (BPD), brain injury, retinopathy of prematurity (ROP), and parenteral nutrition associated cholestasis(PNAC). Methods: We retrospectively analyzed the medical records of 80 extremely low birthweight (ELBW) infants admitted to the neonatal intensive care unit (NICU) of the Severance Children's Hospital, and who survived to a postmenstrual age of 36 weeks. We analyzed the relationship between 4 neonatal morbidities (severe BPD, severe brain injury, severe ROP, and severe PNAC) and poor outcome. Poor outcome indicated death after a postmenstrual age of 36 weeks or survival with neurosensory impairment (cerebral palsy, delayed development, hearing loss, or blindness) between 18 and 24 months of corrected age. Results: Each neonatal morbidity correlated with poor outcome on univariate analysis. Multiple logistic regression analysis revealed that the odds ratios (OR) were 4.9 (95% confidence interval [CI], 1.0-22.6; $P$=0.044) for severe BPD, 13.2 (3.0-57.3; $P$<.001) for severe brain injury, 5.3 (1.6-18.1; $P$=0.007) for severe ROP, and 3.4 (0.5-22.7; $P$=0.215) for severe PNAC. Severe BPD, brain injury, and ROP were significantly correlated with poor outcome, but not severe PNAC. By increasing the morbidity count, the rate of poor outcome was significantly increased (OR 5.2; 95% CI, 2.2-11.9; $P$<.001). In infants free of the above-mentioned morbidities, the rate of poor outcome was 9%, while the corresponding rates in infants with 1, 2, and more than 3 neonatal morbidities were 46%, 69%, and 100%, respectively. Conclusion: In ELBW infants 3 common neonatal mornidifies, severe BPD, brain injury and ROP, strongly predicts the risk of poor outcome.

• Journal of Korean Neurosurgical Society
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• 제30권3호
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• pp.334-341
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• 2001

Objective : We have currently changed treatment strategies to methotrexate(MTX)-based preirradiation chemotherapy with subsequent planned radiation for the initial therapy of primary central nervous system lymphoma (PCNSL). The aim of this study was to evaluate the results of treating PCNSL with chemotherapy plus radiotherapy (CRT) or radiotherapy(RT) alone. Method and Material : This study involved 10 females and 3 males patients with a mean age of 54.2 years. All patients underwent surgery, open(8 cases) or stereotactic biopsy(5 cases) for histological diagnosis. Eleven tumors were diffuse large B-cell lymphomas. Tumor volume change in the follow-up images and survival time were evaluated in patients treated with CRT and RT alone. In the beginning, two patients received ProMACE-Cytabom chemotherapeutic regimen, but did not complete the course and died of progressive tumor 8 and 9 months after diagnosis, respectively. One patient died at 6 months before chemotherapy. These three were excluded from the survival analysis. Five patients(RT group) completed full courses of cranial irradiation with or without boost. For the current combined modality treatment, high-dose MTXbased chemotherapy(systemic and intrathecal MTX, IV vincristine, and oral procarbazine) followed by whole brain irrdiation to 45Gy to tumor was introduced in 5 patients of CRT group. Result : A complete response was achieved in three of five who received RT only and in all of five who received CRT. All patients in CRT groups are in disease free status at a mean 23 months following therapy. The RT group patients refused any additional salvage therapy at tumor relapse and survived at mean 20 months from diagnosis. The Karnofsky performance status improved in eight of ten patients with treatment. The treatment toxicity included leukoencephalopathy in RT group and severe leukopenia, transient hepatitis, avascular necrosis of femoral head, hearing loss, and amenorrhea in CRT group, respectively. Conclusion : The combined modality therapy of MTX-based chemotherapy plus radiotherapy for PCNSL may enhance tumor response and improve patient survival. The patients who received CRT should be carefully followed up because of the higher risk of treatment-induced late neurotoxicity.

• 한방안이비인후피부과학회지
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• 제24권1호
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• pp.142-170
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• 2011

Objective : The purpose of this study is to investigate dizziness of Plain Questions $\ll$素問$\gg$ and Miraculous Pivot $\ll$靈樞$\gg$. Methods : We conducted a study on the original text paragraphs of Internal Classic $\ll$內經$\gg$ containing the dizziness and analysis of Yang, Ma, Zhang, Wang etc. We drew a parallel between dizziness from Internal Classic $\ll$內經$\gg$and matching diagnoses from western medicine. Results : The results were as follows. 1. Dizziness in Ok Ki Jin Jiang Ron <玉機眞藏論> and Pyo Bon Byeong Jeon Ron <標本病傳論> had relation to liver and was similar to dizziness caused by tension, hypertension, anemia and cerebrovascular accident etc. in western medicine. 2. Dizziness in Ja Yeol<刺熱>, O Sa<五邪> and Hai Ron<海論> had relation to kidney and was similar to dizziness caused by aging and peripheral vertigo concurrent with tinnitus and difficulty in hearing in western medicine. 3. Dizziness in O Sa<五邪> had relation to heart(pericardium) and was similar to dizziness caused by cardiac output loss and psychogenic dizziness in western medicine. 4. In Internal Classic $\ll$內經$\gg$ the main etiology of dizziness was infirmity(虛), which were Qi(氣) of the upper portion of the body being insufficient(上氣不足), blood depletion(血枯), deficiency of marrow-reservoir(髓海不足) etc. 5. In Dae Hok Ron<大惑論> etiology and pathogenesis of dizziness were mentioned and dizziness was similar to dizziness caused by eye disorder, psychogenic dizziness and central dizziness in western medicine. 6. In Internal Classic $\ll$內經$\gg$ the meridian of acupuncture points which was used much for dizziness was Bladder Meridian. Aqupunture points used in treatment of dizziness were Ch'onju(天柱), Kollyun(崑崙), Taejo, Chok-t'ongkok(足通谷) etc. Conclusion : We found out etiology, pathogenesis, treatments of dizziness in Internal Classic $\ll$內經$\gg$. Further we compared with western medicine to develop better understanding of dizziness.

• 부모자녀건강학회지
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• 제6권1호
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• pp.70-81
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• 2003

The otitis media has the highest rate of occurrence in 6-36 month after birth, and relatively high rate of occurrence to six years old. It is one of major cause for hearing loss problem because of its high rate of recurrence. The researcher observed at bed that feeding posture and feeding habit at night have some relationship with occurrence of otitis media. I found that medical research in this area was very weak, and it caused her to concentrate her research on the topic. This paper was undertook a retrospective case-control study to find out the relationship between the mode of feeding and the occurrence of otitis media among the otitis media patients and the healthy persons. As the controling groups, the researcher chose fifty eight mothers whose children received the treatment of otitis media(6-36 months after birth) from the pediatrics clinic of two general hospitals in Seoul, as the patient group, and forty five mothers who consulted with their child to well baby clinic at the general hospital and kindergarten in Seoul as the control group. The results of the survey can be summarized as followed : 1. "Otitis media patient group may have more lying posture mothers while feeding than the healthy control group". The first hypothesis is supported by the fact that the children who have lying posture feeding habit mothers are more easily exposed to otitis media than those who have sitting posture feeding habit mothers as the analysis show : $X^2=8.142$, p = .017 2. "Otitis media patient group may have higher rate of sleeping habit with milk bottle on the month at night than the healthy control group does". The second hypothesis was supported by the fact that the patients group has higher rate of expected sleeping habit than the healthy group dose as the analysis show : $X^2=4.35$, p = .037 3. "Otitis media can be found more in the artificial feeding group than in the healthy children group". The hypothesis is rejected by the analysis, $X^2=1.550$, p = .416. Though the hypothesis is not supported by this research, we need to encourage mothers to feed mother's breast milk on the ground that healthy group has mother's milk feeding tendency, and the best food for infants is their mother's milk, and psychological-sociological effects of breast feeding os quite good for children. It will improve the health of infants. It can be summarized as follows : Otitis media is more concerned with posture of feeding and night feeding habits than feeding modes. On the basis of this survey, feeding education problem for mothers of infants need to be developed. In the education, sitting-embracing posture of feeding, mother's breast feeding, and prohibition of children's lying posture feeding at night need to be emphasized.

• 대한장애인치과학회지
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• 제2권1호
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• pp.39-44
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• 2006

Cerebral palsy(CP) is one of the most common motor disease, due to brain injury during fetal and neonatal development which results in neuromotor paralysis and associated neuromuscular symptoms. Features of CP include motor disability due to the lack of muscle control, often accompanied by sensory disorders, mental retardation, speech disorders, hearing loss, epilepsy, behavior disorders, etc. There are increasing chances of treatment of dental patients with cerebral palsy, as the occurrence of CP is increasing with the decrease in infant mortality and an increase in immature birth and premature birth and also, there is a trend to pursue of higher quality of life. Reports on the relationship between CP and maxillofacial deformity are uncommon, but it is well known that the unbalance and discontrol of the facial muscles, lip, tongue and the jaws leads to malocclusion and temporomandibular joint disorders, and statistics show that class 2 relationship of the jaws and open bite is frequently reported. However, it is difficult to perform maxillofacial deformity treatment, which consists of orthodontic treatment, maxillofacial surgery and muscle adaptation training, due to difficulties in communication and problems of muscle adaptation caused by difficulties in motor control which leads to a high recurrence rate. This case report is to trearment of maxillofacial deformity in CP patient. A 26 year old female patient came to the department with the chief complaint of prognathism of the mandible and facial asymmetry. According to the past medical history, she was diagnosed as cerebral palsy 1 week after birth, classified as GMFC, classII accompanied with left side torticollis. The patient's intelligence was moderate, and there were no serious problems in communication. For two years time, the patient underwent lingual frenectomy, pre-operation orthodontic treatment and then bimaxillary orthognathic surgery to treat mandibular prognathism and facial asymmetry followed by rehabilitatory exercise of facial muscle. After 6 months of follow up, there was a good result. This is to report to the typical signs and symptoms of DFD in CP patient and the limitation of the usual method of the treatment of DFD in CP patient with literature review.

• 한방안이비인후피부과학회지
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• 제23권3호
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• pp.202-215
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• 2010

Objective : This study was performed to investigate the prevalence of otolaryngology and respiratory diseases and characteristics of the outpatients who had visited Chuncheon oriental medical hospital which located in Gangwon province with the diseases. Methods : We analyzed data from 627 patients, who had visited to the Department of ophthalmology & otolaryngology & dermatology of Chuncheon oriental medical hospital from November 1st, 2007 to May 31th, 2010. The data were analyzed and demonstrated by age, gender, season, period between the onset of disease and the first examination, times of treatment, and treatment methods. Results : The results of this study are summarized as follows. 1. Among the 627 outpatients, male patients outnumbered female patients, and the most frequent age group was 0-10 year-old group(24.9%) and it is followed by 31-40 and 41-50 year-old groups. The majority of outpatients, 79.7% of them were from Chuncheon, and Hongcheon and Gapyeong residents were respectively 4.7% and 3.8% of the patients. 2. The shares of outpatients by department were 47.4% in Rhinology disease, 29.8% in respiratory disease, 14.5% in Otology disease, and 8.3% in Laryngology disease. The seasons with the most frequent prevalence by department were spring and winter for otology group, autumn and spring for rhinology group, summer and spring for laryngology group, and winter and spring for respiratory disease group. Overall, most outpatients had visited the hospital for 1-5 times or 6-10 times. Acupuncture and herbal medicine were the most frequent treatment methods that these patients received. 3. The most prevalent diseases were rhinitis, common cold, tinnitus, and sinusitis. The most frequently visited age groups for tinnitus and hearing loss were 41-50 and 51-60 year-old groups, and for rhinitis and sinusitis 0-10 and 11-20 year-old groups. Irritation in larynx was almost evenly prevalent among 31-40, 41-50 and 51-60 age groups. Regarding the period between the onset of disease and the first medical examination, outpatients with tinnitus, rhinitis, sinusitis, and irritation in larynx came to the hospital after one year since the onset and outpatients with common cold first visited the hospital within one week since the onset of disease. Conclusions : This study shows that the most frequent diseases were rhinitis, common cold, sinusitis, tinnitus, and cough. In order to do better treatment for these diseases in the future, there is a need to investigate long-term, multifaceted studies, connected studies with other hospital in Gangwon province.

• 대한전자공학회논문지SD
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• 제47권1호
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• pp.60-68
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• 2010

청신경의 이상으로 발생하는 감각신경성 난청의 경우, 달팽이관이나 청각신경에 전극을 이식하여 전기자극을 가함으로써 청지각을 살릴 수 있다. 이를 위해 우선적으로, 각 청각신경들이 담당하여 인지할 수 있는 소리의 주파수 분포를 표시한 음계소지도를 파악해야 한다. 본 논문에서는 청각신경신호 검출 장치용 다중채널 아나로그 프론트엔드 회로를 제안한다. 제안된 아나로그 프론트엔드의 각 채널은 AC 커플링 회로, 저 전력 4차 Gm-C LPF와 단일 기울기 ADC로 이루어진다. AC 커플링 회로는 청각신호의 불확실한 DC 전압 레벨을 제거하고 AC 신호만 전달한다. Gm-C LPF는 청각신호의 대역폭을 고려하여 설계 되었으며, 플로팅-게이트 기법이 적용된 OTA를 사용하였다. 채널별 ADC를 구현하기 위해서, 최소의 면적으로 구현할 수 있는 단일 기울기 ADC 구조를 사용하였다. 측정 결과, AC 커플링 회로와 4차 Gm-C LPF는 100 Hz - 6.95 kHz의 대역폭을 가지며, 단일 기울기 ADC는 7.7 비트의 유효 해상도를 가진다. 그리고, 채널 당 $12\;{\mu}W$의 전력이 소모 되었다. 전원 전압은 3.0 V가 공급되었고, 코어는 $2.6\;mm\;{\times}\;3.7\;mm$의 실리콘 면적을 차지한다. 제안된 아나로그 프론트엔드는 1-poly 4-metal $0.35-{\mu}m$ CMOS 공정에서 제작 되었다.

• Pediatric Infection and Vaccine
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• 제24권1호
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• pp.65-70
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• 2017

거대세포바이러스 감염은 선천감염의 가장 흔한 원인 중의 하나이다. 본 증례는 쌍생아에서 다른 임상 양상을 보인 선천 거대세포바이러스 감염 증례에 대한 국내 첫 보고이다. 31세 초산부가 쌍생아(2 융모막, 2 양막)를 임신하였다. 임신 34주 산전 초음파에서 한쪽 태아의 크기가 작고 양측 뇌실 확장증이 발견되었으며 임신 37주경에 제왕절개로 분만하였다. 첫 번째 신생아는 남자로 출생 체중 2,410 g, 아프가 점수 8/9점으로 출생하였으며 두 번째 신생아는 여자로 출생 체중 1,380 g, 아프가점수 5/8점으로 출생하였다. 두 번째 신생아는 자궁 내 성장지연, 소두증, 소하악증, 사지 관절의 강직을 보였다. 불일치 쌍생아에 대한 원인을 찾기 위한 검사를 진행하였으며 두 번째 신생아의 혈액검사에서 거대세포바이러스 immunoglobulin M이 양성반응을 보였으며 소변과, 혈액, 뇌척수액에서 거대세포바이러스 중합효소연쇄반응이 양성소견을 보였다. 반면에 정상으로 출생한 남아의 거대세포바이러스에 대한 검사는 모두 음성이었다. 감염된 환자의 안과적 검진에서 거대세포바이러스 망막염이 관찰되었고, 후에 실시한 청력검사에서 양측의 감음 난청이 확인되었다. 환자는 ganciclovir 치료를 받았으며 현재 여아는 심한 발달지연이 있으며 침대에서 누워서 생활하는 중이다. 이와 같이 쌍생아에서의 선천 거대세포 바이러스 감염증이 한 명에게만 발생하는 경우의 원인은 현재까지 명확하지 않다. 하지만 이 증례를 통하여 심한 불일치 쌍생아의 경우에 선천 거대세포바이러스 감염의 가능성을 고려해 보아야 한다.

• 동의생리병리학회지
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• 제19권6호
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• pp.1557-1562
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• 2005

A mechanism of hair cell damage caused by noise and ototoxic agents is mediated through generation of free radicals and reactive oxygen species (ROS). It is known that most of animals have defense systems to protect against ROS, and the cochlea of inner ear in animals also has ROS defense systems including several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), and glutathione (GSH), which efficiently detoxifying ROS generated under normal condition. Steamed roots of Rehmannia glutinosa have been traditionally used in Oriental medicine for the treatment of auditory disease such as tinnitus, vertigo, and hearing loss as well as inflammatory diseases, hectic fever, night sweat, and headache. In the present study, we showed that the ethanol extract from steamed roots of R. giutinosa (ESRG) increased the antioxidant enzymes such as SOD, CAT, GPX, and GR activities and GSH level in HEI-OC1 auditory cells. This extract itself did not show any significant cytotoxicity up to $50{\mu}g/ml$. Our results further support the view that ESRG is promising sources of potential antioxidants. Future studies will be aimed at investigating the effects of ESRG on the regulation of cellular mechanisms and isolating and identifying the substances responsible for the regulation of antioxidant enzyme system from the plant extracts.