• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3077-3084
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• 2016

Various beneficial effects have been described for fermented papaya preparation (FPP: SAIDO-PS501) based on its anti-oxidative and anti-inflammatory functions. The present study was designed to determine the effects of FPP on carcinogenesis in vivo, and immunomodulatory function in vitro. Mice were injected with RL male 1 cells subcutaneously or 3-methylcholantherene (MCA) intravenously to induce cancer and orally or intraperitoneally treated with FPP solution. Human peripheral blood mononuclear cells (PBMC) were obtained from healthy volunteers and patients with atopic dermatitis, treated with FPP, and subjected to measurement of cytokine production and changes in Foxp3-expressing regulatory T cell (Treg) stimulated with phytohemagglutinin (PHA). Administration of FPP suppressed tumor size and the incidence of malignancy. In vitro, treatment of PBMC with FPP induced IL-$1{\beta}$, $TNF{\alpha}$ and $IFN{\gamma}$ production. Moreover, FPP suppressed proliferation of PHA-stimulated Foxp3-expressing Treg. These results suggest that FPP has chemotherapeutic properties.

• The Journal of Korean Medicine
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• v.24 no.2
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• pp.19-31
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• 2003

Objectives : This study examined effects of kyeong points (經穴)' acupuncture of three hand yang collaterals (手三陽經) on the facial thermography in health subjects, because the kyeong point in Yang collaterals belongs to the characteristic of the five elements (五行)meaning fire (火). Methods : The volunteers who participating in this study rested for 20-30 min. atroom temperature (23-$25^{\circ}C$) before the examination and were informed to avoid smoking, drinking and use of any drugsfor the previous day. The thermography of the face was taken using Infra-Red Imaging System (IR 2000, MEDI-CORE Co., Korea) at time intervals of 15 minutes : at 15 min before, just before and after, 15 min after, 30 min after and 45 min after acupuncture stimulation. Acupuncture was applied to the left kyeong points (經穴)' of three hand yang collaterals (手三陽經) for 30 minutes. Results : The results showed that kyeong points (經穴)' acupuncture of three hand yang collaterals (手三陽經) decreased the temperature of all the areas of the facial surface comparing to those of the control group. Also, it was observed that the quantities of thermal changes following acupuncture of ST36 increased in the all ROIs (regions of interest) compared to those of the control group. Conclusions : Observing the thermography classified by ROI, it was clear that acupuncture of kyeong points (經穴) of three hand yang collaterals (手三陽經) could modulate thermogram of the facial area however, it is necessary to undertake more investigation supporting these results.

• CELLMED
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• v.7 no.4
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• pp.18.1-18.8
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• 2017

The Tridosha theory, which is the cornerstone of Ayurvedic physiology governs all the functions of human body and mind. Tridosha are responsible in determining one's Prakriti and their functional status may vary in both gender of different Prakriti. No research work is available to assess the functions of Dosha by objective parameters. Therefore, this study was planned to find out the variation in functional status of different types of Pitta, using certain objective parameters, in 201 young healthy volunteers of both gender belonging to different Prakriti. Serum level of triglycerides, cholesterol, total protein and glucose level were estimated for Pachaka Pitta and hemoglobin concentration for Ranjaka Pitta, visual acuity for Alochaka Pitta, memory and reaction time for Sadhaka Pitta and RGB value for Bhrajaka Pitta were measured. Except the functioning of Bhrajaka Pitta, variation in functional status of all type of Pitta was not the same in different Prakriti of both gender. However these findings were not significant which may have occurred due to small sample size and homogenous population. Thus we propose the consideration of sex differences while planning and evaluating the studies that are based on Prakriti.

• Journal of Acupuncture Research
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• v.20 no.1
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• pp.97-103
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• 2003

Objective : Auricular acupuncture is a method of treatment that involves needling the ear in order to produce relief of symptoms. This concept was first developed by P.Nogier, french doctor and referred to as somatotopic representation. Many authors have commented the fact that the vagus nerve supplies the external auditory and the concha. The aim of this randomised, single blind study was to investigate whether auricular acupuncture of the ear produced changes in the pulse rate, an indicator of vagal tone. Methods: 10 healthy man volunteers were divided into normal and epinephrine stimulation group. Then each group was divided into vagus area acupuncture and control area acupuncture group again. Epinephrine stimulation group was injected by epinephrine 0.3cc twice, first. All of them were needled in either the vagus area or control area of the ear, and pulse rate changes were measured by patient monitor over 1 hour. Results : In the epinephrine stimulation group, there was significant differences in the pulse rate change between vagus area acupuncture and control area acupuncture group. After injection of epinephrine, the basal pulse rate was increased 1.3~1.4 times in the control group. However, in the vagus area acupuncture group the basal pulse rate was increased only 1.1~1.2 times.

• Journal of Acupuncture Research
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• v.27 no.2
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• pp.11-21
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• 2010

Objectives : We tried to investigate the effects of Carthami Semen(CF) pharmacopuncture and Bovis Calculus Fei Ursi(BU) pharmacopuncture on the heart rate variability(HRV) in adult men. As well as we tried to observe how CF pharmacopuncture and BU pharmacopuncture effect on the balance of the autonomic nervous system. Methods : We investigated on 40 healthy volunteers consisted of 20 subjects in CF pharmacopuncture group and 20 subjects in BU pharmacopuncture group respectively. We ruled out subjects whose vital sign isn't in normal range, yet they had taken a rest. The study established by a randomized, single-blind clinical trial. CF pharmacopuncture and BU pharmacopuncture was applied on each group. We measured HRV 7 times : baseline measurement and every 5 minutes for 30 minutes after injection. The SPSS 15.0 for Windows was used to analyze the data by the paired t-test(in group) and Independent sample t-test(between the groups). Results 1. After injection of CF pharmacopuncture, SDNN, Ln(TP), Ln(VLF) and Ln(LF) increased significantly, and Complexity, pNN50 decreased significantly. 2. After injection of BU pharmacopuncture, RMSSD, SDSD and HRV-index increased significantly. Conclusions : We suggest that CF pharmacopuncture activate sympathetic nervous system and BU pharmacopuncture tend to activate the autonomic nervous system.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.289-290
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• 1998

Purpose To investigate the difference of total activation in visual area, motor area, and cerebellum according to the stimulation paradigm. Materials and Methods Functional MR imaging was performed in 5 healthy volunteers with visual and motor activity using EPI technique. LED and Checker-Board stimulation were performed for visual activity. Thumb motion and Finger tapping were performed for motor and cerebellum activity. Time course data was obtained by calculating the total activation which was defined as the number of activated pixels x averaged pixel intensity. Results In the case of visual activity with LED stimulation, we found increased total activity of more than 100% compared with Checker-Board stimulation. In the case of motor area and cerebellum with Finger tapping stimulation, we found increased total activity of more than 100% and 150%, respectively compared with Thumb motion stimulation.

• The Journal of Korean Physical Therapy
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• v.5 no.1
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• pp.39-46
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• 1993

The purpose of this study was to examine the effect and $\beta-endorphin$ level as conventional transcutaneous electrical nerve stimulation (TENS) application on acupuncture paints. Twelve healthy adult male volunteers were participated in this study. The subjects were assigned to TENS group (n=6) and naloxone group (n=6). The LI 3 and M 10 meridian points of dominant arm were stimulated comfortably with 100 pps, $75{\mu}s$ conventional TENS for 30 minutes. Experimental pain threshold measurement and plasma $\beta-endorphin$ level were detected before and after conventional TENS application. Experimental pain threshold increased significantly (p<.01) but plasma $\beta-endorphin$ level was not change in TENS group. Experimental pain threshold increased significantly (p<.01) but plasma $\beta-endorphin$ level was not change in naloxone group. In this study, the conventional TENS induced analgesic effect, and plama $\beta-endorphin$ level was not increase concomitantly with analgesia. These results suggest that the $\beta-endorphin$ did not involved in conventional TENS analgesia.

• The Journal of Internal Korean Medicine
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• v.29 no.1
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• pp.258-264
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• 2008

Objectives : The aim of this study was to confirm the characteristics of oral malodor patients by evaluating the differences of salivary flow rate, secretory immunoglobulin A (sIgA) level in saliva between the patient and control groups, and the correlation with the tongue coating, volatile sulfur compound (VSC), salivary flow rate and sIgA level in saliva in the patients group. Methods : Forty-seven patients with oral malodor and twenty healthy volunteers were included in this study. Their tongue coating was assessed with the Winkel tongue coating index, and salivary flow rate, sIgA concentrations in saliva and the level of VSC in oral cavity were measured. Results : There were no significant differences of the salivary flow rate and the sIgA level in saliva between the patient and control groups, but there was a significant relationship between the accumulation of tongue coating and the level of VSC in oral cavity. Conclusions : Our results suggest that tongue coating is closely related to oral malodor, but further studies are needed to confirm the relationship between tongue coating and sIgA level in saliva.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.1066-1069
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• 2002

Dynamic postural control varies with the environmental context, specific task and intentions of the subject. In this paper, dynamic postural control against forward-backward perturbations of a platform was estimated using tri-axial accelerometers and a force plate. Ten young healthy volunteers stood upright in comfortable condition on the perturbation system which was controlled by an AC servo motor. With anterior-posterior perturbations, movements of ankle, knee and hip Joints were obtained by tri-axial accelerometers. and ground reaction forces with corresponding displacements of the center of pressure(CoP) by the force plate. The result showed that the ankle moved first and the trunk forward, which implies that the mechanism of the dynamic postural control in forward-backward perturbations, occurred in the procedure of the ankle, the knee and the hip. Knee flexion and hip extension in the period of acceleration, constant velocity and deceleration phase is very important fur the balance recovery. These responses depends on the magnitude and timing of the perturbation. From the present study the accelerometry-system appears to be a promising tool for understanding kinematic accelerative In response to a transient platform perturbation. A more through understanding of balance recovery mechanism may aid in designing methods for reducing falls and the resulting injuries.

• Journal of Oriental Neuropsychiatry
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• v.21 no.3
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• pp.19-27
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• 2010

Objectives : This study was designed to report the effect of acupuncture at GV 20(Baihui) evaluated by the second derivative of photoplethysmogram waveform(SDPTG) under stress. Methods : 15 healthy volunteers participated in this study. 1. After 5 minutes rest, mental stress was provided for 5 minutes. And then subjects rested for 15 minutes. SDPTG was recorded before and after mental stress and after 15 minutes restness. 2. After 5 minutes rest, mental stress was provided for 5 minutes. And acupuncture at GV 20 remained for 15 minutes. SDPTG was recorded before and after mental stress and after 15 minutes acupuncture. Results : 1. Mental Stress didn't make significant change at SDPTG. 2. In a comparison of pre-acupuncture and post-acupuncture at the GV 20, b/a ratio(P<0.05) and Sano aging index(P<0.05) was decreased significantly. Conclusions : We concluded that acupuncture at the GV 20 may be effective method to recover vascular function.