• The Korean Journal of Physiology and Pharmacology
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• v.24 no.5
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• pp.395-402
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• 2020

This study has investigated the effect of a potent bioflavonoid, troxerutin, on diabetes-induced changes in pro-inflammatory mediators and expression of microRNA-146a and nuclear factor-kappa-B (NF-κB) signaling pathway in aortic tissue of type-I diabetic rats. Male Wistar rats were randomly divided into four groups (n = 6/each): healthy, healthy-troxerutin, diabetic, and diabetic-troxerutin. Diabetes was induced by streptozotocin injection (60 mg/kg; intraperitoneally) and lasted 10 weeks. Troxerutin (150 mg/kg/day) was administered orally for last month of experiment. Inflammatory cytokines IL-1β, IL-6, and TNF-α, as well as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule (VCAM), cyclooxygenase-II (COX-II), and inducible-nitric oxide synthase (iNOS) were measured on aortic samples by enzyme-linked immunosorbent assay. Gene expressions for transcription factor NF-κB, interleukin-1 receptor-associated kinase-1 (IRAK-1), TNF receptor-associated factor-6 (TRAF-6), and microRNA-146a were determined using real-time polymerase chain reaction. Ten-week diabetes significantly increased mRNA levels of IRAK-1, TRAF-6, NF-κB, and protein levels of cytokines IL-1β, IL-6, TNF-α, adhesion molecules ICAM-1, VCAM, and iNOS, COX-II, and decreased expression of microRNA-146a as compared with healthy rats (p < 0.05 to p < 0.01). However, one month treatment of diabetic rats with troxerutin restored glucose and insulin levels, significantly decreased expression of inflammatory genes and pro-inflammatory mediators and increased microRNA level in comparison to diabetic group (p < 0.05 to p < 0.01). In healthy rats, troxerutin had significant reducing effect only on NF-κB, TNF-α and COX-II levels (p < 0.05). Beside slight improvement of hyperglycemia, troxerutin prevented the activation of NF-κB-dependent inflammatory signaling in the aorta of diabetic rats, and this response may be regulated by microRNA-146a.

• The Journal of Korean Academic Society of Nursing Education
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• v.20 no.2
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• pp.321-331
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• 2014

Purpose: The purpose of this study was to investigate the effects of case management service for hypertensive elderly patients through the customized visiting home health care program. Method: Non-equivalent control group pretest-posttest design was employed. Data were collected from April 2007 to January 2009. Among a total of fifty subjects, 25 subjects were belonged to the case management group and the others were belonged to the general management group. Results: 1) In experimental group, significant increasing rate of number of people within normal blood pressure by time, but no significant increasing rate of number of people within normal blood neutral fat, total cholesterol, HDL, & LDL. 2) In experimental group, the score of knowledge about disease and healthy life practice were increased on 8 week period but decreased on follow up period. Number of people within normal blood HDL and mean score of healthy life practice were significantly higher than control group on follow up period. Conclusion: Case management service was effective on controlling blood pressure but partly effective on blood lipid, knowledge about disease, and healthy life practice in hypertensive patients. Further study is needed to conduct a periodic re-evaluation of the effect of case management and to verify an optimal interval to provide the case management service.

• Parasites, Hosts and Diseases
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• v.46 no.1
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• pp.29-32
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• 2008

The aim of this study is to determine the Toxocara seropositive rate among healthy people with eosinophilia. A total of 97 people residing in Seoul who were healthy and whose blood eosinophilia was over 10%, as shown by regular health check-ups in 2004, were subjected to this study. Their sera were tested by immunoblotting and ELISA with the antigen of larval Toxocara canis excretory-secretory (ES) protein. Sixty-five sera were band-positive (67.0%). The seropositve control sera were positive to band sizes of 66 kDa, 56 kDa, 32 kDa, and 13 kDa. In ELISA, 63 sera (65.0%) were positive to T. canis ES protein. There was no significant correlation between the IgG ELISA titer and the level of eosinophilia (r = 0.156, P = 0.156). As there were insufficient data to determine whether there were cross-reactions with other helminthic infections, or whether atopy occurred, further studies are required to verify the cause of the seropositive reactions against T. canis ES antigen. Toxocariasis seropositivity is suggested to be the major cause of eosinophilia, since the Toxocara seroprevalence among Korean rural adults was shown to be approximately 5%.

• Journal of Families and Better Life
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• v.22 no.5
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• pp.345-355
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• 2004

The purpose of this study is to recommend the roles, Qualification, and fostering system of healthy families specialist. In 2003, 'Organic Law to Develop the healthy Families' was legislated. The law endows the responsibilities and duties of the government, local government, and families, in order to embody the healthy families. Also, this suggests appropriate ways to solve diverse families problems and identifies the necessities of establishing social policies to increase the well-being of family members. The enactment system of this law is to place 'Healthy Families Center' under the Prime Minister, and to foster 'healthy families specialist' who have professional knowledge and skills for strengthen diverse families. The major recommend are as follow. First, the roles of healthy families specialist are a practician, deliverer, and administrator to enact the law's philosophy and ideal. Secondly, to protect the competency of those, the qualification is restricted to university and the same level school graduate people, who majored in Home Economics, Social Work. and Women Studies. Finally. to foster and qualify this specialist. the Council of Healthy Families will be compound.

• Korean Journal of Community Nutrition
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• v.26 no.5
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• pp.337-349
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• 2021

Objectives: The purpose of this study was to analyse the relationship between eating behaviour and healthy dietary competency of single and multi-person households, to improve healthy eating behavior. Methods: This study was conducted on 6,355 adult household members who participated in the Food Consumption Behavior Survey 2020. The subjects were divided into age groups comprising young people in their 20s and 30s, middle-aged people in their 40s and 50s, and the elderly in their 60s and above. The eating behavior and healthy dietary competency of single-person and multi-person households were then analyzed. Results: The average age of the members in the single-person households was found to be higher. Single-person households were also found to have a lower marriage rate and lower monthly household income than multi-person households across the age groups of young, middle-aged, and elderly people (P < 0.05). Among each of the age groups, single-person households had significantly higher rates of skipping breakfast and eating breakfast, lunch, and dinner alone than multi-person households (P < 0.05). Young single-person households had lower average scores on healthy dietary competency than multi-person households (P = 0.032). When adjusted for age, gender, marriage, education, occupation, and household income, single-person households had a higher risk of delivery/take-out, eating out, or skipping meals compared to multi-person households (P < 0.05). In multi-person households, the risk of skipping meals, eating alone, eating out, or delivery/take-out decreased as healthy dietary competency improved (P < 0.05). On the other hand, in single-person households, as healthy dietary competency increased, the risk of delivery/take-out or eating alone decreased (P < 0.05). Conclusions: The results of this study suggest that healthy dietary competency and eating practices can be improved by providing customized dietary education by age group for single and multi-person households.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6533-6535
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• 2013

Background: The purpose of this study was to evaluate a new type of tumor biomarker, eukaryotic elongation factor 2 (eEF2), in serum for the early diagnosis, confirmative diagnosis as well as assessment of treatment of non-small cell lung cancer (NSCLC). Methods: 130 patients with NSCLC and 50 healthy individuals undergoing physical examination in our hospital provided the observation and healthy control groups. An enzyme linked immune sorbent assay (ELISA) method was applied to determine serum eEF2 levels. Serum neuron specific enolase (NSE) and squamous cell carcinoma antigen (SCC) levels in the observation group were assessed with an automatic biochemical analyzer. Results: The median levels of eEF2 in the serum of NSCLC patients was found to be significantly higher than the healthy control group (p < 0.01) and it was markedly higher in stages III, IV than stages I, II (p < 0.05). eEF2 was higher with tumor size ${\geq}2$ cm than <2 cm (P< 0.01). Furthermore, two weeks after surgery patients showed a significant trend for eEF2 decrease (p < 0.05). Conclusions: The eukaryotic elongation factor 2 (eEF2) has certain clinical values for early diagnosis, verification, and prognosis as well as classification of lung cancer patients.

• PNF and Movement
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• v.1 no.1
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• pp.33-41
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• 2003

Objectives : The purpose of this study was to describe and compare the temporo-spatial gait characteristics of healthy young people with those of healthy elderly people. Methods: The data were collected by 40 volunteers. 20 subjects were between 20 and 31 years of age, and 20 subjects were between 65 and 84 years of age. Temporal and spatial parameters of gait were analysed for using the computerized GAITRite system. Results : The system integrates specific components of locomotion to provide a single, numerical representation of gait, the Functional Ambulation Performance score. Differences in gait characteristics between the two groups were examined using a correlated t-test(p<.05). Significant differences were observed between the groups for step length, step/extremity ratio and velocity. Young people demonstrated a significantly larger velocity, step length and step/extremity ratio than the elderly people. Conclusions: These results indicate that the GAITRite system can be useful in detecting footfall patterns and selected time and distance measurements of young and older persons. Additionaly, differences in walking velocity, step length and step/extremity ratio between old and young people may have influenced the gait characteristics measured.

• Human Ecology Research
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• v.53 no.2
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• pp.131-141
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• 2015

The purpose of this study is to examine a potential association between community factors and the establishment of Local Healthy Family Support Centers (LHFSCs). Community factors were population size, community size, local finance independency, number of workplaces per 1,000 people, number of colleges, political party affiliation of mayor, and political party affiliation of congressman. Data of this study were collected from the census indicators of 222 communities from 2004 to 2014 and analyzed by frequency, mean, geographical information system mapping, and the binary logit analysis. The results of this study are as follows. First, LHFSCs are less likely to be established in communities in the provinces of Gangwon, Chungbuk, and Gyeongbuk. Second, the population size was positively related to the establishment of LHFSCs. Third, finance independency was positively associated with the establishment of LHFSCs. Forth, a mayor was more likely to establish LHFSCs if they were affiliated with the ruling conservative political party. However, the establishment of LHFSCs was not affected by other factors such as community scale, number of workplaces per 1,000 people, the number of colleges, and party affiliation of congressman. Thus, the conclusion suggests family policy implications to improve the geographical imbalance of LHFSCs based on the analysis results.

• Journal of Korean society of Dental Hygiene
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• v.8 no.4
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• pp.1-10
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• 2008

The purpose of this study was to compare the oral health status of elderly people living in nursing home with private home in Busan, Kimhae and Jinju in Gyeongnam province for development oral healthy policy of elderly people. 253 elderly subjects aged more than 65 in a hall for the aged and special medical treatment hospital are made up questions. The date was analysed using the SPSS 13.0 program. The obtained result were as follows. 1. 39.5 percent elder people recognize that their subjective oral health is not good. In the case of above three times in brushing tooth a day, 29 percent people are less their oral health is good. As the number of times of brushing tooth decreases, the percent feeling their oral status good decrease(p<.05). 2. The respondents who have visited the dentist within one year are less than people with no visit. Also the percent having a mind that their oral health status is good is higher in the respondents having scaling than them without scaling(p<.05). The respondents who answer that their diet is not bad is most in the ratio of people feeling subjective oral health status good(p<.001). 3. The portion of people feeling their oral status not healthy is highest in the respondents without tooth(p<.05). 4. Among the respondents answering their subjective oral health is not good, the some problem of conversation due to no tooth or denture and relation with others is issued each(p<.001). This study suggests that perceived toothbrusing frequency and periodic scaling with oral health among the elderly. The finding of this study will helpful to policy makers to design plants to increase the oral health related quality of life among the elderly.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.3 no.2
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• pp.201-211
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• 1996

The purpose of this study was to compare the comfort level between healthy people and adult in-patients in Korea. The sample consisted of 248 adults(healthy adults : 124, patients admitted in university hospitals in Seoul and Jinju : 124). The research tool used for the study was General Comfort Questionnaire(GCQ) which was developed by Kolcaba(1992) and was translated by Korean. The research tool consisted of 28 items(6 items on physical dimension, 9 items on psychospritual dimension, 7 items on environmental dimension, 6 items on social dimension). Data were analyzing using the SPSS, yielding t-test, ANOVA. The results are as follows : 1) Mean scores for comfort level in healthy adults were 2.92 on a 4 point scale. 2) Mean scores for comfort level in-patient adult were 2.72 on a 4 point scale. 3) There was a significant difference between the two groups on the comfort level. The healthy adults had higher comfort level than in-patients(t=4.44, p=0.000). 4) There was a significant difference between the two groups on the comfort level of physical and environmental dimension. The healthy adults had higher comfort level than in-patients(t=2.99, p=0.003) and environmental dimension(t=8.81, p=0.000).