• Journal of the Korean Society of Safety
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• v.24 no.6
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• pp.132-135
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• 2009

The population over 65 years of age in Korea will be 10.3% of the entire population in 2008 indicating that Korea is already in an aging society. In addition, it is expected that Korea will be in an aged society in 2018 (population over 65 years of age : 14.3%) and that it will be in a post-aged society in 2026 (20.8%). Consequently, aged workers may also increase. It is well-known that the possibility to work longer and to live better is highly related to the work ability of individual. The objective of this study was to evaluate the work ability of each age group using the Work Ability Index(WAI) in the shipbuilding industry, and to assess the effects of social psychological stress, drinking characteristics, smoking characteristics, etc. on the WAI score. The results showed no significant difference on the effects of aging, drinking, and smoking characteristics. Interestingly, a statistical analysis on the effects of social psychological stress revealed a significant difference by stress levels. The difference of the average WAI score between the healthy group and the high risk group was about 10 points. Based on this result, it can be concluded that the stress level is an influential factor on WAI.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.25 no.3
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• pp.173-181
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• 2018

Purpose: This study examined the effects of physical fitness and aging anxiety on life satisfaction among the elderly. Methods: The participants were 119 elderly. Data collection was conducted from July 1 to 10, 2018. Data were analyzed using descriptive statistics, t-tests, ANOVA, Pearson's correlation coefficients, and multiple linear regression analysis with SPSS software. Results: The mean life satisfaction score was 4.10. Life satisfaction differed significantly according to several general characteristics: education level (p=.014), income (p<.001), living with partner (p=.041), perceived health status (p<.001), and number of chronic diseases (p<.001). Statistically significant positive relationships were observed between life satisfaction with muscle strength (r=.20) and, flexibility (r=.21), and a negative relationship was observed with aging anxiety (r=-.66). A total of 60.0% of life satisfaction was explained by income, perceived health status, muscle strength, flexibility, and aging anxiety. Conclusion: These results can be used to develop life sports programs to improve physical, social, and emotional health promotion with consideration for support to alleviate economic burden. Effect of life sports are evident as a way for healthy and energetic elderly. It should not be a simple exercise program but an integrated plan for improving physical, mental, and social health of the elderly.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.323-335
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• 2016

Breast cancer risk assessment has developed during years and evaluation of genetic factor affecting risk of breast cancer is an important component of this risk assessment. The aim of this meta-analysis was to investigate the role of XRCC1 polymorphisms (Arg194Trp, Arg280His and Arg399Gln) in risk of breast cancer among different population and categories of menopausal status.PubMed, Medline, Web of Science, and PubMed Central were systematically searched to identify studies evaluating association between breast cancer and XRCC1 gene polymorphisms (Arg194Trp, Arg280His and Arg399Gln). Two authors independently extracted required information. Odds Ratios were pooled for four genetic inheritance models using both fixed and the DerSimonian and Laird random-effect models. Egger's test and contour-enhanced funnel plot was used to evaluate publication bias and small study effect. Additional subgroup analysis was performed for menopausal status, ethnicity, and source of controls. After evaluation and applying inclusion criteria on extracted studies, fifty three studies were included in this meta-analysis. For polymorphisms of Arg194Trp and Arg280His, no significant association was observed in all genetic models. Arg194Trp had a protective effect in post-menopausal status only in homozygote model (OR=0.57 [0.37-0.88]). Arg399Gln showed significant association with breast cancer in homozygote (OR=1.21 [1.10-1.34]), dominant (OR=1.09 [1.03-1.15]) and recessive (OR=1.21 [1.09- 1.35]) genetic models. Arg399Gln was associated with higher risk in post-menopausal status for homozygote and heterozygote models. Our findings suggest that XRCC1 gene polymorphisms modify breast cancer risk in different populations and different categories of menopausal status.

• Journal of Life Science
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• v.26 no.12
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• pp.1367-1375
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• 2016

Cilostazol is known to be a selective inhibitor of phosphodiesterase III and is generally used to treat stroke. Our previous findings showed that cilostazol enhanced capillary density through angiogenesis after focal cerebral ischemia. Angiogenesis is an important physiological process for promoting revascularization to overcome tissue ischemia. It is a multistep process consisting of endothelial cell proliferation, migration, and tubular structure formation. Here, we examined the modulatory effect of cilostazol at each step of the angiogenic mechanism by using human brain microvascular endothelial cells (HBMECs). We found that cilostazol increased the migration of HBMECs in a dose-dependent manner. However, it did not enhance HBMEC proliferation and capillary-like tube formation. We used a cDNA microarray to analyze the mechanisms of cilostazol in cell migration. We picked five candidate genes that were potentially related to cell migration, and we confirmed the gene expression levels by real-time PCR. The genes phosphoserine aminotransferase 1 (PSAT1) and CCAAT/enhancer binding protein ${\beta}$ ($C/EBP{\beta}$) were up-regulated. The genes tissue factor pathway inhibitor 2 (TFPI2), retinoic acid receptor responder 1 (RARRES1), and RARRES3 were down-regulated. Our observations suggest that cilostazol can promote angiogenesis by promoting endothelial migration. Understanding the cilostazol-modulated regulatory mechanisms in brain endothelial cells may help stimulate blood vessel formation for the treatment of ischemic diseases.

• Journal of Preventive Medicine and Public Health
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• v.53 no.2
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• pp.89-97
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• 2020

Objectives: The quality of life (QoL) of the elderly and elder abuse are growing public health concerns. This study aimed to evaluate the prevalence of abuse and the association between QoL and abuse in older adults. Methods: Multistage random cluster sampling, along with valid QoL (LEIPAD: LEIden, the Netherlands; PADua, Italy; Helsinki, Finland) and abuse questionnaires, were used to assess QoL and elder abuse. Path analysis was performed using Mplus. SPSS and AMOS were used for the other analyses. Results: A total of 386 elderly individuals with a mean age of 68.00±6.10 years were interviewed, of whom 200 (51.8%), 289 (74.9%), and 376 (97.4%) were women, educated, and married, respectively. Moreover, 167 (43.2%) had low-to-moderate QoL, and 108 (27.9%) had experienced a moderate level of abuse. QoL and abuse were inversely associated (r=-0.253), with men (β=-0.24) more affected than women (β=-0.21). Musculoskeletal disorders were also strong determinants of QoL in the elderly. QoL was strongly associated with emotional abuse, while abuse was highly related to the social component of QoL. Furthermore, emotional abuse was the type of abuse most significantly associated with the self-care, depression/anxiety, cognitive, and social components of QoL. Sexual abuse, violation of personal rights, and neglect were the main determinants of the physical functioning, life satisfaction, and sexual domains of QoL, respectively. Conclusions: Nearly half of the elderly individuals lacked a high QoL, and at least one-fourth had experienced some form of abuse. Elder abuse was correlated inversely with QoL. Therefore, preventive interventions are recommended to decrease elder abuse in the family, community, and other settings.

• Korean Journal of Health Education and Promotion
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• v.26 no.5
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• pp.15-26
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• 2009

Objectives: This paper is intended to illustrate and to discuss the organization and functioning of community resident groups (CRGs) in a community-based participatory health promotion program for healthy aging. Methods: CRGs were convened in 12 government-subsidized apartment communities for low-income seniors in Pennsylvania, U.S.A., to promote healthy aging. Researchers facilitated CRG meetings following a 6-step process of community empowerment and utilizing a social ecological model for assessment and planning. Almost 200 project-related documents were qualitatively analyzed using matrix analysis principles such as cross-classification of multiple dimensions to identify patterns in the data and matrix building for displaying such patterns. Results: CRGs were venues at which apartment building residents could interact, discuss health priorities, and become change agents in their building. CRG members' community health priorities were about their daily living, including building conditions, poor access to fresh food, and unhealthy resident relations. Specific patterns arose in analysis indicating that leadership withing the CRGs, consistency of meetings and participants' attendance, and ability to link health concerns to daily experience impacted the CRGs' capability to identify and accomplish their goals. Conclusion: Community health issues and solutions to those issues identified by CRGs were unique to community contexts and interests. Consistent participation by community members, a consistent pattern of group activities such as monthly meetings, and having established leadership to manage CRG activities were prominent characteristics of community group functioning.

• The Journal of Korean Medicine
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• v.45 no.1
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• pp.17-43
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• 2024

Objectives: Underpinned by the context of a Korean traditional medicine cohort study on healthy aging, this research primarily aims to guide the selection of Clinical Outcome Assessments (COAs) for elderly healthy aging patient registry research, offering insights into the selection process; and secondly, to streamline the resource-intensive process of obtaining permissions for validated COAs, benefiting future traditional Korean medicine clinical researchers. Methods : In this study, we identified outcomes through a review of previous studies, followed by a process involving expert consultations to select the final outcomes. Subsequently, for the selected outcomes that were Clinical Outcome Assessments (COAs) developed tools, we searched in commercial databases to confirm the availability of Korean versions and the necessity of obtaining permissions. Finally, we obtained permissions for their utilization and, when needed, acquired the original instrument questionnaire through payment. Results: Through a literature review of existing observational studies, a total of 57 outcomes were selected, with 19 of them identified as COA instruments. Upon verifying usage permissions for these 19 instruments, it was found that 17 required author-specific permissions, and among these, 2 needed a purchase as they were commercially available. Conclusion: This study provides a detailed overview of outcome selection and permission acquisition for elderly patient registry research. It underscores the importance of Clinical Outcome Assessment (COA) tools and the rigorous approval process, aiming to enhance research reliability. Continuous verification of COA information is essential, and future research should explore Core Outcome Set (COS) development through consensus-building approaches like Delphi studies.

• Journal of Digital Convergence
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• v.15 no.2
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• pp.493-501
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• 2017

This study aimed to present cosmetic countermeasures for preventing fast aging process in the middle age and accepting healthy aging both physically and mentally by investigating the perception of aging according to the health condition, lifestyle and psychological condition targeting mid-aged women in 40s to 50s residing in Seoul and Gyeonggi-do Province. The data collection period was from July 25 to Sept 1, 2015. The data was analyzed by descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients, and stepwise multiple regression. It was shown that as the age was higher, the menopause ratio was higher, drinking, exercise volume and hours of sleep were reduced and the stress and psychological pressure were higher. According to the menopausal status, the status of facial aging showed a significant difference (${\chi}^2=39.692^{***}$, p<.001), and it also showed a difference according to the status of leisure (hobby) activity (${\chi}^2=22.470^{***}$, p<.01). Also, as higher the age and closer to the menopause in items including the progress of aging, anxiety about aging and improvement efforts, more negative perception was shown, indicating that it is necessary to prepare cosmetic countermeasures for mid-aged women in like a second puberty 40s to 50s although aging and menopause around 50s are very natural. If a beauty alternative is provided, it will help them to have a successful retirement.

• Journal of Family Resource Management and Policy Review
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• v.13 no.3
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• pp.137-155
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• 2009

The purpose of this study is to analyze the effects of the degree of preparation for old age and perception of successful aging on the life satisfaction of middle-aged women. The participants in this study were 300 women ranging in age from 35 years to 65years who reside in Seoul, Gyeonggi-do, and other cities. Two hundred eight self-reported questionnaires were used for final analysis by SPSS WIN14. The major results of this study were as follows: First, there were differences in the degree of preparation for old age of middle-aged women by age, academic career, income, area, and religion. Second, there were differences in self-efficacy in the perception of successful aging by academic career, an income, and area. Third, there were differences in the degree of life satisfaction of middle-aged women by academic career and income. Finally, the most effective variables on the degree of life satisfaction were the degree of preparation for old age, perception of successful aging, and income. Consequently, to improve the life satisfaction of middle-aged women, social groups, local self-governments, and the government have to educate women on economic management for preparation for old age and human relationship progress programs, as well as promote healthy leisure cultures.

• Biomedical Science Letters
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• v.12 no.4
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• pp.337-341
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• 2006

Platelets clearly play an important role in inflammatory responses. In this study, we aimed to evaluate the relationship between aging and platelet activation. A total number of 799 persons (383 males and 416 females), who were apparently healthy and aged more than 20 years were recruited by a health promotion center in a community-based hospital in Seoul, Korea. We collected material data about their medical history and health behavior. Platelet parameters including mean platelet component (MPC), mean platelet volume (MPV), and platelet component distribution width (PCDW) were determined within 1 hour after blood collection using the ADVIA 120 automated hematology analyzer. The MPC of the women ($27.2{\pm}1.2$) was significantly love. than that of the men ($27.5{\pm}1.3$). The MPC of all participants was found to decrease with increasing age (P<0.01). Study participants in their twenties had the highest MPC ($27.7{\pm}1.1$), followed by those in their thirties ($27.6{\pm}1.1$), forties ($27.4{\pm}1.3$), fifties ($27.2{\pm}1.3$), sixties ($27.2{\pm}1.2$) and seventies ($27.1{\pm}1.2$). Multiple regression analysis showed that aging and gender were related with MPC after adjusting for confounding factors, including age, gender, smoking habit, hypertension, diabetes, body mass index and total cholesterol level. The this study shows that aging is related to platelet activation. Future research will need to determine the implications of increased platelet activation with aging, especially regarding the increased incidence of cardiovascular diseases and related mortalities that occur in older age groups.