• The Journal of Korean Physical Therapy
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• v.24 no.3
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• pp.202-207
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• 2012

Purpose: The purpose of this study was to determine the effect of monochromatic infrared energy (MIRE) on the blood flow of the superficial radial artery and local skin temperature in healthy subjects. Methods: Forty healthy volunteers were recruited and randomly assigned to MIRE group (n=20) and placebo group (n=20). The MIRE group received a 890 nm MIRE irradiation on the forearm using two therapy pads for 30 minutes. The therapy pad was composed of an array of 60 diodes. MIRE unit was set at bar 8, that corresponds to a diode power of 10 mW and a power density of $63mW/cm^2$. The placebo group received sham MIRE. Peak blood flow velocity (PBFV), mean blood flow velocity (MBFV), and skin temperature (ST) were measured pre- and post-MIRE irradiation. Results: There was a significant difference in PBFV (p<0.001), MBFV (p<0.001), and ST (p<0.001) between the pre- and post-treated values in the MIRE group. In contrast, no significant difference was found between the pre- and post-treated values in the placebo group. There was significant difference in mean change values from baseline of PBFV (p<0.001), MBFV (p<0.001), and ST (p<0.001) between the MIRE group and the placebo group. There was a significant increase in PBFV (p<0.001), MBFV (p<0.001), and ST (p<0.001) following MIRE irradiation. Conclusion: The arterial blood flow and local skin temperature of the forearm in the healthy subjects were significantly increased following MIRE irradiation.

• Journal of Acupuncture Research
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• v.29 no.3
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• pp.89-99
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• 2012

Objectives : This study was performed to investigate the effect of simple acupuncture and electroacupuncture at Bai Hui($GV_{20}$) on heart rate variability in healthy adults with stress task. Methods : 40 healthy volunteers participated in this study. HRV was recorded before and after stress. And then simple acupuncture(SA group) was applied at $GV_{20}$ or electroacupuncture(EA group) was applied at the same spot in each treatment group for 20 minutes. No treatment was performed in control group for 20 minutes. Then HRV was recorded. Results : 1. In all groups, LF norm, LF/HF, HF norm showed significant changes after mental stress. 2. Control group showed no significant change. In SA group, HF norm LF, LF norm and LF/HF showed a significant change after treatment. In EA group, Mean HR, HF, LF norm, HF norm and LF/HF showed a significant change after treatment. In both treatment groups, there were significant differences after treatment compared to control group. 3. In EA group, HF and HF norm decreased significantly after treatment compared to SA group. Conclusions : These results suggest that simple acupuncture and electroacupuncture at $GV_{20}$ affect the balance of the autonomic nervous system and that electroacupuncture at $GV_{20}$ enhances parasympathetic activation more than simple acupuncture.

• Korean Journal of Community Nutrition
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• v.8 no.5
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• pp.699-707
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• 2003

This study examined the effectiveness of two commonly used dietary assessment methods (the 24-hour recall and the food frequency questionnaire) in the epidemiological investigations of health-related habits and degenerative diseases. This cross sectional project in the Seoul area was conducted for the purpose of establishing cohort subjects and collecting reliable nutrient intake data for a further large-scale cross sectional study. The subjects were 91 volunteers from the Seoul area with a mean age of 53.5 \pm 9.6 for the males and 52.2 \pm 8.9 for the females. The subjects had a relatively high educational background, were from high socioeconomic levels, and were greatly concerned about healthrelated life styles. There was a significantly negative correlation between their smoking and their nutrient intake. Their drinking habits, their self-estimated health status and their concern or stress about being healthy did not have any influence on their nutrient intakes. Skipping meals was the most undesirable dietary habit influencing their nutrient intakes, and the next was their irregularity of eating meals. The subjects who liked legumes and fish had higher intakes of iron and niacin and those who liked milk and dairy products had higher intakes of calcium, vitamin \B_2 and fat. The subjects who considered themselves not to be healthy consumed higher amounts of fish and shell-fish, and those who considered themselves to be healthy consumed higher amounts of vegetables. The smokers consumed less fruits than non-smokers, but there was no correlation between their drinking and consumption of the food groups. There was no correlation between their food consumption frequency and their skipping meals or meal irregularity. There were positive correlations between their food likes and food consumption frequency for foods such as meat, milk and dairy products, seaweeds and fruits. Therefore, their smoking, skipping meals and meal irregularity appeared to greatly influence their nutrient intakes. Significant correlations were found between their health-related habits and their food group preferences and food frequencies. This implies that simple surveying methods using criteria such as smoking, skipping meals and meal irregularity, food group preferences and eating frequencies can be used as useful tools in the assessment of nutritional statuses.

• Annals of Clinical Neurophysiology
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• v.21 no.2
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• pp.87-93
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• 2019

Background: The standardized autonomic function test has become widely available. However, there are no reference data for this test for the Korean population. This study explored reference data for sudomotor and cardiovagal function tests for the Korean population. Methods: The sweat volume by quantitative sudomotor axon reflex test, heart-rate response to deep breathing (HRdb), expiration:inspiration (E:I) ratio, and Valsalva ratio (VR) were measured in 297 healthy Korean volunteers aged from 20 to 69 years. Multivariate regression analysis was performed to evaluate the effects of age, sex, and body mass index on these variables. The 2.5th, 5th, 10th, 90th, 95th, and 97.5th percentile values were obtained for each investigation. Results: The sweat volume was higher in males than in females. The HRdb and E:I ratio were negatively correlated with age, and were higher in males than in females. The VR was negatively correlated with age, but it was not correlated with sex. Conclusions: This study has provided data on the reference ranges for sudomotor and cardiovagal function tests in healthy Korean adults.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.4
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• pp.91-103
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• 2021

Purpose : This study aimed to evaluate the effects of a cognitive enhancement brain yoga program on short-term memory and serum brain-derived neurotrophic factor (BDNF) levels according to the cognitive state in men aged 20-29 years. Methods : Thirty healthy volunteers aged 20-29 years were divided into four groups: brain yoga group, yoga group, combined exercise group, and control group. Seven people were assigned randomly per group. A single-session intervention was conducted over 50 min and consisted of three parts: warm-up, main exercise (brain yoga, yoga, combined exercise, or non-exercise), and cool-down. Serum BDNF levels were measured using enzyme-linked immunosorbent assay, and short-term memory was evaluated using the forward number span test before and after the intervention. Results : BDNF levels significantly increased within the brain yoga group after the intervention (from 28874.37±5185.57 to 34074.80±7321.12, p=.003), whereas there were no significant differences pre-and post-intervention in the other groups. The inter-group comparison showed a significant interaction between the brain yoga group and the combined exercise group (p=.036) but no significant interaction between any of the other groups. Forward number span scores were significantly increased in the brain yoga group (from 9.43±9.83 to 23±7.92, p=.012) and theyoga group after the intervention (from 13.43±9.41 to 24.14±8.45, p=.011), whereas there were no significant changes after the intervention in any other groups. Conclusion : Our findings showed that a single-session, 50-minute brain yoga exercise improved short-term memory and increased serum BDNF levels in healthy men aged 20-29 years and that yoga improved only short-term memory in healthy men of this age group.

• Journal of Veterinary Science
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• v.21 no.2
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• pp.23.1-23.10
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• 2020

The identification of biomarkers that distinguish diseased from healthy individuals is of great interest in human and veterinary fields. In this research area, a metabolomic approach and its related statistical analyses can be useful for biomarker determination and allow non-invasive discrimination of healthy volunteers from breast cancer patients. In this study, we focused on the most common canine neoplasm, mammary gland tumor, and herein, we describe a simple method using ultra-high-performance liquid chromatography to determine the levels of tyrosine and its metabolites (epinephrine, 3,4-dihydroxy-L-phenylalanine, 3,4-dihydroxyphenylacetic acid, and vanillylmandelic acid), tryptophan and its metabolites (5-hydroxyindolacetic acid, indoxyl sulfate, serotonin, and kynurenic acid) in canine mammary cancer urine samples. Our results indicated significantly increased concentrations of three tryptophan metabolites, 5-hydroxyindolacetic acid (p < 0.001), serotonin, indoxyl sulfate (p < 0.01), and kynurenic acid (p < 0.05), and 2 tyrosine metabolites, 3,4-dihydroxy-L-phenylalanine (p < 0.001), and epinephrine (p < 0.05) in urine samples from the mammary gland tumor group compared to concentrations in urine samples from the healthy group. The results indicate that select urinary tyrosine and tryptophan metabolites may be useful as non-invasive diagnostic markers as well as in developing a therapeutic strategy for canine mammary gland tumors.

• Archives of Pharmacal Research
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• v.15 no.3
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• pp.208-210
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• 1992

Comparative bioavailability of two tablet dosage forms of ofloxacin (either as Hoechst (India) or Ranbaxy preparation ) was investigated. In a randomized cross-over study, eitht healthy human volunteers received single 200 mg dose of film coated ofloxacin in fasting state. The concentration of ofloxacin in the collected saliva and serum samples were measured by high performance liquid chromatography. No significant difference in bioavailability of both preparations was judged from various serum and seliva pharmacokinetic parameters such as peak concentration, time to peak concentration and are under the curves. Intersubject variation was also found to be insignificant.

• Journal of Ginseng Research
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• v.27 no.3
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• pp.115-119
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• 2003

There has been continuing interest in the development of synthetic and natural compounds that modify the immune response particularly for the treatment of AIDS and cancer. During the past fifty years, numerous scientific studies have been published on ginseng. Modem human studies have investigated preventive effect of ginseng on several kinds of cancer, its long term immunological effect on HIV patients, its effect on cell mediated immune functions in healthy volunteers. Similarly non clinical studies on animal model system have studied the chemopreventive action of ginseng on cancer and immunological properties of ginseng. The precise mechanism of action of ginseng, however, not clearly understood. Considering its wide-ranging therapeutic effects, this study is being undertaken to elucidate the general mode of action of ginseng, especially to test our hypothesis that its biological action may be mediated by the immune system.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.11a
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• pp.139-145
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• 2006

Kaneka Corporation (Kaneka) has been manufacturing CoQ10 under GMP regulation since 1977. Kaneka has a sophisticated quality control system and has been supplying high quality CoQ10 materials to the worldwide customers (Kaneka CoQ10) for about 30 years. Kaneka CoQ10 is characterized by a lot of safety data, which are derived from clinical trials with healthy volunteers (single-dose and 4-week multi-dose safety studies), animal studies (13-week sub-chronic study in dogs and 52-week chronic study in rats), three types of mutagenicity test, six type of skin irritation test (for cosmetics), and others. The risk assessment of CoQ10 was performed by Council for Responsible Nutrition (USA). They reviewed many of available clinical data including clinical trials using Kaneka Q10, and concluded that the upper level for supplements (ULS) of CoQ10 is 1,200 mg/day (Hathcock and Shao. 2006, Regulatory Toxicology and Pharmacology, 45, 282 - 288).

• Journal of the Korean Society of Physical Medicine
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• v.6 no.3
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• pp.353-360
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• 2011

Purpose : The purpose of this study was to compare the effect of muscle strength by stimulation of russian current and low frequency. Methods : The subjects were thirty young healthy volunteers who were divided into two groups including russian current group(n=15) and low frequency group(n=15). The intervention was applied totally 12 times (1 time, 10 minute) for 4weeks in each group. The peak torque and average power were measured and analysed using Biodex system 4 before the treatment, after 2 weeks, 4 weeks. Results : As a result, russians currents and low frequency stimulation increased significantly average power and peak torque with the lapse of time. However, there were not significant differences of the average power and peak torque between the groups in all periods. Conclusion : In conclusion, russians currents and low frequency stimulation had no differences in the increase of muscle strength.