• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.97-107
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• 2023

Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic and is known to cause aristolochic acid nephropathy (AAN). AA-induced acute kidney injury (AKI) is a syndrome in AAN with a high morbidity that manifests mitochondrial damage as a key part of its pathological progression. Melatonin primarily serves as a mitochondria-targeted antioxidant. However, its mitochondrial protective role in AA-induced AKI is barely reported. In this study, mice were administrated 2.5 mg/kg AA to induce AKI. Melatonin reduced the increase in Upro and Scr and attenuated the necrosis and atrophy of renal proximal tubules in mice exposed to AA. Melatonin suppressed ROS generation, MDA levels and iNOS expression and increased SOD activities in vivo and in vitro. Intriguingly, the in vivo study revealed that melatonin decreased mitochondrial fragmentation in renal proximal tubular cells and increased ATP levels in kidney tissues in response to AA. In vitro, melatonin restored the mitochondrial membrane potential (MMP) in NRK-52E and HK-2 cells and led to an elevation in ATP levels. Confocal immunofluorescence data showed that puncta containing Mito-tracker and GFP-LC3A/B were reduced, thereby impeding the mitophagy of tubular epithelial cells. Furthermore, melatonin decreased LC3A/B-II expression and increased p62 expression. The apoptosis of tubular epithelial cells induced by AA was decreased. Therefore, our findings revealed that melatonin could prevent AA-induced AKI by attenuating mitochondrial damage, which may provide a potential therapeutic method for renal AA toxicity.

• The Korean Society of Law and Medicine
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• v.24 no.1
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• pp.67-98
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• 2023

In the early stages of the COVID-19 pandemic, Korea took the lead in implementing "social distancing" policies more strongly than other countries. In addition to making it mandatory to wear a mask according to the policy, all patients using medical institutions are tested for COVID-19 to prevent Healthcare-Associated Infections, and only those patients who test negative have been regulated to receive face-to-face medical treatment. In this process, situations such as the disabled, who have difficulty wearing masks, were not taken into account, and emergency patients did not receive timely treatment or surgery from medical personnel. In response, the National Human Rights Commission of Korea has decided that forcing everyone to wear a mask and restricting access to medical institutions constitutes discrimination against the disabled. Therefore, the purposes this study has that, the first is to review cases of human rights discrimination against persons with disabilities due to measures to prevent the transmission of infectious diseases that did not consider the characteristics of persons with disabilities in the COVID-19 situation and issues regarding the decisions of the National Human Rights Commission of Korea, the second is to find a reasonable plan and the need for measures to prevent refusal of treatment by medical institutions for the disabled who have difficulty wearing masks.

• 한국체육학회지인문사회과학편
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• v.51 no.4
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• pp.407-417
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• 2012

The purpose of the study was to determine the effects of pilates mat exercise on cardiovascular disease risk factors and inflammation markers in sarcopenic obesity elderly. All subjects were sarcopenic obesity(height for each of the arms, legs, appendicular muscle mass ratio of 1.16kg/m², 4.31kg/m², 5.21kg/m² under and % body fat is more than 30%) elderly performed the pilates mat exercise during 12-week for 60 minutes 3 times a weeks. All subjects of this study were examined the changes in cardiovascular disease risk factors(TC, TG, HDL-C, LDL-C, Glucose, Insulin) and inflammation markers(fibrinogen, adiponectin, leptin, CRP). The results of the study in the exercise group were as follows; The weight, % body fat, TC, TG, LDL-C, fibrinogen, CRP had significantly decreased and muscle mass, HDL-C, adiponectin had significantly increased. And also, pilates mat exercise can effective to improve sarcopenic obesity, and pilates mat exercises performed coy shrink obesity to cardiovascular disease and inflammatory response indicators of older women as old man's physical features of the deterioration of the prevention of obesity and muscle strength loss, causing the effective exercise method is meant to be.

• Journal of the Korean Association of Geographic Information Studies
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• v.26 no.1
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• pp.89-113
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• 2023

This study aimed to identify heat wave vulnerable areas and discuss spatial typology and policy directions through spatial coincidence analysis of heat wave damage. By utilizing the climate change vulnerability assessment of the Intergovernmental Panel on Climate Change (IPCC) and Spatial Statistics Comparison Analysis, this study examined cities, counties, and districts in South Korea for five years (2015-2019), including 2018, when the heat wave was most extreme. It was determined that the number of heat wave days (exposure) was the most impactful among various factors for heat wave vulnerability. Sensitivity and adaptive capacity to heat waves were found to vary according to regional characteristics. The relationship between heat wave vulnerability and damage was categorized into four types through spatial coherence. Hot to Hot and Cold to Cold types have a positive relationship between vulnerability and damage, while Hot to Cold and Cold to Hot types have a negative relationship. The findings suggest that since different types of regions have distinct characteristics and conditions, policies and research for improvement should be directed to address each region separately. This study may be used as basic data for establishing heat-related policies in the future, as it categorizes regions by considering both heat vulnerability and damage and examines the direction of response by type.

• Journal of Korea Water Resources Association
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• v.56 no.6
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• pp.393-402
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• 2023

Drought, which has been increasing in frequency and magnitude due to recent abnormal weather events, poses severe challenges in various sectors. To address this issue, it is important to develop technologies for drought monitoring, forecasting, and response in order to implement effective measures and safeguard the ecological health of aquatic systems during water scarcity caused by drought. This study aimed to predict water quality fluctuations during drought periods by integrating the watershed model HSPF and the water quality model QUAL-MEV. The researchers examined the SPI and RCP 4.5 scenarios, and analyzed water quality changes based on flow rates by simulating them using the HSPF and QUAL-MEV models. The study found a strong correlation between water flow and water quality during the low flow. However, the relationship between precipitation and water quality was deemed insignificant. Moreover, the flow rate and SPI6 exhibited different trends. It was observed that the relationship with the mid- to long-term drought index was not significant when predicting changes in water quality influenced by drought. Therefore, to accurately assess the impact of drought on water quality, it is necessary to employ a short-term drought index and develop an evaluation method that considers fluctuations in flow.

• Journal of Intelligence and Information Systems
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• v.29 no.2
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• pp.267-283
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• 2023

The COVID-19 pandemic, which began in December 2019 and continues to this day, has left the public needing information to help them cope with the pandemic. However, COVID-19-related fake news on social media seriously threatens the public's health. In particular, if fake news related to COVID-19 is massively spread with similar content, the time required for verification to determine whether it is genuine or fake will be prolonged, posing a severe threat to our society. In response, academics have been actively researching intelligent models that can quickly detect COVID-19-related fake news. Still, the data used in most of the existing studies are in English, and studies on Korean fake news detection are scarce. In this study, we collect data on COVID-19-related fake news written in Korean that is spread on social media and propose an intelligent fake news detection model using it. The proposed model utilizes the frequency information of parts of speech, one of the linguistic characteristics, to improve the prediction performance of the fake news detection model based on Doc2Vec, a document embedding technique mainly used in prior studies. The empirical analysis shows that the proposed model can more accurately identify Korean COVID-19-related fake news by increasing the recall and F1 score compared to the comparison model.

• 한국체육학회지인문사회과학편
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• v.55 no.4
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• pp.85-107
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• 2016

By examining the constitutive characteristics of Yon-Ko-Jeon and analyzing the lived meanings and experiencing essence of students, this study details the students' awareness, responses, and strategies with regards to the phenomenon of women's alienation from Yon-Ko-Jeon. Students from the two colleges were divided into two groups- one which was aware of women's alienation from Yon-Ko-Jeon, and another group that was unaware of such a phenomenon. Students without awareness tended to perceive the alienation of women from Yon-Ko-Jeon as a natural phenomenon. On the other hand, the members who had awareness tended to see it as a phenomenon that was either justified, unequal, or in need of change. In the latter group, those who saw women's alienation as a justified phenomenon responded with tolerance and adopted a bystander strategy. Conversely, those who saw it as an unequal phenomenon responded with rejection and instead chose to adopt anti-/alternative Yon-Ko-Jeon strategies. The last group, which perceived women's alienation as a phenomenon in need of change, adopted correcting responses as well as intercollegiate solidarity and cooperation strategies. A generalization of the findings reveals that the students' experiencing essence of the phenomenon extends from critical thinking to awareness, response, and strategy in a step-by-step and sequential process. Through this study, it was found that the students' experiencing essence all follow a continuous thinking pattern, as illustrated in the diagram provided.

• The Journal of the Convergence on Culture Technology
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• v.9 no.4
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• pp.259-268
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• 2023

The purpose of this study was to verify the effectiveness of mental simulation practice training using standardized patients for nursing students. This study is a single-group pre- and post-design study, and for data collection, a structured questionnaire was provided to 95 nursing students from a university located in J. The collected data was analyzed using the SPSS/WIN 27.0 program. Results of the study The mental simulation practice training program using standardized patients improved the subject's learning motivation (t=-2.011, p=.046), learning self-efficacy (t=-2.225, p=.027), and learning satisfaction (t=-). 3.428, p=.001) and transfer motivation (t=-2.628, p=.009). In addition, as a result of analyzing the self-assessment contents by text mining, words related to mental simulation practice education using standardized patients included situation, experience, acting, communication, scenario, and mental nursing clinical practice, and words related to satisfaction were actual, There was help, response, understanding, variety, etc. As a result of this study, an environment similar to the actual situation was implemented, and the mental simulation training program applying various cases was found to be effective in practical education of nursing students, so it is necessary to actively utilize it to improve the ability to adapt to the field in the future.

• The Journal of the Convergence on Culture Technology
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• v.9 no.4
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• pp.67-75
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• 2023

The object of this study was to analyze factors influencing adult dementia knowledge, fear of dementia, and intention of dementia prevention behavior on the demand for dementia prevention education. The subjects of the study were 265 adults aged 19 to 64 living in Chungnam and Chungbuk, who understood the purpose of the study and agreed to participate in the study. The collected research data were analyzed using frequency, percentage, mean, standard deviation, t-test, ANOVA, and multiple regression analysis. As a result of the study, adult dementia knowledge (p=.055) and dementia fear (p=.302) were found that they did not significantly affect the demand for dementia prevention education, and the intention of dementia prevention behavior (β=.329, p<.001) was found to have a significant effect on the demand for dementia prevention education. Based on these research results, understanding of dementia and dementia management projects, early screening for dementia and health guidelines for dementia prevention, chronic disease management for dementia prevention, exercise for dementia prevention, healthy eating for dementia prevention, and cognitive enhancement for dementia prevention In addition to the national dementia prevention publicity and national response efforts such as programs, it is necessary to actively participate in the dementia prevention program centered on the community to practice the correct dementia prevention behavior and provide sufficient opportunities to prevent it.

• The Journal of the Convergence on Culture Technology
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• v.9 no.4
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• pp.291-301
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• 2023

The purpose of this study is to examine the perception of early childhood teachers on ecological art activities oriented to education for sustainable development. The research results are as follows. First, Early childhood teachers recognized the visual art of natural media, the pursuit of community values, and the participation and communication of social members as educational significance of ecological art activities. And difficulties in practicing ecological art were recognized as lack of educational environment, lack of ecological art teaching materials and specific examples, and teachers' lack of understanding of ecological art. Also, they recognized that ecological art activities foster core competencies in art experience area, such as nature-friendly communication skills, eco-friendly sensibility, and creative convergence skills. Second, regarding ecological art activities and sustainable development education, early childhood teachers considered the difficulties in practice as lack of awareness about sustainable development, lack of play meia and materials, lack of educational policies and support, and insufficient teacher training programs. Also, regarding the SDGs that can be practiced in ecological art activities, teachers were found to be highly aware of 'grow affordable and clean energy', 'improve clean water and sanitation', 'provide quality education' in the order. In the contents of education for sustainable development that can be practiced in ecological art activities, teachers are given the order of 'climate change response', 'clean energy', 'water and sanitation', 'quality education', 'health and well-being' and 'marine ecosystem'. was highly recognized. If an ecological art activity program is developed, the rate of responding that it will be used is high, so it is considered that the development of an ESD-oriented ecological art activity program is urgent.