• Title/Summary/Keyword: Health research and development

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Development of Quantitative Vitellogenin ELISAs for Bullfrog (Rana catesbeiana) used in Endocrine Disrupter Screening (내분비계 장애물질 검색을 위한 효소면역측정법을 이용한 황소개구리 비텔로제닌 정량법 개발)

  • Lee Sang-Hoon;Kang Yun-Ju;Li Chun-Ri;Kim Andre;Jin Chun-Feng;Chung Kyu-Hyuck;Kim Dong-Kyoo;Park Nam-Gyu;Park Kwang-Sik;Kang Shin-Won;Park Jang-Su
    • Environmental Analysis Health and Toxicology
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    • v.21 no.2 s.53
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    • pp.147-151
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    • 2006
  • 난생 생물의 알 생성유도 단백질인 비텔로제닌(viteILogenin, VTG)을 성숙한 암컷 황소개구리 (Rana catesbeiana)혈청으로부터 음이온 교환 크로마토그래피를 이용하여 정제 하였으며 정제한 비텔로제닌을 BALB/c mice에 주사하여 폴리크로날 항체를 생산하였고 이것은 protein A column으로 정제 하였다. 이렇게 정제된 폴리크로날 항체를 이용하여 황소개구리 비탈로제닌 측정용 효소면역측정법을 개발하였으며 그 측정 범위는 $12{\sim}1,560ng/mL$였다. 또한 이 효소면역측정법을 평가하기 위해 성숙한 수컷 황소개구리를 청정지역과 폐수처리장 하류 하천에서 서식하는 황소개구리 혈액 속의 비텔로제닌을 측정하였다. 그 결과 폐수처리장 하류 하천에 서식하는 수컷 황소개구리 비텔로제닌이 청정지역보다 현저하게 높게 유도됨을 알 수 있었다.

Amplitude dependency of damping of tall structures by the random decrement technique

  • Xu, An;Xie, Zhuangning;Gu, Ming;Wu, Jiurong
    • Wind and Structures
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    • v.21 no.2
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    • pp.159-182
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    • 2015
  • This study focuses on the amplitude dependency of damping of tall structures by the random decrement technique (RDT). Many researchers have adopted RDT to establish the amplitude dependency of damping ratios in super-tall buildings under strong wind loads. In this study, a series of simulated examples were analyzed to examine the reliability of this method. Results show that damping ratios increase as vibration amplitudes increase in several cases; however, the damping ratios in the simulated signals were preset as constants. This finding reveals that this method and the derived amplitude-dependent damping ratio characteristics are unreliable. Moreover, this method would obviously yield misleading results if the simulated signals contain Gaussian white noise. Full-scale measurements on a super-tall building were conducted during four typhoons, and the recorded data were analyzed to observe the amplitude dependency of damping ratio. Relatively wide scatter is observed in the resulting damping ratios, and the damping ratios do not appear to have an obvious nonlinear relationship with vibration amplitude. Numerical simulation and field measurement results indicate that the widely-used method for establishing the amplitude-dependent damping characteristics of super-tall buildings and the conclusions derived from it might be questionable at the least. More field-measured data must be collected under strong wind loads, and the damping characteristics of super-tall buildings should be investigated further.

The role of lysophosphatidic acid receptor 1 in inflammatory response induced by lipopolysaccharide from Porphyromonas gingivalis in human periodontal ligament stem cells

  • Kim, Dong Hee;Seo, Eun Jin;Tigyi, Gabor J.;Lee, Byung Ju;Jang, Il Ho
    • International Journal of Oral Biology
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    • v.45 no.2
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    • pp.42-50
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    • 2020
  • Lysophosphatidic acid (LPA) is a lipid messenger mediated by G protein-coupled receptors (LPAR1-6). It is involved in the pathogenesis of certain chronic inflammatory and autoimmune diseases. In addition, it controls the self-renewal and differentiation of stem cells. Recent research has demonstrated the close relationship between periodontitis and various diseases in the human body. However, the precise role of LPA in the development of periodontitis has not been studied. We identified that LPAR1 was highly expressed in human periodontal ligament stem cells (PDLSCs). In periodontitis-mimicking conditions with Porphyromonas gingivalis-derived lipopolysaccharide (Pg-LPS) treatment, PDLSCs exhibited a considerable reduction in the cellular viability and osteogenic differentiation potential, in addition to an increase in the inflammatory responses including tumor necrosis factor-α and interleukin-1β expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Of the various LPAR antagonists, pre-treatment with AM095, an LPAR1 inhibitor, showed a positive effect on the restoration of cellular viability and osteogenic differentiation, accompanied by a decrease in NF-κB signaling, and action against Pg-LPS. These findings suggest that the modulation of LPAR1 activity will assist in checking the progression of periodontitis and in its treatment.

A Study on Development of Casual Hanbok Design made of Hanji Yarn Textiles for the New Silver Generation Woman (뉴실버세대 여성을 위한 한지직물 활용 생활한복 디자인 개발 연구 - 대전 지역을 중심으로 -)

  • Han, Nam-Ki;Park, Eun-Hee
    • Fashion & Textile Research Journal
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    • v.10 no.5
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    • pp.702-712
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    • 2008
  • The aim of this study is to develop Casual Hanbok design made of Hanji yarn textiles for New Silver generation women. The New silver generation is a coined word which has meaning of a newly silver generation and it is distinguished from pre-silver generation. New silver generation is a generation that is independent and given active role by their age groups and generational characteristic. The concept of silver generation was introduced from maturity market in Japan. This study was based on analysis about their preference of forms, colors, and materials of Casual Hanbok. The survey target were 270 female over age 50 living in Daejeon City. The analysis methods used frequency and percentage. The results were summarized as following. Although almost of them haven't worn Casual Hanbok, they had the positive recognition on wearing one. They preferred longer length jacket to traditional Korean style, shorter length of skirt. They also preferred the traditional sleeve shape and knotted buttons. On the foundation of this fact, 2 styles consist of 5 Casual Hanbok design items made of functional material - Hanji yarn textiles that have antimicrobial, deodorant, quick drying, far infrared radiation which are not harmful to health - for New silver women were suggested. One style was 3 items - blouse, vest, skirt - which are the sense of Korean tradition with activity by patch. The other was 2 items - jacket and skirt - which are the sense of Korean tradition with modern way by quilting. Lastly, these garments were evaluated by 13 experts, they were satisfied with 2 styles and all items. As this study were based on the Elderly women living in Daejeon city, it had the limitation on applying of preference styles to all the New silver generation.

A study on the EMF strength standard in propulsion system on ship (선내 추진시스템에 대한 전자파 강도기준 연구)

  • Choi, Gi-Do;Kim, Jong-Woo;Cho, Hyung-Rae
    • Journal of Advanced Marine Engineering and Technology
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    • v.39 no.9
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    • pp.929-934
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    • 2015
  • Because of the recent rapid advances in the development of ships with a larger proportion of electrical and electronic equipment, The usable frequency spread spectrum on ships is global trend. Therefore, concerns have been raised regarding the possible hazardous health effects of electromagnetic fields radiating from electronic devices. Although studies and investments on electro-magnetic fields in terrestrial areas are being conducted, they are not applied to a ship. In this paper, we measured electromagnetic fields in ship propulsion systems, and we analyzed the measured values against Korean and international standards. While the measured results satisfied the Korean standard, the Italian standard was not met in the switchboard area. However, the measured values were close to meeting the Italian standard. Therefore, further studies should be conducted for performing a comparative analysis of data in order to specify a standard of electromagnetic fields in propulsion systems that can be applied in the construction of government infrastructures.

A2 Allele Polymorphism of the CYP17 Gene and Prostate Cancer Risk in an Iranian Population

  • Karimpur-Zahmatkesh, Arezu;Farzaneh, Farah;Pouresmaeili, Farkhondeh;Hosseini, Jalil;Azarghashb, Eznollah;Yaghoobi, Mohammad
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.2
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    • pp.1049-1052
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    • 2013
  • Background: Studies have shown that alterations of steroid hormone metabolism, particularly involving testosterone, affect the risk of prostate cancer. Therefore, genetic variation in genes of enzymes which are involved could be of importance. The gene most interest is CYP17, whose enzyme product has an essential role in testosterone hormone synthesis. Some studies have indicated that the A2 allele polymorphism of CYP17 associated with increased risk of prostate cancer that could be affected by ethnicity. Therefore, the aim of this study was determination of presence or absence of the A2 allele in patients with prostate cancer. Materials and Methods: We studied the association of A2 allele and prostate cancer among 74 patients with prostate cancer and 128 healthy men which were referred to hospitals of SBMU. Results: This study revealed a significant association between prostate cancer risk and the A2 allele in an Iranian population so that A1A2 and A2A2 genotypes were more common in cases than controls with P-values of 0.029 and 0.010, respectively. Conclusions: Results of our study support a possible role of the A2 allele in sporadic prostate cancer development in Iran, in line with findings elsewhere.

A study on attitude and satisfaction of the students in department of dental hygiene (치위생과 재학생의 전공학과에 대한 태도 및 만족도 조사)

  • Jung, Jin-Ah;Jang, Yun-Jung
    • Journal of Korean society of Dental Hygiene
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    • v.11 no.5
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    • pp.649-657
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    • 2011
  • Objectives : The purpose of this study was to research attitude and satisfaction of the students in the department of dental hygiene in Jeolla-do and Chungcheong-do. Methods : We surveyed 499 students at the department of dental hygiene at colleges. During the period from October 2 to October 30, 2009 using a self-administered questionnaires. The data were analyzed with chi-square, t-test and one-way ANOVA, person correlation coefficients and multiple regression using the SPSS 13.0 program. Results : As for entrance motive with Dental Hygiene, 63.9% of the employment and selection information was 36.3% by oneself. As for pre-knowledge before entrance about dental hygiene by grade(p<0.01), as for satisfaction in the department dental hygiene by regional groups(p<0.05), as for aptitude suitability by educational system(p<0.05), as for encourage of enter school by grade and regional groups(p<0.05), by educational system(p<0.01) were statistically significant. As for encourage of enter school, aptitude suitability, pre-knowledge before entrance about dental hygiene were positive relation to satisfaction in the department dental hygiene. Multiple regression analysis indicated with explanatory power of 30.8% about satisfaction in the department dental hygiene. Conclusions : This study reports that it is necessary to carry out further studies on the various educational process and development of program in college. Dental hygiene education for the whole man and for promote efficiency in the department of dental hygiene, should be positive information activity via various media get the correct information of a department choice.

Quality Characteristics of Soybean Dasik Containing Different Amount of Letinus edodes Powder (표고버섯분말 첨가량에 따른 콩다식의 품질특성)

  • Hwang, Su-Jung
    • Korean journal of food and cookery science
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    • v.25 no.6
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    • pp.650-654
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    • 2009
  • The quality characteristics of soybean Dasik with Letinus edodes powder was studied as follows. In general compositions, the moisture content was increased with increase of the amount of the Letinus edodes powder added, The content of crude protein was significantly increased (p<0.05) with increase of the added poweder amount, while the crude fat content was decreased significantly (p<0.05). In textural properties, with increase of the amount of the Letinus edodes powder added, the hardness, the gumminess and the chewiness showed a tendency to be increased significantly, whereas the springiness and the cohesiveness were going to be significantly decreased (p<0.05). In chromacity, with increase of the amount of the Letinus edodes powder added, the value L of lightness was much decreased, showing a significant difference (p<0.05), while the value a of redness and the b of yellowness were significantly high (p<0.001). In sensory acceptability, the appearance, the texture and the softness showed the highest points at the samples with no Letinus edodes powder added, but the taste recorded the top point at the treatment with 40% of the Letinus edodes powder added. From the results said above, a good synergistic effect on health and taste could be expected in point of nutrition and sensory acceptability by using Letinus edodes as a food ingredient. In addition, the possibility to commercialize items like soybean Dasik with Letinus edodes powder was confirmed. Therefore, the research and development of new product using Letinus edodes should be more activated from now on.

Secure Authentication Protocol based on a Chameleon Hash Function for Ambient Living Assisted-Systems (전천 후 생활보조 시스템을 위한 카멜레온 해시 함수 기반의 안전한 인증 프로토콜)

  • Yi, Myung-Kyu;Choi, Hyunchul;Whangbo, Taeg-Keun
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.20 no.4
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    • pp.73-79
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    • 2020
  • Due to the rapidly ageing population and low birth rates, most countries have faced with the problems of an ageing population. As a result, research into aging and the means to support an aging population has therefore become a priority for many governments around the world. Ambient Assisted Living(AAL) approach is the way to guarantee better life conditions for the aged and for monitoring their health conditions by the development of innovative technologies and services. AAL technologies can provide more safety for the elderly, offering emergency response mechanisms and fall detection solutions. Since the information transmitted in AAL systems is very personal, however, the security and privacy of such data are becoming important issues that must be dealt with. In this paper, we propose a Chameleon hash-based secure authentication protocol for AAL systems. The proposed authentication protocol not only supports several important security requirements needed by the AAL systems, but can also withstand various types of attacks. In addition, the security analysis results show that the proposed authentication protocol is more efficient and secure than the existing authentication protocols.

A Survey on Breakfast of Workers in Daegu Area (대구지역 직장인의 아침식사 현황 - 생산직과 사무직의 비교 -)

  • Cho Sung-Hee;Jang Jeong-Hee;Ha Tae-Youl;Lee Kyeung-Soon;Kim Mi-Kyoung;Seo Jung-Sook
    • Korean Journal of Community Nutrition
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    • v.9 no.6
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    • pp.673-682
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    • 2004
  • Breakfast is an important factor for health status of people. This study was carried out to investigate the dietary life related to breakfast of workers and to develope some nutritional convenient diets for the workers. The collected data were consisted of items about general characteristics of the subjects, breakfast pattern, factors affecting on breakfast and opinions on convenient foods. The subjects were classified into labor workers (n=202) and office workers (n=227) aged from twenties to fifties. The rate of skipping breakfast in workers was $31.5\%$ and higher according to the increase of age. Their favorite style of breakfast was mostly Korean traditional diets, but only $38.1\%$ of the subjects had cooked rice as breakfast. The main reason for skipping breakfast was that they had no time for it. But $65.4\%$ of total workers had experiences of using convenience diets. They had these kinds of diets because of convenience. These results suggest that recipe development of convenient breakfast is very important for the good dietary life of the workers.