• BMB Reports
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• v.45 no.6
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• pp.365-370
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• 2012

Hepatitis B virus (HBV) DNA is often integrated into hepatocellular carcinoma (HCC). Although the relationship between HBV integration and HCC development has been widely studied, the role of HBV integration in HCC development is still not completely understood. In the present study, we constructed a pooled BAC library of 9 established cell lines derived from HCC patients with HBV infections. By amplifying viral genes and superpooling of BAC clones, we identified 2 clones harboring integrated HBV DNA. Screening of host-virus junctions by repeated sequencing revealed an HBV DNA integration site on chromosome 11q13 in the SNU-886 cell line. The structure and rearrangement of integrated HBV DNA were extensively analyzed. An inverted duplicated structure, with fusion of at least 2 HBV DNA molecules in opposite orientations, was identified in the region. The gene expression of cancer-related genes increased near the viral integration site in HCC cell line SNU-886.

• Bulletin of the Korean Chemical Society
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• v.31 no.7
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• pp.1833-1834
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• 2010

• Health Policy and Management
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• v.17 no.2
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• pp.68-90
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• 2007

Nurse staffing level is an important factor that influences the quality of health service and patient outcomes. This study was carried out to examine the current state of acute hospital nurse staffing and find out factors that affect the nurse staffing level. Nurse staffing of individual hospitals was measured using the number of registered nurses per 100 beds. Descriptive and multiple regression analyses were conducted using 592 acute care hospitals' data. Regression model included structure factors such as referral level, ownership, medical and general staffing, and financial outcome factors such as occupancy rate, inpatient and outpatient revenues. Market characteristics included strength of competition, supply of nurses, and income and health status level of consumers. The average number of nurses per 100 beds was 28 and showed a great variation according to the referral level. Regression model explained this variation as much as 76.87%. Hospital structure variables which affecting the hospital nurse staffing level positively were ICU bed ratio, the staffing level of specialist, training doctor and employees except doctor and nursing personnel, while the negative factor was nurse aid staffing level. General hospitals employed more nurses than hospitals. Among outcome characteristics, occupancy rate and the amount of health insurance inpatient revenue affected positively on the hospital nurse staffing level. The more supply of the new nurse and the higher consumer income and health status in the medical service markets, the more nurses were employed by the medical institutes. According to the study result, hospitals employed more nurses when they had more financial incentive by increasing nurses. This means appropriate hospital incentive policy and regulation policy, which hospital violate nurse staffing level have to pay penality, should be needed. Clarifying job description between nurses and nurse aids and the reentry program for unemployed experienced nurses will be helpful to increase nurse staffing level.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.2
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• pp.20-26
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• 2013

We propose PHY Frame Structure for M2M direct communications in licensed frequency band. Especially, the proposed PHY Frame Structure coexists in the same licensed frequency band as currently operating cellular systems. Recently, Machine to Machine (M2M) service markets, including SmartGrid, Mobile Health, and Smart Car, are being rapidly expanded. Supporting M2M services in a specific case can waste Radio Resource in cellular systems. For example, when two M2M terminals communicating to each other are closely located, direct communication is radio resource efficient. In this paper, we set the requirement of maintaining the existing PHY frame structure in cellular systems to meet the backward compatibility. Based on this backward compatibility requirement, PHY frame structure for M2M direct communications is developed while satisfying coexistence with current operating cellular system. The proposed PHY frame structure meets backward compatibility. Accordingly, it is expected that the proposed M2M frame structure is useful for its frequency resource efficiency.

• Proceedings of the Zoological Society Korea Conference
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• 1999.10b
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• pp.165.1-165
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• 1999

No Abstract, See Full Text

• Safety and Health at Work
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• v.3 no.2
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• pp.92-100
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• 2012

Objectives: The French National Occupational Diseases Surveillance and Prevention Network (RNV3P) is a French network of occupational disease specialists, which collects, in standardised coded reports, all cases where a physician of any specialty, referred a patient to a university occupational disease centre, to establish the relation between the disease observed and occupational exposures, independently of statutory considerations related to compensation. The objective is to compare the relevance of disproportionality measures, widely used in pharmacovigilance, for the detection of potentially new disease ${\times}$ exposure associations in RNV3P database (by analogy with the detection of potentially new health event ${\times}$ drug associations in the spontaneous reporting databases from pharmacovigilance). Methods: 2001-2009 data from RNV3P are used (81,132 observations leading to 11,627 disease ${\times}$ exposure associations). The structure of RNV3P database is compared with the ones of pharmacovigilance databases. Seven disproportionality metrics are tested and their results, notably in terms of ranking the disease ${\times}$ exposure associations, are compared. Results: RNV3P and pharmacovigilance databases showed similar structure. Frequentist methods (proportional reporting ratio [PRR], reporting odds ratio [ROR]) and a Bayesian one (known as BCPNN for "Bayesian Confidence Propagation Neural Network") show a rather similar behaviour on our data, conversely to other methods (as Poisson). Finally the PRR method was chosen, because more complex methods did not show a greater value with the RNV3P data. Accordingly, a procedure for detecting signals with PRR method, automatic triage for exclusion of associations already known, and then investigating these signals is suggested. Conclusion: This procedure may be seen as a first step of hypothesis generation before launching epidemiological and/or experimental studies.

• Journal of Preventive Medicine and Public Health
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• v.27 no.4 s.48
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• pp.777-791
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• 1994

For developing the Group Health Care System, health managers' job structure were analysed in the aspects of content, amount, and process. As a trial research, data were collected by a standardized job analysis table to 6 doctors, 40 nurses, and 11 industrial hygienists of Group Health Care System. Health care managers were performing complex and intellectual jobs such as healh education for workers, managing health care, conference as well as more simple jobs like as filling diary. Especially, job was consisted of general job and health care management job in the proportion of 1:2.18. The major general job were data management related with the health statistics, and major health care management jobs were managing health care, health counselling, environmental management of working sites. Each specific jobs were required differentiated intellectual capacity, creativity, autonomy, psychic stress, and physical work; most respondents perceived that health care management jobs should require more inputs than general jobs. Additionally job satisfaction and perceived need on specific Job items were anzlysed. Results of this research, suggested through the field experiences in working sites, should be considered for improving the Group Health Care System.

• Journal of Digital Convergence
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• v.15 no.2
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• pp.251-262
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• 2017

This study distinguishes between factors that affect mental health of college students, establishes an effective approach to integrating model building, mental health promotion, and development of nursing intervention based on the Bronfenbrenner's ecological system theory. The study method investigate the causal relationship between the factors. The SPSS 20.0 program was used for general characteristics and mental health related characteristics. The fitness of the model was verified and the Amos 20.0 program was used for hypothesis verification. In the study, the fit index of the model was $x^2=614.90$ (p = .000), Q value = 3.5, GFI = .88, AGFI = .84, NFI = .92, NNFI = .94, CFI = .02, and RMSEA = .08, respectively. The results showed that stress was the most influential on mental health, and that stress coping strategies, self - esteem and parenting attitude affect mental health. In order to improve the mental health of college students, intervention should be carried out to develop nursing interventions to improve stress management, self - esteem, and coping with stress.

• Korea Journal of Hospital Management
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• v.15 no.4
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• pp.1-26
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• 2010

We achieved both industrialization and democratization during the shortest period in the world. We also achieved good performance in national health insurance: universal coverage, solidarity in financing, equitable access of health care. However, national health insurance system has faced the problem of sustainability: various expenditure and financing problems. The problem of sustainablity has two facets of economic sustainability and fiscal sustainability. Economic sustainability refers to growth in health spending as a proportion of gross domestic product(GDP). Rapid increasing rate of health spending exceeds the growth rate of domestic product. Growth in health spending is more likely to threaten other areas of economic activity. Concern on fiscal sustainability relates to revenue and expenditure on health care. Health care financing face demographic and technical obstacles. Democratic obstacle is aging problem. Technical obstacle is collection of contribution. Expenditure of health care has various problems in benefit structure and efficiency of health care system. In this article, I suggest several policy reforms to enhance sustainability: generating additional revenue from value added tax, changing method of levying contribution, increasing efficiency of health care system by introducing the competition principle. restructuring of benefit scheme of health insurance. contracting with health care institutions to provide health care services.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.2
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• pp.387-395
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• 2013

It is important to collect reliable measured data for proper bridge health monitoring. However, in reality incomplete and unreliable data may be acquired due to sensor problems and environmental effects. In case of sensor malfunction, parts of measured data are missing and thus health monitoring cannot be carried out reliably. Due to environmental effects such as temperature variation, dynamic characteristics of natural frequencies may change as if the structure is damaged. The paper proposes a systematic procedure of data processing and data analysis for reliable structural health monitoring. Also, it applies the Mahalanobis distance as a health index computed statistically using revised data. The proposed procedure has been examined using numerically simulated data from a truss structure and then applied to a set of field data measured from Seohae cable-stayed bridge.