• Journal of Preventive Medicine and Public Health
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• v.39 no.2
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• pp.177-183
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• 2006

Objectives : In this study we examined the association between the genetic markers ACE (A-240T, C-93T, I/D, A2350G), AGT (M235T), AT1R (A1166C), CYP11B2 (T344C, V386A), REN (G2646A), ADRB2 (G46A, C79G, T47C, T1641), GNB3 (C825T) and ADD1 (G460W) and the presence of essential hypertension in adolescents. Methods : The Kangwha Study is an 18-year prospective study that is aimed at elucidating the determinants of the blood pressure level from childhood to early adulthood. For this study, we constructed a case-control dataset of size of 277 and 40 family trios data from the Kangwha Study. For this purpose, we perform a single locus-based case-control association study and a single locus-based TDT (transmission/disequilibrium test) study. Results : In the case-control study, the single locus-based association study indicated that the ADD1 (G460W) (p=0.0403), AGT (M235T) (p=0.0002), and REN (G2646A) (p=0.0101) markers were significantly associated with the risk of hypertension. These results were not confirmed on the TDT study. This study showed that genetic polymorphisms of the ADD1, AGT and REN genes might be related to the hypertension in Korean adolescents. Conclusions : This study provided useful information on genetics markers related to blood pressure. Further study will be needed to confirm the effect of the alpha adducin gene, the angiotensinogen gene and the renin gene on essential hypertension.

• Journal of Korean Public Health Nursing
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• v.1 no.1
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• pp.5-16
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• 1987

This study was carried out to assess the self-care ability of the adged diabetic patients. To achieve such a purpose, thirty cases of the adged patients were sampled the regular and' the irregular hospital visiting group respectively from 20th, Oct. to 29th, Oct. in 1985. The data were collected by means of personal & telephone interview, chart review, and home visiting, and analysed by use of percentage, t-test, $X^2-test$ and Pearson-correlation coefficient. The obtained results were as follows: the regular group scored more than the irregular one (1) on the knowledge of the D. M .. , (2) in expecting internal control on the Health Locus of Control, (3) on the self-care behaviors. The results show us that the self-care of the aged diabetic patient could and must be developed by the adequate nursing intervention.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.7
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• pp.4711-4722
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• 2015

This study was performed to determine the smartphone addiction and it's association with various related factors such as sociodemographic characteristics, family life characteristics, school life characteristics, health related characteristics, psychosocial factors(self esteem, anxiety, locus of control) among the middle school students in rural areas. The self-administered questionnaire were given to 630 middle school students during the period from May 1st to 31th, 2014. As a result, the distribution of smartphone addiction group among all subjects was 24.1%, and smartphone addiction is so complicatedly influenced by various factors as well as sociodemographic characteristics, school life characteristics and health related characteristics, to a greater extent, by self esteem, anxiety and locus of control. Therefore the effective strategy for decrease of smartphone addiction among the middle school students requires the efforts to improve their psychosocial factors.

• Korean Journal of Health Education and Promotion
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• v.20 no.2
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• pp.179-196
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• 2003

This study was aimed at examining the self-reported health-promoting life- style (HPL) and related factors among teachers assumed to be role models for students. The subjects were 300 teachers who were conviently drawn from nine elementary schools and three high schools. The conceptual framework for this study was based on the Pender's revised Health Promotion Model(1996). Data was collected by a mailed survey (response rate, 62.5％) with structured questionnaire. The score of health-promoting life-style was 2.8(full mark： 5.0), harmonized relationship was the highest(3.2), and professional helath management was the lowest(2.0). The related factors to health-promoting life-styles were age, marital stauts, career, perceived health status, self esteem, intermal locus of control, perceived benefit, perceived barrier, self efficacy, and social support in univariate analysis. In the final regression model, predictors of HPL were social support, self esteem, perceived benefit. self efficacy, and perceived health status after control the effects of demographic characteristics (p＜.0001, R2＝0.494). The results generally supported the Pender Model. It is recommended to develop the health promotion program for teachers based on these results, and to evaluate the effect of that program for teacher.

• Genomics & Informatics
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• v.9 no.3
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• pp.114-120
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• 2011

Chronic inflammation has been implicated as one of the important etiological factors in insulin resistance and type 2 diabetes mellitus (T2DM). To investigate the role of anti-inflammatory cytokines in the development of T2DM, we conducted a case-control study to assess the association between IL4/IL4R polymorphisms and disease risk. We firstly identified single nucleotide poly-morphisms (SNP) at IL4 and IL4RA loci by sequencing the loci in Korean participants. Case-control studies were conducted by genotyping the SNPs in 474 T2DM cases and 470 non-diabetic controls recruited from community-based cohorts. Replication of the associated signals was performed in 1,216 cases and 1,352 controls. We assessed effect of IL4 -IL4RA interaction on T2DM using logistic regression method. The functional relevance of the SNP associated with disease risk was determined using a reporter expression assay. We identified a strong association between the IL4 promoter variant rs2243250 and T2DM risk (OR=0.77; 95% CI, 0.67~0.88; p=$1.65{\times}10^{－4}$ in the meta-analysis). The reporter gene expression assay demonstrated that the presence of rs2243250 might affect the gene expression level with ~1.5-fold allele difference. Our findings contribute to the identification of IL4 as a T2D susceptibility locus, further supporting the role of anti-inflammatory cytokines in T2DM disease development.

• The Korean Journal of Emergency Medical Services
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• v.6 no.1
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• pp.87-102
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• 2002

Injury has now replaced disease as the biggest single cause of death in children after their first birthday. Each day child dies from preventable, unintentional injury and the medical cost of these injury is increasing remarkably. It is necessary to develope injury prevention models to explain, predict, manage, evaluate and analyze the information about accident. The purpose of this paper is, firstly, to investigate parent's actions regarding safety measures at home and secondly, to identify the influencing factors of parents' safety behaviors. The selection of such factors is guided by the theoretical framework of the Pender's Health Promotion Model. Method ; The questionnaire was developed on the basis of other investigations, through pilot testing, peer review, and review by field health workers. The questionnaire was completed by 231 mothers of young children. Data was collected between April and May 2002. Variable Use of three different domains of safety behavior, safety habits, supervision and perception of safety devices, were listed. Mothers were self reported on internal locus of control, mother & child relationships, and marital intimacy. Also the elements of the Health Promotion Model: perceived benefit, barrier, threat, and self-efficacy, were surveyed. Results & discussion The results indicate that most parents take considerable action to reduce household hazards. The constructs derived from the Model were statistically significant differences for a small part of the variables on parental behavior to reduce hazards in the home, such as age, education, economic status, self-efficacy, perceived benefit, internal locus of control. Future studies ought to include social influences, such as expectations, perceived norms, knowledge, and child-related variables, relevant to parental safety measures in their home.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2031-2037
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• 2012

Background: Analysis of gene-gene and gene-environment interactions for complex multifactorial human disease faces challenges regarding statistical methodology. One major difficulty is partly due to the limitations of parametric-statistical methods for detection of gene effects that are dependent solely or partially on interactions with other genes or environmental exposures. Based on our previous case-control study in Chongqing of China, we have found increased risk of colorectal cancer exists in individuals carrying a novel homozygous TT at locus rs1329149 and known homozygous AA at locus rs671. Methods: In this study, we proposed statistical method-crossover analysis in combination with logistic regression model, to further analyze our data and focus on assessing gene-environmental interactions for colorectal cancer. Results: The results of the crossover analysis showed that there are possible multiplicative interactions between loci rs671 and rs1329149 with alcohol consumption. Multifactorial logistic regression analysis also validated that loci rs671 and rs1329149 both exhibited a multiplicative interaction with alcohol consumption. Moreover, we also found additive interactions between any pair of two factors (among the four risk factors: gene loci rs671, rs1329149, age and alcohol consumption) through the crossover analysis, which was not evident on logistic regression. Conclusions: In conclusion, the method based on crossover analysis-logistic regression is successful in assessing additive and multiplicative gene-environment interactions, and in revealing synergistic effects of gene loci rs671 and rs1329149 with alcohol consumption in the pathogenesis and development of colorectal cancer.

• The Journal of Korean Physical Therapy
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• v.13 no.1
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• pp.107-114
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• 2001

Recently the number of elderly have been increasing at a rapid pace in Korea. Accompanying this aged society are numerous health problems. Whit this in mind health-promotion behaviors such as physical activity. good nutrition and stress management are vitally important to the elderly in reducing the risk of Health problems, maintaining health and improving the overall quality of life. Health promotion programs for the elderly must be developed. The purpose of th is study was to determine influential cognitive factors on health-promotion behaviors and the effects of previously implemented Health promotion programs. For this, previous studies were reviewed and analyzed. The results were as follows. 1. Cognitive factors on health-promotion behaviors were internal locus of control, perceived health status, self-efficacy, concerns about health, social support, attending social activities. 2. Components of health promotion programs were exercise and health education. Exercise was performed in most programs. The effects of exercise programs were improved flexibility, muscle strength. balance, cardiopulmonary function and elevated ability of daily living, perceived health status, quality of lift and a decrease depression. The results strongly suggest that complex health promotion programs should be developed. Health promotion programs need to include exercise, health education, health counseling and social activities. We have to consider cognitive factors on health-promotion behaviors.

• Journal of Korean Public Health Nursing
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• v.13 no.1
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• pp.12-24
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• 1999

In Korea. the investigation were related of health promotion is actively expanded Since 1990. We analysed the characteristics of the theses for an academic degree. relate to lifestyle of health promotion. have published since 1980. According to age group. analysing causal factors affection the health-promotion and will sugesting for health promotion program strateges. The results were summarized as follows: 1. Health promoting caocept is related to health locus of control. self respect. perceived health status. self ifficacy and gender role. 2. Among health promoting lifestyle. emotional support, self-realizationhygienic lifestyle were significantly positive. and the older. the lesser health-promoting complicnce. 3. Causal factors affecting the health-promoting lifestyle were identified health promoting behaviors wire affected by demographic factors which were gender. age. marrige status. education level. relision. vocation. job satisfaction. economic status and by social support factors which were familiarity. family function personal relationship. gender role. 4. In school age. daily lifestyle behaviors were significantly positive. middle and high schllo age froup were affected by stress. nutrition. social support. self-realization were causal factors explaining health promoting behavior of middle age and old age but. there was problems of exercise behaviors. therefore. the need to develop a health education program for the all age group to improve the health-promoting lifestyle.

• Korean Journal of Health Education and Promotion
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• v.15 no.2
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• pp.185-198
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• 1998

This study was designed to investigate the content of health behavior and to examine factors determining health behavior of nursing students(n=159) in relation to sociodemographic and cognitive variables. Cognitive variables were categorized into saliency of health, susceptibility to illness, and health locus of control. Data analysis prodecure included factor analysis and stepwise multivariate regressions using health behavior as dependent variables. Analysis showed; 1. As a whole, nursing students showed a tendency of lack in positive health behavior, especially in diet-related health behavior. 2. Multiple regression analysis revealed that the factors such as grade, saliency of health, and birth place were to be independently and significantly associated with health behavior: Upper grade students, high level of saliency, urban-born students tend to take health behavior positively. 3. The most influential factor among them was grade, but cognitive inspite of stereotype, poorly impact on health behavior with the exception health. We can guess the effect of education indirectively from these findindgs, but longitudinal studies need to consider the direct effect of education. The results also indicate that the respondents should be encouraged to take health behavior positively. The studies including more other cognitive variables would be conducted for the nursing students in relation to health behavior.