• Archives of Plastic Surgery
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• 제40권5호
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• pp.496-504
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• 2013

Background Amniotic-fluid-derived stem cells and amniocytes have recently been determined to have wound healing effects, but their mechanism is not yet clearly understood. In this study, the effects of amniotic fluid stem cells and amniocytes on wound healing were investigated through animal experiments. Methods On the back of Sprague-Dawley rats, four circular full-thickness skin wounds 2 cm in diameter were created. The wounds were classified into the following four types: a control group using Tegaderm disc wound dressings and experimental groups using collagen discs, amniotic fluid stem cell discs, and amniocyte discs. The wounds were assessed through macroscopic histological examination and immunohistochemistry over a period of time. Results The amniotic fluid stem cell and amniocyte groups showed higher wound healing rates compared with the control group; histologically, the inflammatory cell invasion disappeared more quickly in these groups, and there was more significant angiogenesis. In particular, these groups had significant promotion of epithelial cell reproduction, collagen fiber formation, and angiogenesis during the initial 10 days of the wound healing process. The potency of transforming growth factor-${\beta}$ and fibronectin in the experimental group was much greater than that in the control group in the early stage of the wound healing process. In later stages, however, no significant difference was observed. Conclusions The amniotic fluid stem cells and amniocytes were confirmed to have accelerated the inflammatory stage to contribute to an enhanced cure rate and shortened wound healing period. Therefore, they hold promise as wound treatment agents.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권6호
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• pp.473-480
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• 2010

Introduction: Tooth requiring extraction before radiotherapy in head and neck cancer patients should be performed as long as possible before the initiation of radiation therapy. Conventionally, a minimum 2-week waiting primary healing period is recommended. Although the above 2-week period is ideal, it is not uncommon for the radiotherapist and cancer patient to feel an urgent need to proceed with radiotherapy despite the need for dental care. Therefore, alternative approaches for early radiotherapy, including conservative endodontic treatment and a 1-week waiting primary healing period after dental extraction at the time of radiotherapy were considered and applied based on a literature review Materials and Methods: The clinical study involved 120 head and neck cancer patients who were treated at Wonju Christian Hospital, Wonju College of Medicine, Yonsei University, from January 1995 to December 2004. Results: In the clinical study, there were no specific complications, such as, post-extraction wound infections, radiation osteitis and osteoradionecrosis over the recent 10 years despite the early radiotherapy. Conclusion: Based on the clinical study, a minimum 1-week waiting primary healing period for oral care before radiotherapy is suitable for early radiotherapy in head and neck cancer patients.

• 대한임상전기생리학회지
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• 제6권1호
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• pp.43-55
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• 2008

The purpose of this study was to investigate the effect of microcurrent stimulation intensity($50{\mu}A,\;100{\mu}A,\;300{\mu}A$ - 5 pps pulse frequency was same) on wound healing in rat. Sixty male Korean rats were randomly divided into 4 groups of 15 for 4 different treatment protocols(none-control group, $50{\mu}A,\;100{\mu}A,\;300{\mu}A$ experimental groups). Experimental 20 mm linear wound were made and all animals in the experimental groups were received microcurrent stimulation once a day for 20 minutes until sacrifice days(1st day, 3rd day, 6th day). A vernier caliper was used to measure a wound healing length and an optical microscope was used to determine any histological changes. The repeated measures two-way ANOVA was used for statistical differences in wound healing length. Experimental results were as follows: 1. In the examination with the naked eye, all groups showed similar changes until 1st day. But from 3rd day, a little intercellular fluid soaked through wound region in control group. In experimental groups, little intercellular fluid soaked through wound region, and swelling and redness did not appear. 2. Wound length of experimental $50{\mu}A$ group was significantly decreased than control group(p<0.001). And in the aspect of application period, wound length was significantly decreased in 3th, 6th day than 1st day and 6th day than 3th day (p<0.001). In conclusion, it has been found that the microcurrent stimulation had a positive effect on wound healing. And $50{\mu}A$ stimulation intensity was more effective than other intensities($100{\mu}A,\;300{\mu}A$) in wound healing. Also, low-intensity microcurrent stimulation was more effective on the purpose of wound healing.

• Journal of Korean Neurosurgical Society
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• 제50권1호
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• pp.17-22
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• 2011

Objective : In the present study, authors retrospectively reviewed the clinical outcomes of halo-vest immobilization (HVI) versus surgical fixation in patients with odontoid fracture after either non-surgical treatment (HVI) or with surgical fixation. Methods : From April 1997 to December 2008, we treated a total of 60 patients with upper cervical spine injuries. This study included 31 (51.7%) patients (22 men, 9 women; mean age, 39.3 years) with types II and III odontoid process fractures. The average follow-up was 25.1 months. We reviewed digital radiographs and analyzed images according to type of injury and treatment outcomes, following conservative treatment with HVI and surgical management with screw fixation. Results : There were a total of 31 cases of types II and III odontoid process fractures (21 odontoid type II fractures, 10 type III fractures). Fifteen patients underwent HVI (10 type II fractures, 5 type III fractures). Nine (60%) out of 15 patients who underwent HVI experienced successful healing of odontoid fractures. The mean period for bone healing was 20.2 weeks. Sixteen patients underwent surgery including anterior screw fixation (6 cases), posterior C1-2 screw fixation (8), and transarticular screw fixation (2) for healing the odontoid fractures (11 type II fractures, 5 type III fractures). Fifteen (93.8%) out of 16 patients who underwent surgery achieved healing of cervical fractures. The average bone healing time was 17.6 weeks. Conclusion : The overall healing rate was 60% after HVI and 93.8% with surgical management. Patients treated with surgery showed a higher fusion rate and shorter bony healing time than patients who received HVI. However, prospective studies are needed in the future to define better optimal treatment and cost-effective perspective for the treatment of odontoid fractures.

• Archives of Plastic Surgery
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• 제32권6호
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• pp.727-732
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• 2005

The treatment of wounds of the lower extremity caused by diabetes or vascular dysfunction remains a difficult problem for the plastic surgeon. The use of negative pressure in wound healing is a relatively new method to facilitate chronic wound healing by secondary healing. The use of vacuum-assisted closure(VAC) system is purposed to reduce local edema, increase regional blood flow, enhance epithelial migration, preserve a moist wound environment, reduce bacterial colonization, promote granulation tissue formation, and mechanically enhance wound closure. The VAC also can be used as a dressing for anchoring an applied split thickness skin graft. We reviewed the data from 20 consecutive patients with non-healing wound in lower extremity at Dong-A University from March 2002 to December 2004. We used the VAC in 20 patients and compared the results with the control group. In the VAC using group, mean application duration was about 3 weeks and dressing change was done every other day. The follow-up period of patients ranged from 3 months to 30 months with a mean of 17 months. The points of comparison with control group are wound size, granulation tissue proliferation rate, operation method, preoperative time, postoperative healing time, complication, and cost. With those points, we propose to approve the efficiency of the VAC in non-healing wound. As a result, the VAC used in non-healing wound decrease wound size, accelerate granulation tissue formation, do a wound closure with less invasive operation method, make less postoperative complication, can make operation time shorter. Therefore it is cost effect. Our results demonstrate the usefulness of VAC as an adjunct in management of chronic wounds with other extrinsic factors.

• Journal of Yeungnam Medical Science
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• 제38권3호
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• pp.219-224
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• 2021

Background: Omental transposition has been used to facilitate perineal wound healing in patients undergoing abdominoperineal resection (APR). However, there is no high-level evidence supporting the effectiveness of omental transposition in this regard. This study aimed to investigate the clinical efficacy of omental transposition in facilitating perineal wound healing after APR. Methods: In this systematic review, we systematically searched the PubMed/MEDLINE, Embase, Scopus, Cochrane Library, and Web of Science databases for literature regarding the topic of our study. Studies published since the inception of each database were considered for review. The outcomes of interest were the perineal wound healing rate at 1 and 3 months postoperatively, perineal wound infection rate, and perineal wound healing period. Results: Of the 1,923 studies identified, four articles representing 819 patients (omental transposition patients, n=295) were included in the final analysis. The wound healing rates at 1 and 3 months postoperatively in the omental transposition group (68.5% and 79.7%, respectively) did not significantly differ from those in the control group (57.4% and 78.7%, respectively) (p=0.759 and p=0.731, respectively). Perineal wound infection and chronic wound complication rates, including sinus, dehiscence, and fistula rates, also did not significantly differ between the omental transposition (8% and 7%, respectively) and control (11% and 7%, respectively) groups (p=0.221 and p=0.790, respectively). Conclusion: Our results suggest that omental transposition does not affect perineal wound healing in patients who undergo APR.

• 한국건설순환자원학회논문집
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• 제11권4호
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• pp.568-575
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• 2023

본 논문은 스마트 시티 구축을 위한 핵심 기술로서 자기치유 기술을 적용한 프리캐스트 콘크리트의 품질 특성과 치유 성능을 평가하는 것을 목표로 하였다. 연구 결과는 하이브리드 캡슐을 혼합한 프리캐스트 콘크리트가 슬럼프와 공기량에서 감소하는 경향을 보이며, 이는 품질 특성에 일정한 영향을 미치는 것으로 나타났다. 특히, 슬럼프는 최대 14 %, 공기량은 최대 9 % 감소하였다. 또한, 하이브리드 캡슐을 혼합한 콘크리트는 압축강도와 휨강도에서 각각 최대 16 %와 18 % 감소하는 결과를 보였다. 그러나 하이브리드 캡슐을 혼합함으로써 균열 치유 성능이 증진되는 결과를 얻었다. 정수위 투수 시험을 통한 평가에서, 치유기간 28일 후 0.3 mm 균열 폭의 치유율은 혼합률이 증가함에 따라 향상되었으며, 하이브리드 캡슐의 혼합률 1 %, 3 %, 5 %에서 각각 약 16 %, 25 %, 32 %의 치유율 향상이 확인되었다.

• 한국임상수의학회지
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• 제17권1호
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• pp.62-69
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• 2000

The effects of vaselin, silver sulfadiazine and propolis on healing of full-thickness skin defects were evaluated in rabbits. Two wounds measuring 2{times}2cm$ were created bilaterally (4 wounds/rabbit) on the dorsolateral aspect of the trunk of 17 Ne Zealand white. Wound treatments were evenly distributed 4 sites, using a Latin square design. Treatments evaluated were: vaselin(group A), silver sulfadiazine(group B), 5% propolis (group C) and 10% propolis(group D). On days 3, 7 and 14, mean percentage of wound in group A, B, and C. On days 21 and 28, mean percentage of wound contraction in group D were significantly higher than those of groups B and C, but were not higher than that of group A. Microscopically fibersis and epithelialization were noticed on days 14 and 28 after wounding in all group. Rates of fibrosis of collagen fiber and epithelialization of groups C and D were exceeded those of groups A and B. All wounds in all group achieved 100% healing during the 28-day study period. Results indicate that use of propolis as would ointment on full-thickness skin wounds in rabbits increase rate of healing.

• 한국산림휴양학회지
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• 제22권4호
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• pp.1-9
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• 2018

본 연구는 2015년 8월부터 2016년 4월까지 산림청이 조사한 국유치유의 숲에서 진행된 프로그램 활동내용을 분석하여 산림치유 프로그램의 질적 향상을 위한 방안을 모색하였다. 조사된 치유의 숲에서 진행된 프로그램 활동내용 DB자료 99개를 수집하여 활동내용을 확인하고, 조사 양식에 따라 대상자, 6대 요법(인자), 장소, 계절, 시간대, 운영시간, 다면평가에 따라 구분하여 분석하였다. 분석 결과 산림치유 프로그램 활동을 구성할 때 대상자는 대체로 일반적인 대상을 상대로 구성하며, 6대 요법 중 가장 많이 고려된 인자는 정신건강인자였다. 장소는 치유숲길을 가장 많이 활용하였으며, 계절은 봄 여름 가을, 시간대는 오전 오후 모두 가능한 활동이 대부분이었다. 또한, 1개 활동의 운영시간은 60분이, 다면평가에서는 동적인 활동이 프로그램 개발 시 가장 선호되었다. 개발된 산림치유 프로그램의 활동내용을 분석한 결과 산림치유 프로그램의 질적 향상을 위하여 산림치유 프로그램을 개발하는 산림치유지도사의 세분화된 전문성이 강화되어야 할 것이다. 그러나 질환별 산림치유 효과에 대한 연구가 먼저 선행되어야 입증된 연구를 바탕으로 전문성을 갖출 수 있을 것이다.

• 한국건설순환자원학회논문집
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• 제8권1호
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• pp.134-142
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• 2020

본 연구에서는 시멘트 복합체의 자기치유 성능평가를 위해 정수위투수시험, 염소이온 확산시험, 반복휨시험을 활용한 시험방법 및 분석방법을 제시하였고, 균열 유발방법과 균열폭 제어방법을 제안하였다. 정수위 투수시험은 시험체의 균열부를 통과하는 단위유출수량의 감소율을 이용하여 치유성능을 평가하는 시험방법으로 등가 균열폭을 활용하여 치유재령에 따른 치유효과를 직관적으로 규명할 수 있다. 염소이온 확산계수시험은 ASTM C 1202의 시험장치를 활용하여 구한 염소이온 확산계수의 감소율로 치유율을 평가하는 방법이다. 또한, 반복 휨 시험을 통하여 얻은 하중과 CMOD의 관계 그래프로부터 강도회복지수(ISR)과 손상복구지수(IDR)을 산정하여 역학적 치유성능을 평가할 수 있다. 마지막으로, 자기치유 소재의 혼입 유무에 따른 균열 시험체의 실험을 통해 본 연구에서 제시한 자기치유 평가방법의 적용성을 검토하였다.