• Journal of Korean Neurosurgical Society
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• 제29권2호
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• pp.188-195
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• 2000

Objective : Essential tremor(ET) is the most common movement disorder, however, there has been little agreement in the neurologic literature regarding diagnostic criteria for ET. Familial ET is an autosomal dominant disorder presenting as an isolated postural tremor. The main feature of ET is postural tremor of the arms with later involvement of the head, voice, or legs. In previous studies, it was reported that ET susceptibility was inherited in an autosomal dominant inheritance. As previous results, it would suggest that ET might be associated with defect of mitochondrial or nuclear DNA. Recent studies are focusing on molecular genetic detection of movement disorders, such as essential tremor and restless legs syndrome. Moreover, authors have analysed mitochondrial DNA(mtDNA) from the blood cell of positive control(PC) and ET patients via long and accurate polymerase chain reaction(LA PCR). Materials & Methods : Blood samples were collected from PC and 9 ET patients. Total DNA was extracted twice with phenol followed by chloroform : isoamylalcohol. For the analysis of mtDNA, LA PCR was performed by mitochondrial specific primers. Results : With this technique, deletions of large quantities were detected within several regions of mtDNA in ET patients except for D-loop and CO I regions. Conclusion : The authors believe that ET is a genentic disorder with deficiency of mitochondrial DNA multicomplexes and mitochondiral dysfunction could be one of major causative factors of ET. Mitochondrial dysfunction may play an important role in the pathogenesis and possibility of disease progression among familial group with ET patients.

• 한국임상수의학회지
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• 제23권3호
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• pp.337-339
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• 2006

4년령의 중성화된 암컷 말티즈 견이 급성으로 발병하고 4일 동안 지속된 진신 진전 우측으로의 사경 수평성 안구진탕, 그리고 약간의 보행실조에 대한 평가를 위해 내원하였다. 환견은 의식이 뚜렷하고 외부자극에 잘 반응하였다. 신경계 검사 상에서 양안의 수평성-, 위치성 안구진탕 그리고 약간의 보행실조가 나타났다. 또한 양안의 위협반사가 소실된 상태였다. 중등도의 전신 긴장성 진전이 사지와 두부에서 특이적으로 관찰되었다. 혈액검사, 방사선, 그리고 자기공명영상에서 이상소견이 관찰되지 않았다. 뇌척수액의 세포학적 검사를 통해 약간의 비화농성 염증 소견을 확인하였다. 이와 같이 염증성 그리고 특발성의 특징을 가지고 있었기 때문에 스테로이드 반응성 진전 증후군이 강하게 의심되었다. 환견은 면역억제 용량으로 투여된 코르티코스테로이드에 매우 잘 반응하였다. 따라서 진전을 유발하는 다른 원인들을 배제하고, 임상증상 및 치료에 대한 반응에 근거하여 스테로이드 반응성 진전 증후군으로 최종 진단하였다. 이것은 국내에서 스테로이드 반응성 진전 증후군의 최초 보고이며, 이 질환의 임상적 그리고 신경학적 특징들을 기술하고 있다.

• 대한후두음성언어의학회지
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• 제25권2호
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• pp.82-85
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• 2014

Functional dysphonia is a specific voice disorder refers to dysphonia without abnormal anatomical vocal fold findings at larynx. The proportions of this disorder are estimated up to 40% of dysphonia patients at ENT clinics. In this article, we will discuss about other functional dysphonia and neurological dysphonia except for muslce tension dysphonia and spasmodic dysphonia. For details, will describe about phonatory charateristics and treatment options about paradoxical vocal fold motion disorder, mutational dysphonia, essential vocal tremor, conversion dysphonia, and vocal tremor related with parkinson's disease.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2007년도 한국음성과학회 공동학술대회 발표논문집
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• pp.143-145
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• 2007

Muscle groups that are located in and around the vocal tract can produce audible changes in frequency and/or intensity of the voice. Vocal vibrato is a characteristic feature in the singing of performers trained in the western classical tradition and vibrato is generally considered to result from modulation in frequency amplitude and timbre. Vocal tremor is also characterized by periodic fluctuations in the voice frequency or intensity and vocal tremor is symptom of a neurological disease as Spasmodic dysphonia , Parkinson's disease. Vocal vibrato and Vocal tremor may have many of the same origins and mechanisms in the voice production systems. The purpose of this study is to find acostic character of Korean traditional song Pansori singer's vibrato and Spasmodic dysphonia patient's vocal tremor. twelve Pansori singers and seven Spasmodic dysponia patients participated to this study. Power spectrum and Real time Spectrogram are used to analyze the acoustic characteristics of Pansori singing and Spasmodic dysphonia patient's voice The results are as follows; First, vowel formant differences between Pansori singing and Spasmodic dysphonia patient's voice are higher F1, F3. Second, The vibrato rate show differences between Pansori singing and Spasmodic dysphonia patients;$4^{\sim}6/sec$ and $5{\sim}6/sec$ Vibrato rate of pitch is 5.7 Hz ${\sim}$ 42.4 Hz for Pansori singing , 3.8 Hz ${\sim}$ 27.9 Hz for Spasmodic dysphonia patients ;Vibrato rate of intensity range is 0.07 dB ${\sim}$ 8.26 dB for Pansori singing and 0.07 dB ${\sim}$ 4.81 dB for Spasmodic dysphonia patients

• Journal of Korean Neurosurgical Society
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• 제29권11호
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• pp.1415-1420
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• 2000

Essential tremor(ET) is the most common movement disorder however there has been little agreement in the neurologic literature regarding diagnostic criteria for ET. Familial ET is an autosomal dominant disorder presenting as an isolated postural tremor. The main feature of ET is postural tremor of the arms with later involvement of the head, voice, or legs. In previous studies, it was reported that ET susceptibility was inherited in an autosomal dominant inheritance. As with previous results, it would suggest that ET might be associated with defect of mitochondrial or nuclear DNA. Recent studies are focusing molecular genetic detection of movement disorders, such as essential tremor and restless legs syndrome. Parkinson's disease(PD) is a neurodegenerative disease involving mainly the loss of dopaminergic neurons in substantia nigra by several factors. The cause of dopaminergic cell death is unknown. Recently, it has been suggested that Parkinson's disease many result from mitochondrial dysfunction. The authors have analysed mitochondrial DNA(mtDNA) from the blood cell of PD and ET patients via long and accurate polymerase chain reaction(LA PCR). Blood samples were collected from 9 PD and 9 ET patients. Total DNA was extracted twice with phenol followed by chloroform : isoamylalcohol. For the analysis of mtDNA, LA PCR was performed by mitochondrial specific primers. With LA PCR, 1/3 16s rRNA~1/3 ATPase 6/8 and COI~3/4 ND5 regions were observed in different patterns. But, in the COI~1/3 ATPase 6/8 region, the data of PCR were observed in same pattern. This study supports the data that ET and PD are genentic disorders with deficiency of mitochondrial DNA multicomplexes.

• Journal of Korean Neurosurgical Society
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• 제49권3호
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• pp.178-181
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• 2011

Congenital anomalies in arches of the atlas are rare, and are usually discovered incidentally. However, a very rare subgroup of patients with unique radiographic features is predisposed to transient quadriparesis after minor cervical or head trauma, A 46-year-old male presented with a 2-month history of tremor and hyperesthesia of the lower extremities after experiencing a minor head trauma. He said that he had been quadriplegic for about 2 weeks after that trauma. Radiographs of his cervical spine revealed bilateral bony defects of the lateral aspects of the posterior arch of C1 and a midline cleft within the anterior arch of the atlas. A magnetic resonance imaging revealed an increased cord signal at the C2 level on the T2-weighted sagittal image. A posterior, suboccipital midline approach for excision of the remnant posterior tubercle was performed. The patient showed significant improvement of his motor and sensory functions. Since major neurologic deficits can be produced by a minor trauma, it is crucial to recognize this anomaly.

• 대한기관식도과학회지
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• 제17권2호
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• pp.83-88
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• 2011

Robotic thyroidectomy has been developed to minimize neck scarring, and several authors have described its feasibility and safety, and have reported surgical outcomes comparable with conventional open thyroidectomy. The da Vinci surgical system robot provides a three-dimensional $10-12{\times}$magnified view of the surgical area. It also provides hand-tremor filtration, fine motion scaling, and precise and multi-articulated hand-like motions. Recently, robotic technology has also been applied to lateral compartment neck dissection in thyroid cancer. We have developed a new novel selective neck dissection procedure by a gasless unilateral axillo-breast (GUAB) approach with a da Vinci Surgical System for well-differentiated thyroid carcinoma to avoid a long visible neck scar. Based on our early experience, robotic selective neck dissection by GUAB approach is a safe, feasible and cosmetically excellent procedure. It can be an alternative to conventional open surgery in the highly selected patients with well-differentiated thyroid carcinoma. The oncologic safety of robotic selective neck dissection should be verified with long-term follow-up data.

• 한국동물위생학회지
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• 제22권3호
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• pp.257-262
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• 1999

Riemerella anatipestifer (RA) infection is a contagious disease of domestic ducks, turkey, and various other birds. In a flock of mallard ducklings, about 30% of the birds, 3 weeks old, showed lethergy, greenish diarrhea, tremor of head and neck, and died 2-3 days after signs appeared. Grossly, fibrinous exudates covered the heart and surface of the live. Microscopically, mononuclear cells and heterophils were primarily inflammatory cells in the exudate. These were also observed in the meninges in brain. Microbiologically, gram (-) short rod bipolar shaped bacteria were recovered on blood agar and agglutinated by antisera of R anatipestifer. Sulfamethoxasole/trimethoprim were administered and clinically effective. This case was a R anatipestifer infection caused fibrinous pericarditis, hepatitis and meningitis in mallards.

• 대한물리치료과학회지
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• 제11권2호
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• pp.46-56
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• 2004

The purpose of this study was to investigate the effect of watsu therapy on muscle tone in adult hemiparesis patient after stroke. The subject was a 66 year old patient with left hemiparesis whose self gait was independent with minimal assist. The subject was ambulatory with some degree of limitation and demonstrated a little tremor and asymmetry in the body. A multiple treatment design(A-B-C-B) for a single-subject research was used for this study. The watsu therapy consisted of basic moves, head cradle, underfar leg, near leg cradle in watsu I (transition flow), for 25 minutes, which lasted 12 sessions for a total 21 sessions. A baseline was conducted for a first time and a general ROM exercise was conducted after the first watsu therapy. Tone assessment scale was tested : 1. posturing at rest 2. response to passive movement 3. associated reaction Comparing to the baseline and general ROM exercise, The results showed that the watsu therapy had some positive effects on improvement of three tests and there was a more positive effects of both response to passive movement and associated reaction.

• 한국동물위생학회지
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• 제31권1호
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• pp.37-42
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• 2008

Riemerellosis, contagious disease of domestic ducks in Korea, occurred in December of 2007 in a farm located in Eumsung, Chungbuk province. The affected ducks were 22 days old and the owner reported that almost one hundred of ducks had died everyday for a few days after infection. Clinical signs were listlessness, ocular and nasal discharge, greenish diarrhea, ataxia, tremor of head and legs, and coma. On necropsy we found fibrinous exudate, which involved serosal surfaces in general, but most evidences were in the pericardial cavity and over the surface of the liver. The causative agent was isolated from the liver of the affected ducks and identified as Riemerella anatipestifer using biochemical tests. Also, the isolate was susceptible to ampicillin, cephalothin, sulfamethazole/trimethoprim, Florfenicol among the 23 species antibiotics (AST Discs, OXOID) used in our laboratory. Further studies should be needed for the more effective control and better epidemiological information such as pathogenicity, serotype, genotype and treatment.