• 공업화학
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• 제4권4호
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• pp.701-708
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• 1993

$CoMo/{\gamma}-Al_2O_3$ 촉매상에서 $300{\sim}400^{\circ}C$의 온도와 $15-30{\times}10^5$ Pa의 압력 그리고 접촉시간 0.008-0.020 gcat. hr. /ml feed 범위에서 VO-TPP(VO-tetraphenylporphyrin)의 수소 첨가 탈금속반응에 관하여 연구하였다. VO-TPP의 수소 첨가 탈금속반응에서 pyridine 농도 4mole%까지는 농도가 증가함에 따라 전화율의 감소가 나타났으므로 pyridine은 수소 첨가 탈금속반응을 억제한다. $350^{\circ}C$ 이상의 온도에서는 VO-TPP의 외관상 반응차수가 1차였으며, Arrhenius plot에서 얻은 활성화 에너지는 약 23kcal/mole이었다. Fresh 촉매와 aged 촉매의 pore size distribution과 흡착, 탈착 isotherm으로부터 pore mouth-plugging 현상을 확인할 수 있었다.

• 한국임상수의학회지
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• 제22권1호
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• pp.26-30
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• 2005

The purpose of this study is to investigate the prevalent allergens causing canine atopic dermatitis in Daejeon area. Twenty two dogs were diagnosed with atopic dermatitis by an using intradermal skin test (IDST). Allergens used for the IDST included 33 allergen extracts from nine allergen groups: house dust mites (HDM), house dust, moulds, trees, weeds, grasses, insects/fleas, epithelia and others. The 22 purebred dogs with atopic dermatitis enrolled in this study included Shi-tzus (10/22, 45.5%), Yorkshire terriers (5/22, 22.7%), Miniature pinschers (4/22, 18.2%), Pugs (2/ 22, 9.1 %) and Cocker spaniels (1/22, 4.5%). The age of onset of atopic dermatitis ranged from 5 months to 5 years old (median: 1.79 years). The males (12/22, 54.5%) and females (10/22, 45.5%) were almost equal. The number of positive reactions to allergens recorded in each dog with atopic dermatitis was 3 (9/22, 40.9%), 2 (8/22, 36.4%), 1 (3/ 22, 13.6%) and 4 (2/22, 9.1 %), respectively. The most common positive allergen reaction was HDM (52.6%). The other positive allergen reactions recorded were from house dust (17.5%), insects/fleas (15.8%), trees (5.3%), moulds (3.5%), kapok (3.5%), silk (3.5%), epithelia (1.8%), weeds (0%) and grasses (0%), respectively. Positive reactions recorded to Dermatophagoides farinae and D. pteronyssinus were in 53.3% and 46.7%, respectively. The IDST results demonstrate that the most common causative allergens in canine atopic dermatitis in Daejeon area were HDM.

• 대한의생명과학회지
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• 제21권2호
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• pp.122-125
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• 2015

House dust mite (HDM) as a major allergen and damage-associated molecular pattern (DAMP) such as S100A8 and S100A9 trigger the pathogenesis and severity of allergic disease such as asthma. Regulation of neutrophil apoptosis is an important immune response and its dysregulation is involved in pathogenesis of allergic diseases. In this study, we examined the effects of HDM, S100A8 and S100A9 on spontaneous apoptosis of normal neutrophils. We considered the importance of the difference between in vitro and in vivo results and developed a new in vitro system consisting of a combination of immune cells and T helper (Th) cytokines. Extract of Dermatophagoides pteronyssinus (DP), S100A8, and S100A9 inhibited neutrophil apoptosis in culture of neutrophils alone without other leukocytes. DP and S100A8 more strongly suppressed neutrophil apoptosis in combinations of neutrophils, eosinophils, lymphocytes or monocytes than in a culture of neutrophils alone. Anti-apoptotic effect of S100A9 in the mixture of immune cells was similar to that in neutrophils. DP, S100A8, and S100A9 blocked neutrophil apoptosis, regardless of pretreatment with a T helper (Th) 1 cytokine (IFN-$\gamma$), Th2 cytokines (IL-4 and IL-10), a Th9 cytokine (IL-9), a Th17 cytokine (IL-17), a Treg-producing cytokine (TGF-$\beta$). These findings may enable elucidation of allergy pathogenesis due to HDM and DAMP.

• 한국식품과학회지
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• 제13권3호
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• pp.171-175
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• 1981

국내(國內) 산란(産卵)노계(老鷄)와 브로일러로부터 수동(手動) 및 기계발골(機械拔骨)을 할 때의 수율(收率), 발골육(拔骨肉)의 화학적(化學的) 조성(組性), 기계적(機械的) 특성(特性) 저장성(貯藏性), 미생물수(微生物數) 등을 조사하여 다음과 같은 결과를 얻었다. 1. 수동발골의 경우 35%, 기계발골의 경우 45%의 산육수율(産肉收率)을 보여 1차 수동발골을 거친 후 기계발골을 병행(竝行)할 경우 총 산육량(産肉量)은 도체중(屠體重)의 80%에 이르렀다. 2. 기계발골육(器械拔骨肉)은 수분(水分) 65%, 단백질(蛋白質) 12%, 지방(脂肪) 1.7%, Ca $0.2{\sim}0.4%$로서 수동(手動)발(拔)골육(骨肉)에 비해 수분(水分)과 단백질은 낮고 지방(脂肪), 회분(灰分) 및 Ca은 현저히 높았다. 또한 기계(器械)발(拔)골육(骨肉)의 총색소(色素)함량(含量)은 수동발골역(手動拔骨肉)의 2.5배로서 이는 주로 해모그로빈의 증가에 기인하였다. 3. 기계발골육(機械拔骨肉)의 고기 g당 유화능력(乳化能力)은 수동발골육(手動拔骨肉)의 70%에 불과하였으나 단백질 g당 유화능력은 오히려 더 높았는데 이는 기계발골육(機械拔骨肉)의 염용성(鹽溶性) 단백질(蛋白質)의 구성비(構成比)가 수동발골육(手動拔骨肉)보다 높았기 때문이었다. 4. $-20^{\circ}C$에서 냉동(冷凍)저장(貯藏)하는 동안 기계발골육(機械骨肉)의 TBA값은 4주(週)후부터 급격히 증가하였으며 유화능력(乳化能力)도 4주후부터는 낮아져 기계발골육(機械拔骨肉)의 저장(貯藏)은 4주(週) 이내가 권장되었다. 또한 저장 중의 미생물수(微生物數)는 큰 변화없이 $1.8{\times}10^{6}\;cells/g$으로서 수동발골육(手動拔骨肉)의 미생물수(微生物數)와 큰 차이가 없었다.

• Journal of Welding and Joining
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• 제6권3호
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• pp.37-42
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• 1988

The Hole Drilling Method(HDM) is widely used to measure residual stresses in the welded structures. The purpose of this study is to evaluate the accuracy fo measuring residual stresses when drilling the hole by Air-abrasive Jet machine(AJM). Simulated residual stresses wre introduced by applying known stresses to steel bars. These known streses were then compared with measured stresses relaxed from hole drilling. the obtained results are summarized as follows; 1) It was possible to obtain well defined holes with the nozzle designed for this study. 2) If the hole shape is not cylindrical, critical may occur. 3) In the uniaxial strain field, the measurement error of the maximum principal stress was within .+-.10 percent. The orientation angle of the maximum principal stress was within 8.deg. from the given directioin. 4) meausrements were made varying hole depths. Little or no change of stresses occurs since holse were drilled more than the depth of the 0.6 times diameter. 5) The air-abrasive jet machining for drilling holse does not cause appreciable apparent stresses which si critical to measure residual stresses.

• 대한의생명과학회지
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• 제18권4호
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• pp.435-437
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• 2012

House dust mite (HDM) is important in the pathogenesis of allergic diseases including asthma and atopic dermatitis. Dermatophagoides pteronissinus (Dp) is one of major HDM allergens. In this study, we investigated that Dp extract (DpE) affects on the chemotactic activity of monocytes isolated from the peripheral blood. DpE inhibited the migration of human monocytes in response to CC chemokines such as MIP-$1{\alpha}$, RANTES, HCC-4, MCP-1, and TARC. DpE did not alter the expression of CC chemokine receptors (CCRs) such as CCR1, CCR2, CCR3, CCR4, and CCR5. These results indicate that DpE blocks the chemotaxis of human monocytes and its mechanism is not involved in alteration of CCR expression. Better understanding of the effect of DpE on monocytes will enable elucidation of the role of Dp in the development of allergic diseases.

• 한국재난정보학회:학술대회논문집
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• 한국재난정보학회 2016년 정기학술대회
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• pp.433-434
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• 2016

본 논문에서는 최근 발생하는 다양한 기후변화 문제에 따라 복합적인 침수가 많이 발생한다고 판단하여 침수의 복합원인을 찾아내고 그에 따른 값을 모의하게 된다. 침수의 요인으로는 크게 제내지 배수불량에 따른 내수침수와 하천의 수위가 높아져 월류하게 되는 외수범람이 존재한다. 기존의 연구들은 내수침수와 외수범람을 독립적으로 침수해석하여 단순한 선형합의 형태로 내외수 침수를 산정하였으나, 본 연구에서는 2차원 동수역학모형인 HDM-2D 모델을 이용하여 내수침수와 외수범람의 독립적인 모의는 물론 복합적인 모의를 하여 비교, 분석 하고자 한다. HDM-2D모델은 3가지 모형으로 구성된다. 첫째는 2차원 천수방석식과 유한요소법 이산화로 구성된 흐름해석 모형이다. 둘째는 ERG (Exponentially Growth Rate) 기법에 의하여 생성/소멸 기작이 적용된 내수침수 해석 모듈이다. 마지막은 Petrov 안정화 기법에 의한 충격파 전달 해석이 적용되며, Flux-blocking 알고리즘으로 마름/젖음을 안정적 모의할 수 있는 외수범람 해석 모듈이다. 이러한 모델을 통해 내수침수와 외수범람을 독립적, 복합적으로 모의를 진행한다.

• 대한의생명과학회지
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• 제20권1호
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• pp.39-42
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• 2014

Asthma is an allergic inflammation and house dust mite (HDM) is a major allergen to induce asthma pathogenesis. Regulation of eosinophil apoptosis is an essential immune process and its dysregulation is implicated in asthma. In the present study, we examined the effects of HDM on spontaneous apoptosis of asthmatic eosinophils and on cytokine secretion in eosinophils of normal subjects including non-atopic and atopic normal. Extract of Dermatophagoides pteronissinus (DP) inhibited eosinophil apoptosis in a time-dependent manner. DP increased the secretion of G-CSF, GM-SCF, and IL-4, which is involved in suppression of eosinophil apoptosis, but IL-5 expression was not altered after DP stimulation. DP also elevated the release of IL-6, IL-8, tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and CCL2, which are anti-apoptotic or survival factors. The secretion of G-CSF, GM-CSF, IL-6, IL-8, and TNF-${\alpha}$ due to DP is higher in atopic normal than that in non-atopic normal. In conclusion, DP increases the survival of eosinophils and its mechanism may be associated with cytokine release. These findings may enable elucidation of asthma pathogenesis induced by HDM.

• BMB Reports
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• 제50권7호
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• pp.373-378
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• 2017

The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation, but the underlying mechanism is poorly understood. Here, we show that phosphorylation at the threonine 155 residue is essential for Jab1-mediated p53 nuclear export. Jab1 stimulated phosphorylation of p53 at T155 was inhibited by curcumin, an inhibitor of COP9 signalosome (CSN)-associated kinases. The T155E mutant, which mimics phosphorylated p53, exhibited spontaneous cytoplasmic localization in the absence of Jab1. This process was prevented by leptinomycin B (LMB), but not by curcumin. The substitution of threonine 155 for valine (T155V) abrogated Jab1-mediated p53 nuclear export, indicating that phosphorylation at this site is essential for Jab1-mediated regulation of p53. Although T155E can be localized in the cytoplasm in the absence of Mdm2, the translocation of T155E was significantly enhanced by ectopic Hdm2 expression. Our data suggests that Jab1-mediated phosphorylation of p53 at Thr155 residue mediates nuclear export of p53.

• Current Photovoltaic Research
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• 제7권2호
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• pp.51-54
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• 2019

The high density module (HDM) has advantages for its larger active area and smaller current density. This new way of making a photovoltaic (PV) module method has benefit for increasing module power with the same installed area. Because HDM consisted with serially connected PV strings, loss of strings during the fabrication process can increase the overall production cost.1-2 This study investigates the rework conditions of the shingled strings with electrically conductive adhesives (ECA). By heating the electrically connected area of a fabricated string, cured area become soft and a string can be detached for the rework process. After rework process, a refabricated string showed 5~10% increased output power compared to before rework process and reached to the 90~95% output power compare to the undamaged strings.