• 제목/요약/키워드: HbA1c level

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A Study on the Hypoglycemic Effect and Safety of Combined-Therapy of Baekhogainsam-tang and Hypoglycemic Agent for Type 2 Diabetes Mellitus Patients without Complications: A Systematic Review and Meta-Analysis (합병증을 동반하지 않은 2형 당뇨병 환자에 대한 백호가인삼탕과 혈당강하제 병행치료의 혈당 강하 효과 및 안전성 연구 : 체계적 문헌 고찰과 메타분석)

  • Shin, Jae-ik;Baek, Ji-soo;Shin, Seon-mi;Cho, Chung-sik
    • The Journal of Internal Korean Medicine
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    • 제42권4호
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    • pp.672-686
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    • 2021
  • Objectives: The purpose of this study is to assess the efficacy and safety of Baekhogainsam-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: For a systematic review and meta-analysis, we set a key question in accordance with PICOT-SD. We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, and ScienceON. A meta-analysis was conducted by synthesizing the results, including fasting plasma glucose level, postprandial 2-hour plasma glucose level, and Glycated Hemoglobin (HbA1c). Results: A total of five trials are included in this systemic review. The treatment group (Baekhogainsam-tang plus conventional treatment) showed more statistically significant effect than did the control group (conventional treatment only) in fasting plasma glucose level, postprandial 2-hour plasma glucose level, and glycated hemoglobin (HbA1c). Conclusions: Baekhogainsam-tang showed statistically significant effects in hypoglycemic effect and in improving insulin resistance. However, the number of studies included in the meta-analysis was insufficient, and the BIT used in the included studies was not standardized. This topic requires further attention and more clinical research.

Effects of Internet Diabetic Education on Blood Glucose in Hyperglycemic Patients (인터넷 당뇨교육이 고혈당환자 혈당 개선에 미치는 효과)

  • Kim, Hee-Seung
    • Korean Journal of Adult Nursing
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    • 제17권3호
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    • pp.444-451
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    • 2005
  • Purpose: The purpose of this study was to evaluate whether the effect of the Internet diabetic education on plasma glucose in people with hyperglycemic diabetes. Method: A randomized design with control and experimental groups being assessed pre- and post-intervention was used. Twenty-two patients were randomly assigned to an intervention group and 21 to a control group. Participants were requested to input the blood glucose level weekly in http://www.biodang.com by cellular phone or wire Internet for 3 months. The researcher sends optimal recommendations to each patient using short message service(SMS) of cellular phone and wire Internet weekly. Results: Patients in the intervention group had a mean decrease of 1.3% in glycosylated haemoglobin ($HbA_1c$) levels and those in the control group had no significant difference. There was a significant mean change in 2-hour postprandial blood glucose(2HPPG) for the intervention group, with a mean change of-75.2mg/dl. The mean change in the control group was, however, not significant. Conclusion: These findings indicated that a web-based intervention using SMS of cellular phone improved $HbA_1c$ and 2HPPG.

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Identification of Subgroups with Poor Glycemic Control among Patients with Type 2 Diabetes Mellitus: Based on the Korean National Health and Nutrition Examination Survey from KNHANES VII (2016 to 2018) (제 2형 성인 당뇨병 유병자의 혈당조절 취약군 예측: 제7기(2016-2018년도) 국민건강영양조사 자료 활용)

  • Kim, Hee Sun;Jeong, Seok Hee
    • Journal of Korean Biological Nursing Science
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    • 제23권1호
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    • pp.31-42
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    • 2021
  • Purpose: This study was performed to assess the level of blood glucose and to identify poor glycemic control groups among patients with type 2 diabetes mellitus (DM). Methods: Data of 1,022 Korean type 2 DM patients aged 30-64 years were extracted from the Korea National Health and Nutrition Examination Survey VII. Complex samples analysis and a decision-tree analysis were performed using the SPSS WIN 26.0 program. Results: The mean level of hemoglobin A1c (HbA1c) was 7.22±0.25%, and 69.0% of the participants showed abnormal glycemic control (HbA1c≥6.5%). The characteristics of participants associated with poor glycemic control groups were presented with six different pathways by the decision-tree analysis. Poor glycemic control groups were classified according to the patients' characteristics such as period after DM diagnosis, awareness of DM, sleep duration, gender, alcohol drinking, occupation, income status, low density lipoprotein-cholesterol, abdominal obesity, and number of walking days per week. Period of DM diagnosis with a cut-off point of 6 years was the most significant predictor of the poor glycemic control group. Conclusion: The findings showed the predictable characteristics of the poor glycemic control groups, and they can be used to screen the poor glycemic control groups among adults with type 2 DM.

Effect of cassia cinnamon intake on improvement of the glycemic response: An updated meta-analysis - Focus on preparation of dehydrated powder and water extract (계피의 혈당 개선 기능성 평가 : 메타분석 - 건조분말과 물추출물을 중심으로)

  • Kwak, Jin Sook;Park, Min young;Kwon, Oran
    • Journal of Nutrition and Health
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    • 제50권5호
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    • pp.437-446
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    • 2017
  • Purpose: This meta-analysis aimed to evaluate the effect of cassia cinnamon (Cinnamomum. cassia and C. aromaticum) on the glycemic response with a focus on the preparation of dehydrated powder and water extract. Methods: We searched Pubmed, Cochrane, EMBASE, Science Direct, and the Korean Studies Information Service System (KISS) through May 2017. In the meta-analysis for the preparation of powder, eight trials reporting fasting blood glucose (FBG), four trials reporting HbA1c, and three trials reporting the postprandial glycemic response were included. For the water extract, six trials reporting FBG and four trials reporting HbA1c were eligible for this study. A random-effects model was used to calculate the pooled effect size. Results: Cassia cinnamon powder intake significantly lowered FBG by -1.55 mmol/L (95% CI, -2.45, -0.64; p = 0.001) and the AUC of postprandial blood glucose level by $-51.8mmol/L{\cdot}min$ (95% CI, -85.5, -18.1; p = 0.003). There was a significant difference in FBG between water extract of cinnamon and placebo of -0.76 mmol/L (95% CI, -1.09, -0.43; p = 0.000). However, blood HbA1c level was not significantly altered by any preparation of cinnamon. No statistical heterogeneity was observed for any analysis except in the case of FBG for cinnamon powder. Results of funnel plots and Egger's regression suggest a low likelihood of publication bias in all biomarkers (p > 0.05). Conclusion: According to this meta-analysis, there was possible evidence to support a relationship between cassia cinnamon intake and fasting glucose in both preparation of powder and water extract. Furthermore, new evidence of the health benefits on postprandial glucose regulation of cinnamon powder was obtained.

Motor and Somato Sensory Evoked Potentials During Intraoperative Surveillance Testing in Patients with Diabetes

  • Lee, Kyuhyun;Kim, Jaekyung
    • International journal of advanced smart convergence
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    • 제9권1호
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    • pp.37-46
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    • 2020
  • Cerebral vascular surgery can damage patients' motor and sensory nerves; therefore, neuromonitoring is performed intraoperatively. Patients with diabetes often have peripheral neuropathy and may be prone to nerve damage during surgery. This study aimed to identify factors that should be considered when diabetic patients undergo intraoperative neuromonitoring during brain vascular surgery and to present new criteria. Methods: In patients with and without diabetes who underwent cerebrovascular surgery (n = 30/group), we compared the intraoperative stimulation intensity, postoperative motor power and sensory, glycated hemoglobin (HbA1c) and glucose levels, and imaging findings. Results: Fasting glucose, blood glucose, and HbA1c levels were 10%, 12.1%, and 9.7%, respectively; they were higher in patients with than in patients without diabetes. Two patients with diabetes had weakness, and 10 required increased Somato sensory evoked potential (SSEP) stimulation, while in 16, motor power recovered over time rather than immediately. The non-diabetic group had no weakness after surgery, but 10 patients required more increased SSEP stimulation. The diabetic group showed significantly more abnormal test results than the non-diabetic group. Conclusion: For patients with diabetes undergoing surgery with intraoperative neuromonitoring, whether diabetic peripheral neuropathy is present, their blood glucose level and the anesthetic used should be considered.

Molecular Cloning of Pseudomonas sp.Inulinase Gene and its Expresstion in E. coli (Pseudomonas sp. Inulinase 유전자의 클로닝 및 Escherichia coli에서의 발현)

  • 엄수정;권영만;최용진
    • Microbiology and Biotechnology Letters
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    • 제23권5호
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    • pp.550-555
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    • 1995
  • A strain of Pseudomonas sp. isolated from soil was shown to produce a high level of extracellular endo-inulinase. In this work, the endo-inulinase gene (inu1) of the bacterial strain was cloned into the plasmid pBR322 by using EcoRI restriction endonuclease and E. coli HB101 as a host strain. One out of 7, 000 transformants obtained from the above cloning experiment formed a clear zone around its colony on the selective medium supplemented with 2.0% inulin after a prolonged incubation at 37$\circ$C and subsequent cold shock treatment. The functional clone was found to carry a recombinant plasmid (pKMG50) with a 3.7 kb genomic insert containing the genetic information for the inulinase activity. The inulinase from E. coli HB101/pKMG50 was proved to be an endo-acting enzyme and produced constitutively in the recombinant E. coli cells. Zymogram of the enzyme from the recombinant cells with inulin substrate indicated that the molecular mass of the active protein was 190 Kd, while that of the endo-inulinase from the Pseudomonas strain was 170 Kd. This size discrepancy suggested that the inulinase from the recombinant E. coli HB101 cells might be the initial product of translation, not the mature form produced in the strain of Pseudomonas sp..

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Effect of Self-Efficacy Promoting Program on Self-Efficacy, Metabolic Control and Self-Care Behaviors in Patients with NIDDM (자기효능증진프로그램이 당뇨환자의 자기효능, 혈당대사 및 자기간호실천행위에 미치는 효과)

  • Lee, Sook-Hee
    • The Korean Journal of Rehabilitation Nursing
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    • 제8권1호
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    • pp.59-67
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    • 2005
  • Purpose: The purpose of this study is to investigate the effect of Self-Efficacy Promoting Program on Self-Efficacy, Metabolic Control and Self-Care Behaviors in Patients with NIDDM. Method: Data was collected from March 15th to July 15th, 2001. The subjects of the study consisted of 23 NIDDM patients who had visited regularly the endocrinology out-patient department of Gwangju Christian Hospital. The instrument used in the study Paek's self-efficacy measurement scale, was modified by the researcher, self-care behaviors were created by health care teams, and HbA1c for the sugar metabolic control were measured from the patients blood. The Interventions of the self efficacy promoting program were applied 4 hours a week for 6weeks. Data were analyzed with SPSS/PC+, using T-test and Wilcoxon rank sum test. Result: The mean score for self-efficacy was $70.61{\pm}15.48$ of a 140 point scale, the mean score for $HbA_{1c}$ level was $8.07{\pm}1.86%$. The self efficacy promoting program significantly increased the score of self efficacy(Z=-4.198, P=.000). And the self efficacy promoting program was significantly decreased in metabolic control(Z=-2.585, p=.010). Taking medicine and controlling alcohol were the best self care behaviors of this program. Conclusion: It was established that the self efficacy promoting program was effective for improving self efficacy, metabolic level and self care behaviors in patients with NIDDM.

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A Survey of Blood Glucose Testing, Medication, Diet, and Exercise Adherence in Korean Patients with Type2 Diabetes (당뇨병환자의 자가혈당검사, 약물, 식이 및 운동 치료지시이행)

  • Kim Hee-Seung
    • Journal of Korean Academy of Fundamentals of Nursing
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    • 제10권2호
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    • pp.181-186
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    • 2003
  • Purpose: The purpose of this study was to investigate the adherence to diabetes control recommendations (blood glucose testing, medication, diet, exercise) in patients with type 2 diabetes at home and to analyse the correlation between adherence and blood glucose level. Method: Participants, numbering 214, were recruited from the endocrinology outpatient department of a tertiary care hospital in an urban city. The data were collected by a self report adherence questionnaire. Glycosylated haemoglobin (HbA1c) was determined by the high-performance liquid chromatography technique and fasting blood glucose was analyzed by the glucose oxidase method. Result: Medication adherence was higher than diet or exercise adherence. The frequency of blood glucose testing was lower for middle school graduates than college graduates. Diet adherence was significantly lower for participants who were obese, who did not have a spouse, and who had hyperglycemia. Medication and diet adherence were negatively correlated with HbA1c. Conclusion: A diet education program should be developed for patients with type 2 diabetes who are obese, who do not have a spouse, and who have hyperglycemia.

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Effects of Phytoestrogens on Glucose Metabolism in C57BL/KsOlaHsd-db/db Mice (주요 Phytoestrogen들이 제2형 당뇨 마우스의 당질대사에 미치는 효과)

  • Seo, Bo-Hyeon;Kim, Kwang-Ok;Lee, Ji-Hye;Lee, Hye-Sung
    • Journal of Nutrition and Health
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    • 제44권4호
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    • pp.275-283
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    • 2011
  • This study was conducted to evaluate the antihyperglycemic effects of three phytoestrogens, genistein, coumestrol, and enterolactone, in type 2 diabetic animals. Forty male C57BL/KsOlaHsd-db/db mice were used as a diabetic animal model. The animals were divided into four groups and fed a phytoestrogen-free AIN-76 diet (control), or one of three phytoestrogen-supplemented (3.75 mg/100 g diet) AIN-76 diets for six weeks. During the experimental period, fasting blood glucose levels were measured on week 0, 2, 5, and 6 of the experiment, and oral glucose tolerance tests were performed on the 5th week. After the experimental period, blood concentrations of HbA1c, insulin, and glucagon were measured, and hepatic glycogen content and glucose regulating enzyme activities were analyzed. Fasting blood glucose, HbA1c level, and the area under the blood glucose curve in the oral glucose tolerance test were significantly lower in all of the phytoestrogen-supplemented groups compared to the control group. Plasma glucagon levels were also significantly lower in all of the phytoestrogen-supplemented groups compared to the control group. Hepatic glycogen level was significantly higher in the coumestrol-supplemented group compared to the other groups. However, there were no significant differences in the activities of glucokinase and glucose-6-phosphatase between the groups. These results suggest that all of the three major phytoestrogens tested in the present study were effective in lowering blood glucose levels in type 2 diabetic animals. However, further studies need to be conducted to elucidate the exact mechanism for the hypoglycemic effects of phytoestrogens.

Comparison of the Effects of Internet Diabetes Education by Gender in Type 2 Diabetic Patients (제 2형 당뇨병환자 성별에 따른 인터넷 당뇨 교육 효과 비교)

  • Kim, Hee-Seung;Park, Chai-Soon
    • Women's Health Nursing
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    • 제10권2호
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    • pp.144-149
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    • 2004
  • Purpose: The purpose of this study was to evaluate whether the effect of Intenet diabetes education varied by gender. Method: An experimental group assessed pre- and post intervention was used to assess the effectiveness of diabetes education by nurses. Forty patients separated into two groups by gender partook in the study. The goal of the intervention was to keep blood glucose concentrations close to normal range. The intervention was applied weekly for 3 months. Participants were requested to input their blood glucose level, diet, and exercise diary everyday at http://www.biodang.com by cellular phone or wire Internet. The researcher sent optimal recommendations to each patient using the short message service of cellular phones and wire Internet. All medication adjustments were communicated to the subjects' doctors. The plasma glucose levels, serum lipids, and care satisfaction were measured before and after the intervention. Result: Glycosylated hemoglobin (HbA1c) decreased 1.6% and 0.8% in male and female patients respectively after 3 months of education. Total cholesterol decreased 37.2mg/dl in male patients but increased 80.5mg/dl in female patients. Conclusion: These findings indicated that Internet diabetes education could improve HbA1c and total cholesterol in male patients.

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