• 대한인간공학회지
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• 제35권2호
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• pp.97-109
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• 2016

Objective: The aim of this study is to identify the domestic and foreign laboratory safety management system and to suggest domestic laboratory safety management policy priority. Background: Various types of accidents are occurred in research laboratories according to a variety of laboratory safety risks. However, there are only lists of incidents without any precise accident analysis. Method: We analyzed statistically the survey on current status of laboratory safety management of universities, research institutes, and industrial research institutions carried out by Ministry of Science, ICT and Future Planning in Korea. We also investigated laboratory safety management systems and safety organization carried out mainly in overseas countries such as USA, Japan, Switzerland and France. In addition, we analyze the UCLA College laboratory explosion occurred in the US in 2010. Results: More than 75 percent of 2015 domestic laboratory accidents were occurred in the field of operation management and chemistry research. Also, approximately 55% of accidents took place due to careless use mechanical instruments & dangerous chemicals. In addition, common difficulties of lab safety act applicable organizations are overlapping and comprehensive application of legal requirements. Conclusion: There is a need for laboratory safety professional organizations. Also, the high frequency of use of hazardous substances in the high-risk, such as the chemical field must be strengthened the laboratory safety management. In addition, it is needed to minimize the problems of the research organizations through close cooperation between related ministries and government support policy such as professional development program. Application: The result of this analysis might help to present a differentiated safety management policy and advanced safety management system in laboratory.

• 한국직업건강간호학회지
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• 제15권2호
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• pp.144-152
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• 2006

Purpose: This study was conducted to understand the effects of daily hassle stress on the psycho-social health of male workers in manufacturing industry. Methods: Daily hassle stress and psycho-social health in manufacturing industry workers were estimated by using the Daily Hassles Scale for Korea Workers (DHS-KW) and general health questionnaire (GHQ), respectively. Results: The subjects were 553 male workers who had never been occupationally exposed to hazardous chemicals, were mean age 39.6 years and mean work duration was 15.66 years. DHS-KW total mean score had significantly higher in young ages (twenties and thirties ages), office workers, managers and daytime workers than other groups. GHQ total mean scores were significantly higher in un-married, daytime and overtime workers than others. DHS-KW and GHQ score correlated that they were negative correlation with age and working years, but was positive correlation with working hours and overtime work. The significant correlation between DHS-KW and GHQ were observed almost variables of DHS-KW and GHQ except a domestic and daily problem in DHS-KW variables. Domestic and daily problems were only significantly correlated with anxiety and insomnia of GHQ variables. Conclusion: This study indicated that physical health was associated with work condition and psychsocial health was mainly associated with domestic and daily problems of DHS-KW variables. Thus, the study on Daily Hassles stress and related with work stress should be further investigated for the comprehensive health program including stress management and coping behavior.

• 한국직업건강간호학회지
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• 제15권2호
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• pp.133-143
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• 2006

Purpose: The purpose of this study was to examine the relationship between perceived job stress and work environmental factors related with socioeconomics factors and physical burden in the golf caddies. Methods: Job stress in golf caddies was estimated by using the Karasek's job content questionnaire (JCQ) and work environmental factors were estimated by self-reported questionnaire and interview. Results: The subjects were 316 woman caddies who had never been occupationally exposed to hazardous chemicals, was mean age 31.1 years. Mean work duration was 6.44 years and working hours per day on low- and high-demand season were 6.16 and 10.51, respectively. The golf caddies displayed higher scores of job stress due to multiple factors such as working hours and frequency of rounding per week, physical burden, confliction, income satisfaction and employment stability. We found that high strain group was positive correlation with age, career, working hour (including frequency of rounding) and job demand, however, showed negative correlation with job decision latitude and support of supervisor and coworker. Conclusion: In conclusion, we suggest that the golf caddies be regard divided into high strain group as appropriate. Thus, stress management and health promotion program for golf caddies should be developed.

• 한국직업건강간호학회지
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• 제19권1호
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• pp.88-96
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• 2010

Purpose: The aim of the present study was to clarify effects of long term, low-level monocyclic aromatic hydrocarbons exposure (MAHs) such as styrene, toluene and xylene on physiological levels of epinephrine (EP) and norepinephrine (NEP) and these hormones influences diagnosis indices of metabolic syndrome (MetS). Methods: Blood pressure and serum biochemical parameters were measured using digital sphygmomanometer and autochemical analyzer. EP and NEP were analyzed by using ELISA kit and exposure level of MAHs was measured by NIOSH method. Results: The differences of general characteristics such as age, smoking and drinking habits in both groups were not significantly different except working hours per day. In exposed workers, exposure levels of MAHs showed very low concentrations. Serum HDL-cholesterol concentration was significantly higher in exposed group, but concentration of NEP was significantly higher in control group. On multiple logistic regression analysis for the diagnosis indices of MetS, EP was WC (OR=0.970), NEP was blood pressure (OR=1.002) and MAHs exposure were significantly associated with HDL-cholesterol (OR=0.257), fasting glucose (OR=3.028) and MetS (OR=0.372). Conclusion: These findings suggest that the chronic exposure of low level MAHs maycontribute to glucose metabolism and induction of MetS. And also, changes of EP and NEP levels by exposure of MAHs affect blood pressure.

• 한국대기환경학회지
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• 제24권1호
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• pp.1-15
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• 2008

Chemical Accident Response Information System (CARIS) which has been designed for the efficient emergency response of chemical accidents produces the real-time atmospheric fields through the Regional Atmospheric Modeling System, RAMS. The previous studies were emphasized that improving an initial input data had more effective results in developing prediction ability of atmospheric model. In a continuous effort to improve an initial input data, we replaced the land-use dataset using in the RAMS, which is a high resolution USGS digital data constructed in April, 1993, with the latest land-use data of the Korea Ministry of Environment over the South Korea and simulated atmospheric fields for developing a real-time prediction in dispersion of chemicals. The results showed that the new land-use data was written in a standard RAMS format and shown the modified surface characteristics and the landscape heterogeneity resulting from land-use change. In the results of sensitivity experiment we got the improved atmospheric fields and assured that it will give more reliable real-time atmospheric fields to all users of CARIS for the dispersion forecast in associated with hazardous chemical releases as well as general air pollutants.

• 한국환경농학회지
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• 제30권3호
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• pp.346-356
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• 2011

BACKGROUND: Chemical fungicides not only may pollute the ecosystem but also can be environmentally hazardous, as the chemicals accumulate in soil. Biological control is a frequently-used environment-friendly alternative to chemical pesticides in phytopathogen management. However, the use of microbial products as fungicides has limitations. This study isolated and characterized a three-antifungal-enzyme (chitinase, cellulase, and ${\beta}$-1,3-glucanase)-producing bacterium, and examined the conditions required to optimize the production of the antifungal enzymes. METHOD AND RESULTS: The antifungal enzymes chitinase, cellulase, and ${\beta}$-1,3-glucanase were produced by bacteria isolated from an sawmill in Korea. Based on the 16S ribosomal DNA sequence analysis, the bacterial strain AM50 was identical to Streptomyces sp. And their antifungal activity was optimized when Streptomyces sp. AM50 was grown aerobically in a medium composed of 0.4% chitin, 0.4% starch, 0.2% ammonium sulfate, 0.11% $Na_2HPO_4$, 0.07% $KH_2PO_4$, 0.0001% $MgSO_4$, and 0.0001% $MnSO_4$ at $30^{\circ}C$. A culture broth of Streptomyces sp. AM50 showed antifungal activity towards the hyphae of plant pathogenic fungi, including hyphae swelling and lysis in P. capsici, factors that may contribute to its suppression of plant pathogenic fungi. CONCLUSION(S): This study demonstrated the multiantifungal enzyme production by Streptomyces sp. AM50 for the biological control of major plant pathogens. Further studies will investigate the synergistic effect, to the growth regulations by biogenic amines and antifungal enzyme gene promoter.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 추계학술대회 논문집 Vol.16
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• pp.607-610
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• 2003

Ozonic use of sterilization and heat treatment of raw material to extend the conservation period of food recently is increased by hard vegetable or microorganism sterilization purpose of fruit. If ozone can create as is easy comparatively because do air or oxygen by raw material and schedule period passes, there is advantage that do not leave the second contaminant because being gotten restored by oxygen. Also, because the effect is big to decolorization beside disinfection effect about microorganism, deodorization, disjointing of venomousness hazardous substance, food save, Indoor air purge, good hand processing, hydrospace agricultural chemicals processing etc. the use extent is wide. This research ran parallel a sterilization experiment of E.coli colitis germs by ozone that manufacture ozonizer that use doped diamond maund electrode (BDD) by boron and searched special quality electrochemistry enemy of the ozonizer and is created. After cultivate E.coli colitis germs during 37C 1 day is LB ship, after do ozonation, was sterilized more than 90% by ozone as result that examine disinfection effect by substance microscope and could confirm excellency of diamond electrode.

• 한국산업보건학회지
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• 제28권1호
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• pp.91-99
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• 2018

Objectives: From a policy perspective, the introduction of confidential information reviews is a vital task for expanding workers' right to know and improving hazardous materials information communication. In this study, rational methods for introducing and administering confidential information reviews were examined as a part of advancing chemical information communication. Methods: The domestic status, social demands, and control cases from other countries about confidential information in material safety data sheets(MSDSs) were all examined. Additionally, principles for introducing MSDS confidential information review, what needs to be revised prior to its introduction, and procedures and manners of reviewing confidential information were suggested. Results and Conclusions: When composition information on MSDS needs to be protected in the EU and Canada, confidential information should be claimed and then approved by competent authorities with a principle of reviewing confidential information prior to rescinding information from MSDS. Applying the same principle, certain information on an MSDS that needs to be protected should be reviewed and approved in Korea. As a result, the MSDS is communicated with approval numbers replacing composition information. MSDS confidential information review has five steps, including deciding whether chemicals claimed to be confidential are excluded from applying for a confidentiality exemption, the names and concentration ranges of ingredients are adequate, and the claimed information is valid in terms of confidentiality.

• 한국산업보건학회지
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• 제29권3호
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• pp.310-321
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• 2019

Objectives: The purpose of this study was to investigate types and characteristics of chemical substances used in LCD(Liquid crystal display) panel manufacturing process. Methods: The LCD panel manufacturing process is divided into the fabrication(fab) process and module process. The use of chemical substances by process was investigated at four fab processes and two module processes at two domestic TFT-LCD(Thin film transistor-Liquid crystal display) panel manufacturing sites. Results: LCD panels are manufactured through various unit processes such as sputtering, chemical vapor deposition(CVD), etching, and photolithography, and a range of chemicals are used in each process. Metal target materials including copper, aluminum, and indium tin oxide are used in the sputtering process, and gaseous materials such as phosphine, silane, and chlorine are used in CVD and dry etching processes. Inorganic acids such as hydrofluoric acid, nitric acid and sulfuric acid are used in wet etching process, and photoresist and developer are used in photolithography process. Chemical substances for the alignment of liquid crystal, such as polyimides, liquid crystals, and sealants are used in a liquid crystal process. Adhesives and hardeners for adhesion of driver IC and printed circuit board(PCB) to the LCD panel are used in the module process. Conclusions: LCD panels are produced through dozens of unit processes using various types of chemical substances in clean room facilities. Hazardous substances such as organic solvents, reactive gases, irritants, and toxic substances are used in the manufacturing processes, but periodic workplace monitoring applies only to certain chemical substances by law. Therefore, efforts should be made to minimize worker exposure to chemical substances used in LCD panel manufacturing process.

• 한국환경보건학회지
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• 제45권5호
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• pp.457-464
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• 2019

Objectives: Quantitative structure-activity relationship (QSAR) is one of the effective alternatives to animal testing, but its credibility in terms of toxicity prediction has been questionable. Thus, this work aims to evaluate its predictive capacity and find ways of improving its credibility. Methods: Using $TOPKAT^{(R)}$, OECD toolbox, and $Derek^{(R)}$, all of which have been applied world-wide in the research, industrial, and regulatory fields, an analysis of prediction credibility markers including accuracy (A), sensitivity (S), specificity (SP), false negative (FN), and false positive (FP) was conducted. Results: The multi-application of QSARs elevated the precision credibility relative to individual applications of QSARs. Moreover, we found that the type of chemical structure affects the credibility of markers significantly. Conclusions: The credibility of individual QSAR is insufficient for both the prediction of chemical toxicity and regulation of hazardous chemicals. Thus, to increase the credibility, multi-QSAR application, and compensation of the prediction deviation by chemical structure are required.