• 한국환경보건학회지
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• 제33권4호
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• pp.242-249
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• 2007

Indoor air quality has become a topic of interest and concern. Especially changes in construction design and the increased use of synthetic products may result in an increasing of complaints and health effects about the quality of indoor air at home. In this study, nitrogen dioxide($NO_2$) and volatile organic compounds(VOCs) within new and established apartments on the basis of 4 years of building year were measured every 3 days consecutively during 60 days. We selected each 10 house in Seoul, Asan and Daegu, respectively, and produced risk numbers for hazard quotients, and predicted increases in incidence of cancer. The calculations were made for the adult with default exposure values and also made for a worst case scenario using Monte-Carlo simulation as describing the reasonable exposure(RME). Mean of Monte carlo analysis by benzene, in the construction under 4 years (male: $9.2{\times}10^{-5}$, female: $1.0{\times}10^{-4}$) and over 4 years (male: $6.8{\times}10^{-5}$, female: $8.3{\times}10^{-5}$) exceeded $10^{-6}$ of permitted standards in US EPA, RME of Monte carlo analysis. In construction under 4 yews (male: $9.9{\times}10^{-3}$, female: $9.6{\times}10^{-3}$) and over 4 years (male: $9.8{\times}10^{-3}$, female: $7.8{\times}10^{-3}$) exceeded $10^{-4}$ of maximum permitted standards in US EPA. The hazard index of non-carcinogenic pollutants by nitrogen dioxide, toluene, m,p-xylene and o-xylene, both male and female in apartment constructed under 4 yews and over 4 years was found less than the permitted standards of hazardous health effects in CTE. Significant cancer risks and non-cancer hazard quotients were predicted in under 4 yews of building year.

• 대한환경공학회지
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• 제39권7호
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• pp.403-411
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• 2017

본 연구는 낙동강 본류와 연계한 지천중심을 대상으로 항생제(clarithromycin, sulfathiazole, sulfamethazine, sulfamethoxazole, trimethoprim), 항정간제(carbamazepine), 진통제(acetylsalicylic acid, naproxe)를 포함한 8종의 의약물질의 현황 및 시기별 변화에 대해 조사를 실시하였다. 조사 대상물질의 검출 수준은 $1.076{\mu}g/L$까지 나타났으며, 조사 대상물질에서 clarithromycin($0.0316{\mu}g/L$)이 가장 높은 평균 농도로 검출되었고, 다음으로 sulfamethazine ($0.0170{\mu}g/L$), sulfamethoxazole ($0.0161{\mu}g/L$), naproxen ($0.0129{\mu}g/L$), carbamazepine ($0.0093{\mu}g/L$), acetylsalicylic acid ($0.0047{\mu}g/L$), sulfathiazole ($0.0024{\mu}g/L$), trimethoprim ($0.0022{\mu}g/L$) 순으로 나타났다. 낙동강 수계의 지점별 검출 수준은 하류의 농도수준이 상류의 검출 농도보다 상대적으로 높게 나타났다. 2월 조사시기에서 높은 검출 수준을 보였으나, 시기별 차이는 뚜렷하게 나타나지 않았다. 대상 의약물질 8종의 유해지수를 산정한 결과 모두 1보다 낮은 값을 나타내어 낙동강 수계에 미치는 생태위해성은 낮은 것으로 평가되었으나 추후 본 연구대상 물질 외 사용되고 있는 다른 의약물질로 확장 한 연구가 더 수행될 필요가 있는 것으로 판단된다.

• Environmental Analysis Health and Toxicology
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• 제10권1_2호
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• pp.37-46
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• 1995

The purpose of this research is to estimate a safe environmental level of human exposure to thresholding-acting toxicants in drinking water and recommend the acceptable levels and management plans for maintaining good quality of drinking water' and protecting health hazard. This research has been funded as a national project for three years from 1992 to 1995. This study(the second year, 1993-1994) was conducted to monitor 39 species of noncarcinogenic chemicals such as volatile organic compounds(VOCs), polynuclear aromatic hydrocarbens(PAHs), pesticides and heavy metals of drinking water at some area in six cities of Korea, and evaluate health risk due to these chemicals through four main steps (hazard identification, exposure assessment, dose-response assessment and risk characterization) of risk assessment in drinking water. In hazard identification, 39 species of non-carcinogenic chemicals were identified by the US EPA classification system. In the step of exposure assessment, sampling of tap water from the public water supply system had been conducted from 1993 to 1994, and 39 chemicals were analyzed. Inclose-response assessment for non-carcinogens, reference doses(RfD) and lifetime health advisories(HAs) of lifetime acceptable levels were calculated. In risk characterization of detected chemicals, the hazard quotients of noncarcinogens were less than one except those of manganese and iron in D city.

• 한국환경보건학회지
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• 제36권1호
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• pp.14-19
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• 2010

Based on a nationwide survey of the consumption of oriental medicine by the Korean population, we estimated the potential risk from the inadvertent ingestion of heavy metals such as Pb, Hg, As, and Cd as a result such consumption. Compared to the provisional daily intake limit, heavy metal intake through oriental medicine resulted in hazard quotients of less than one. The upper $90^{th}$ percentile exposure estimates for each metal also showed insignificant risk. In relation to inorganic forms that are known carcinogens the excess cancer risk was less than $1{\times}10^7$. Based on the results of this study exposure to Pb, Hg, As, or Cd through oriental medicine intake appeared to be negligible and would not cause a significant impact on health.

• Advances in environmental research
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• 제7권3호
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• pp.201-212
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• 2018

In this study, conditions of solid phase extraction (SPE) for determination of some antibiotics such as trimethoprim, oxytetracycline, erythromycin, clarithromycin, azythromycin, doxycycline, sulfamethazine, ciprofloxacin, chlortetracycline, sulfamethoxazole in wastewaters were optimized. After the optimum volume and pH of the sample were determined, the effect of the concentration of the compounds and matrix were investigated. The highest recovery rates for antibiotic compounds were determined between 82% and 105% in 200 mL sample volume and pH 2.5. Then, antibiotic compounds were investigated in influent and effluent samples taken from Konya Urban Wastewater Treatment Plant. The concentration of the antibiotics was detected range of 0.11-101 ng/L in influent waters and

• 한국환경보건학회지
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• 제45권2호
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• pp.113-125
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• 2019

Objectives: Although the risk assessments for nitrogen dioxide ($NO_2$) and ozone ($O_3$) have been extensively studied, most of the existing risk assessments were limited mainly to indoor environments such as workplaces, schools, and multi-use facilities. Therefore, integrated risk assessment is needed to consider exposure in all microenvironments, including outdoors. The purpose of this study was to assess the differences in risk among sub-population groups according to time-activity patterns and reported concentrations, as well as the lifetime risk of Koreans. Methods: In this study, we estimated time-weighted average exposure concentrations of $NO_2$ and $O_3$ for preschool children, students, housewives, workers, and seniors using residential time and indoor concentrations (house, school or workplace, other), outdoors, and transport by meta-analysis method. The risk for $NO_2$ and $O_3$ were assessed by hazard quotient using reference concentrations 30 and 60 ppb, respectively. The risk assessments were conducted through 1,000,000 Monte-Carlo simulations for probabilistic analysis. Results: Preschool children, students, housewives, workers, and seniors spent 91.9, 86.0, 79.8, 82.2, and 77.3% of their day in a house, school, or workplace, respectively. The risk assessment for the lifetime of a housewife and a worker showed that 33.8 and 28.4% of hazard quotients of $NO_2$ exceed 1, respectively, and more than 99% of hazard quotient of $O_3$ were less than 1. Conclusions: The risk of $NO_2$ and $O_3$ by sub-population group and for the lifetime of housewives and workers were assessed. The risk for $NO_2$ was higher than for $O_3$ and showed a different risk by sub-population group. Both $NO_2$ and $O_3$ showed a higher risk for housewives than for workers. This study can be used as a basis for lifetime exposure and risk assessment for $NO_2$ and $O_3$.

• 한국환경과학회지
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• 제17권1호
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• pp.45-56
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• 2008

This study was to assess the lifetime cancer and non-cancer risk of exposure of worker and user at public facilities in Korea to volatile organic compounds (VOCs). We measured the concentrations of two aldehydes and five VOCs in indoor air at 424 public buildings that 8 kinds of public facilities (70 movie theaters, 86 offices, 86 restaurants, 70 academies, 22 auditoriums, 30 PC-rooms, 30 singing-rooms and 30 bars) all over the country. There were estimated the human exposure dose and risks with averages of the using-time and frequency for facility users and office workers, respectively. Carcinogens (formaldehyde, acetaldehyde, and benzene) were estimated the lifetime excess cancer risks (ECRs). non-carcinogens (toluene, ethylbenzene, xylene, and styrene) were estimated the hazard quotients (HQs). The average ECRs of formaldehyde and benzene for facility worker and user were $1{\times}10^{-3}{\sim}1{\times}10^{-4}\;and\;1{\times}10^{-4}{\sim}1{\times}10^{-5}$ level, respectively, in all facilities. HQs of four non-carcinogens did not exceed 1.0 for all subjects in all facilities. The estimated ECRs for restaurant and auditorium were the highest, and the PC-room and bar were the next higher facilities. Furthermore, people in a smoking facility had the highest cancer risk. Higher ECRs of formaldehyde and benzene were observed in indoor smoking facilities such as restaurant and auditorium. Higher HQs of toluene and xylene were observed at the restaurant and office building.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2005년도 국제학술대회
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• pp.345-350
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• 2005

Acute toxicities of five pharmaceutical products were evaluated with aquatic microbes, invertebrates, and fish. The test pharmaceuticals, i.e., cimetidine, carbamazepine, diltiazem, acetaminophene, and metformin have been often detected in aquatic environment, but theire cological hazard on receptors of various trophic levels has seldom been evaluated. In the present study, we conducted acute toxicity assays with a marine bacterium, Vibrio fischeri, an invertebrate, Daphnia magna, and a fish, Japanese medake (Oryzias latipes). In general, D. magna, showed the most sensitive response to the test chemicals. Diltiazem exhibited the lowest EC50 value after 96 hr of exposure at 7.6 mg/L, followed by cimetidine >acetaminophen > metformin = carbamazepine in an order of decreasing susceptibility. With the fish, diltiazem and carbamazepine showed the 96 hr EC50 values at 14.1${\sim}$35.4 mg/L while acetaminophen, cimetidine, and metformin did not cause 50% mortality at 100 mg/L. Similar pattern was noted with the Microtox Assay, with which the median effective concentrations for acetaminophen, cimetidine, and metformin were found at the range between 301.8 and 755.4 mg/L. Carbamazepine and diltiazem exposure to the microbes resulted in EC50 values around 50 mg/L. Predicted no effect concentrations (PECs) of these pharmaceuticals derived from the EC5O values obtained from this study, and predicted environmental concentrations (PECs) obtained from available literatures were utilized to estimate ecological risks of the test compounds. No test pharmaceuticals resulted in risk quotients (PEC/PNEC) greater than 1, which suggests no serious potential ecological concerns. It should be noted however that further studies including the refinement of PEC derivation, identification and toxicity assessment of the metabolites and/or their interactions with other stressors may be warranted to better understand the environmental consequences of the residual pharmaceutical discharge to the waterway.

• Environmental Analysis Health and Toxicology
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• 제25권1호
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• pp.41-55
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• 2010

The aims of this study were to develop the suitable "system software" in chemical ranking and scoring (CRS) for the food hazardous chemicals associated with environmental emission and to suggest the priority lists of food contamination by environmental-origined pollutants. Study materials were selected with reference to the priority pollutants list for environment and food management from domestic and foreign research and the number of study materials is 103 pollutants (18 heavy metals, 10 PBTs, 10 EDs, and 65 organic compounds). The Food-CRS-Korea system consisted of the environmental fate model via multimedia, transfer environment to food model, and health risk assessment by contaminated food intake. We have established that health risks of excess cancer risks, hazard quotients (HQs) by chronic toxicity and HQs by reproductive toxicity convert to score, respectively. The creditable scoring system was designed to consider uncertainty of quantitative risk assessment based on VOI (Value-Of-Information). The predictability of the Food-CRS-Korea model was evaluated by comparing the presumable values and the measured ones of the environmental media and foodstuffs. The priority lists based on emissions with background-level-correction are 15 pollutants such as arsenic, cadmium, and etc. The priority lists based on environmental monitoring date are 17 pollutants including DEHP, TCDD, and so on. Consequently, we suggested the priority lists of 13 pollutants by considering the several emission and exposure scenarios. According to the Food-CRS-Korea system, arsenics, cadmium, chromes, DEHP, leads, and nickels have high health risk rates and reliable grades.

• Environmental Analysis Health and Toxicology
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• 제25권1호
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• pp.57-68
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• 2010

This study assessed the lifetime cancer and non-cancer risk of aldehydes and volatile organic compounds exposure of young children at child-care facilities and indoor playgrounds in Korea. The samples were collected at various children's facilities (40 day-care houses, 42 child-care centers, 44 kindergartens, and 42 indoor playgrounds) in summer (Jul~Sep, 2007), winter (Jan~Feb, 2008) and Spring (Mar~Apr, 2008) periods, and analyzed by GC-MS. We estimated the lifetime excess cancer risks (ECRs) of formaldehyde, acetaldehyde, benzene, chloroform, CCI4 and tetrachloroethylene, and the hazard quotients (HQs) of Non-carcinogens (toluene, xylene, benzaldehyde and formaldehyde). Formaldehyde evaluated both cancer and non-cancer risk. The average ECRs of formaldehyde for young children were $1\times10^{-4}{\sim}1\times10^{-5}$ level in all facilities. HQs of four non-carcinogens did not exceed 1.0 for all subjects in all facilities.