Characteristic Occurrence and Distributions of Pharmaceuticals in the Nakdong River |
Lee, Heon-Jun
(Department of Civil and Environmental Engineering, Pusan National University)
Kim, Hee-Young (Department of Civil and Environmental Engineering, Pusan National University) Kim, Ki Yong (Department of Civil and Environmental Engineering, Pusan National University) Yang, Duk-Seok (Nakdong River Environment Research Center, National Institute of Environmental Research) Lee, Injung (Nakdong River Environment Research Center, National Institute of Environmental Research) Lim, Young-Kyong (Nakdong River Environment Research Center, National Institute of Environmental Research) Kim, Jae-Hyuk (Department of Civil and Environmental Engineering, Pusan National University) Oh, Jeong-Eun (Department of Civil and Environmental Engineering, Pusan National University) |
1 | Water Information System Home Page, http://wems.nier.go.kr/, March(2017). |
2 | Nakdong River Basin Environmental Office, "A Survey on the Monitoring of Potentially Hazardous Compounds and Contamination Routes in Tributary of the Nakdong River System," pp. 1-212(2015). |
3 | Nakdong River Basin Environmental Office, "Water Quality and Discharge Monitering of Tributaries in the Nakdong River System," pp. 1-465(2015). |
4 | Kim, H. Y., Jung, H. J., Yoo, J. J., Lim, T. H., Lim, Y. K. and Jung, E. O., "Occurrence of Pesticides in the Nakdong River Basin and Risk Assessment," J. Korean Soc. Environ. Anal., 19(1), 1-11(2016). |
5 | Daegu Regional Environmental Office, "Survey on the Hazardous Substances of the Kumho River Basin," pp. 1-207(2015). |
6 | Son, H. J. and Jang, S. H., "Occurrence of Residual Pharmaceuticals and Fate, Residue and Toxic Effect in Drinking Water Resources," J. Korean Soc. Environ. Eng., 33(6), 453-479(2011). DOI |
7 | Korea Meteorological Administration Home Page, http://www.kma.go.kr/weather/climate/past_tendays.jsp, March(2017). |
8 | Choi, K., Kim, Y., Park, J., Park, C. K., Kim, M., Kim, H. S. and Kim, P., "Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea," Sci. Total Environ., 405(1), 120-128(2008). DOI |
9 | Bae, S. M., "Respiratory bacteria and viruses in the aetiology of acute pharyngitis in Korea," Public Health Weekly Report, KCDC, 5(4), ISSN:2005-811X(2012). |
10 | Health Insurance Review and Assessment Service (HIRA), http://opendata.hira.or.kr/home.do, March(2017). |
11 | Nam, S. W., Jo, B. I., Yoon, Y. and Zoh, K. D., "Occurrence and removal of selected micropollutants in a water treatment plant," Chemosphere, 95, 156-165(2014). DOI |
12 | Gros, M., Petrovic, M., Ginebreda, A. and Barcelo, D., "Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes," Environ. Int., 36(1), 15-26(2010). DOI |
13 | Lindholm-Lehto, P. C., Ahkola, H. S., Knuutinen, J. S. and Herve, S. H., "Widespread occurrence and seasonal variation of pharmaceuticals in surface waters and municipal wastewater treatment plants in central Finland," Environ. Sci. and Pollut. Res., 23(8), 7985-7997(2016). DOI |
14 | Santos, J. L., Aparicio, I. and Alonso, E., "Occurrence and risk assessment of pharmaceutically active compounds in wastewater treatment plants. A case study: Seville city (Spain)," Environ. Int., 33(4), 596-601(2007). DOI |
15 | Mano, H. and Okamoto, S., "Preliminary Ecological Risk Assessment of 10 PPCPs and their Contributions to the Toxicity of Concentrated Surface Water on an Algal Species in the Middle Basin of Tama River," J. Water and Environ. Technol., 14(6), 423-436(2016). DOI |
16 | Korea Pharmaceutical Manufacturers Association (KPMA), "Pharmaceutical production in 2009," (2010). |
17 | Korea Institue for Health and Social Affairs (KIHASA), "The Development of Health Care System for Older Koreans," Research Report 2005-04(2005) |
18 | Statistics Korea Home Page, http://kostat.go.kr/portal/korea, March(2017). |
19 | Statistics Korea Home Page, http://www.index.go.kr/potal/main/EachDtlPageDetail.do?idx_cd=1007, March(2017). |
20 | Ministry of Food and Drug Safety (MFDS) Home Page, http://www.mfds.go.kr/index.do?mid=1577&area=04, March(2017). |
21 | National Institute of Environmental Research (NIER), "Development of Analytical Method and Study of Residual Pharmaceuticals (I)," (2008). |
22 | National Institute of Environmental Research (NIER), "Development of Analytical Method and Study of Residual Pharmaceuticals (II)," (2009). |
23 | National Institute of Environmental Research (NIER), "Development of Analytical Method and Study of Residual Pharmaceuticals (III)," (2010). |
24 | National Institute of Environmental Research (NIER), "Development of Analytical Method and Study of Residual Pharmaceuticals (IV)," (2011). |
25 | Da Silva, B. F., Jelic, A., Lopez-Serna, R., Mozeto, A. A., Petrovic, M. and Barcelo, D., "Occurrence and distribution of pharmaceuticals in surface water, suspended solids and sediments of the Ebro river basin, Spain," Chemosphere, 85(8), 1331-1339(2011). DOI |
26 | Carlsson, C., Johansson, A. K., Alvan, G., Bergman, K. and Kuhler, T., "Are pharmaceuticals potent environmental pollutants?: Part I: Environmental risk assessments of selected active pharmaceutical ingredients," Sci. Total Environ., 364(1), 67-87(2006). DOI |
27 | Yoon, Y., Ryu, J., Oh, J., Choi, B. G. and Snyder, S. A., "Occurrence of endocrine disrupting compounds, pharmaceuticals, and personal care products in the Han River (Seoul, South Korea)," Sci. Total Environ., 408(3), 636-643(2010). DOI |
28 | Sim, W. J., Lee, J. W. and Oh, J. E., "Occurrence and fate of pharmaceuticals in wastewater treatment plants and rivers in Korea," Environ. Pollut., 158(5), 1938-1947(2010). DOI |
29 | Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B. and Buxton, H. T., "Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: A national reconnaissance," Environ. Sci. & Technol., 36(6), 1202-1211(2002) DOI |
30 | Fent, K., Weston, A. A. and Caminada, D., "Ecotoxicology of human pharmaceuticals," Aquat. Toxicol., 76(2), 122-159(2006). DOI |
31 | Bound, J. P. and Voulvoulis, N., "Pharmaceuticals in the aquatic environment -- a comparison of risk assessment strategies," Chemosphere, 56(11), 1143-1155(2004). DOI |
32 | EMEA, "Note for Guidance on Environmental Risk Assessment of Medicinal Products for Human Use," CPMP/SWP/4447/00 draft corr(2006). |
33 | FDA, "Guidance for industry Environmental assessment of human drugs and biologics applications," FDA, CDER/CBER, CMC 6, rev.1(1998). |
34 | Nakdong River Basin Environmental Office Home Page, https://www.me.go.kr/ndg/web/main.do, March(2017). |
35 | Yu, J. J., "Management Strategy of Trace Hazardous Compounds in Nakdong River," J. Korean Soc. Environ. Eng., 31(6), 412-416(2009). |
36 | Kim, G. A., Seo, C. D., Lee, S. W., Ryu, D. C. and Kwon, K. W., "Monitoring of Hazardous Chemicals for Effluents of STPs and WWTP in the Nakdong River Basin," J. Environ. Sci. Int., 23(7), 1253-1268(2014). DOI |
37 | Park, C. G., "The problems and countermeasures of the water management in Nakdong river (in Korean)," Nakdong River Res., 4, 4-13(2007). |
38 | Lee, I. J., Lee, C. G., Heo, S. N.., Lee, J. G., Kim, H. R., Yang, D. S. and Lee, Y. H., "Monitoring of hazardous chemicals for wastewater discharge facilities in the Nakdong River basin," J. Korean Soc. Environ. Anal., 14(3), 128-136(2011). |
39 | National Institute of Environmental Research (NIER) Home Page, https://wems.nier.go.kr/, April(2017). |
40 | TGD, "E. U. Technical guidance document on risk assessment in support of commission directive 93/67/EEC on risk assessment for new notified substances, Commission Regulation (EC) No 1488/94 on Risk Assessment for existing substances, and Directive 98/8/EC of the European Parliament and of the Council concerning the placing of biocidal products on the market. Part I-IV," European Chemicals Bureau (ECB), JRC-Ispra (VA), Italy, April 2003. Part II. European Commission Joint Research Centre. EUR, 20418(2003). |
41 | Cleuvers, M., "Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid," Ecotoxicol. and Environ. Saf., 59(3), 309-315(2004). DOI |
42 | Praskova, E., Zivna, D., Stepanova, S., Sevcikova, M., Blahova, J., Marsalek, P. and Svobodova, Z., "Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio," Neuroendocrinol. Lett., 33, 72-76(2012). |
43 | Minguez, L., Pedelucq, J., Farcy, E., Ballandonne, C., Budzinski, H. and Halm-Lemeille, M. P., "Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France," Environ. Sci. and Pollut. Res., 23(6), 4992-5001(2016). DOI |
44 | Jos, A., Repetto, G., Rios, J. C., Hazen, M. J., Molero, M. L., Del Peso, A. and Camean, A., "Ecotoxicological evaluation of carbamazepine using six different model systems with eighteen endpoints," Toxicol. in Vitro, 17(5), 525-532(2003). DOI |
45 | Cunningham, V. L., Buzby, M., Hutchinson, T., Mastrocco, F., Parke, N. and Roden, N., "Effects of human pharmaceuticals on aquatic life: Next steps," Environ. Sci. Technol., 40, 3456-3462(2006). DOI |
46 | Li, Z. H., Zlabek, V., Velisek, J., Grabic, R., Machova, J., Kolarova, J. and Randak, T., "Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): effects on antioxidant responses, hematological parameters and hepatic EROD," Ecotoxicol. and Environ. saf., 74(3), 319-327(2011). DOI |
47 | Isidori, M., Lavorgna, M., Nardelli, A., Pascarella, L. and Parrella, A., "Toxic and genotoxic evaluation of six antibiotics on non-target organisms," Sci. Total Environ., 346(1), 87-98(2005). DOI |
48 | Straub, J. O. and Stewart, K. M., "Deterministic and probabilistic acute-based environmental risk assessment for naproxen for Western Europe," Environ. Toxicol. and Chem., 26(4), 795-806(2007). DOI |
49 | Yang, L. H., Ying, G. G., Su, H. C., Stauber, J. L., Adams, M. S. and Binet, M. T., "Growth-inhibiting effects of 12 antibacterial agents and their mixtures on the freshwater microalga pseudokirchneriella subcapitata," Environ. Toxicol. and Chem., 27(5), 1201-1208(2008). DOI |
50 | Jung, J., Kim, Y., Kim, J., Jeong, D. H. and Choi, K., "Environmental levels of ultraviolet light potentiate the toxicity of sulfonamide antibiotics in Daphnia magna," Ecotoxicol., 17(1), 37-45(2008). DOI |
51 | Paiga, P., Santos, L. H., Ramos, S., Jorge, S., Silva, J. G. and Delerue-Matos, C., "Presence of pharmaceuticals in the Lis river (Portugal): Sources, fate and seasonal variation," Sci. Total Environ., 573, 164-177(2016). DOI |
52 | Kim, Y., Choi, K., Jung, J., Park, S., Kim, P. G. and Park, J., "Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea," Environ. Int., 33(3), 370-375(2007). DOI |
53 | Park, S. and Choi, K., "Hazard assessment of commonly used agricultural antibiotics on aquatic ecosystems," Ecotoxicol., 17(6), 526-538(2008). DOI |
54 | Shanmugam, G., Sampath, S., Selvaraj, K. K., Larsson, D. J. and Ramaswamy, B. R. "Non-steroidal anti-inflammatory drugs in Indian rivers," Environ. Sci. and Pollut. Res., 21(2), 921-931(2014). DOI |
55 | Komori, K., Suzuki, Y., Minamiyama, M. and Harada, A., "Occurrence of selected pharmaceuticals in river water in Japan and assessment of their environmental risk," Environ. Monitoring and Assess., 185(6), 4529-4536(2013). DOI |
56 | Li, W., Gao, L., Shi, Y., Liu, J. and Cai, Y., "Occurrence, distribution and risks of antibiotics in urban surface water in Beijing, China," Environ. Sci.: Proc. & Impacts, 17(9), 1611-1619(2015). DOI |
57 | Patrolecco, L., Ademollo, N., Grenni, P., Tolomei, A., Caracciolo, A. B. and Capri, S. "Simultaneous determination of human pharmaceuticals in water samples by solid phase extraction and HPLC with UV-fluorescence detection," Microchem. J., 107, 165-171(2013). DOI |
58 | Lee, S. H., Jung, H. W., Jung, J. Y., Min, H. J., Kim, B. R., Park, S. G. and Oh, J. E., "Characteristics of Occurrence of Pharmaceuticals in the Nakdong River," J. Environ. Sci. Int., 35(1), 45-56(2013). |