• Title/Summary/Keyword: Harbin

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Expression and Effects of JMJD2A Histone Demethylase in Endometrial Carcinoma

  • Wang, Hong-Li;Liu, Mei-Mei;Ma, Xin;Fang, Lei;Zhang, Zong-Feng;Song, Tie-Fang;Gao, Jia-Yin;Kuang, Ye;Jiang, Jing;Li, Lin;Wang, Yang-Yang;Li, Pei-Ling
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.7
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    • pp.3051-3056
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    • 2014
  • Previous studies have demonstrated that JMJD2A is a potential oncogene and is overexpressed in human tumors. However, its role in the endometrial carcinoma remains largely unknown. In this study, we discovered that JMJD2A was overexpressed in endometrial carcinoma, using immunohistochemistry, quantitative realtime polymerase chain reaction, and western blotting. Downregulation of JMJD2A led to reduced endometrial carcinoma RL95-2 and ISK cell proliferation, invasion and metastasis as asessed with cell counting kit-8, cell migration and invasive assays. Collectively, our results support that JMJD2A is a promoter of endometrial carcinoma cell proliferation and survival, and is a potential novel drug target.

From Fragmented Development to Three-Dimensional and Coordinated Development - Research on Renewal Strategies of Existing Underground Commercial Space in Harbin

  • Xue, Minghui;Su, Yiming;Hu, Jiayu
    • International Journal of High-Rise Buildings
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    • v.10 no.1
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    • pp.17-28
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    • 2021
  • In Harbin, a network of underground commercial spaces has been developed to occupy spaces that were originally created as civil defense shelters. With the gradual extension of the local metro rail system, the existing underground commercial space is no longer an isolated regional development, but a space that represents "three-dimensional city" and coordinated development taking place in many Chinese cities. Based on the analysis of the unique development process taken in underground space of Harbin, this paper summarizes three characteristics of its early model of "fragmented development" of underground space. By conducting a comprehensive field research and survey, the researchers analyzed 472 questionnaires related to the development trend, and proposed multi-level synergistic elements for the renewal and development of underground commercial space. The paper concludes by discussing the trend of "three-dimensional and collaborative development," suitable for the development needs of the new era, and the corresponding development strategies for the renewal of underground space.

A New Green Clustering Algorithm for Energy Efficiency in High-Density WLANs

  • Lu, Yang;Tan, Xuezhi;Mo, Yun;Ma, Lin
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.8 no.2
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    • pp.326-354
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    • 2014
  • In this paper, a new green clustering algorithm is proposed to be as a first approach in the framework of an energy efficient strategy for centralized enterprise high-density WLANs. Traditionally, in order to maintain the network coverage, all the APs within the WLAN have to be powered-on. Nevertheless, the new algorithm can power-off a large proportion of APs while the coverage is maintained as its always-on counterpart. The two main components of the new approach are the faster procedure based on K-means and the more accurate procedure based on Evolutionary Algorithm (EA), respectively. The two procedures are processes in parallel for different designed requirements and there is information interaction in between. In order to implement the new algorithm, EA is applied to handle the optimization of multiple objectives. Moreover, we adapt the method for selection and recombination, and then introduce a new operator for mutation. This paper also presents simulations in scenarios modeled with ray-tracing method and FDTD technique, and the results show that about 67% to 90% of energy consumption can be saved while it is able to maintain the original network coverage during periods when few users are online or the traffic load is low.

Design and implementation of AMD system for response control in tall buildings

  • Teng, J.;Xing, H.B.;Xiao, Y.Q.;Liu, C.Y.;Li, H.;Ou, J.P.
    • Smart Structures and Systems
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    • v.13 no.2
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    • pp.235-255
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    • 2014
  • This paper mainly introduces recently developed technologies pertaining to the design and implementation of Active Mass Damper (AMD) control system on a high-rise building subjected to wind load. Discussions include introduction of real structure and the control system, the establishment of analytical model, the design and optimization of a variety of controllers, the design of time-varying variable gain feedback control strategy for limiting auxiliary mass stroke, and the design and optimization of AMD control devices. The results presented in this paper demonstrate that the proposed AMD control systems can resolve the issues pertaining to insufficient floor stiffness of the building. The control system operates well and has a good sensitivity.

Simplified Rotor and Stator Resistance Estimation Method Based on Direct Rotor Flux Identification

  • Wang, Mingyu;Wang, Dafang;Dong, Guanglin;Wei, Hui;Liang, Xiu;Xu, Zexu
    • Journal of Power Electronics
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    • v.19 no.3
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    • pp.751-760
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    • 2019
  • Since parameter mismatch seriously impacts the efficiency and stability of induction motor drives, it is important to accurately estimate the rotor and stator resistance. This paper introduces a method to directly calculate the rotor flux that is independent of stator and rotor resistance and electrical angle. It is based on obtaining the rotor and stator resistance using the model reference adaptive system (MRAS) method. The method has a lower computation burden and less adaptation time when compared with other rotor resistance estimation methods. This paper builds three coordinate frames to analyze the rotor flux error and rotor resistance error. A number of implementation issues are also considered.

Analysis of Different Activation Statuses of Human Mammary Epithelial Cells from Young and Old Groups

  • Feng, Chen-Chen;Chen, Li-Na;Chen, Mei-Jun;Li, Wan;Jia, Xu;Zhou, Yan-Yan;He, Wei-Ming
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.8
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    • pp.3763-3766
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    • 2014
  • Human mammary epithelial cells have different proliferative statuses and demonstrate a close relationship with age and cell proliferation. Research on this topic could help understand the occurrence, progression and prognosis of breast cancer. In this article, using significance analysis of a microarray algorithm, we analyzed gene expression profiles of human mammary epithelial cells of different proliferative statuses and different age groups. The results showed there were significant differences in gene expression in the same proliferation status between elderly and young groups. Three common differentially expressed genes were found to dynamically change with the proliferation status and to be closely related to tumorigenesis. We also found elderly group had less status-related differential genes from actively proliferating status to intermediate status and more statusrelated differential genes from intermediate status than the young group. Finally, functional enrichment analyses allowed evaluation of the detailed roles of these differentially-expressed genes in tumor progression.

Statics variation analysis due to spatially moving of a full ocean depth autonomous underwater vehicle

  • Jiang, Yanqing;Li, Ye;Su, Yumin;Cao, Jian;Li, Yueming;Wang, Youkang;Sun, Yeyi
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.11 no.1
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    • pp.448-461
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    • 2019
  • Changes in gravity and buoyancy of a Full Ocean Depth Autonomous Underwater Vehicle (FOD-AUV) during its descending and ascending process must be considered very carefully compared with a Human Occupied Vehicle (HOV) or a Remotely Pperated Vehicle (ROV) whose activities rely on human decision. We firstly designed a two-step weight dropping pattern to achieve a high descending and ascending efficiency and a gravity-buoyancy balance at designed depth. The static equations showed that gravity acceleration, seawater density and displacement are three key aspects affecting the balance. Secondly, we try our best to analysis the gravity and buoyancy changing according to the previous known scientific information, such as anomaly of gravity acceleration, changing of seawater states. Finally, we drew conclusion that gravity changes little (no more than 0.1kgf, it is impossible to give a accurate value). A density-depth relationship at the Challenger Deep was acquired and the displacement changing of the FOD-AUV was calculated preciously.