• 근관절건강학회지
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• 제14권1호
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• pp.77-84
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• 2007

Purpose: The purpose of the study was to compare the effects of Tai Chi exercise, Tai Chi self help program, and self help management program on arthritic pain, stiffness, fatigue and difficulties in performing daily activities in patients with osteoarthritis. Method: The pre-post experimental design was utilized with convenient sampling at Public Health Centers. Total of 38 subjects agreed to participate in the study with the inclusion criteria of being diagnosed as osteoarthritis and no previous regular exercise. The 12 subjects were assigned to Tai Chi exercise group, 13 subjects to Tai Chi exercise combined with self help management program, and the other 13 to self help management program. Tai Chi exercise group performed exercise twice a week for one hour per each session. Tai Chi self help management group came to the class twice a week, one hour for Tai Chi exercise, and another hour for self help management program. The third group came to the class once a week for one hour to participate self help management program. At the completion of 6 week programs, 10 subjects from Tai Chi exercise, 9 from Tai Chi self help, another 10 from self help management groups completed the post-test measures. The data were analyzed by SPSSWIN 11.0. The homogeneity tests for three experimental groups were conducted by $X^2-test$, Fisher's exact test, Kruskal-Wallis test. The final analysis of the post-test measures was conducted by ANCOVA with fatigue, pain, stiffness, and difficulties in daily activities of the pretest measures as covariates. Results: The results were as follows. There were no significant differences in fatigue, pain, and difficulties of daily activities among three groups for the pretest measures. The score of arthritic stiffness was significantly different among groups after controlled for covariates, but the post-hoc tests showed no group differences. Conclusion: The nursing interventions applied for osteoarthritis patients have been previously tested to show the cost effectiveness of symptoms management of this population.

• Archives of Pharmacal Research
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• 제28권11호
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• pp.1287-1292
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• 2005

KR-33028 (N-[4-cyano-benzo[b]thiophene-2-carbonyl]guanidine) is a new cardioprotective agent for preventing ischemia-reperfusion injury. This study was performed to identify the metabolic pathway of KR-33028 in human liver microsomes and to compare its metabolism with that of cryopreserved human hepatocytes. Human liver microsomal incubation of KR-33028 in the presence of NADPH and UDPGA resulted in the formation of four metabolites, M1, M2, M3, and M4. M1 and M2 were identified as 5-hydroxy-KR-33028 and 7-hydroxy-KR-33028, respectively, on the basis of LC/MS/MS analysis with the synthesized authentic standard. M3 and M4 were suggested to be dihydroxy-KR-33028 and hydroxy-KR-33028-glucuronide, respectively. Metabolism of KR-33028 in cryopreserved human hepatocytes resulted in the formation of M1, M2, and M4. These data show a good correlation between major metabolites formed in human liver microsomes and cryopreserved human hepatocytes. In addition, KR­33028 was found to inhibit moderately the metabolism of CYP1A2 substrates. Based on the results obtained metabolic pathway of KR-33028 is proposed.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권1호
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• pp.12-21
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• 2015

In an effort to expand working opportunities for women and encourage childbirth, the government of Korea introduced the free infant care policy in 2013. This policy, however, was controversial with regard to issues, such as budget shortages and dissatisfaction based on socioeconomic status. In addition, the lack of evidence-based data regarding adequate age criteria for the entry of children into childcare facilities was noted as a challenge. As child development professionals who are concerned with mental health issues, we investigated the influence and challenges of the free infant care policy with regard to infant mental health. In this review, we examined the policies enacted by developed countries, such as the United Kingdom (UK), and compared them with those in Korea. The childcare systems in Korea and the UK differ historically and socially, but show some similarities, such as maternal responsibility for parenting and household issues. Like Korea, the need for UK childcare facilities increased in the 1990's in response to market recovery and associated increase in female employment. Among the new policies in the UK, the Sure Start program has begun to provide integrated services for infants, particularly to those 0-4 years of age, who are vulnerable to social exclusion. Similar to the Dream Start program in Korea, it has been successful in providing family-related services, resulting in improvements in problematic behaviors of children, enhanced parenting skills, and decreased rates of severely injured children.

• 대한치과보철학회지
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• 제39권1호
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• pp.105-113
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• 2001

The purpose of this study is to compare effects of denture cleansers and disinfectants on the color. surface hardness, and surface roughness of reinforced acrylic resin using polyhedral oligosilsesquioxane molecules(POSS resin) to those of common resins. According to manufacturer's instructions, 45 specimens were made from three denture resins(Luciton 199, Paladent 20, POSS resin), and polished. Five denture cleansers(distilled water, glutaraldehyde, alkaline hypochlorites, chlorhexidine, alkaline peroxides) in combination with three denture resins were evaluated before and after immersion for 7 days. Color data in $L^*a^*b^*$ system were measured with a colorimeter. Surface hardness data were measured with a microhardness tester. Surface roughness data were measured with a 3-dimensional surface analyzer. Data were analyzed with two-way ANOVA, one-way ANOVA, and t-test. The results were as follows : 1. All resins(Luciton 199, Paladent 20, POSS resin) showed significant differences in color after immersion in hypochlorites(p<0.05). 2. POSS resin showed significant differences in color compared with Paladent 20 in all denture cleansers, but no statistically significant differences with Luciton 199(p<0.05). 3. Luciton 199 showed significant differences of surface hardness in chlorhexidine, Paladent 20 showed significant differences in glutaraldehyde and chlorhexidine. POSS resin showed a little change of surface in all denture cleanser, but no statistically significant differences(p<0.05). 4. Luciton 199 and Paladent 20 showed significant differences of surface roughness in hypochlorites and glutaraldehyde, and POSS resin showed no statistically significant differences in all denture cleansers(p<0.05).

• 한국식품영양과학회지
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• 제46권5호
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• pp.630-638
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• 2017

본 연구는 2015년 7월부터 2016년 6월까지의 연구기간 동안 내원한 광주선한병원의 건강검진 수진자들의 인스턴트 커피믹스 섭취량을 조사하여 대사증후군 위험인자와의 연관성을 분석하고자 하였다. 그 결과 인스턴트 커피믹스 섭취와 대사증후군의 위험인자 중 특히 허리둘레와 혈중 중성지방 농도는 양의 상관성을 보였고, 인스턴트 커피믹스 섭취빈도가 증가할수록 공복혈당과 혈중 중성지방 농도가 증가하는 유의적인 상관성을 보였다. 또한, 다중회귀분석에서도 1 cup/d 이상 인스턴트 커피믹스를 섭취하는 대상자에서 보정 여부와 상관없이 대사증후군 위험인자인 혈중 중성지방 농도가 상승하는 유의적인 연관성을 나타냈다. 이와 같은 인스턴트 커피믹스와 관련한 연구 조사와 선행 연구 결과를 통하여 볼 때 건강인은 물론 지방 섭취에 주의해야 할 대상자는 섭취 커피 종류에 따른 섭취 빈도와 섭취량 조절 교육이 중요하다.

• 한국전산구조공학회논문집
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• 제27권6호
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• pp.625-633
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• 2014

본 논문에서는 액화천연가스 운송을 위해 사용되는 맴브레인형 Mark III 화물창 시스템의 주요 구조물인, 방열 판 구조물의 파손 강도 평가를 수행한 내용을 다루고 있다. Mark III 방열 판 구조물을 복합적층 구조물로 고려하였으며 상용화된 범용 유한요소 프로그램인 MSC사의 PATRAN과 MARC를 사용하여 Mark III 방열 판 구조물의 유한요소 모델을 개발하였다. 특히, 액화천연가스 화물의 특성으로 인해 Mark III 방열 판 구조물이 접하는 상온에서 극저온에 이르는 광범위한 온도 분포에 따른 재료 물성치 변화를 유한요소 모델에 포함하였다. 이 유한요소 모델을 기반으로 파손 강도 평가 절차가 확립되었으며, 이 때 Mark III 방열 판 구조물의 파손 발생 여부를 판단하기 위해 Hashin, Hill, Hoffman, maximum stress, 그리고 Tsai-Wu와 같은 이방성 파손 기준들을 사용하였다. Mark III 방열 판 구조물의 전반적인 구조적 거동을 이해하였으며 이후 초기 파손 영역에서 강도 평가를 수행하여 파손이 발생되었을 때의 위치와 하중 등을 알 수 있었다.

• 한국통신학회논문지
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• 제35권8B호
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• pp.1197-1203
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• 2010

최근 파일 공유를 위해 널리 사용되는 BitTorrent의 강점은 BitTorrent의 핵심 메커니즘인 peer 선택 기법에 기인한다. Peer 선택 기법은 해당 호스트가 업로드 할 peer를 선택하는 것인데, 이 때 자신에게 각 peer가 업로드한 비율을 비교해서 가장 많이 업로드한 peer들에게 업로드를 하게 된다. 그런데 BitTorrent에서는 업로드할 peer의 개수 (즉, unchoked peer 개수)를 4개로 고정하고 있다. 하지만 peer들의 개수나 다운로드 속도, 업로드 속도와 같은 공유집단 (즉, swarm)의 특성은 계속 변하기 때문에 unchoked peer 개수를 고정하는 것은 효율적이지 않다. 본 논문에서는 BitTorrent에서 unchoked peer 개수가 고정된 4개가 아니라 변할 때 전체 시스템 성능에 어떠한 영향이 끼치는지 분석한다. 분석을 위해 본 논문에서는 서울대학교 캠퍼스 망에 테스트베드를 설치하였고, 실제로 널리 사용되는 오픈 소스 BitTorrent 클라이언트를 수정해서 사용하였다. 테스트베드에서의 다양한 실험을 통해 BitTorrent의 성능이 unchoke 개수에 따라 달라지게 되는 것을 보였고, 이에 따라 swarm의 상황을 고려해서 unchoke개수를 적절하게 조절하는 메커니즘이 필요하다는 것을 보였다.

• 농약과학회지
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• 제10권4호
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• pp.272-278
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• 2006

국내 등록농약 중 용탈 가능성이 있는 농약을 발굴할 목적으로 토양잔류반감기를 체계적으로 정리하고 이동성을 결정하는 결정적인 변수인 흡착성적을 수집하여, 용탈 가능성 평가수단인 groundwater ubiquity score(GUS)값을 산출하여 국내 등록농약의 용탈 가능성 순위를 결정하였다. 용탈성 평가 대상 농약 성분 382성분 중 297성분의 국내 토양잔류성적을 정리 평가하였다. 논토양과 밭토양 각각 107성분 및 244성분에 대한 국내잔류성적을 보유하고 있는 것으로 나타났다. 외국의 농약 DB자료 등에서 조사한 농약성분별 유기탄소기준흡착계수(Koc) 성적은 미국 오레곤 주립대학 DB에서 148성분이었고, PSD 및 Pesticide Manual을 포함하는 영국/스웨덴 DB자료에서 276성분으로 공통성분을 제하면 317성분에 해당하였다. 국내외 토양잔류 반감기와 외국 DB자료의 Koc값을 이용하여 산출한 GUS에 의하여 313 국내등록 농약성분의 용탈성 구분이 가능하였으며, 용탈 가능성이 매우 높은 농약성분이 18종, 그 다음으로 용탈 가능성이 높은 농약성분이 44종이었다.

• Nutrition Research and Practice
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• 제2권4호
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• pp.289-294
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• 2008

Pre-B-cell leukemia transcription factor 1 (PBX1), which is located on chromosome 1q23, was recently reported to be associated with type 2 diabetes mellitus. We examined whether single nucleotide polymorphisms (SNPs) of the PBX1 gene are associated with overweight/obesity in a Korean population. We genotyped 66 SNPs in the PBX1 gene and investigated their association with clinical phenotypes found in 214 overweight/obese subjects and 160 control subjects using the Affymetrix Targeted Genotyping chip array. Seven SNPs (g.+75l86C>T, g.+78350C>A, g.+80646C>T, g.+138004C>T, g.+185219G>A, g.+191272A>C, and g.+265317T>A) were associated with the risk of obesity in three models (codominant, dominant, and recessive) (P=0.007-0.05). Haplotype 1 (CAC) and 3 (TAC) of block 3 and haplotype 2 (GGAAT) of block 10 were also strongly associated with the risk of obesity. In the control group, subjects that had homozygote for the major allele for both g.+185219G>A and g.+191272A>C showed lower high density lipoprotein-cholesterol (HDL-C) level compared to those possessing the minor allele, suggesting that the association between the homozygote for the major allele for both g.+185219G>A and g.+191272A>C and HDL-C is attributable to the increased risk of obesity. This study suggests that the PBX1 gene is a possible risk factor in overweight/obese patients.

• Journal of Ginseng Research
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• 제39권1호
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• pp.22-28
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• 2015

Background: Sun ginseng (SG), a specific formulation of quality-controlled red ginseng, contains approximately equal amounts of three major ginsenosides (RK1, Rg3, and Rg5), which reportedly has antitumor-promoting activities in animal models. Methods: MTT assay was used to assess whether SG can potentiate the anticancer activity of epirubicin or paclitaxel in human cervical adenocarcinoma HeLa cells, human colon cancer SW111C cells, and SW480 cells; apoptosis status was analyzed by annexin V-FITC and PI and analyzed by flow cytometry; and apoptosis pathway was studied by analysis of caspase-3, -8, and -9 activation, mitochondrial accumulation of Bax and Bak, and cytochrome c release. Results: SG remarkably enhances cancer cell death induced by epirubicin or paclitaxel in human cervical adenocarcinoma HeLa cells, human colon cancer SW111C cells, and SW480 cells. Results of the mechanism study highlighted the cooperation between SG and epirubicin or paclitaxel in activating caspase-3 and -9 but not caspase-8. Moreover, SG significantly increased the mitochondrial accumulation of both Bax and Bak triggered by epirubicin or paclitaxel as well as the subsequent release of cytochrome c in the targeted cells. Conclusion: SG significantly potentiated the anticancer activities of epirubicin and paclitaxel in a synergistic manner. These effects were associated with the increased mitochondrial accumulation of both Bax and Bak that led to an enhanced cytochrome c release, caspase-9/-3 activation, and apoptosis. Treating cancer cells by combining epirubicin and paclitaxel with SG may prove to be a novel strategy for enhancing the efficacy of the two drug types.