• Journal of Pharmaceutical Investigation
• /
• 제23권4호
• /
• pp.225-229
• /
• 1993

The stability of omeprazole in the aqueous solutions containing arginine or sodium phosphate dibasic(SPD) was examined at 30, 40 and $50^{\circ}C$. Arginine or anhydrous SPD was added to omeprazoie solution ($200{\mu}g/\;ml$ in distilled water) to yield $100{\mu}g/\;ml$ concentration of each. Then, the solution was kept at 30, 40 or $50^{\circ}C$ for 90 hrs. Aliquots of the solution were withdrawn at specified time intervals and assayed by HPLC for intact omeprazole. The remaining percentage-time curves revealed that omeprazole was degraded rapidly as funtions of time and temperature following pseudo first-order kinetics. The rate constant in the SPD solution was much higher than in the arginine solution. In other words. the degradation half-lives of omeprazole at $30^{\circ}C$, for example, was 148 and 76 hr in arginine and SPD solutions respectively. The initial pH of the solution containing $100{\mu}g/\;ml$ of arginine or SPD was 9.7 or 8.7, respectively. Since omeprazole is more stable as the pH of its solution becomes more alkaline, the longer half-life of omeprazole in arginine solution could be explained by the more alkaline characteristics of arginine than SPD in the solution. The activation energy necessary for the degradation reaction was almost identical in both solutions, indicating similar degradation mechanisms of omeprazole in the solutions. In conclusion, omprazole was more stable in the presence of arginine than of SPD.

• 성인간호학회지
• /
• 제17권3호
• /
• pp.452-463
• /
• 2005

Purpose: The purpose of the present study was to analyze and evaluate prior studies published in Korea on the cardiovascular disease-related quality of life, in order to make recommendations for further research. Methods: A total of 15 studies were selected from four databases(Digital library of Research Information Center for Health, Korea Medical Database, MedRic, and National Assembly Library). The selected studies were analyzed according to criteria, such as diagnosis/operation, used instrument, generic/specific instrument, dimension of quality of life, translation/ back-translation, sample size, reliability, validity, responsiveness, number of items, type of scale, time required, and independent variables. Results: Of the 15 cardiovascular disease-related quality of life studies, approximately half of them were conducted with hypertension or ischemic heart disease patients. All studies asserted that the concept of quality of life had multidimensional attributes. With respect to the questionnaire used for measuring the quality of life, only one study used a cardiovascular disease specific-instrument and most studies did not consider whether or not the validity of their instrument had been established. In addition, when using questionnaires developed in other languages, only one study employed a translation/back-translation technique. The types of variables tested for their influence on quality of life were quite limited. Conclusion: It is recommended to develop a reliability and validity established cardiovascular disease specific-quality of life for Korean patients and to identify associated new variables.

• Smart Structures and Systems
• /
• 제21권3호
• /
• pp.305-320
• /
• 2018

The second half of the 20th century was marked with a significant raise in amount of railway bridges in Austria made of reinforced concrete. Today, many of these bridges are slowly approaching the end of their envisaged service life. Current methodology of assessment and evaluation of structural condition is based on visual inspections, which, due to its subjectivity, can lead to delayed interventions, irreparable damages and additional costs. Thus, to support engineers in the process of structural evaluation and prediction of the remaining service life, the Austrian Federal Railways (${\ddot{O}}$ BB) commissioned the formation of a concept for an anticipatory life cycle management of engineering structures. The part concerning concrete bridges consisted of forming a bridge management system (BMS) in a form of a web-based analysis tool, known as the LeCIE_tool. Contrary to most BMSs, where prediction of a condition is based on Markovian models, in the LeCIE_tool, the time-dependent deterioration mechanisms of chloride- and carbonation-induced corrosion are used as the most common deterioration processes in transportation infrastructure. Hence, the main aim of this article is to describe the background of the introduced tool, with a discussion on exposure classes and crucial parameters of chloride ingress and carbonation models. Moreover, the article presents a verification of the generated analysis tool through service life prediction on a dozen of bridges of the Austrian railway network, as well as a case study with a more detailed description and implementation of the concept applied.

• 가족자원경영과 정책
• /
• 제15권1호
• /
• pp.51-70
• /
• 2011

This study is to explore the effects of leisure life on multi-cultural family from a view of marriage migrants women. For this purpose, data were collected by in-depth interviews of 24 marriage migrants women who came from 7 countries such as Vietnam, China, Japan etc. They are living in Daejeon city, Okcheon gun(Chungbuk), Gumi city(Gyungbuk) and the length of residence is ranging from 4 and half month to 13 years and 6 months. Data were analyzed by qualitative method. Major findings are as follows: First, individual and family leisure of marriage migrant women had positive effects on adaptation of her family life. Especially, in the early marriage stage, family leisure contributed women's emotional stability. Second, time was the most limiting constraints in family leisure of multi-cultural family. Third, early in the marriage, marriage migrant women who is not fluent in Korean language, customs, and courtesy hinders them from joining their family leisure. Fourth, leisure may seem to contribute to family life satisfaction, but marital relationships and household economy has to be settled beforehand.

• 만화애니메이션 연구
• /
• 통권49호
• /
• pp.465-491
• /
• 2017

본고는 카툰의 외양적 모습을 충실하게 따르는 애니메이션 <플랫 라이프>를 분석하고, 그 외양의 뒤편에 숨겨진 주제와 서사의 방식에 대한 세밀한 분석을 목표로 삼은 연구논문이다. 이 과정에서 모자이크 영상의 내용 전달 방식을 이용해서 <플랫 라이프>가 말하고 있는 주제를 분석한다. 카툰의 서사는 일반적으로 양태적인 부분에서 그 차이점을 논하는 것이 대다수이지만, 이 작품은 나아가 일반 내러티브 영화의 선형적 서사에 도달하는 것이 특징이다. 미자넷 머레이가 설명하듯, 모자이크적 사고방식(mosaic approach)을 통해 모자이크적 접근방식으로 주제에 다가가는 영상 이미지를 '모자이크 영상'이라 칭한다면, 그들 중 영화(film)의 포맷으로 소개되는 작품을 '모자이크 영화'라고 한정시킬 수 있다. 우선 <플랫 라이프>는 개념적으로 '모자이크 영상'의 특성을 이용하면서, 나아가 '모자이크 영화'의 서사 특징을 활용하는 작품이다. 작품을 분기별로 분석하면, 전반부가 개방된 모자이크 영상 플랫폼의 성향을 한껏 드러내고, 후반부는 영화서사의 선형적 내러티브 방식을 도입한다는 것을 알게 된다. 본고는 '멀티 플롯 필름'의 서사 방식을 모자이크 내러티브(mosaic narrative) 영화와, 네트워크 내러티브(network narrative) 영화, 그리고 멀티 드래프트 필름(multi-draft film)의 세 가지로 구분하고, 병렬되거나 병치되는 이야기가 함께 엮이는 '네트워크 내러티브 필름'의 서사가 <플랫 라이프>의 결말부를 이끌고 있다고 분석한다. 다시 말해, 초반부가 '앙상블 필름의 확장판'으로서 '모자이크 내러티브' 를 따른다면, 후반부는 충실하게 '네트워크 내러티브'를 따르는 것이다. 주제를 말하는 방식에서도 이 애니메이션 영화는 모자이크 영상의 말하기 방식을 활용한다. 그러므로 카툰의 양태적 성향을 따라서 개방적인 방식으로 '유머' 나 '풍자'의 의미를 도출해낸다고 말할 수 있다. 전반부의 모자이크 내러티브 방식에서 다소 모호한 일상성이 드러난다면, 후반부에서는 선형 서사를 통해 '현대 사회에서 인간 이기심의 실체'라는 다소 심도 있는 주제로 나아간다. 이렇듯 풍자화의 외향을 지닌 <플랫라이프>는 실제로 의미를 '해석'할 수 있는 어른들을 대상으로 한 광범위한 사회비판적인 목표를 바라보는 애니메이션이다.

• 한국보건간호학회지
• /
• 제29권3호
• /
• pp.582-593
• /
• 2015

Purpose: This study was conducted to examine the effectiveness of a self-management program on patients with thyroid cancer, particularly during the time of waiting for surgery after cancer diagnosis. Psychological distress, biological responses of immune cell counts, and quality of life were the variables of this study. Methods: One group pre-post test design was used with the nature of a pilot study. Ten newly diagnosed thyroid cancer patients were recruited through physicians' referrals. After drop out of 4 participants, final data were collected from six participants. Small group technique, a one and half hour-session per week for one month (total 4 sessions, 6 hours) was used. Relaxation techniques, meditation training, and strategies to reduce distress were provided by researchers. Standardized questionnaires and an established bio-assay were used for collection of data. Results: Participants showed significant lowering of psychological distress (p<.05) and improvement in global quality of life (p<.05). Biological responses of immune cell counts did not show statistical significance. Conclusion: The self-management program may reduce psychological distress and improve quality of life of patients with thyroid cancer between the time of diagnosis and surgery. The self-management program would be a valuable approach for patients with an unexpected cancer diagnosis to prepare for their disease experience in a community setting.

• Journal of Radiation Protection and Research
• /
• 제41권3호
• /
• pp.268-273
• /
• 2016

Background: This study was a long-term evaluation of $^{137}Cs$ and $^{90}Sr$ activity concentrations in seawater samples from the East Sea, Korea, in order to establish current activity levels. Results and long-term monitoring trends will be useful in the future monitoring of environmental radioactivity. Materials and Methods: Surface seawater samples were collected quarterly from Guryongpo and Jangho in the East Coast between 1998 and 2010 and the quarterly deep seawater samples were collected from three sites in the sea adjacent to Ulleung-do between 2012 and 2015. The activity concentrations of $^{137}Cs$ were measured using a gamma-spectrometer. The activity concentrations of $^{90}Sr$ and $^{90}Y$ in a radioactive equilibrium state were measured using a gas flow proportional counter. Results and Discussion: We found the annual average activity concentrations of $^{137}Cs$ in the surface seawater was $1.66-2.89mBq{\cdot}kg^{-1}$ in Guryongpo and $1.68-2.43mBq{\cdot}kg^{-1}$ in Jangho. The annual average activity concentrations of $^{90}Sr$ in the surface seawater was $0.83-1.98mBq{\cdot}kg^{-1}$ in Guryongpo and $0.82-1.57mBq{\cdot}kg^{-1}$ in Jangho. The annual average activity concentrations of $^{137}Cs$ in the deep seawater sites were $1.51-1.73mBq{\cdot}kg^{-1}$, $1.19-1.60mBq{\cdot}kg^{-1}$ and $0.87-1.15mBq{\cdot}kg^{-1}$ in TH, JD, and HP. The annual average activity concentrations of $^{90}Sr$ in the same deep seawater sites were $1.00-1.94mBq{\cdot}kg^{-1}$, $0.82-1.26mBq{\cdot}kg^{-1}$, and $0.79-1.32mBq{\cdot}kg^{-1}$. The effective half-life was calculated by analyzing change over time in the activity concentration in the surface seawater. The effective half-life of $^{137}Cs$ was $15.3{\pm}0.1years$ in Guryongpo and $102{\pm}3years$ in Jangho. The effective half-life of $^{90}Sr$ was $28.3{\pm}4.3years$ in Guryongpo and $16.6{\pm}0.1years$ in Jangho. The ratio of the average activity concentration ($^{137}Cs/^{90}Sr$) was 1.72 in the surface seawater, which is similar to the reported ratio of the global radioactive fallout. The ratio in the deep seawater was 1.24, which is somewhat low compared to the global ratio (1.6, 1.8). Conclusion: Activity concentrations of $^{137}Cs$ and $^{90}Sr$ in the seawaters of the East Sea were similar to the previously reported activity levels in the East Sea and northwestern Pacific as a result of global radioactive fallout following atmospheric nuclear weapon tests.

• 농약과학회지
• /
• 제7권3호
• /
• pp.182-187
• /
• 2003

제초제 mefenacet의 토양 중 분해 특성을 알아 보고자 2 종의 토양을 비살균 토양을 대조로 하여 몇가지 조건으로 전처리한 다음 120일 동안 항온배양하면서 그 잔류량을 분석한 결과 약제처리 후 70일 경과시 대조토양은 $55\sim63%$가 분해 소실되었으나 살균토양에서는 $32\sim33%$, 담수토양에서는 $33\sim35%$가 소설 되어 mefenacet의 분해에 토양 미생물의 활성이 크게 영향을 끼치는 것으로 나타났다. 또한 mefenacet의 토양 중 분해에 미치는 수분함량의 영향을 조사한 결과 90 일간 배양 시 그 반감기는 포장 용수량의 20%와 50%에 해당하는 7.8%, 19.5%의 수분이 첨가된 토양에서는 각각 83과 82일 이었으며 80%인 31.2%의 수분이 첨가된 토양의 반감기가 61일로 단축되어 토양 수분 함량이 높을수록 mefenacet의 토양 중 분해 소실이 빠르게 일어남을 알 수 있었다. 결과적으로 mefenacet의 토양 중 분해 소실에는 토양 성분 중 유기물 함량과 토양 수분 함량이 중요한 인자로 작용하며 토양 미생물이 토양 성분과 더불어 mefenacet의 분해에 중요한 역할을 하고 있음을 시사하고 있다.

• 한국방사선학회논문지
• /
• 제15권2호
• /
• pp.257-263
• /
• 2021

본 연구는 한국원자력연구원에서 보유하고 있는 100 MeV 선형가속기를 사용하여 천연텅스텐과의 핵반응으로 부터 발생시켜 발생되는 감마선을 측정하여 natW(p,xn)176Re 핵반응에 대한 상대핵반응단면적을 도출하였다. 일반적으로 반감기가 짧은 동위원소에 대한 연구는 항상 짧은 시간 내에 방사능의 강도가 급격하게 작아지는 경향을 보이기 때문에 측정자체가 매우 어려운 것이 현실이다. 특히 176Re의 경우는 반감기가 5.3 분으로 상대적으로 매우 짧은 방사성핵종 중의 하나이다. 본 연구에서는 이런 짧은 반감기를 가지는 176Re 동위원소로부터 발생되는 109.08 keV 감마선을 고순도 Ge검출기를 이용하여 측정하였다. 얻어진 상대 측정값들은 1967년에 Richard G.에 의해 발표된 8 ~ 14 MeV 양성자에너지 영역에서의 결과와 이를 기반으로 계산에 의한 핵반응단면적에 대한 평가한 2019년 A. J. Koning의 결과인 TENDL-2019값과 비교분석하였다. 이 연구의 결과는 미래의 에너지원으로 알려져 있는 핵융합로의 설계, 천체 물리학, 핵의학 및 양성자치료 분야에 요긴하게 활용될 것으로 생각된다.

• 펄프종이기술
• /
• 제48권1호
• /
• pp.93-99
• /
• 2016

The extraction efficiency depending on the extracting methods and the conditions of extraction was investigated. The common steam extraction was compared to the distillation extraction method. The effects of the samples size and the extraction time on the extract yield were also investigated by using UV-Vis spectrophotometer. One of the functional components of pine needle extract as the natural phenol base components were detected by the UV-VIS at around 235 nm wavelength range. The absorbance intensity at around 235 nm wavelength of the pine needle extract was used as the indicator of the extraction efficiency in this experiment. The distillation extraction showed the higher extract yield than the steam extraction. The grinding treatment of pine needles also resulted in the better extract performance, but the severe grinding showed a little decrease in the extract yield especially in case of the distillation extraction method. More than half of the extract was collected at the first stage of the extraction, that was the first 15 minutes in the total 60 minutes extraction.