• 보건의료기술평가
• /
• 제6권2호
• /
• pp.133-141
• /
• 2018

Objectives: In the past, the pharmaceutical drug heparin was mostly used as the anticoagulant for continuous renal replacement therapy (CRRT), but the duration time is long to have the risk of a bleeding adverse effect, and in that case the drug therapy Nafamostat mesilate was utilized instead, as it is more safe in this case, with a short half-life and is increasing in use to permit lower concerns for bleeding incidents. However, there are insufficient number of large-scale studies on the comparison of Nafamostat mesilate and heparin. Methods: In this study, a systematic review are used to compare the bleeding risk of Nafamostat mesilate and Heparin, as subjected to patients and procedures for measuring risks performed with a CRRT, and the filter life span is to be evaluated as well in this patients. Results: As a result of literature review search, a total of 6 studies were included in systematic review. The reducing risk of bleeding and filter life span was analyzed. The retrospective cohort studies confirm that Nafamostat mesilate is less at risk of bleeding than heparin. And a cohort study confirms that Nafamostat mesilate is longer filter lifespan than heparin and randomized controlled trial studies show that Nafamostat mesilate is longer filter lifespan than not using the anticoagulants. Conclusion: Nafamostat mesilate is considered to be a good therapeutic option because it has a longer filter life span as well as the advantage of reducing bleeding.

• 약학회지
• /
• 제46권1호
• /
• pp.47-51
• /
• 2002

Although acebutolol (ABT) is almost completely absorbed in the gastrointestinal (Gl) tract, oral bioavailability of the drug is low due to extensive first-pass metabolism in the Gl tract and liver. In the present study, bioavailability and pharmacokinetics of ABT was studied in bile duct-bypassed rabbits after oral administration. For ABT the time to reach the plasma peak (T$_{max}$) and mean resident time (MRT) were increased by the treatment. For diacetolol (DAT), a metabolite of ABT area under the plasma concentration-time curve (AUC), T$_{max}$ and plasma half-life were increased by the treatment. These results indicate that oral bioavailability of ABT is associated with the enterohepatic recycling of bile juice components.nts.

• 디지털융복합연구
• /
• 제11권9호
• /
• pp.159-166
• /
• 2013

본 연구에서는 소프트웨어 제품을 개발하여 테스팅을 거친 후 사용자에게 인도하는 시기를 결정하는 방출문제에 대하여 연구 하였다. 소프트웨어의 결함을 제거하거나 수정 작업과정에서 유한고장수를 가진 비동질적인 포아송과정에 기초하였다. 수명강도는 다양한 형상모수와 척도모수에 이용 할 수 있기 때문에 신뢰성 분야에서 많이 사용되는 비선형 특성을 가진 반-로지스틱 분포 모형을 이용한 방출시기에 관한 문제를 제시하였다. 소프트웨어 요구 신뢰도를 만족시키고 소프트웨어 개발 및 유지 총비용을 최소화 시키는 최적 소프트웨어 방출 정책에 대하여 논의 되었다. 본 논문의 수치적인 예에서는 고장 시간 자료를 적용하였으며 모수추정 방법은 최우추정법을 이용하고 최적 방출시기를 추정하였다. 따라서 소프트웨어 방출시기를 사전 정보로 활용하면 잠재적 보안피해액을 줄 일 수 있다고 판단된다.

• 대한방사선기술학회지:방사선기술과학
• /
• 제32권2호
• /
• pp.213-218
• /
• 2009

감마선 원천핵을 두 개의 금속 평행판 사이, 실린더나 구와 같은 유한한 공간 내부에 놓았을 때 에너지 준위폭이 어떻게 변경되는가에 대하여 이론적으로 조사했다. 2개의 금속판에 의해 뒤쪽 산란된 감마선이 원천핵에 재흡수됨으로써 $^{133}Cs$핵의 여기상태(81 keV)의 에너지폭은 평행판 간격이 1.0 mm일 때 4.2 K에서 3.7% 정도 감소됨을 볼 수 있었다. 여기서 금속판은 두께 0,5 mm, 반경이 3 cm이며 금으로 만들었다. 반경 1.0 mm, 두께 0.5 mm, 길이 5 cm의 실린더 금판에 의해 뒤쪽 산란되었을 때에는 4.2 K에서 6.5% 에너지 폭이 좁아지는 결과를 얻었다. 또한, 두께 0.5 mm, 반경 1.0 mm의 금으로 된 구 안에 원천핵을 놓았을 때 4.2 K에서 18.2% 에너지준위 폭이 감소하였다. 이러한 에너지 준위 폭의 감소는 그 준위의 반감기가 연장된 것을 의미한다.

• International Journal of Advanced Culture Technology
• /
• 제8권1호
• /
• pp.218-225
• /
• 2020

Purpose Wearable devices are widely used in our daily life. The purpose of this study is to investigate the relationship between persuasive designs of fitness trackers and users' physical activity behavior. Methods To test the research model, data was collected from a web-based survey in China, resulting in an effective sample of 166 usable questionnaires. The survey was restricted only to respondents who wear a fitness tracker. Results The sample surveyed in this study indicated that half of the respondents had been wearing a smart fitness tracker shorter than one year, and only 27% were long-time users (longer than two years). Dialogue support and social support strategies were both proved to be effective in increasing users' workout behavior intention. Social support strategies had a greater effect on behavior change than dialogue support strategies. Conclusion The findings from this study make several contributions to the practice. Wearable devices developers can employ the result from this study to help them design devices, which can persuade people to do more exercises and preserve a healthier life.

• 한국응용과학기술학회지
• /
• 제27권2호
• /
• pp.196-201
• /
• 2010

The influence of red lead($Pb_3O_4$) to curing and formation reaction properties when it was added in positive material of lead acid battery for vehicle use has been investigated. At the results, it was confirmed that the addition of red lead led 4BS crystal size to be smaller and increased the rates of 4BS formation and Pb consumption. Consequently the curing time was shortened to half compared with that of red lead-free one. In addition to this, the lead acid battery prepared by adding red lead showed 14% higher efficiency at the life cycle test than that without red lead.

• 생명과학회지
• /
• 제11권3호
• /
• pp.273-278
• /
• 2001

Removal of nitrogen compound from waste water is essential and often accomplished by biological process. Deni-trification bacterium. Paracoccus denitrificans(KCTC 2350) is employed to estimate the ability and the characteristics of denitrification. In the immobilized biological reactor system, the measurement of absolute amount of active strain in the reactor is comparatively difficult or impossible. In this study, strain immobilized denitrification reactor was designed with the unwoven texture wrapped peeped hole plastic tube to calculated the absolute amount of active strain by comparing the activity of the immobilized reactor adn the free cell reactor. The reactor system was continuous stirred tank reactor and the rate of substrate consumption was assumed to be Michaelis-Menten equation. As a result, we found that the amount of immobilized active strain was the half of the total active strain in the reactor and the time required to reach in the equilibrium state in the immobilized reactor system was shorter than that of the free cell reactor system.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제22권3호
• /
• pp.207-216
• /
• 2019

Functional gastrointestinal disorders (FGIDs) such as infantile colic, constipation and colic occur in almost half of the infants. The aim of this paper is to provide a critical and updated review on the management of FGIDs and their impact on the health of the infant and family to health care physicians. Guidelines and expert recommendations were reviewed. FGIDs are a frequent cause of parental concern, impairment in quality of life of infants and relatives, and impose a financial burden to families, health care, and insurance. Therefore, primary management of the FGIDs should be focused on improving the infants' symptoms and quality of life of the family. If more than parental reassurance is needed, available evidence recommends nutritional advice as it is an effective strategy and most of the time devoid of adverse effects. The role of healthcare providers in reassuring parents and proposing the correct behavior and nutritional intervention by avoiding inappropriate use of medication, is essential in the management of FGIDs.

• 대한치과기공학회지
• /
• 제12권1호
• /
• pp.73-93
• /
• 1990

The study objected to the 120 persons out of 360 persons who have registered under the association of the dental technicians in Pusan to grasp contents about improvement of life long education of the present day of November, 1987, and its results, which we have acquired by this study were as follows : 1. A sense of satisfaction toward the system of life long education appeared as unsatisfaction and its unsatisfaction decreased from the rate of member's attendance or exam. marks, the contents of education, and place of education. 2. The problem of the exam. mark which derived by the presence by the substitute appeared which 46.7 percent(56 persons), lack of opportunity for the recompletion at branch association appeared which 19.2%(23 persons), given 4. exam. marks at the over all scientific contest was appeared 14.2 percent(17 persons), relation which legal treatment when ones didn't completed exam. mark was appeared 10.8 percent(13 persons) and lastly, appeared 8.3 percent (10 persons) with time of delivery of the exam mark card. 3. The frequency of the opening for the life long education which related with the rate of members attendance was fixed as nowadays two times per annually, but they perferred the opening per academic blanch once out of the firest half year and the latter half of the year and, they liked the openings at the first week or second week and preferred the holding on saturdays and sundays. 4. The subject of the life long education have appeared the opinion that the thesis was lop-sided toward the allocation of time schedule of lecture appeared the opinion of which they perferred the rate of an hour of cultural subject and two hours of major studies, and invitation for an instructor they preferred one dentist, one member, one dean for the cultural subject, and there are lots of opinions which they wished display of materials. 5. A sence of satisfaction about the place they perferred was decreased such as ; an auditorium concerned of the colleges was 46.7 Percent(56 Persons), hotels 26.7 Percent(32 Persons), an auditorium of the general hospital 20 percent(24 persons) 6. And lastly, there are lots of opinions who have required the necessities to constitute for the academic branch.

• 한국농업기계학회:학술대회논문집
• /
• 한국농업기계학회 1996년도 International Conference on Agricultural Machinery Engineering Proceedings
• /
• pp.918-925
• /
• 1996

The effect of structured water by dissolution of xenon was examined from the view point of the suppression of both browning and respiratory metabolism of broccoli. The structured water is formed duet to hydrophobic interaction when xenon gas dissolves into water. NMR measurements were carried out to determine proton spin-spin relaxation time, T2, for water. There was a difference in proton T2 between distilled water and structured water. This can be interpreted as the change of water structure. Fro the broccoli cut in half stored for 16 days at 279K, the section color did not change appreciably for the sample whose water was structured by dissolution of xenon whose initial partial pressure was 0.39MPa. In contrast to this, the browning of section surface was observed for the sample stored under the condition of nitrogen gas at the same partial pressure as xenon and for the sample stored under atmospheric condition . These results led to the conclusion that the suppression of b owning by oxidation was due to structured water but not to applied pressure. Adding to this, the water structured by xenon has resulted in suppression of respiratory metabolism of broccoli.