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Effect of Bile juice on the Bioavailability and Pharmacokinetics of Acebutolol in Rabbits  

최준식 (조선대학교 약학대학)
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YAKHAK HOEJI / v.46, no.1, 2002 , pp. 47-51 More about this Journal
Abstract
Although acebutolol (ABT) is almost completely absorbed in the gastrointestinal (Gl) tract, oral bioavailability of the drug is low due to extensive first-pass metabolism in the Gl tract and liver. In the present study, bioavailability and pharmacokinetics of ABT was studied in bile duct-bypassed rabbits after oral administration. For ABT the time to reach the plasma peak (T$_{max}$) and mean resident time (MRT) were increased by the treatment. For diacetolol (DAT), a metabolite of ABT area under the plasma concentration-time curve (AUC), T$_{max}$ and plasma half-life were increased by the treatment. These results indicate that oral bioavailability of ABT is associated with the enterohepatic recycling of bile juice components.nts.
Keywords
Acebutolol; diacetolol; bioavailability bypass of bile duct;
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