• Journal of the East Asian Society of Dietary Life
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• v.9 no.2
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• pp.135-148
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• 1999

This is a descriptive study of consumption Patterns of how to take meals in everyday life. The data used was collected from a probability sample by multi-stage cluster sampling, drawn from those who were living in the Ulsan Metropolitan Area. Face-to-face interviews were conducted by trained interviewers with a household member who was between the ages of 15 and 60 in 1989 and had the earliest birthday, resulting in a sample of 1,232 respondents. Univariate and bivariate analyses were made to describe behavioral patterns of taking meals. Meal-taking behaviors under this study include frequency of taking meals per day, regularity of taking meals, which meal to skip, number of frequency of taking a meal by oneself. reasons of skipping and irregular meals, and eatting out. Half of the respondents reported to take meals three times a day, while those who skipped at least a meal reported as one most frequently skipped. Of reasons not to take a meal on a regular basis, "too busy to eat" was most frequently mentioned. Only 32.8% of the respondents reported dining-out once a week.ce a week.

• Korean Journal of Oriental Medicine
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• v.17 no.3
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• pp.25-34
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• 2011

Gang Myeong-gil(康命吉) wrote Jejung sinpyeon(濟衆新編), one of three major medical books produced in the latter half of the Joseon Period. Jejung sinpyeon, edited at the behest of King Jeongjo, was intended to overcome the shortcomings of the then best medical book, Donguibogam(東醫寶鑑), and to update medical knowledge in a bid to spread that knowledge widely to the general public. Jejung sinpyeon contains the life and medical theories of the physician Gang Myeong-gil. In order to examine Gang Myeong-gil's life and medical theories, which influenced the edition and characteristics of Jejung sinpyeon, this paper studies his family lineage, medical records and the editorial characteristics of Jejun sinpyeon. Gang Myeong-gil and his ancestors served in government medical offices for some 200 years, and Gang Myeong-gil himself served as a physician at Naeuiwon for thirty years. His descendants also served as physicians upon passing the state-administered examination. Gang Myeong-gil preferred to prescribe drugs, and this inclination led him to include Yakseongga in Jejung sinpyeon, and he took an open and practical attitude towards the editing of the book. This approach is supported by the chapter on experience-based prescriptions in Jejung sinpyeon and the prescriptions of the Royal Infirmary, thus revealing his humanitarian and open thinking on medicine.

• Journal of the Korean Society for Heat Treatment
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• v.32 no.1
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• pp.12-16
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• 2019

In this study, strain-controlled low cycle fatigue test for hot rolled STS304 steel was carried out at $400^{\circ}C$ and $600^{\circ}C$, respectively. High temperature fatigue test was done using an electric furnace attached on the hydraulic fatigue test machine. The results of this study show that STS304 hot rolled steel has excellent static strength and fatigue characteristics. The hysteresis loop at half life was obtained in order to calculate the elastic and plastic strain. Also, Relationship between strain amplitude and fatigue life was examined in order to predict the low cycle fatigue life of STS304 steel by Coffin-Manson equation.

• International conference on construction engineering and project management
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• 2007.03a
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• pp.625-634
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• 2007

Energy-saving is one of important issues in multi-family housing projects in South Korea. According to the study by Yu et al. (2002), the balcony conversion causes energy loss approximately one and a half times. Therefore, it is important to select the economical glass type in the balcony window. In order to identify the most economical glass type of balcony conversion in multi-family housing projects, the most typical type of the multifamily housing projects in the metropolitan area was selected as a candidate project. The selected candidate project has been simulated using ENERGY-10 program to estimate the heat load by the different five types of glasses as well as their life cycle cost analysis (LCCA) using present worth method. Finally, sensitivity analysis has been conducted to determine the most economical glass types under a different discount rate (interest rate) and service life of building.

• The Korean Journal of Pesticide Science
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• v.14 no.2
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• pp.157-163
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• 2010

This study was performed to investigate the hatching rate and eggs period until hatching in the laboratory against lantern fly, Lycorma delicatula eggs with different collecting date of eggs, and the susceptibility of 26 insecticides to the eggs, 1st and 2nd nymphs of Lycorma delicatula. The eggs of L. delicatula were increased the hatching rates as passed collecting date of eggs, and shorten in eggs period until hatching. By screening the susceptibility of 26 insecticides to the eggs, 1st, and 2nd nymphs, chlorpyrifos (312.5 ppm) showed the perfect inhibition effect of hatching against the eggs, however, the other insecticides did not show that effect. According to the collecting date of eggs, chlorpyrifos bioassayed the inecticidal effect with different concentration (625 ppm at double conc., 312.5 ppm at recommended conc., and 156.3 ppm at half conc.). The eggs collected from Apr. 20th 2010, were showed the inhibition effect of hatching over 94.5%, but the eggs collected from May 10th, 2010 were showed the inhibition effect of hatching as 86.7, 71.1, and 47.1%, respectively. However, hatched eggs were all killed perfectly within 24 hours. At recommended and half concentrations, the eggs collected from 15, May, are decreased the effect as 48.6%, 53.7%, respectively, and the mortality of eggs hatched also decreased as 61.0 and 22.0%, respectively, however, double concentrations did not show the changes. From the above results, it will be anticipate to show the higher mortality against the eggs of L. delicatula when treated chlorpyrifos until late-April.

• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.253-263
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• 1997

To investigate the interaction of omeprazole (OMP) and meglumine (MEG), a complex was prepared by freeze-drying method in ammoniacal aqueous medium at room temperature and subjected to IR, DSC, and 1H NMR analysis. In addition, the stability of the complex was tested by accelerated stability analysis, and the dissolution rate of both powder and enteric coated was determined pellet by paddle method. The results are as follows; i) IR, DSC, and $^{1}H$ NMR studies indicate the formation of inclusion complex between OMP and MEG probably by electrostatic forces as $[OMP]\;[MEGH]^+$ form in a stoichiometric ratio (1:1) of OMP : MEG. ii) The dissolution rate of enteric coated OMP-MEG complex pellet in simulated enteric fluid was 90.6% in 10 minutes, which may satisfy the requirement for the regulation of dissolution. iii) OMP-MEG complex were decomposed according to pseudo 1st order kinetics: while the decomposition of OMP showed a rate constant $(k_{25^{\circ}C})$ of $5.13{\times}10^{-4}{\cdot}\;day^{-1}$, a half-life$(t_{1/2})$ of 1,350 days, a shelf-life$(T_{90%})$ 205 days and an activation energy of 23.53 kcal/mole. OMP-MEG complex inhibited a rate $(k_{25})$ of $2.92{\times}10^{-4}{\cdot}\;day^{-1}$, a half-life$(t_{1/2})$ of 2,373 days, a shelf-life $(T_{90%})$ of 306 days and an activation energy of 20.18 kcal/mole. iv) OMP was stabilized markedly by the formation of OMP-MEG complex between OMP and MEG, and the humidity increased the stability of OMP-MEG complex by decreasing the decomposition rate$(k_{50^{\circ}C})$ from $1.27{\times}10^{-2}{\cdot}\;day^{-1}$ at 31% R.H. to $2.54{\times}10^{-2}{\cdot}\;day^{-1}$ at 90% R.H.

• The Korean Journal of Pesticide Science
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• v.17 no.2
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• pp.77-83
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• 2013

This study was performed to investigate pre-harvest residue limit (PHRL) in amaranth, to estimate biological half-life of emamectin benzoate and identify the characteristics of the residue. Pesticides of standard and double appplication rate, were sprayed once on amaranth at 0, 1, 2, 3, 5, 7, 10, 14 days before harvest. Amaranth sample was extracted with acetonitrile and partitioned with dichloromethane, and pesticide residues were determined with LC/MS/MS. The limit of detection of emamectin benzoate was 0.01 mg/kg. Recoveries of emamectin benzoate ($B_{1a}$, $B_{1b}$) at two fortification levels of 0.1 and 0.5 mg/kg, $B_{1a}$ were $93.3{\pm}0.7%$ and $93.2{\pm}7.7%$, $B_{1b}$ were $106.6{\pm}1.9%$ and $80.5{\pm}6.6%$, respectively. The biological half-lives of emamectin benzoate were about 2.0 days at standard application rate and 1.7 days at double application rate, respectively. The PHRL of emamectin benzoate were recommended as 0.84 mg/kg for 10 days before harvest.

• Journal of Life Science
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• v.25 no.1
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• pp.1-7
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• 2015

Cyclin D is a member of the cyclin protein family, which plays a critical role as a core member of the mammalian cell cycle machinery. D-type cyclins (D1, D2, and D3) bind to and activate the cyclin-dependent kinases 4 and 6, which can then phosphorylate the retinoblastoma tumor suppressor gene products. This phosphorylation in turn leads to release or derepression of E2F transcription factors that promote progression from the G1 to S phase of the cell cycle. Among the D-type cyclins, cyclin D3 encoded by the CCND3 gene is one of the least well studied. In the present study, we have investigated the biochemistry of the proteolytic mechanism that leads to loss of cyclin D3 protein. Treatment of human prostate carcinoma PC-3-M cells with lovastatin and actinomycin D resulted in a loss of cyclin D3 protein that was completely reversible by the peptide aldehyde calpain inhibitor, LLnL. Additionally, using inhibitors for various proteolytic systems, we show that degradation of cyclin D3 protein involves the $Ca^{2+}$-activated neutral protease calpain. Moreover, the half-life of cyclin D3 protein half-life increased by at least 10-fold in PC-3M cells in response to the calpain inhibitor. We have also demonstrated that the transient expression of the calpain inhibitor calpastatin increased cyclin D3 protein in serum-starved NIH 3T3 cells. These data suggested that the function of cyclin D3 is regulated by $Ca^{2+}$-dependent protease calpain.

• Journal of Applied Biological Chemistry
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• v.59 no.4
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• pp.331-336
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• 2016

Analytical methods for methiozolin in soil, water and turfgrass were established and dissipation patterns of methiozolin in soil and turfgrass were elucidated. Analysis was done using a high performance liquid chromatography with an ultra violet detector at the wavelength of 280 nm after extraction with acetone, liquid-liquid partition with dichloromethane, and a solid phase extraction purification. Limit of determination and Limit of quantitation were 1.0, 0.5, 1.0 ng, and 0.001, 0.1, 0.01 mg/kg for water, turfgrass, and soil, respectively. Recovery rates of methiozolin from soil, water, and turfgrass were ranged 87.5~111.3, 92.8~97.4, and 78.2~98.5 %, respectively. The turfgrass and soil samples were collected at 0, 1, 4, 7, 14, 30, 45, and 60 after spray on green area in golf course. Residues of methiozlolin were not translocated to lower soil layer but detected only in turfgrasses and root area of turfgrass. Half-lives of methiozolin in turfgrass were 10.7 days and 8.8 days in soil from root area.

• Journal of Life Science
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• v.16 no.4
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• pp.598-604
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• 2006

The $Ca^{2+}-activated$ neutral protease calpain induced proteolysis has been suggested to play a role in certain cell growth regulatory proteins. Cyclin proteolysis is essential for cell cycle progression. D-type cyclins, which form an assembly with cyclin-dependent kinases (cdk4 and cdk6), are synthesized earlier in G1 of the cell cycle and seem to be induced in response to external signals that promote entry into the cell cycle. Here we show that cyclin D3 protein levels are regulated at the posttranscriptional level by calpain protease. Treatment of human breast carcinoma MDA-MB-231 cells with lovastatin and actinomycin D resulted in a loss of cyclin D3 protein that was completely reversible by the peptide aldehyde calpain inhibitor, LLnL. The specific inhibitor of the 26S proteasome, lactacystin, the lysosome inhibitors, ammonium chloride and chloroquine, and the serine protease inhibitor, phenylmethylsulfonylfluoride (PMSF), did not block the degradation of cyclin D3 by lovastatin and actinomycin D. Results of in vitro degradation of cyclin D3 by purified calpain showed that cyclin D3 protein is degraded in a $Ca^{2+}-dependent$ manner, and the half-life of cyclin D3 protein was dramatically increased in LLnL treated cells. These data suggested that cyclin D3 protein is regulated by the $Ca^{2+}-activated$ protease calpain.