• Journal of the Korean Institute of Oriental Medical Informatics
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• v.15 no.2
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• pp.7-56
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• 2009

Objective: The purpose of this study is to compare the original texts with quotations in 16 Kinds of Cough Part in Haesu Chapter of Dong-Yi-Bo-Gam and to find out the ideas of Huh Jun(許浚, 1546-1615; the author of Dong-Yi-Bo-Gam) in there. Methods: I compared the original texts with quotations in 16 Kinds of Cough Part in Haesu Chapter of Dong-Yi-Bo-Gam. Results: 1. There is only one quoted sentence which perfectly matches with original text in 16 Kinds of Cough Part in Haesu Chapter of Dong-Yi-Bo-Gam. The other sentences are all modified while they are quoted by Huh Jun, at least one word. 2. The arrangement order of 'medical effect', 'consisting medicines and their dosages' and 'doctrine in application' were rearranged following the form of Dong-Yi-Bo-Gam when being quoted. 3. In cases of reciting the text, Huh Jun tries to clarify the original source of the context. However, instead of using original quotations he recited rephrased quotes from other sources. 4. Huh Jun cites from not only cough parts of other texts but also asthma(喘症) or heat(積熱) parts. 5. Titles of original text books are recorded in the end of all sentences of Dong-Yi-Bo-Gam, but there are a few wrong titles recorded. Conclusion: In consideration of the above-mentioned, the Dong-Yi-Bo-Gam is not the mere collection of various Oriental Medical books, but the Classic of Oriental Medicine to hold Huh Jun's own opinion.

• The Journal of Pediatrics of Korean Medicine
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• v.17 no.1
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• pp.131-140
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• 2003

Introduction : Pneumonia is an inflammation of alveolus and pneumal parenchyma and it is one of common pediatric diseases. According to, pneumonia belongs to the Haesu(咳嗽), Chunsik(喘息), Phechng(肺脹), Pungon(風溫). Purpose : The purpose of this study is to find out whether Socheongryongtanggamibang has any effects on children with pneumonia. Method : The subjects are in regard to children with pneumonia who visited Dae Jeon Oriental Medicine Hospital from December 2002 to April 2003. The herbal medicine therapy are applied for one week. Result and Conclusion : After treatment, the symptoms (coughing, rhinorrhea, sputum, fever) of pneumonia were improved. More studies about the Oriental Medicine treatment and conception on pneumonia are needed.

• The Journal of Korean Medicine
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• v.39 no.1
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• pp.63-74
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• 2018

Objectives: Periodontitis is an inflammatory disease with the destruction of periodontal ligament, alveolar bone loss and inflammation of gingva, leading to teeth loss. Eclipta prostrata L. (Ecliptae Herba) has been used to treat the inflammatory disease as a Korean traditional medicine. The aim of this study is to investigate the effects of E. prostrata L. on periodontitis. Methods: E. prostrata L. was extracted with water and lyophilized. The aqueous extract of E. prostrata L. (EP) was topically applied to the periodontal lesion for 2 weeks. To induce the periodontitis, a 3-0 nylon ligature was placed around the cervix of the lower first molar in rat. Rats were divided into 3 groups (n = 7); NL group (non-ligatured and non-treated), L group (ligatured and vehicle-treated) and EP group (ligatured and EP-treated). After sacrifice, the mandibles was dissected and stained with methylene blue solution to analyze the alveolar bone loss. The expression of MMP-9 was determined in gingival tissues. To confirm the effect of EP on recovery of gingiva, mRNA expressions of type I pro-collagen and MMP-9 levels were investigated in LPS-treated HS68 fibroblast cells. In addition, inflammatory mediators were evaluated in LPS-treated RAW264.7 cells. Results: Alveolar bone loss was significantly inhibited by EP treatment. The mRNA expression of MMP-9 was attenuated in rats treated with EP. In addition, treatment with EP increased the expression of type I pro-collagen, while the expression of MMP-9 was decreased in LPS-stimulated HS68 fibroblast cells. Furthermore, EP down-regulated the LPS-induced IL-6, $TNF-{\alpha}$, COX-2 and iNOS production in RAW264.7 cells. Conclusions: These results suggest that EP have ameliorative effects on periodontitis through inhibiting alveolar bone loss and modulating the inflammatory mediators. Therefore, E. prostrata L. may be an alternative on patients with periodontitis.

• Journal of Periodontal and Implant Science
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• v.45 no.4
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• pp.145-151
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• 2015

Purpose: The aim of this study was to investigate the therapeutic effects of a herbal formula, PerioH-035, containing Angelica sinensis, steamed Rehmannia glutinosa, Angelica dahurica, Cimicifuga heracleifolia, and Zanthoxylum piperitum on the periodontal breakdown in a well-established ligature-induced periodontitis model in rats. Methods: Sprague-Dawley rats were randomly assigned to 1 of 4 groups: NL (non-ligatured), L (ligatured), P1 (ligatured and treated with 1 mg/mL PerioH-035), P100 (ligatured and treated with 100 mg/mL PerioH-035). Periodontitis was induced by placing a ligature around the mandibular first molars. PerioH-035 was topically applied to both sides of the first molar for 2 weeks. The right side of the mandibles was retrieved for micro-computed tomography (CT) and methylene blue staining to analyze alveolar bone loss. The left side of the mandibles was histologically analyzed by TRAP and H&E staining. The MMP-9 mRNA level in gingival tissue was investigated by RT-PCR. Results: Alveolar bone resorption was significantly reduced in the PerioH-035-treated groups. The number of dense multi-nucleated cells found to be TRAP-positive by staining in the ligatured rats was markedly decreased by PerioH-035 application. In addition, periodontal tissue destruction, especially cementum demineralization, was ameliorated in the P1 and P100 groups. Moreover, gingival tissue from the PerioH-035-treated group showed a decrease in the MMP-9 mRNA level, resulting in recovery of collagen degradation. Conclusions: These results suggest that PerioH-035 has therapeutic effects on periodontitis, and thus, PerioH-035 shows promise as a treatment for periodontitis.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.25 no.3
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• pp.649-664
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• 2015

Recently, the risk of security incidents has been increased due to change of IT environment and development of new hacking methods. Event study methodology that measures the effect of a specific security incident on the stock price is widely adopted to analyze the damage cost of security incidents on market value. However, analysis of company's temporary stock price change is limited to immediate practical implication, and reputation loss should be considered as a collateral damage caused by security incidents. We analyzed 52 security incidents of listed Korean companies in the last decade; by refining the criteria presented by Tobin's q, we quantitatively showed that the companies has significantly higher reputation loss due to security loss than the other companies. Our research findings can be used in order that the companies can efficiently allocate its resource and investment for information security.

• Korean Journal of Culture and Social Issue
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• v.14 no.3
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• pp.1-19
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• 2008

The purpose of this study is to examine the family perception according to abused children's sex, age, and abusive type. The subjects were 45 abused children including 15 physically abused, 15 neglected, and 15 physically and emotionally abused children from age 7 to 14. The results were that boys showed more noncomplient behaviors to their parents, more concerns and more rejective behaviors to examination. Girls perceived their mothers as stressors more than those of boys. School-aged children perceived their mothers as allies than those of adolescents. Adolescents showed more rejective behaviors to examination and more anger. Physically and emotionally abused children experienced more family conflicts and showed more negative resolutions, and more noncomplient behaviors than those of abused children. Neglected children showed more depressive mood than those of abused children.

• Journal of Life Science
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• v.29 no.1
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• pp.1-8
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• 2019

In Hanwoo cattle (Korean native cattle), there is a scarcity of comparative analysis papers using highdepth sequencing and haplotype phasing, particularly a comparative analysis of the Truseq Synthetic Long-Read Haplotyping sequencing platform serviced by Illumina (TSLRH) versus the Chromium Genome Sequencing platform serviced by 10X Genomics (10XG). DNA was extracted from the sperm of a Hanwoo breeding bull (ID: TN1505D2184/27214) provided by Hanwoo research canter and used for the generation of sequence data from both the sequencing platforms. We then identified SNVs using an appropriate analysis pipeline tailored for each platform. The TSLRH and 10XG platforms generated a total of 355,208,304 and 1,632,772,004 reads, respectively, corresponding to a Q30 (%) of 89.04% and 88.60%, respectively, of which 351,992,768(99.09%) and 1,526,641,824(93.50%) were successfully mapped. For the TSLRH and 10XG platforms, the mean depth of the sequencing was 13.04X and 74.3X, the longest phase block was 1,982,706 bp and 1,480,081 bp, the N50 phase block was 57,637 bp and 114,394 bp, the total number of SNVs identified was 4,534,989 and 8,496,813, and the total phased rate was 72.29% and 87.67%, respectively. Moreover, for each chromosome, we identified unique and common SNVs using both sequencing platforms. The number of SNVs was directly proportional to the length of the chromosome. Based on our results, we recommend the use of the 10XG platform for haplotype phasing and SNV identification, as it generated a longer N50 phase block, in addition to a higher mean depth, total number of reads, total number of SNVs, and phase rate, than the TSLRH platform.