• Title/Summary/Keyword: Ha-Treatment

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3,4-Dihydroxytoluene suppresses UVB-induced wrinkle formation by inhibiting Raf-1

  • Park, Sang-Hee;Kang, Nam Joo
    • Korean Journal of Food Science and Technology
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    • v.52 no.4
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    • pp.385-395
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    • 2020
  • This study examined the effect of 3,4-dihydroxytoluene (DHT) on UVB-induced photoaging and determined its molecular mechanisms, using HaCaT human keratinocytes and SKH-1 hairless mice. DHT suppressed UVB-induced matrix metalloproteinase-1 (MMP-1) expression in HaCaT cells. In vivo data from mouse skin supported that DHT decreased UVB-induced wrinkle formation, epidermal thickness, and matrix metalloproteinase-13 (MMP-13) expression. DHT appeared to exert its anti-aging effects by suppressing UVB-induced Raf-1 kinase activity and subsequent attenuation of UVB-induced phosphorylation of MEK, ERK, and p90RSK in HaCaT cells. In vitro and in vivo pull-down assays revealed that DHT bound with Raf-1 in ATP-noncompetitive manner. Overall, DHT appears to anti-photoaging effects in vitro and in vivo through the suppression of Raf-1 kinase activity and may have potential as a treatment for the prevention of skin aging.

Hyaluronic Acid Subdermal Filler for Correction of Lower Eyelid Entropion in a Cat

  • Kim, Youngsam;Kang, Seonmi;Seo, Kangmoon
    • Journal of Veterinary Clinics
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    • v.37 no.5
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    • pp.292-294
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    • 2020
  • A 14-year-old castrated male Persian cat presented with epiphora, blepharospasm, brownish ocular discharge, corneal neovascularization, and corneal opacity in the left eye. Medial lower eyelid entropion was diagnosed through an ophthalmic examination. Since the cat was old and suffered from chronic kidney disease, we decided to perform a hyaluronic acid (HA) subdermal filler injection without general anesthesia rather than surgical correction. After topical anesthesia by lidocaine jelly and disinfection, HA filler was injected into the medial lower eyelid under minimal physical restraint. At the last follow-up 139 days later, lower eyelid entropion was not observed and related clinical signs disappeared. Therefore, HA subdermal filler can be an effective intervention for the treatment of entropion in cats.

Furrow Covering Effects with Rice Straw on Nutrient Discharge from Upland Soil Used for Red Pepper Cultivation (고추밭 고랑 볏짚피복에 의한 양분유출 특성)

  • Hong, Seung-Chang;Kim, Min-Kyeong;Jung, Goo-Buk;So, Kyu-Ho
    • Journal of the Korea Organic Resources Recycling Association
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    • v.24 no.1
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    • pp.11-19
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    • 2016
  • Excessive application of nutrient supplement on the upland soil may increase the amount of discharge to surrounding water systems. The chemical fertilizer (CF), cow manure compost (CMC), and pig manure compost (PMC) are used as a nutrient supplement for cultivation of red pepper. Rice straws are widely used as a soil covering material in order to reduce weed occurrence, to protect soil moisture, and to supply organic matter in upland soil. This study was conducted to evaluate the furrow covering effect with rice straw on nutrient discharge in upland soil used for red pepper cultivation. The experimental plots of nutrient supplement were consisted of CF, CMC, and PMC and the amount of nutrient application were as recommended amount after soil test for red pepper cultivation. Each nutrient supplement treatment plot has no furrow covering (CFC) as a control and furrow covering with rice straw (FCS), respectively. Furrow covering with rice straw (FCS) of CF treatment and CMC treatment reduced the amount of T-N(total nitrogen) discharge by $1.4kg\;ha^{-1}$, $2.1kg\;ha^{-1}$, respectively, compared to control. While the amount of T-P(total phosphorus) discharge of the furrow covering with rice straw of CF, CMC, and PMC increased by $2.1kg\;ha^{-1}$, $2.1kg\;ha^{-1}$, and $0.2kg\;ha^{-1}$, respectively, compared to control. The phosphorus and nitrogen content of straw were 0.4 % and 0.3 % respectively. In addition, in three week the phosphorus was eluted from the straw which soaked in distilled water. Thus, it was assumed that T-P discharging originated from rice straw which applied as a furrow covering material. The furrow covering with rice straw reduced weed occurrence compared to control. But production of fresh red pepper was not influenced significantly by furrow covering with rice straw. In conclusion, excessive furrow covering with rice straw could induce T-P discharge from upland soil used for red pepper cultivation. Further studies are needed to evaluate the appropriate amount of rice straw as a furrow covering material.

Applicability of PAM(Polyacrylamide) in Soil Erosion Prevention: Rainfall Simulation Experiments (경사지 토양유실 방지를 위한 PAM(Polyacrylamide) 시제품의 효율성 비교평가: 실내 인공강우 실험)

  • Choi, Bong-Su;Lim, Jung-Eun;Choi, Yong-Beum;Lim, Kyoung-Jae;Choi, Joong-Dae;Joo, Jin-Ho;Yang, Jae-E.;Ok, Yong-Sik
    • Korean Journal of Environmental Agriculture
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    • v.28 no.3
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    • pp.249-257
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    • 2009
  • Surface runoff and erosion are responsible for extensive losses of top soil and agricultural productivity. In this study, a laboratory experiment was conducted to investigate the effects of different polyacrylamides (PAM) on the protection of soil from erosion and turbidity in loamy sand soil. To accomplish this, 10 and 40 kg $ha^{-1}$ of PAM were applied to the soil surface. The effects of rainfall on 10 and 20% slopes were then evaluated in the laboratory using a rainfall simulator. After air drying, the surface was subjected to rain at 30 mm $hr^{-1}$. The silt+clay of the runoff from samples treated with 10 kg PAM $ha^{-1}$ reduced by 43% and 13% when the 10% and 20% slopes were evaluated, respectively, when compared with the tap water without PAM treatment as control. The mean contents of silt+clay were reduced as the amount of PAMs applied increased at both slopes. Specifically, samples treated with 40 kg PAM $ha^{-1}$ showed reductions in the silt+clay of the runoff to 88% and 85% when the 10% and 20% slopes were evaluated, respectively, when compared to control. Furthermore, the mean turbidity of runoff in the 40 kg PAM $ha^{-1}$ treatment was reduced to 94.7% and 84.8% when the samples were subjected to 10% and 20% slopes, respectively, when compared to the control. Taken together, these findings indicate that PAM treatment will improve water pollution and agricultural productivity on sloped land via a reduction in soil erosion.

Reduction of headache intensity and frequency with maxillary stabilization splint therapy in patients with temporomandibular disorders-headache comorbidity: a systematic review and meta-analysis

  • Manrriquez, Salvador L.;Robles, Kenny;Pareek, Kam;Besharati, Alireza;Enciso, Reyes
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.21 no.3
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    • pp.183-205
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    • 2021
  • This systematic review and meta-analysis aimed to analyze the effectiveness of maxillary stabilization splint (SS) therapy to reduce headache (HA) intensity and HA frequency in patients with temporomandibular disorders (TMD)-HA comorbidity. Randomized controlled trials (RCTs) using full-arch coverage, hard resin, and maxillary SS therapy were included. Electronic databases, including Cochrane Library, MEDLINE through PubMed, Web of Science, and EMBASE, were searched. The risk of bias was analyzed based on Cochrane's handbook. The search yielded 247 references up to January 28, 2020. Nine RCTs were included at a high risk of bias. The comparison groups included other splints, counseling, jaw exercises, medications, neurologic treatment, and occlusal equilibration. Four studies reported a statistically significant reduction in HA intensity, and five studies reported significant improvement in HA frequency from baseline at 2-12 months in patients with TMD-HA comorbidity treated with a full-arch hard maxillary SS. HA frequency in tension-type HA (TTH) comorbid with TMD diagnoses of myofascial pain (MFP) or capsulitis/synovitis improved significantly with SS than that with full-arch maxillary non-occluding splint (NOS) in two studies. Comparison groups receiving hard partial-arch maxillary splint nociceptive trigeminal inhibition (NTI) showed statistically significant improvements in HA intensity in patients with mixed TMD phenotypes of MFP and disc displacement comorbid with "general HA." Comparison groups receiving partial-arch maxillary resilient/soft splint (Relax) showed significant improvements in both HA intensity and frequency in patients with HA concomitant with MFP. The meta-analysis showed no statistically significant difference in the improvement of pain intensity at 2-3 months with comparison of the splints (partial-arch soft [Relax], hard [NTI], and full-arch NOS) or splint use compliance at 6-12 months with comparison of the splints (partial-arch Relax and full-arch NOS) versus the SS groups in patients with various TMD-HA comorbidities. In conclusion, although SS therapy showed a statistically significant decrease in HA intensity and HA frequency when reported, the evidence quality was low due to the high bias risk and small sample size. Therefore, further studies are required.

Yield and Seed Quality Changes According to Delayed Harvest with Rainfall Treatment in Soybean (Glycine max L.) (강우처리 및 수확 지연에 따른 콩 종실 특성 및 수량성 변화)

  • Lee, Inhye;Seo, Min-Jung;Park, Myoung Ryoul;Kim, Nam-Geol;Yi, Gibum;Lee, Yu-young;Kim, Mihyang;Lee, Byong Won;Yun, Hong-Tae
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.65 no.4
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    • pp.353-364
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    • 2020
  • Recently in Korea, soybean harvesting has been delayed due to rainfall during the harvesting season, resulting in a reduction in yield and seed quality. This study was conducted to analyze the changes in yield and seed quality during delayed harvest with rainfall treatment using different harvesting methods, including field harvesting and polyethylene film covering after cutting fully-matured soybean plants (PE covering after cutting), with two major Korean soybean cultivars (Glycine max L), Pungsannamulkong and Daewonkong. The shattering rate of Pungsannamulkong, which is higher than that of Daewonkong, increased up to 41.8% when the harvest was delayed for 40 days without rainfall treatment by harvesting with PE covering after cutting. The weight of 100 seeds tended to decrease slightly as harvesting was delayed. When Daewonkong was harvested using the PE covering after cutting method with rainfall treatment, the yield decreased to the lowest level with a 0.8 kg ha-1 daily reduction rate. Pungsannamulkong showed the lowest yield when harvested using PE covering after cutting without rainfall treatment with a 3.4 kg ha-1 daily reduction rate. The infected seed rate increased according to the harvest delay in both cultivars, and significant differences were observed according to rainfall treatment and harvesting method. The germination rate was maintained above 95% even after 40 days of delayed harvest if there was no rainfall treatment. However, with rainfall treatment, the germination rate was significantly lowered as harvesting time was delayed. In the field harvesting with rainfall treatment, the germination rate decreased to 77.2% for Daewonkong and 76.5% for Pungsannamulkong after 40 days of harvest delay. For the 100-seed weight, effects of individual treatments and interactions between treatments were not observed. In contrast, the effect of interactions between treatments on the shattering rate was significant in both cultivars, indicating that the shattering rate had the greatest impact on the yield changes during delayed harvest.

The effect of supercritical water treatment on the chemical variations of lignin (목질바이오매스의 초임계수 처리에 의한 리그닌의 화학적 변환)

  • Lee, Soo-Min;Lee, Oh-Kyu;Choi, Seok-Hwan;Choi, Joon-Weon;Choi, Don-Ha
    • 한국신재생에너지학회:학술대회논문집
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    • 2008.05a
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    • pp.206-209
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    • 2008
  • The modified supercritical water treatment method is adopted for hydrolysis of wood powder, Populus alba$\times$glandulosa. This modified method is containing 0.05% HCl or $HNO_3$ as acid catalyst. The supercritical water treatment(SCW) was performed for 1 min. with $350^{\circ}C$, $380^{\circ}C$, $400^{\circ}C$ and $425^{\circ}C$, respectively, under 230 $\pm$ 10 atm using continuous flow system. When acid was added to powder prepared for SCW treatment, the yields of monomeric sugars were significantly increased. The lignin remained after supercritical treatment was applied to gel permeation chromatography(GPC) for molecular weight distribution analysis. Compared to the lignin produced from SCW treatment without acid catalyst, the average molecular weight of lignin compounds treated with acid was clearly decreased. Particularly, Mn/Mw ratio is decreased. This result shows supercritical water treatment of wood powder can change the molecular weight of lignin to small size. However, it is necessary to be further studied for exactly characterizing the lignin produced from supercritical water treatment.

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Roller Design of IRB Seismic Isolation Device Using Test Evaluation : Part II. Heat Treatment of Material (시험평가법을 이용한 IRB 면진장치 롤러 설계 : Part 2. 소재 열처리)

  • Park, Young-Gee;Ha, Sung Hoon;Seong, Min-Sang;Jeon, Junchul;Choi, Seung-Bok
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.23 no.4
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    • pp.332-337
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    • 2013
  • This paper presents a subsequent research work on the roller design of IRB(isolation roller bearing) seismic isolation device presented in Part 1 by focusing on heat treatment. The hardness and friction factor are very important factors of material and after-treatment process selection. Normally, roller bearing consists of roller and retainer. The roller gets high pressure constantly, while the retainer gets tensile and compressive stress. Therefore, sensitive material selection and heat treatment of each part is quite important. In this experimental evaluation, carbon steel, chrome special steel and others are employed and their characteristics after heat treatment are identified. Each material is prepared by refining high frequency heat treatment. The friction factor and static load capacity of manufactured material are experimentally identified and destructive test of material is processed. Optimal material and heat treatment conditions for IRB roller bearing are determined based on experiment results.

Korean Medical Treatment after Surgical Treatment of Necrotizing Fasciitis on Thigh : A Case Report (대퇴부 괴사성 근막염의 외과적 수술 후 한방치료에 대한 증례 보고)

  • Geum, Ji-Hye;Ha, Won-Bae;Lee, Jung-Han
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.13 no.2
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    • pp.85-95
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    • 2018
  • Objectives : The aim of the present study was to report the clinical progress of a patient who underwent surgical treatment of necrotizing fasciitis. Methods : During the admission period, The patient was treated with acupuncture, cupping, Korean Medicine, Chuna therapy every day and observed by Numeric Rating Scale(NRS), Pain Disability Index(PDI), Beck Depression Inventory(BDI), and assessment about range of motion(ROM) and manual muscle test(MMT) for hip & knee joint. Results : After treated by using above treatment, NRS, PDI, BDI and ROM, MMT were improved. Conclusions : Korean Medical treatment are estimated to be good for patients after surgical treatment of necrotizing fasciitis. But more cases are required to prove the effectiveness of the treatment.

Effects of Oyster Shell Lime on Barley Growth and Soil Microbe in an Upland Soil (패화석이 보리생육과 토양 미생물상에 미치는 영향)

  • Lee, Young-Han;Sonn, Yeon-Kyu;Lee, Seong-Tae;Heo, Jae-Young;Kim, Min-Keun;Kim, Eun-Seok;Song, Won-Doo;Kim, Dae-Ho;Ok, Yong-Sik
    • Korean Journal of Soil Science and Fertilizer
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    • v.45 no.4
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    • pp.610-613
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    • 2012
  • Oyster shell has a high content of $CaCO_3$ to be used as a acidic soil amendment. To enhance productivity of barley and soil microbe in an upland soil, oyster shell and calcium-magnesium carbonate were selected as a soil amendments in this study. A field experiment was treated no treatment (hereafter, control), oyster shell lime $3.09Mg\;ha^{-1}$ and $2.38Mg\;ha^{-1}$, and calcium-magnesium carbonate $2.38Mg\;ha^{-1}$ as amount of lime requirement in silt loam soil. The yield of barley from the oyster shell lime treatment was the highest. The protein content of barley was the highest of 11.1% in the calcium-magnesium carbonate, followed by 10.7% for the control, 10.6% for the oyster shell lime $3.09Mg\;ha^{-1}$, and 10.4% for the oyster shell lime $2.38Mg\;ha^{-1}$. Soil pH value was higher than that of control in harvesting stage. In addition, the population of soil bacteria was highest in oyster shell lime $2.38Mg\;ha^{-1}$, actinomycetes was highest in calcium-magnesium $2.38Mg\;ha^{-1}$. We concluded that the oyster shell lime can be effective to restore soil nutrient and microbe balance in an upland soil.