통합 검색 | Korea Science

Jin, Yu-Jin;Ubonvan, Termsarasab;Kim, Dae-Duk
- Journal of Pharmaceutical Investigation
- /
- 제40권spc호
- /
- pp.33-43
- /
- 2010
Hyaluronic acid (HA) is a biodegradable, biocompatible, non-toxic, non-immunogenic and non-inflammatory linear polysaccharide, which has been used for various medical applications including arthritis treatment, wound healing, ocular surgery, and tissue augmentation. Because of its mucoadhesive property and safety, HA has received much attention as a tool for drug delivery system development. It has been used as a drug delivery carrier in both nonparenteral and parenteral routes. The nonparenteral application includes the ocular and nasal delivery systems. On the other hand, its use in parenteral systems has been considered important as in the case of sustained release formulation of protein drugs through subcutaneous injection. Particles and hydrogels by various methods using HA and HA derivatives as well as by conjugation with other polymer have been the focus of many studies. Furthermore, the affinity of HA to the CD44 receptor which is overexpressed in various tumor cells makes HA an important means of cancer targeted drug delivery. Current trends and development of HA as a tool for drug delivery will be outlined in this review.
https://doi.org/10.4333/KPS.2010.40.S.033 인용 PDF KSCI

Park, Jin-Sam;Huh, Jeung-Soo;Kim, Hyung-Sun
- 한국세라믹학회지
- /
- 제37권12호
- /
- pp.1131-1134
- /
- 2000
Hydroxyapatite (HA) ceramic was prepared using tuna bone powders and was characterized on properties of sintered samples. The aim was to prepare dense and bulk HA sintered suitable for clinical applications. Thermal analysis, X-ray diffraction analysis, microscopic observation, and mechanical evaluation were applied to characterize sintered HA to find optimum processing condition. The major phase of sintered HA was observed up to 1300$\^{C}$ and $\beta$-TCP was observed as temperature increased. The density of sintered HA was increased up to 1350$\^{C}$ and decreased with further increasing temperature. The flexural strength of sintered HA at 1350$\^{C}$ showed 58 MPa as the highest value in this work. The results suggest that the crystal phase and transformation characteristics of HA prepared from tuna bone are the same as the behavior of HA powders made by chemical synthesis.
PDF

김경진;김재홍
- 농업과학연구
- /
- 제34권2호
- /
- pp.189-200
- /
- 2007
The purpose of this study is to evaluate the farmland scale improvement project and to present basic data for establishing a long-term improvement scheme of this project. Professional rice cultivators' farming scale after receiving the farmland scale improvement fund has increased compared to the situation before receiving the fund support. The average paddy fields increased by 220% (from 2.75ha to 8.82ha), the average upland increased by 27% (from 0.44ha to 0.56ha), and the average orchard land increased by 44% (from 0.25ha to 0.36ha). The rice production costs per 10a are estimated as 608,678won for below 3ha, 488,721won for 3-6ha, 487,431won for 6~10ha, and 425,313won for over 10ha, which decreased with increasing farming scale. The effects of the farmland scale improvement project on income variation are summarized as follows. 1) Average farm household income for all subjects has increased by 223 % (from 40,517,000won to 90,295,000won). 2) For each category, the results show that average farm household income has increased by 9,766,000won for below 3ha, 35,898,000won for 3~6ha, 42,822,000won for 6~10ha, and 72,697,000won for over 10ha.
PDF

강경진;강나진;한상철;구동환;김영수;이진혁;김상철;박덕훈;이종성;강희경;유은숙
- 생약학회지
- /
- 제43권3호
- /
- pp.217-223
- /
- 2012
In the present study, we investigated anti-inflammatory activity of artemisinic acid in HaCaT cells and RAW264.7 cells. Artemisinic acid showed inhibitory activity on macrophage-derived chemokines (MDC) expression, a factor related with atopic dermatitis (AD), in interferon (IFN)-${\gamma}$ and tumor necrosis factor (TNF)-${\alpha}$-stimulated HaCaT cells. In the study on action mechanism, pretreated artemisinic acid reduced the phosphorylation of STAT1 and p38 and the degradation of $I{\kappa}B$ by IFN-${\gamma}$ and TNF-${\alpha}$ stimulations. However, artemisinic acid didn't show the inhibitory activity on LPS-induced inflammatory mediators (NO, $PGE_2$, IL-6) in RAW264.7 cell. These results indicate that artemisinic acid inhibits IFN-${\gamma}$ and TNF-${\alpha}$-induced MDC expression through inhibition of signal factors, STAT1, NF-${\kappa}B$, and p38, in HaCaT keratinocytes.
PDF KSCI