• International Journal of Internet, Broadcasting and Communication
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• 제14권2호
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• pp.30-35
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• 2022

Rendering is widely used for visual effects in animations and movies. Although rendering is computing-intensive, we observe that it accompanies heavy I/O because of large input data. This becomes technical hurdles for multi-node rendering performed on public cloud nodes. To reduce the overhead of data transmission in multi-node rendering, this paper analyzes the characteristics of rendering workloads, and presents the cooperative caching scheme for multi-node rendering. Our caching scheme has the function of synchronization between original data in local storage and cached data in rendering nodes, and the cached data are shared between multiple rendering nodes. We perform measurement experiments in real system environments and show that the proposed cooperative caching scheme improves the conventional caching scheme used in the network file system by 27% on average.

• Molecules and Cells
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• 제45권5호
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• pp.284-290
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• 2022

Exosome, a type of nanoparticles also known as small extracellular vesicles are gaining attention as novel therapeutics for various diseases because of their ability to deliver genetic or bioactive molecules to recipient cells. Although many pharmaceutical companies are gradually developing exosome therapeutics, numerous hurdles remain regarding manufacture of clinical-grade exosomes for therapeutic use. In this mini-review, we will discuss the manufacturing challenges of therapeutic exosomes, including cell line development, upstream cell culture, and downstream purification process. In addition, developing proper formulations for exosome storage and, establishing good manufacturing practice facility for producing therapeutic exosomes remains as challenges for developing clinical-grade exosomes. However, owing to the lack of consensus regarding the guidelines for manufacturing therapeutic exosomes, close communication between regulators and companies is required for the successful development of exosome therapeutics. This review shares the challenges and perspectives regarding the manufacture and quality control of clinical grade exosomes.

• Educational Technology International
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• 제24권1호
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• pp.81-114
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• 2023

The study aimed to qualitatively examine middle school students' engagement in distance instruction during the COVID-19 pandemic. The participants comprised 119 students from a girls' middle school in Seoul, South Korea. To gain an in-depth understanding of the students' experiences, we collected their reflective journals, which included structured items about their learning engagement at three timepoints in 2020: April, July, and December. The following are the results: 10 themes and 18 concepts were derived, and they were integrated into causal conditions (sudden transition due to COVID-19), contextual condition (technology readiness, school education context), central phenomena (high level of behavioral engagement, low emotional engagement), interventional conditions (recognizing the potential of online learning, situational awareness about COVID-19 and online learning), action/interaction phenomena (development and use of self-regulated learning strategies), and consequences (changes in practices and perception towards online learning). Based on the findings, engagement patterns of the participants were classified into five types: proactive, conservative, receptive, reactive, passive learners. The present study demonstrated important findings that are essential for the improvement and development of engaging online learning strategies in the future.

• 대한의생명과학회지
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• 제29권4호
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• pp.371-375
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• 2023

Natural killer (NK) cells are innate immune cells and play important roles as the first immune cells to recognize and kill cancer. In patients with advanced and terminal cancer, NK cells are often inactivated, suggesting that NK cells may play important roles in cancer treatment. In particular, the proportion of NK cells among immune cells infiltrating tumor tissues is often low, which suggests that NK cells do not survive in tumor microenvironment (TME). In order to overcome these hurdles of NK cells in cancer treatment, it is critical to develop strategies that enhance the proliferation and cytolytic activity of NK cells. We applied Vemurafenib to NK cells and measured the degree of NK cell proliferation and functional activation. We obtained unexpected results of increased NK cell numbers and anti-tumor activity after Vemurafenib treatment. Although further investigation is required to uncover the detailed mechanisms, our results suggest that Vemurafenib is a promising candidate to increase the efficacy of cancer immunotherapy using NK cells.

• 동아시아경상학회지
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• 제12권2호
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• pp.29-34
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• 2024

Purpose: The primary objective of this study was to examine the influence of economic democratization on economic development from diverse perspectives. Research design, Data methodology: Justification of the qualitative literature methods used in this study is essential, as extensive descriptions, justifications, and explanations of the methods used allow researchers to increase the reliability of their studies for specific or specified audiences. Initially, the concept and principal attributes of economic democratization were scrutinized, followed by an exploration of its manifold effects on economic development. Results: Consequently, this study facilitated a comprehensive comprehension of how economic democratization fosters economic growth and advancement in contemporary society. Additionally, the study deliberated on the constraints and hurdles of economic democratization, proposing policy recommendations for future mitigation. Conclusion: In conclusion, this study is anticipated to furnish foundational data for regional economic development to both academia and policymakers. It achieves this by thoroughly evaluating the impact of economic democratization on economic development and delving into the dynamic interaction between democracy and economic progress.

• Journal of applied mathematics & informatics
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• 제42권1호
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• pp.77-83
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• 2024

Chung defined a pebbling move on a graph G as the removal of two pebbles from one vertex and the addition of one pebble to an adjacent vertex. The monophonic pebbling number guarantees that a pebble can be shifted in the chordless and the longest path possible if there are any hurdles in the process of the supply chain. For a connected graph G a monophonic path between any two vertices x and y contains no chords. The monophonic pebbling number, µ(G), is the least positive integer n such that for any distribution of µ(G) pebbles it is possible to move on G allowing one pebble to be carried to any specified but arbitrary vertex using monophonic a path by a sequence of pebbling operations. The aim of this study is to find out the monophonic pebbling numbers of the sun graphs, (C_n × P₂) + K₁ graph, the spherical graph, the anti-prism graphs, and an n-crossed prism graph.

• 반도체디스플레이기술학회지
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• 제23권1호
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• pp.79-83
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• 2024

Digital Twin technology is rapidly transforming various industries by providing comprehensive virtual models that replicate physical objects or processes. In the context of agriculture, digital twin can be a game-changer. This technology can help in creating precise simulations of farming scenarios, thereby enabling farmers to make data-driven decisions and optimize farm operations. The potential benefits include improved crop yields, resource efficiency, and environmental sustainability. However, the implementation of digital twin technology in agriculture poses challenges, such as data management issues and the need for robust IoT infrastructure. Despite these hurdles, the future of digital twin in agriculture looks promising, with ongoing research and developments aimed at overcoming these obstacles.

• Clinical Endoscopy
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• 제55권5호
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• pp.594-604
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• 2022

Over the past decade, technological advances in deep learning have led to the introduction of artificial intelligence (AI) in medical imaging. The most commonly used structure in image recognition is the convolutional neural network, which mimics the action of the human visual cortex. The applications of AI in gastrointestinal endoscopy are diverse. Computer-aided diagnosis has achieved remarkable outcomes with recent improvements in machine-learning techniques and advances in computer performance. Despite some hurdles, the implementation of AI-assisted clinical practice is expected to aid endoscopists in real-time decision-making. In this summary, we reviewed state-of-the-art AI in the field of gastrointestinal endoscopy and offered a practical guide for building a learning image dataset for algorithm development.

• 한국운동역학회지
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• 제15권3호
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• pp.117-132
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• 2005

It was to study a following research of "A Kinematic Analysis of Air-rolling-breakfall in Judo". The purpose of this study was to analyze the Center of Gravity(COG) variables when performing Air-rolling-breakfall motion, while passing forward over(PFO) to the vertical-hurdles(2m height, take off board 1m height) in judo. Subjects were four males of Y. University squad, who were trainees of the demonstration exhibition team, representatives of national level judoists and were filmed by four 5-VHS 16mm video cameras(60field/sec.) through the three dimensional film analysis methods.COG variable were anterior-posterior directional COG and linear velocity of COG, vertical directional COG and linear velocity of COG. The data collections of this study were digitized by KWON3D program computed The data were standardized using cubic spline interpolation based by calculating the mean values and the standard deviation calculated for each variables. When performing the Air-rolling-breakfall, from the data analysis and discussions, the conclusions were as follows : 1. Anterior-posterior directional COG(APD-COG) when performing Air-rolling-breakfall motion, while PFO over to the vertical-hurdles(2m height) in judo. The range of APD-COG by forward was $0.31{\sim}0.41m$ in take-off position(event 1), $1.20{\sim}1.33m$ in the air-top position(event 2), $2.12{\sim}2.30m$ in the touch-down position(event 3), gradually and $2.14{\sim}2.32m$ in safety breakfall position(event 4), respectively. 2 The linear velocity of APD-COG was $1.03{\sim}2.14m/sec$. in take-off position(event 1), $1.97{\sim}2.22m/sec$. gradually in the air-top position(event 2), $1.05{\sim}1.32m/sec$. in the touch-down position (event 3), gradual decrease and $0.91{\sim}1.23m/sec$. in the safety breakfall position(event 4), respectively. 3. The vertical directional COG(VD-COG) when performing Air-rolling-breakfall motion, while PFO to the vertical-hurdles(2m height) in judo. The range of VD-COG toward upward from mat was $1.35{\sim}1.46m$ in take-off position(event 1), the highest $2.07{\sim}2.23m$ in the air-top position(event 2), and after rapid decrease $0.3{\sim}0.58m$ in the touch-down position(event 3), gradual decrease $0.22{\sim}0.50m$ in safety breakfall position(event 4), respectively. 4. The linear velocity of VlJ.COG was $1.60{\sim}1.87m/sec$. in take-off position(event 1), $0.03{\sim}0.08m/sec$. gradually in the air-top position(event 2), $-4.37{\sim}\;-4.76m/sec$. gradual decrease in the touch-down position(event 3), gradual decrease and -4.40${\sim}\;-4.77m/sec$. in safety breakfall position(event 4), respectively. When performing Air-rolling-breakfall showed parabolic movement from take-off position to air-top position, and after showed vertical fall movement from air-top position to safety breakfall. In conclusion, Ukemi(breakfall) is safety fall method Therefore, actions need for performing safety fall movement, that decrease and minimize shock and impact during Air-rolling-breakfall from take-off board action to air-top position must be maximize of angular momentum, and after must be minimize in touch-down position and safety breakfall position.

• 한국식품과학회지
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• 제38권1호
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• pp.35-41
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• 2006

Fresh-cut 사과의 미생물학적 품질 보존성 향상을 위해 미생물 생육억제 효과가 크다고 알려진 다양한 hurdle 인자를 개별 평가하고 이들의 병용처리 효과를 검토하여 적용 가능성을 확인하고자 하였다. Chitooligosaccharide와 GSE(grapefruit seed extrat)를 처리한 fresh-cut 사과는 저장 후반으로 혹은 농도가 높을수록 무처리구에 비해 총균수가 증가하는 현상이 나타나 미생물 증식억제를 위한 hurdle로써의 적용이 어렵다고 판단되었다. Citric acid의 경우 malic acid와 유사한 결과를 보였으나 0.75% 이상의 citric acid 처리구에서는 malic acid 처리구와 달리 $18^{\circ}C$ 저장 4일을 전후해 총균수가 증가하는 현상을 보였다. 이에 미생물 증식억제의 주요 hurdle로 malic acid를 선정하였고, 부가적인 hurdle로는 미생물 생육억제 효과를 나타내면서 갈변 및 조직연화를 지연시켜 주는 ascorbic acid와 calcium chloride로 선정하였다. 이들의 최적 dipping solution의 구성 및 함량은 미생물 저해 및 갈변 방지측면을 모두 고려하여 최소 0.25% malic acid: 0.5% ascorbic acid: 0.25% calcium chloride, 최대 0.75% malic acid: 1.0% ascorbic acid: 0.75% calcium chloride로 결정하였다.